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1 1 von :42 Your source for the latest research news Breaking: Master Orchestrator of Genome Dis Science News from research organizations Oral milk thistle extract stops colorectal cancer stem cells from growing tumors Date: April 20, 2015 Related Stories Plant Extract Fights Brain Tumor Source: Summary: University of Colorado Denver A new study shows that orally administering the chemical silibinin, purified from milk thistle, slows the ability of colorectal cancer stem cells to grow the disease. When stem cells from tumors grown in silibinin-fed conditions were re-injected into new models, the cells failed to develop equally aggressive tumors even in the absence of silibinin. Feb. 11, 2015 Silibinin from milk thistle seeds could be a novel, non-invasive treatment strategy for Cushing Disease. Cushing Disease, not to be confused with Cushing's Syndrome, is caused by a tumor in the... read more Share: FULL STORY Total shares: 198 In results presented at the American Association for Cancer Research (AACR) Annual Meeting 2015, a University of Colorado Cancer Center study shows that orally administering the chemical silibinin, purified from milk thistle, slows the ability of colorectal cancer stem cells to grow the disease. When stem cells from tumors grown in silibinin-fed conditions were re-injected into new models, the cells failed to develop equally aggressive tumors even in the absence of silibinin. "It's very simple: tumors from mice that were initially fed silibinin had fewer cancer stem cells, were smaller, had lower metabolisms and showed decreased growth of new blood vessels. Importantly, when these cancer stem cells from tumors in mice fed silibinin were re-injected into new mice, we found these stem cells had lost their potential to repopulate even in the absence of silibinin exposure," says Rajesh Agarwal, PhD, co-program leader of Cancer Prevention and Control at the CU Cancer Center and professor at the Skaggs School of Pharmacy and Pharmaceutical Sciences. Silibinin is a non-toxic, potentially chemopreventive agent derived from milk thistle seeds. Results presented by Agarwal and colleagues at last year's AACR Annual Meeting showed that, in cell cultures, silibinin affects cell sig- Silibinin, Found in Milk Thistle, Protects Against UV-Induced Skin Cancer Jan. 30, 2013 Milk thistle extract, silibinin, kills skin cells mutated by UVA radiation and protects against damage by UVB radiation -- thus protecting against UV-induced skin cancer and photo-aging, according to... read more Cancer Stem Cell Vaccine in Development Shows Antitumor Effect Apr. 2, 2012 Stem cells had greater effect than differentiated tumor cells in eliciting antitumor immunity in vivo. Antibodies and T cells targeted cancer stem cells in laboratory models. Data could provide a... read more Milk Thistle Extract Stops Lung Cancer in Mice, Study Shows Nov. 15, 2011 A new study shows that the milk thistle extract, silibinin, interferes with cell signaling that otherwise leads to the production of tumor-causing enzymes COX2 and... read more Strange & Offbeat HEALTH & MEDICINE

2 2 von :42 naling associated with the formation and survival of colorectal cancer stem cells. The current study extends this promising line of research into mouse models. Specifically, the group used sorted colorectal cancer stem cells to grow tumors in mice that were either fed or not fed with silibinin. Tumor growth was measured by visible size, MRI scan and measurement of tumor metabolism (glucose use). These tumors cells either unsorted or sorted for cancer stem cells were then re-injected in mice to measure their growth pattern in next generations in the absence of silibinin feeding. "We have been deeply involved in this line of research that extends from silibinin to its chemopreventive properties in colorectal cancer, and the current study takes another important step: we see both a likely chemopreventive and a therapeutic mechanism and the result of this mechanism in animal models," says Sushil Kumar, PhD, postdoctoral fellow in the Agarwal Lab. The group continues to investigate the molecular mechanisms, cell culture, and animal model effects of silibinin toward a likely human clinical trial of silibinin in cancer preventative and/or treatment settings. Story Source: The above story is based on materials provided by University of Colorado Denver. Note: Materials may be edited for content and length. Cite This Page: University of Colorado Denver. "Oral milk thistle extract stops colorectal cancer stem cells from growing tumors." ScienceDaily. ScienceDaily, 20 April <www.sciencedaily.com/releases/2015/04/ htm>. Share This Page: MLA APA Chicago 'Make Like a Bat : Two Ears Attuned to High Frequencies Help People Find Objects Using Echoes Viagra to Prevent Transmission of the Malaria Parasite? Antioxidant Effects of Coffee by-products 500 Times Greater Than Vitamin C MIND & BRAIN Rewards Mapping App Turns Art Into a Sharable Walking Route More Sex Doesn't Lead to Increased Happiness Cooperative Video Game Play Elicits Pro-Social Behavior, Research Finds Carrot or Stick? Punishments May Guide Behavior More Effectively Than Popular Electric Brain Stimulation Method Used to Boost Brainpower Is Detrimental to IQ Scores LIVING & WELL RELATED TOPICS Health & Medicine Stem Cells Brain Tumor Colon Cancer Sounds First Evolutionary History of 50 Years of Music Charts Using Big Data Analysis of Late-Night Snacking: Is It Your Brain's Fault? Social Factors May Not Be Necessary to Produce or Explain Conformity Plants & Animals Mice Framing Time in Days Instead of Years Could Spur Action Toward Goals Biotechnology Biotechnology and Bioengineering Other News SCIENCE from NewsDaily

3 3 von :42 RELATED TERMS Stem cell Embryonic stem cell Adult stem cell Cancer Bone marrow transplant Brain tumor Failed Russian spacecraft falls from orbit, burns up Huffing and puffing won't blow these straw homes down SpaceX puts Dragon passenger spaceship through test run Deep-sea microbes called missing link for complex cellular life Brain technology patents soar as companies get inside people's heads HEALTH Recommended Content Health & Medicine News May 9, 2015 Liberia declared Ebola-free, but outbreak continues over border California may require warnings on products containing chemical BPA China to increase health care subsidies, deepen reform Master Orchestrator of Genome Discovered Sleep Loss Impedes Decision Making in Crisis People Using Echoes to Locate 'Silent' Objects How Bacteria Fight Off Invaders Heroin sends more young adults to California emergency rooms After cuts in California dental insurance, ER visits went up ENVIRONMENT Tornado kills one in north Texas, several twisters touch down in Colorado Transformer fire causes shut-down of nuclear reactor north of New York City Tropical Storm Ana threatens Carolinas with rough surf, rain Nepal earthquake survivors turn to rebuilding homes and lives 'Ana' becomes tropical storm as it moves toward Carolinas Latest Headlines Altering Genes With the Aid of Light updated 12:56 pm ET May 8, 2015 Scientists have been manipulating genes for a while. Now researchers have found a way to control the process with higher precision, by using... read more Eat Dark Chocolate to Beat the Midday Slump? TECHNOLOGY Fiat Chrysler CEO says met with Tesla, Apple CEOs EU, U.S. close to data sharing deal for security cases: sources Seeing and believing: Virtual reality set to conquer living rooms USAA creates research team to study use of bitcoin technology Cuba says in advanced talks with China's Huawei over telecoms May 8, 2015 An EEG study shows chocolate can increase brain characteristics of attention and significantly affect blood pressure levels. Historically, chocolate has been recognized as a... read more

4 4 von :42 New Combination Treatment Strategy to 'Checkmate' Glioblastoma May 8, 2015 Therapies that specifically target mutations in a person's cancer have been much-heralded in recent years, yet cancer cells often find a way around them. To address this,... read more When Do Mothers Need Others? May 8, 2015 New research examines how mothers underwent a remarkable transition from the past when they had one dependent offspring at a time, ended support of their young at weaning... read more Clinical Decision Tools in Electronic Medical Records Can Reduce Childhood Radiation Exposure May 8, 2015 Childhood exposure to ionizing radiation increases lifetime malignancy risk, but a team of researchers has found that with just a little bit of... read more Why Do Some Prostate Cancer Patients Experience More Hot Flashes Than Others? May 8, 2015 Androgen deprivation therapy (ADT) is a common treatment option for patients with advanced stage prostate cancer. But nearly 80 percent of patients... read more Protein Aggregates Save Cells During Aging May 8, 2015 As organisms age, a gradual loss of cellular protein quality control occurs. This results in increased production of toxic protein clumps, so-called aggregates. Using a... read more It Doesn't Take a Brain Injury to Have Headache, Dizziness and Cognitive Impairment May 8, 2015 Researchers have provided an explanation for why many people with even very trivial head injuries, or even injuries to other parts of their bodies,... read more Discovery Accelerates Targeted Cancer Treatment May 8, 2015 A method to help shorten the road to better cancer treatment has been developed by an international team of researchers. When DNA is damaged, several different proteins start pouring in to repair the... read more

5 5 von :42 Environmental Exposure to Hormones Used in Animal Agriculture Greater Than Expected May 8, 2015 Research by environmental scientists finds that potentially harmful growth-promoting hormones used in beef production are expected to persist in the... read more more stories Latest Videos from news services Why It Took So Long For A City To Ban Tobacco In Baseball Ebola Found In Survivor's Eye Months After Treatment How Ebola Can Hide In The Body Millennials More Open To Premarital Sex, Fewer Partners more videos Free Subscriptions Get the latest science news with ScienceDaily's free newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader: Newsletters RSS Feeds Follow Us Keep up to date with the latest news from ScienceDaily via social networks: Facebook Twitter Google+ LinkedIn Mobile Apps Get the latest news from ScienceDaily via our free mobile apps, available for download on the following platforms: Have Feedback? Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?

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