Assoc. Prof. Muharrem Kaya. Dumlupinar University, Faculty of Science and Arts Department of Biochemistry, Evliya Çelebi Campus 43100, Kütahya, TURKEY

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1 Assoc. Prof. Muharrem Kaya Dumlupinar University, Faculty of Science and Arts Department of Biochemistry, Evliya Çelebi Campus 43100, Kütahya, TURKEY EDUCATION Gazi University, Institute of Sciences and Technology, Ph.D, Organic Chemistry Ph.D Thesis and Advisor: Thesis Title: Synthesis of Acridinedion Type Organic Dye Laser and Investigation of Their Applicability Advisor: Prof. Dr. Yılmaz YILDIRIR Dumlupınar University, Institute of Sciences and Technology, M.S, Organic Chemistry Master Thesis and Advisor: Thesis Title: Synthesis and Characterization of Transition Metal Complexes with A New Imine-oxime Ligand Advisor: Assist. Prof. Cengiz YENİKAYA Nigde University, Arts and Sciences Faculty, B.Sc, Chemistry RESEARCH EXPERIENCE 2014 Currently Assoc. Prof., Dumlupinar University, Biochemistry Department Assoc. Prof., Dumlupinar University, Chemistry Department Assist. Prof., Dumlupinar University, Chemistry Department Research Assistant, Gazi University, Chemistry Department Research Assistant, Dumlupinar University, Chemistry Department

2 RESEARCH PROJECTS 2014 Dumlupınar University Research Project: Synthesis of 5-substituted-1H-tetrazole using new generation nanocatalyst Project Coordinator Turkish Sciences Foundation Research Project: 114Z044 Synthesis of acridine-acetazolamide derivatives of use as drug Glaucoma Project Coordinator Dumlupınar University Research Project: The synthesis of benzoxanthene ring system containing new sulfonamide compounds and investigation of the biological properties Project Coordinator Dumlupınar University Research Project: Synthesis of Novel Sulphaguanidine-Acridinediones Derivates Project Coordinator Dumlupınar University Research Project: Determination of the Ionization Constants of Some Acridinedione Compounds in Ethanol-Water Mixture, Assistant Researcher Dumlupınar University Research Project: Synthesis of Novel Sulfonamide-Xanthene Derivates Project Coordinator Dumlupınar University Research Project: Synthesis and Antimicrobial Activities of Novel 1,8- octahydroxanthene Derivates using phase transfer catalyst in water Project Coordinator Turkey Republic State Planning Organization Research Project: 2003 K Synthesis of Novel Acridinediones Derivates Organic Dye Lasers and Their Applications Investigated Assistant Researcher Dumlupınar University Research Project: Synthesis and Characterization of Novel Amines-metal Complexes and Their Polymer Derivates, Assistant Researcher.

3 ADMINISTRATIVE TASKS Advanced Technologies Research Center, a member of the Board of Directors Tavşanlı Vocational High School Director Vice President of the Department of Chemistry AWARDS 2012 Dumlupınar University Publication Awards 2011 Dumlupınar University Publication Awards 2009 Dumlupınar University Publication Awards 2008 Tübitak Publication Awards 2008 Tübitak Publication Awards 2007 Tübitak Publication Awards 2007 Tübitak Publication Awards ADMINISTERED MASTER THESES One-pot, Facile, Highly Efficient, and Clean Synthesis of Acridinedione Derivatives Using VB 1 As a Novel Catalyst, Ahmet Işık Synthesis of novel Sulfonamide Compounds based on 4- aminobenzenesulfonamide and investigation of carbonic anhydrase activity, Erhan Başar Synthesis and characterization of novel acridinedione containing sulphapyrdine derivatives, Ersin Demir Synthesis and characterization of acridine sulfonamide derivatives catalyzed sulfuric acid in aqueous medium at room temperature, İbrahim Yeşildağ Synthesis and characterization of new acridine sulfonamide derivatives as inhibitors of carbonic anhydrase, Ramazan Ulus.

4 ADMINISTERED PhD THESIS Microwave-based synthesis of novel hybrid acridine compounds that could be drug for treating Alzheimer's disease and assessment of inhibition applications on acetylcholinesterase enzyme PUBLICATIONS Esirden İ., Ulus R., Aday B., Tanç M., Supuran C.T., Kaya M., Synthesis of novel acridine bis-sulfonamides with effective inhibitory activity against the carbonic anhydrase isoforms I, II, IX and XII, Bioorg. Med. Chem., 2015, 23, Işık A., Aday B., Ulus R., Kaya M., One-Pot, Facile, Highly Efficient, and Green Synthesis of Acridinedione Derivatives using Vitamin B1, Synth. Commun., Accepted, Erken E., Esirden İ., Kaya M., Sen F., A Rapid and Novel Method for the Synthesis of 5-Substituted 1H-tetrazole Catalyzed by Exceptional Reusable Monodisperse Pt NPs@AC under the Microwave Irradiation, RSC Adv., 2015, 5, Aday B., Sola P., Çolak F., Kaya M., Synthesis of Novel Sulfonamide Analogs Containing Sulfamerazine/Sulfaguanidine and Their Biological Activities, J. Enzym. Inhib. Med. Chem., 2015, DOI: / Esirden İ., Erken E., Kaya M., Sen F., Monodisperse Pt NPs@rGO as Highly Efficient and Reusable Heterogeneous Catalyst for the Synthesis of 5-substituted 1H-tetrazole Derivatives, Catal. Sci. Technol., 2015, 5, Ulus R., Yeşildağ İ., Elmastaş M., Kaya M., Rapid synthesis of novel 1,8-dioxoacridine carboxylic acid derivatives by microwave irradiation and their free radical, Med. Chem Res., 2015, 24, Demir İ., Budak Diler S., Uçan S. Y., Kaya M., Synthesis, Characterization, Genetoxic Effect of Some Novel Schiff Base Ligand Derivativies, Russ. J. Gen. Chem., Accepted, 2015.

5 Pamuk H., Aday B., Sen F., Kaya M., Pt as Highly Efficient and Reusable Catalyst for One-Pot Synthesis of Acridinedione Derivatives, RSC Adv., 2015, 5, Esirden İ., Başar E., Kaya M., A facile, highly efficient and novel method for the synthesis of 5-substituted 1H-tetrazoles catalyzed by copper (I) chloride, Chem. Pap., 2015, 69, Saygılı R., Ulus R., Yeşildağ İ., İnal E. K., Kaya M., Kalfa O. M., Zeybek B., Synthesis of some 1,8-dioxoacridine carboxylic acid derivatives and the determination of their ionization constants in ethanol water mixtures, J. Mol. Struct., 2015, 1083, Kaya M., Yıldırır Y., Çelik G. Y., Synthesis, characterization, in vitro antimicrobial and antifungal activity of novel acridines. Pharm. Chem. J., 2015, 48:11, Yeşildağ İ., Ulus R., Başar E., Aslan M., Kaya M., Bülbül M., Facile, highly efficient and clean one-pot synthesis of acridine sulfonamide derivatives at room temperature and their inhibition of human carbonic anhydrase isoenzymes, Monatsh. Chem., 2014, 145:6, Ulus R., Yeşildağ İ., Tranç M., Bülbül M., Kaya M., Supuran C. T., Synthesis of novel acridine and bis acridine sulfonamides with effective inhibitory activity against the cytosolic carbonic anhydrase isoforms II and VII. Bioorganic and Med. Chem., 2013, 21: Kaya M., Demir E., Bekci H., Synthesis, characterization and antimicrobial activity of novel xanthene sulfonamide and carboxamide derivatives, J. Enzym. Inhib. Med. Chem., 2013, 28:6, Kaya M., Basar E., Çakir E., Tunca E., and Bülbül M., Synthesis and characterization of novel dioxoacridine sulfonamide derivatives as new carbonic anhydrase inhibitors, J. Enzym. Inhib. Med. Chem., 2012, 27:04, Kaya M., Aldol condensation and Michael addition of 4,4- dimethylcyclohexane-1,3-dione and aromatic aldehydes. Unconventional substituent effects, Chin. J. Chem., 2011, 29, Kaya M., Yıldırır Y., Çelik G. Y., Synthesis and antimicrobial activities of novel bisacridine-1,8-dione derivates, Med. Chem. Res., 2011, 20:

6 Kaya M., Başer E., Çolak F., Synthesis and antimicrobial activities of some bisoctahydroxanthene-1,8-dion derivatives, Med. Chem. Res., 2011, 20: Kaya M., Yıldırır Y., Türker L., Synthesis and Laser Activity of Halo-acridinedione Derivatives, J. Heterocycl. Chem., 2009, 46, Odabaşoğlu M., Kaya M., Yıldırır Y., Büyükgüngör O., 9-(4- Methoxyphenyl)-3,3,6,6-tetramethyl-3,4,6,7-tetrahydro-2Hxanthene-1,8(5H,9H)-dione, Acta Cryst., 2008, E64, 681. Kaya M., Yenikaya C., Colak T. A., Colak F., Synthesis, Spectral, Thermal and Biological Studies of Co(III) and Binuclear Ni(II) Complexes with a Novel Amine Imine Oxime Ligand, Russ. J. Gen. Chem., 2008, 78(9), Yenikaya C., Kaya M., Demir İ., Synthesis of a Novel Imine vic-dioxime Ligand and Preperation of Its Ni (II), Co (II), Cu (II) Complexes, Asian J. Chem., 2008, 20(7), Kaya M., Demir İ., Yenikaya C., Synthesis and Characterization of Complexes of vic-dioxime Derivatives with Transation Metal, Asian J. Chem., 2008, 20(3), Kaya M., Yenikaya C., Demir İ., Kalfa O. M., Synthesis and Characterization of N-(Glyoxyldioxime)-N'-(2- hydroxybenzylidene)-1,4-diaminonaphthalene and Its Metal Complexes, Russ. J. Gen. Chem., 2008, 78(5), Odabaşoğlu M., Kaya M., Büyükgöngör O., Yıldırır Y., Türker L.,9-(4-Methoxyphenyl)-3,3,6,6-tetramethyl-10-p-tolyl- 1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione, Acta Cryst., 2007, E63, Odabasoğlu M., Kaya M., Büyükgöngör O., Yıldırır Y., 10-4(- Bromophenyl)-9-(4-methoxyphenyl)-3,3,6,6-tetramethyl- 3,4,6,7-tetrahydroacridine- 1,8(2H,5H,9H,10H)-dione, Acta Cryst., 2007, E63, Büyükgöngör O., Kaya M., Odabaşoğlu M., Yıldırır Y., 10-2(- Fluorophenyl)-9-(4-methoxyphenyl)-3,3,6,6-tetramethyl- 3,4,6,7-tetrahydroacridine 1,8(2H,5H,9H,10H)-dione, Acta Cryst., 2007, E63,

7 INTERNATIONAL CONGRESSES 2015 Esirden İ., Kaya M., Synthesis of novel biologically active acridine-sulfonamide hybrid compounds containing tetrazole ring, 3rd International BAU Drug Design Congress, 2015 Erken E., Esirden İ., Kaya M., Sen F., Preparation of the pharmaceutical active 5-substituted 1H-tetrazole group with platinum nanoparticles supported on Vulcan carbon, 3rd International BAU Drug Design Congress, 2015 Aday B., Kaya M., Synthesis of new acridine sulfonate esters hybrid compounds including 5-Amino-1,3,4-thiadiazole-2- sulfonamide, 3rd International BAU Drug Design Congress, 2015 Erken E., Esirden İ., Kaya M., Sen F., Efficient Synthesis Of Tetrazole Derivatives Catalyzed By Recyclable Platinum Nanoparticles As Heterogeneous Catalyst Under The Microwave Irradiation, P362, 1st International Turkic World Conference on Chemical Sciences and Technologies, Bosnia and Herzegovina Işık A., Aday B., Ulus R., Kaya M., One-Pot, Facile, Highly Efficient, And Clean Synthesis Of Acridinedione Derivatives Using Vitamin B1 As A Catalyst, P249, 1st International Turkic World Conference on Chemical Sciences and Technologies, Bosnia and Herzegovina Aday B., Pamuk H., Sen F., Kaya M., Highly Dispersed Platinum Nanoparticles Supported With Graphene Oxide For The One-Pot Synthesis Of Acridinedione Derivatives, P248, 1st International Turkic World Conference on Chemical Sciences and Technologies, Bosnia and Herzegovina Ulus R., Aday B., Kaya M., Synthesis Of 5-Amino-1,3,4- Thiadiazole-2-Sulfonamide Based Novel Acridindione Compounds, P244, 1st International Turkic World Conference on Chemical Sciences and Technologies, Bosnia and Herzegovina Ulus R., Kaya M., Acetazolamide Derivative Novel Acridindione Compounds as Carbonic Anhydrase Inhibitors, P361, 1st International Turkic World Conference on Chemical Sciences and Technologies, Bosnia and Herzegovina.

8 2015 Saygılı R., Ulus R., Yesildag I., lna1 E. K., Kaya M., Kalfa O. M., Zeybek B., Determination of the Ionization Constants of Some 1,8-Dioxoacridine Carboxylic Acid Derivatives in Ethanol-Water Mixtures, P-44, 11 th International Symposium on Pharmaceutical Sciences, Ankara, 2015 Esirden İ., Sola P., Başar E., Kaya M., Synthesis and Characterization of Novel Antimicrobial Active Benzoxanthene Carboxamide Derivatives, 09B-226, International Conference on Engineering and Natural Sciences, May 15-19, Esirden İ., Erken E., Şen F., Kaya M., Superior Platinum Nanoparticles as Highly Efficient, Stable and Reusable Catalyst for the Synthesis of 5-substituted 1H-tetrazoles, P145, Anatolian Conference on Synthetic Organic Chemistry, Antalya, 2015 Aday B., Pamuk H., Sen F., Kaya M., Graphene oxide as Highly Effective and Readily Recyclable Catalyst using for the One-Pot Synthesis of 1,8-dioxoacridine Derivatives, P144, Anatolian Conference on Synthetic Organic Chemistry, Antalya, 2015 Ulus R., Aday B., Esirden İ., Kaya M., Microwave Assisted Synthesis and Characterizations of Novel Chromenes, P152, Anatolian Conference on Synthetic Organic Chemistry, Antalya, 2012 Investigation of The Inhibitory Effects of New Dioxoacridine Sulfonamide Derivatives On Human Carbonic Anhydrase Isoenzymes (hca I and HCA II), P59, The 9 th International Conference on Anhydrase (CA) Investigation of The Inhibitory Effects of Sulfonamide Moiety Including Novel Dioxoacridine Derivatives On Human Carbonic Anhydrase Isoenzymes (hca I and HCA II), P92, The 9 th International Conference on Anhydrase (CA). NATIONAL CONGRESSES 2015 Synthesis and Characterization of Novel Azo-Acridine Dyes Containing Sulfanilamide Group, A-İL021, 27. National Chemistry Congress, Çanakkale, 2015 Synthesis of Novel Sulfonamide Compounds Containing Tetrazole Ring, A-İL009, 27. National Chemistry Congress, Çanakkale,

9 2015 Microwave Assisted Synthesis and Characterization of Antibacterial Sülfatiyazol-Acridine Compounds, P062, 3. Drug Chemistry Congress, Design of Active Pharmaceutical Ingredients, Synthesis, Production and Standardization, Antalya, 2015 Microwave Assisted Biologically Active Acridinedione Compound Containing Bis-sulfonamide Group, P061, 3. Drug Chemistry Congress, Design of Active Pharmaceutical Ingredients, Synthesis, Production and Standardization, Antalya, 2015 Synthesis and Characterizations of Novel Sulfonamide Compounds Containing Sulfathiazole as Anti-glaucoma, P201, 3. Drug Chemistry Congress, Design of Active Pharmaceutical Ingredients, Synthesis, Production and Standardization, Antalya, 2015 Synthesis of Biologically Active Sulfapyridine Acridinedione Compounds, P065, 3. Drug Chemistry Congress, Design of Active Pharmaceutical Ingredients, Synthesis, Production and Standardization, Antalya, 2015 Synthesis and Investigation of Antimicrobial Activity of Dibenzoxanthene-sulfonamide Compounds, P072, 3. Drug Chemistry Congress, Design of Active Pharmaceutical Ingredients, Synthesis, Production and Standardization, Antalya, 2014 Synthesis and Characterization of Novel Sulfonamides Compounds Containing Acridine Ring, P-67, 2. National Organic Chemistry Congress, Bilkent University, Ankara, 2014 Synthesis and Characterization of Novel Sulfonamides Compounds Containing Sulfamerazine Ring, P-142, 2. National Organic Chemistry Congress, Bilkent University, Ankara, 2014 Synthesis and Characterization of Novel Sulfonamides Compounds Containing Sulfaguanidine Ring, P-1, 2. National Organic Chemistry Congress, Bilkent University, Ankara, 2013 Microwave-assisted Synthesis and Characterization of New Acridine Carboxylic Acid Compounds, S , I. National Organic Chemistry Congress, Sakarya University,

10 2008 Synthesis of the pyrazole ring containing sulfonamides, OKP 147, XXII. National Chemistry Congress, Cyprus, 2006 Synthesis of 4-[[(2-hydroxy-1-naphthalenyl) methylene] amino] Tetrazole Derivatives, OKP 146, XX. National Chemistry Congress, Istanbul, 2004 Synthesis and characterization of anti-n-hydroksi-2- hydroksilimino-n -p-tolil-acetamine compound with transition metals complexes, XVIII. National Chemistry Congress, Kafkas University, Kars, 2003 Synthesis and structural characterization of the metal complex bidentate schiff bases, XVII. National Chemistry Congress, Istanbul, 2003 The synthesis and structure elucidation of new amino glyoxime derivatives with their metal complexes, ANP54, XVII. National Chemistry Congress, Istanbul, REVIEWING RESPONSIBILITIES Monatshefte fur Chemie Medicinal Chemistry Research Current Organic Chemistry Journal of heterocyclic chemistry Fuel Cells Gazi University Journal of Science