Prof. Dr. Matthias Gunzer. Date of birth:

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1 Name: Prof. Dr. Matthias Gunzer Date of birth: Department: University of Magdeburg Institute of Molecular and Clinical Immunology Leipziger Str. 44 D Magdeburg Phone: Fax: Education: Sept July 1979 Primary school, Würzburg, Germany Sept May 1988 Humanistic Wirsberg-Gymnasium, Würzburg, Germany May 1988 A-levels Oct Dec military service, Hammelburg, Germany Jan Sept Anglistic, Julius-Maximilians-Universität, Würzburg, Germany Oct Oct Biology, Julius-Maximilians-Universität, Würzburg, Germany Oct pre-degree Biology Oct Oct Biochemistry, Universitäty of Witten/Herdecke, Witten, Germany Oct oral exam Biochemistry Jan Oct Diploma Thesis, Institute of Immunology, University of Witten/Herdecke, Prof. Zänker: Spontaneous migration of murine dendritic- and Langerhans cells within a threedimensional collagen matrix: modulation by cytokines and signalling via CD40 Jan May 1999 Doctoral Thesis, Institute of Immunology, University of Witten/Herdecke, Prof. Zänker: Charakterisierung und Quantifizierung der Migration dendritischer Zellen sowie ihrer Kommunikation mit T Lymphozyten auf der Basis einzelner Zellen in einer drei-dimensionalen Kollagenmatrix Postdoctoral training: June 1999 July 1999 Scientific assistant, Institute of Immunology, University of Witten/Herdecke, Prof. Zänker Aug Dec Scientific assistant, Institute for Cell biology, University of Münster, Dept. of Dermatology, Westfälische Wilhelmsuniversität Münster, Prof. Grabbe

2 Academic appointment: Jan Sep Leader of the junior research group Immunodynamics, Helmholtz Centre for Infection research, HZI (formerly German Research Centre for Biotechnology, GBF), Braunschweig, Germany State doctorate (Habilitation) in Immunology, Hannover Medical School Since W2 Professor for molecular Immunology and deputy head of the Institute of Molecular and Clinical Immunology, University of Magdeburg Other professional academic activities: Grant reviewer for DFG, IZKF Muenster, Boehringer Ingelheim Fonds, Alexander von Humboldt Stiftung (all Germany), The Wellcome Trust, MRC (both UK), The Marsden Fund Council (New Zealand), US-Israeli Binational foundation (USA), ANR (France) Site reviewer for the Agence d'evaluation de la Recherche et des établissements d'enseignement Supérieur (AERES, French government) Ad hoc reviewer for international journals (Nature Immunology, The Journal of Immunology, European Journal of Immunology, Trends in Immunology, Current Opinion in Immunology, Blood, FASEB Journal, Microbiology, The Journal of Investigative Dermatology, Experimental Dermatology, Cancer Immunology and Immunotherapy. PLoS Computational Biology, PLoS one, Trends in Immunology, Genes & Immunity, The Journal of Leukocyte Biology, PNAS). Advisor for the CDC (Atlanta, USA) and the Howard Hughes Medical Institute (USA) Awards: 2001 Forschungsförderpreis Haut und Umwelt, Fa. Gruenenthal First price fort the best poster of the ADF, Frankfurt 2007 Prize for the best teacher in the PhD program of the HZI Professional societies: Deutsche Gesellschaft für Zellbiologie Deutsche Gesellschaft für Immunologie Arbeitsgemeinschaft Dermatologische Forschung (ADF) Deutscher Hochschulverband (DHV)

3 Publications: Research papers: 1. Bruns S, Kniemeyer O, Hasenberg M, Aimanianda V, Nietzsche S, Thywißen A, Jeron A, Latge JP, Brakhage AA, Gunzer M (2010) Production of Extracellular Traps against Aspergillus fumigatus in vitro and in Infected Lung Tissue is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA. PLoS Pathog 6:e Garin A, Meyer-Hermann M, Contie M, Figge MT, Buatois V, Gunzer M, Toellner KM, Elson G, Kosco-Vilbois MH (2010) Toll-like Receptor 4 Signaling by Follicular Dendritic Cells Is Pivotal for Germinal Center Onset and Affinity Maturation. Immunity 33: Koehler A, Schmithorst V, Filippi MD, Ryan M, Daria D, Gunzer M*, and Geiger H*. (2009) Altered endosteal location and cellular dynamics of aged hematopoietic stem cells in the marrow of long bones in vivo. Blood 114(2): (*Gunzer and Geiger are corresponding authors, A. Koehler is PhD in the lab of Gunzer.) 4. Stegemann S, Dahlberg S, Kröger A, Gereke M, Bruder D, Henriques-Normark B and Gunzer M (2009) Increased susceptibility for superinfection with Streptococcus pneumoniae during influenza virus infection is not caused by TLR7-mediated lymphopenia. PLoS one 4(3):e Herroeder S, Reichardt P, Sassmann A, Zimmermann B, Hogg N, Hollmann MW, Fischer KD, Vogt S, Grosse R, Gunzer M, et al. (2009) G-proteins of the G 12 /G 13 family shape immune functions by controlling CD4 + T-cell adhesiveness. Immunity 30(5): Hosseini BH, Louban I, Djandji D, Wabnitz GH, Deeg J, Bulbuc N, Samstag Y, Gunzer M, Spatz JP, Hämmerling G (2009) Immune synapse formation determines interaction forces between T cells and antigen-presenting cell measured by atomic force microscopy. Proc Natl Acad Sci U S A 106 (42): Schumacher A, Brachwitz N, Sohr S, Engeland K, Langwisch L, Dolaptchieva M, Alexander T, Taran A, Fill Malfertheiner S, Dan Costa S, Zimmermann G, Nitschke C, Volk H-D, Alexander H, Gunzer M, Zenclussen A (2009) Human Chorionic Gonadotropin attracts regulatory T cells into the fetal-maternal interface during early human pregnancy. J Immunol 182(9): Horn J, Wang X, Reichardt P, Stradal TE, Warneke N, Simeoni L, Gunzer M, Yablonski D, Schraven B, Kliche S (2009) SLP76 is mandatory for TCR-mediated inside-out-signaling, but dispensable for CXCR4-mediated LFA-1 activation, adhesion and migration of T-cells. J Immunol 183 (9): Schütte M, Thullier P, Pelat T, Wezler X, Rosenstock P, Hinz D, Kirsch MI, Hasenberg M, Frank R, Schirrmann T, Gunzer M, Hust M, Dübel S (2009) Identification of a putative Crf splice variant and generation of recombinant antibodies for the specific detection of Aspergillus fumigatus. PLoS one 4:e Figge MT, Garin A, Gunzer M, Kosco-Vilbois M, Toellner KM and Meyer-Hermann ME (2008) Deriving a germinal center lymphocyte migration model from two-photon data. J Exp Med 205(13): (Cover) 11. Neumann J, Sauerzweig S, Rönicke R, Gunzer F, Dinkel K, Ullrich O, Gunzer M*, and Reymann KG*. (2008) Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes - a new mechanism of CNS immune privilege. J Neurosci 25: (*Gunzer and Reymann are corresponding authors) 12. Sasse S, Bignell EM, Hasenberg M, Haynes K, Gunzer M, Braus GH and Krappmann S (2008) Basal expression of the Aspergillus fumigatus transcriptional activator CpcA is sufficient to support pulmonary aspergillosis. Fungal Genet Biol 45: Waibler Z, Sender L, Merten C, Hartig R, Kliche S, Gunzer M, Reichardt P, Kalinke U, Schraven B (2008) Signaling Signatures and Functional Properties of Anti-human CD28 Superagonistic Antibodies. PLoS One 3:e1708.

4 14. Niesner RA, Narang P, Spiecker H, Andresen V, Gericke KH, Gunzer M (2008) Selective Detection of NADPH Oxidase in Polymorphonuclear Cells by means of NAD(P)H-Based Fluorescence Lifetime Imaging. J Biophys 2008: Article ID Behnsen J, Narang P, Hasenberg M, Gunzer F, Bilitewski U, Klippel N, Rohde M, Brock M, Brakhage AA, Gunzer M (2007) Environmental Dimensionality Controls the Interaction of Phagocytes with the Pathogenic Fungi Aspergillus fumigatus and Candida albicans. PLoS Pathog 3:e Niesner R, Andresen V, Neumann J, Spiecker H and Gunzer M (2007) The power of singleand multibeam 2-photon microscopy for high-resolution and high-speed deep tissue and intravital imaging. Biophys.J 93, 7, (Cover) 17. Ehrchen J, Helming L, Varga G, Pasche B, Loser K, Gunzer M, Sunderkotter C, Sorg C, Roth J, Lengeling A (2007) Vitamin D receptor signaling contributes to susceptibility to infection with Leishmania major. FASEB J 21: Reichardt P, Dornbach B, Song R, Beissert S, Gueler F, Loser K, Gunzer M (2007) Naive B cells generate regulatory T cells in the presence of a mature immunological synapse. Blood 110: (Cover) 19. Neumann J, Gunzer M, Gutzeit HO, Ullrich O, Reymann KG, Dinkel K (2006) Microglia provide neuroprotection after Ischemia. FASEB J 20: Gunzer M, Riemann H, Basoglu Y, Hillmer A, Weishaupt C, Balkow S, Benninghoff B, Ernst B, Steinert M, Scholzen T, Sunderkotter C, Grabbe S (2005) Systemic administration of a TLR7 ligand leads to transient immune incompetence due to peripheral blood leukocyte depletion. Blood 106: (Gunzer is corresponding author.) 21. Gunzer M, Weishaupt C, Hillmer A, Basoglu Y, Friedl P, Dittmar KE, Kolanus W, Varga G, Grabbe S (2004) A spectrum of biophysical interaction modes between T cells and different antigen presenting cells during priming in 3-D collagen and in vivo. Blood 104: (Gunzer is corresponding author. Cover.) 22. Rharbaoui F, Westendorf A, Link C, Felk S, Buer J, Gunzer M, Guzman CA (2004) The Mycoplasma-Derived Macrophage-Activating 2-Kilodalton Lipopeptide Triggers Global Immune Activation on Nasal Mucosa-Associated Lymphoid Tissues. Infect Immun 72: Shpacovitch VM, Varga G, Strey A, Gunzer M, Mooren F, Buddenkotte J, Vergnolle N, Sommerhoff CP, Grabbe S, Gerke V, Homey B, Hollenberg M, Luger TA, Steinhoff M (2004) Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices. J Leukoc Biol 76: Manitz MP, Horst B, Seeliger S, Strey A, Skryabin BV, Gunzer M, Frings W, Schonlau F, Roth J, Sorg C, Nacken W (2003) Loss of S100A9 (MRP14) results in reduced interleukin-8- induced CD11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitro. Mol Cell Biol 23: Matussek A, Lauber J, Bergau A, Hansen W, Rohde M, Dittmar KE, Gunzer M, Mengel M, Gatzlaff P, Hartmann M, Buer J, Gunzer F (2003) Molecular and functional analysis of Shiga toxin induced response patterns in human vascular endothelial cells. Blood 102: Ständer S, Gunzer M, Metze D, Luger T, Steinhoff M (2002) Localization of µ-opioid receptor 1A on sensory nerve fibers in human skin. Regul Pept 110: Gunzer M, Weishaupt C, Planelles L, Grabbe S (2001) 2-step negative enrichment of CD4 + and CD8 + T cells from murine spleen via nylon wool adherence and an optimized antibody cocktail. J Immunol Methods 258: Entschladen F, Gunzer M, Scheuffele CM, Niggemann B, Zänker KS (2000) T Lymphocytes and Neutrophil Granulocytes Differ in Regulatory Signaling and Migratory Dynamics with Regard to Spontaneous Locomotion and Chemotaxis. Cell Immunol 199: Gunzer M, Schäfer A, Borgmann S, Grabbe S, Zänker KS, Bröcker E-B, Kämpgen E, Friedl P (2000) Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity 13:

5 30. Gunzer M, Friedl P, Niggemann B, Bröcker E-B, Kämpgen E, Zänker KS (2000) Migration of dendritic cells within 3-D collagen lattices is dependent on tissue origin, state of maturation, and matrix structure and is maintained by proinflammatory cytokines. J Leukoc Biol 67: (Gunzer is corresponding author) 31. Schwarz A, Beissert S, Grosse-Heitmeyer K, Gunzer M, Bluestone JA, Grabbe S, Schwarz T (2000) Evidence for Functional Relevance of CTLA-4 in Ultraviolet-Radiation-Induced Tolerance. J Immunol 165: Gunzer M, Kämpgen E, Bröcker E-B, Zänker KS, Friedl P (1997) Migration of dendritic cells in 3D-collagen lattices: visualisation of dynamic interactions with the substratum and the distribution of surface structures via a novel confocal reflection imaging technique. Adv Exp Med Biol 417: Reviews: 1. Reichardt P, Dornbach B, Gunzer M (2010) APC, T cells and the immune synapse. Curr Top Microbiol Immunol 340: (Cover) 2. Reichardt P, Hämmerling G, Gunzer M (2009) Imaging immunity. Eur J Immunol 39: Frischknecht F, Gunzer M, Shorte SL (2009) Retrospective: Birth of the cool - imaging and microbiology from Ibn al-haytham to Jean Comandon. Biotechnol J 4: Nitschke C, Garin A, Kosco-Vilbois M, Gunzer M (2008) 3-D and 4-D imaging of immune cells in vitro and in vivo. Histochem Cell Biol 130: Niesner RA, Andresen V, Gunzer M (2008) Intravital 2-photon microscopy focus on speed and time resolved imaging modalities. Immunol Rev 221: Reichardt P, Dornbach B and Gunzer M (2007) The molecular makeup and function of regulatory and effector synapses. Immunol Rev 218, Reichardt P, Gunzer F and Gunzer M (2007) Analyzing the physicodynamics of immune cells in a 3-D collagen Matrix. Methods Mol Biol 380, Gunzer M (2007) Migration. cell-cell interaction and adhesion in the immune system. Ernst Schering Found Symp Proc 3: Cohen-Kaminsky S, Bousso P and Gunzer M (2007) Imaging the immunological synapse. Eur J Immunol 37, Geiger H, Koehler A and Gunzer M (2007) Stem Cells, Aging, Niche, Adhesion and Cdc42: A Model for Changes in Cell-Cell Interactions and Hematopoietic Stem Cell Aging. Cell Cycle 6 (8), Schiller M, Metze D, Luger TA, Grabbe S and Gunzer M (2006) Immune Response Modifiers Mode of action. Exp Dermatol 15, Reichardt P and Gunzer M (2006) The biophysics of T lymphocyte activation in vitro and in vivo. Results Probl Cell Differ 43, Friedl P, den Boer AT and Gunzer M (2005) Tuning immune responses: diversity and adaption of the immunological synapse. Nat Rev Immunol 5(7), Friedl P and Gunzer M (2001) Interaction of T cells with APCs: the serial encounter model. Trends Immunol 22, (Cover) 15. Gunzer M and Grabbe S (2001) Dendritic cells in cancer immunotherapy. Crit Rev Immunol 21(1-3), Gunzer M, Janich S, Varga G and Grabbe S (2001) Dendritic cells and tumor immunity. Semin Immunol 13,

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