How To Test For Drug Resistance In Africa
|
|
- Chester Dawson
- 3 years ago
- Views:
Transcription
1 High viral load in patients failing first line ART is associated with multidrug resistance in resource limited countries. Avelin Aghokeng 1,2, Emilande Guichet 1,2, Laetitia Serrano 1, Guillaumme Bado 3, Coumba Toure Kane 4, Adrien Sawadogo 4, Cheick Tidiane Ndour 5, Sinata Koulla-Shiro 6, Sabrina Eymard-Duvernay 1, Eric Delaporte 1, Laura Ciaffi 1, Martine Peeters 1 and the 2LADY-study group. 1. UMI233-TransVIHMI, IRD and University of Montpellier, France, 2. IMPM/CREMER, Yaoundé, Cameroun, 3. Hopital de jour de Bobo-Dioulasso, Bobo- Dioulasso, Burkina Faso, 4. Laboratoire de Virologie CHU A Le Dantec, Dakar, Sénégal, 5. UCAD, Dakar, Sénégal, 6. Université Yaoundé 1, Yaoundé, Cameroun
2 ART in resource limited countries number of people receiving ART has tripled over the last five years. About 60% on ART in Africa (WHO 2010 guidelines) Public health approach Standardized first line drug regimens CD4 counts and VL recommended Limited access to viral load monitoring no timely diagnoses of treatment failure < 5% of patients in RLS are on second line
3 Objective describe drug resistance mutations in patients eligible for a second line treatment 2LADY-ANRS12269/EDCTP trial conducted in Africa: Burkina-Faso, Cameroun and Sénégal Evaluation of 3 second line ART regimens during 48 weeks ( ): FTC + TDF + LPV/r (2013 WHO guidelines) ABC + DDI + LPV/r FTC + TDF + DRV/r
4 Patients and methods Cross-sectionnal Viral load for patients on first line ART> 6 months (3TC+AZT/d4T+EFV/NVP) January 2010 september 2012 VL > 1000 copies/ml Adherence intervention during 1 month VL > 1000 copies/ml Switch to second line ART Retrospective genotypic drug resistance testing (ANRS v algoritm)
5 Patients included Cross-sectional consecutive VL screening : 584 patients with VL >1000 adherence intervention: 454 (77%) eligible for inclusion 451 patients included Cameroun n=302 Burkina-Faso n= 90 Sénégal n= 59 First line drugs taken at failure: 3TC (100%) AZT (85%), d4t (15%) EFV (29%), NVP (71%)
6 Patient characteristics with VF on first line ART Age, median (IQR) 38 (32-46) Women, n (%) 324 (72%) Duration first ART months, median (IQR) 49 (33-69) CD4, median (IQR) 183 (87-290) VL log10, median (IQR) 4,5 (4,0-5,1) VL > 4 log10 copies/ml 340 (76%) Asymptomatic at switch, n (%) 411 (91%)
7 HIV drug resistance in patients with VF on first line ART 446/451 (98.9%) samples amplified drug resistance mutations: 440/446 (98.7%) Burkina Faso 85/87 (97.7%) Senegal 56/57 (98.2%) Cameroon 299/302 (99.0%) 2 consecutive VL > 1000 copies/ml + Adherence intervention Good strategy to identify patients with treatment failure
8 HIV drug resistance in patients with VF on first line ART
9 HIV drug resistance in patients with VF on first line ART Number (%) of patients with drug resistance to the different drugs of first line ART Country n 0 drug 1 drug 2 drugs 3 drugs Burkina-Faso 87 2 (2.3%) 4 (4.6%) 39 (44.8%) 42 (48.3%) Cameroon (1.0%) 2 (0.7%) 124 (41.0%) 173 (57.3%) Senegal 57 1 (1.8%) 4 (7.0%) 22 (38.6%) 30 (52.6%) Total (1.3%) 10 (2.2%) 185 (41.5%) 245 (54.9%) > 40 % mono therapy (AZT or D4T) > 50 % NO therapy
10 Accumulation of mutations and cross-resistance At least 3 NRTI mutations(+m184) 80/191 (42%) «3 NNRTI mutations 218/191 (50%)
11 HIV drug resistance and viral load Higher VL in multiresistant strains resistant to 1 or 2 drugs (n=191) 4.2 log10 (IQR: ) resistant to all drugs (n=244) 4.8 log10 (IQR: ) (p<0.001) Proportion of multi-resistant strains increases with VL n=122 n=218 n=106
12 Conclusion Two consecutive VL test with adherence intervention efficient to detect treatment failure (99% drug resistance) > 50% no active drugs 90% of patients with VF and drug resistance were asymptomatic High viral load does not always correspond to non-adherence Increasing probability of transmission of these strains. accumulation of HIVDR may compromise second-line regimens Lower respons to second line regimens
13 Conclusion importance of early detection of treatment failure and biological monitoring Recommend more robust first-line regimens? need continuous surveillance of HIV drug resistance in resource limited countries.
14 Acknowledgements: 2-LADY study group Investigateurs Coordinateurs: KOULLA SHIRO Sinata (Sud) DELAPORTE Eric (Nord) Coordinateur Laboratoire: PEETERS Martine (MPL) AGHOKENG Avelin (Cameroon) COUMBA Toure Kane (Sénégal) BADO Guillaume (Burkina) Coordination Méthodologie: LEMOING Vincent (MPL) IZARD Susanne (MPL) EYMARD DUVERNAY Sabrina (MPL) COURNIL Amandine (MPL) CIAFFI Laura (Chef de Projet) Coordinateurs Administratifs: BUNIOWSKI Annie (IBB) URENA Katia (IBB) WOOMER Barbara (IBB) LAPLACE Sophie (IRD) Site Cameroun IP : KOULLA SHIRO Sinata ARC : ABESSOLO ABESSOLO Hermine MECs : MBEN Jean Marc, TOBY Roselyne, MANGA Nestor, AYANGMA Liliane, TAMAN Bernadette Phar : ESSOMBA Claudine, MANIRAKIZA Geraldine, MBARGA Therese, EPANDA Solange INF : BIKIE Angeline, NKE Thimotee ASSO : MASSAHA Nathalie, NKE Eveline, NGALLE Micheline DB : NGONO BIKOBO Dominique, ABOLOGO Larissa METABODY: AMBANI Landry Agnes et LOWE Tatiana Site Sénégal IP : NDOUR Tediane Cheik ARC : FORTES Louise MECs : NGOM Ndeye Fatou, DIALLO Mouhamadou TEC : DIOP Aïssatou, DIOUF Badara Pharmacie : BARA Ndiaye, KOITA FALL Mame Basty Lab : SECK FALL Bineta Lab (MPL): SERRANO Laëtitia Asso : BA Seydou, NJANTOU Philoméne (DB) DB et METABODY: NDYAYE Amady Site Burkina IP : SAWADOGO Adrien ARC : HEMA Arsene MECs : KABORE M. Firmin, KAMBOULE B. Euloges, ZOUNGRANA Jacques Pharmacie : OUEDRAGO Patricia et TRAORE Richard INF : SANOU Yachinte Lab : BADO Guillaume, COULIBALY Monique Asso : SOME Edwige et KAMBOU Alima SOME Jacqueline DB : TAPSOBA Achille, SOMBIE Diamasso ADM : SANOU Sidia METABODY: PODA 14
Theonest Ndyetabura KILIMANJARO CHRISTIAN MEDICAL CENTRE / KILIMANJARO CLINICAL RESERCH
TREATMENT FAILURE AND PATTERNS OF GENOTYPIC DRUG RESISTANCE MUTATIONS AMONG HAART EXPERIENCED HIV-1 PATIENTS AT KCMC Theonest Ndyetabura KILIMANJARO CHRISTIAN MEDICAL CENTRE / KILIMANJARO CLINICAL RESERCH
More informationProtease Inhibitor Resistance at 2nd-line HIV Treatment Failure in Sub-Saharan Africa
Protease Inhibitor Resistance at 2nd-line HIV Treatment Failure in Sub-Saharan Africa T. Sonia Boender; Raph L. Hamers; Pascale Ondoa; Maureen Wellington; Cleophas Chimbetete; Margaret Siwale; Eman E F
More informationClinical rationale for viral load testing
Clinical rationale for viral load testing Francois Venter Wits Reproductive Health & HIV Institute Caveats I m a believer in VLs My talk looks at resource poor environments Why do we need a rationale???
More information5èmes journées du Site ANRS-Cameroun Yaoundé, 3-4 juin 2013 ANRS-12235
èmes journées du Site ANRS-Cameroun Yaoundé, -4 juin 201 ANRS-122 Le sang total séché sur papier filtre, DBS (Dried Blood Spot), est-il utilisable pour le suivi virologique en routine des patients VIH+
More informationPaediatric HIV Drug Resistance in African Settings
Paediatric HIV Drug Resistance in African Settings Dr Cissy Kityo Mutuluuza INTEREST Meeting May 5-9, 2014 Lusaka, Zambia Background: ART for children in sub- Saharan Africa 2.3 million children with HIV
More informationAntiretroviral therapy for HIV infection in infants and children: Towards universal access
Antiretroviral therapy for HIV infection in infants and children: Towards universal access Executive summary of recommendations Preliminary version for program planning 2010 Executive summary Tremendous
More informationSwitch to Dolutegravir plus Rilpivirine dual therapy in cart-experienced Subjects: an Italian cohort
Switch to Dolutegravir plus Rilpivirine dual therapy in cart-experienced Subjects: an Italian cohort Gaetana Sterrantino Azienda Ospedaliero-Universitaria Careggi Infectious diseases, Florence, Italy Background
More informationChapter 3 South African guidelines and introduction to clinical cases
Chapter 3 South African guidelines and introduction to clinical cases 3.1. South African national antiretroviral guidelines When this book was published in 2012 the current national antiretroviral treatment
More informationEACS 2013. Dominique Braun Universitätsspital Zürich
EACS 2013 Switch data Rilpivirine: Swing-trial Elvitegravir: Flamingo-trial Simplification Dual-Therapy: LPV/r + 3TC in the Gardel-trial Mono-Therapy: Darunavir/r mono in clinical setting Boceprevir/Telaprevir
More informationCombination Anti-Retroviral Therapy (CART) - Rationale and Recommendation. M Dinaker. Fig.1: Effect of CART on CD4 and viral load
Combination Anti-Retroviral Therapy (CART) - Rationale and Recommendation M Dinaker INTRODUCTION The wide availability of effective, safe and mostly well tolerated combined anti-retroviral therapy (CART)
More informationHIV Drug resistanceimplications
HIV Drug resistanceimplications for therapy Deenan Pillay Africa Centre for Health and Population Studies, UKZN University College London Potential implications of HAART without virological monitoring:
More informationConsolidated guidelines on the use of antiretroviral drugs for treating
TB conference, 10-13 June 2014, Durban, South Africa Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection Dr Augustin Ntilivamunda Objectives of 2013 WHO
More informationAids Fonds funding for programmes to prevent HIV drug resistance
funding for programmes to prevent HIV drug resistance Call for proposals July 2012 Page 1 van 10 grants@aidsfonds.nl Documentnumber 20120719/JKA/RAP Universal Access Lifting barriers to universal access
More informationHIV DRUG RESISTANCE EARLY WARNING INDICATORS
HIV DRUG RESISTANCE EARLY WARNING INDICATORS World Health Organization indicators to monitor HIV drug resistance prevention at antiretroviral treatment sites June 2010 Update ACKNOWLEDGEMENTS The preparation
More informationPaediatric HIV treatment update
Paediatric HIV treatment update James Nuttall Red Cross War Memorial Children s Hospital & University of Cape Town ART Resistance & New Treatment Options 6 th FIDSSA Conference, 5-7 November 2015 ART Eligibility
More informationTHE SOUTH AFRICAN ANTIRETROVIRAL TREATMENT GUIDELINES 2013
THE SOUTH AFRICAN ANTIRETROVIRAL TREATMENT GUIDELINES 2013 VERSION 14 March 2013 Contents Acronym glossary... 2 1. Goals of the programme... 3 2. Objectives... 3 3. Specific Objectives... 3 4. Adults and
More informationThe studies reported in this thesis were performed at the department of Viroscience of the Erasmus Medical Center, Rotterdam, the Netherlands.
The studies reported in this thesis were performed at the department of Viroscience of the Erasmus Medical Center, Rotterdam, the Netherlands. This research was supported by the Aids Fonds, Netherlands
More informationLow level viremia and HIV-1 drug resistance in patients with virological rebound after suppression with a first line antiretroviral regimen
Low level viremia and HIV-1 drug resistance in patients with virological rebound after suppression with a first line antiretroviral regimen Manuela Colafigli Catholic University of S. Heart Rome, Italy
More informationDie Toronto Konferenz. K. Arasteh Auguste-Viktoria-Klinikum
Die Toronto Konferenz K. Arasteh Auguste-Viktoria-Klinikum Subjektive Schwerpunkte Medizinische Prävention Monotherapie CD4 guided treatment interuption (CD4-TI) HIV Prävention (Gita Ramjee) Rationale
More informationHIV. Head - Paediatric HIV Treatment Programmes. Right to Care. Dr Leon Levin
HIV Dr Leon Levin Head - Paediatric HIV Treatment Programmes Right to Care Disclaimer This talk represents my personal experience in managing teenagers with HIV over the last 14 years. It does not purport
More informationFARMACI, INNOVAZIONE e INFEZIONE DA HIV / AIDS
FARMACI, INNOVAZIONE e INFEZIONE DA HIV / AIDS Stefano Vella Dipartimento del Farmaco Istituto Superiore di Sanità - Roma Stages of HIV-1 Life Cycle Targeted by Anti-HIV Drugs In: Gulick RM, Topics HIV
More informationLessons from the Stanford HIV Drug Resistance Database
1 Lessons from the Stanford HIV Drug Resistance Database Bob Shafer, MD Department of Medicine and by Courtesy Pathology (Infectious Diseases) Stanford University Outline 2 Goals and rationale for HIVDB
More informationComprehensive Case Management Reassessment
Comprehensive Case Management Reassessment Reassessment Date: Date of previous Assessment/Reassessment: Name: Client ID # Address: If Reassessment early or late explain: Current HIV Status: Asymptomatic
More informationTreatment 2.0 as a catalyst for Tasp through Drug / Treatment Optimization
Treatment 2.0 as a catalyst for Tasp through Drug / Treatment Optimization STEFANO VELLA MD ISTITUTO SUPERIORE DI SANITÀ ROME - ITALY DDF 6 WAFAA EL SADR, CROI 2012 The problem is in how to efficiently
More informationGeneric antiretrovirals in Europe: a blessing or a curse?
Generic antiretrovirals in Europe: a blessing or a curse? Ricardo Jorge Camacho 1 Molecular Biology Laboratory, Centro Hospitalar de Lisboa Ocidental 2 Instituto de Higiene e Medicina Tropical, Universidade
More informationEfficacy of lead-in silibinin and subsequent triple therapy in difficult-to-treat HIV/hepatitis C coinfected patients
Second Silibinin Workshop, Cologne, 23 rd May 2014 Efficacy of lead-in silibinin and subsequent triple therapy in difficult-to-treat HIV/hepatitis C coinfected patients Dominique L Braun, MD Division of
More informationSURVEILLANCE OF INITIAL DRUG RESISTANT HIV-1 AMONG CHILDREN UNDER 18 MONTHS OF AGE NEWLY DIAGNOSED WITH HIV
SURVEILLANCE OF INITIAL DRUG RESISTANT HIV-1 AMONG CHILDREN UNDER 18 MONTHS OF AGE NEWLY DIAGNOSED WITH HIV SURVEY REPORT AIDS & TB UNIT Ministry Of Health And Child Welfare Zimbabwe December 2012 1 Table
More informationPoster # 42 Resistance in PBMCs Can Predict Virological Rebound after Therapy Switch in cart- Treated Patients with Undetectable HIV-RNA
Poster # 42 Resistance in PBMCs Can Predict Virological Rebound after Therapy Switch in cart- Treated Patients with Undetectable HIV-RNA D Armenia 1, M Zaccarelli 2, V Borghi 3, W Gennari 3, A Giannetti
More informationThe World Health Organization s global strategy for prevention and assessment of HIV drug resistance
The World Health Organization s global strategy for prevention and assessment of HIV drug resistance Diane E Bennett 1 *, Silvia Bertagnolio 1, Donald Sutherland 2 and Charles F Gilks 1 1 World Health
More informationGuidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents
Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents Visit the AIDSinfo website to access the most up-to-date guideline. Register for e-mail notification of guideline
More informationhiv/aids Programme Use of Antiretroviral Drugs for Treating Pregnant Women and Preventing HIV Infection in Infants
hiv/aids Programme Programmatic update Use of Antiretroviral Drugs for Treating Pregnant Women and Preventing HIV Infection in Infants EXECUTIVE SUMMARY April 2012 EXECUTIVE SUMMARY Recent developments
More informationHIV AND ADOLESCENTS: HIV TESTING AND COUNSELLING, TREATMENT AND CARE FOR ADOLESCENTS LIVING WITH HIV SUMMARY OF KEY FEATURES AND RECOMMENDATIONS
POLICY BRIEF HIV AND ADOLESCENTS: HIV TESTING AND COUNSELLING, TREATMENT AND CARE FOR ADOLESCENTS LIVING WITH HIV SUMMARY OF KEY FEATURES AND RECOMMENDATIONS NOVEMBER 2013 WHO Library Cataloguing-in-Publication
More informationTransmission of Antiretroviral Drug Resistance and Potential Impact on Selection of First-Line Therapy
Transmission of Antiretroviral Drug Resistance and Potential Impact on Selection of First-Line Therapy Mark A. Wainberg McGill University AIDS Centre Jewish General Hospital Montreal, Canada Lessons from
More informationSurveillance of transmitted HIV drug resistance among women attending antenatal clinics in Dar es Salaam, Tanzania
Antiviral Therapy 13 Suppl 2:77 82 Surveillance of transmitted HIV drug resistance among women attending antenatal clinics in Dar es Salaam, Tanzania Geofrey R Somi 1, Tabitha Kibuka 2, Karidja Diallo
More informationNON-OCCUPATIONAL POST EXPOSURE PROPHYLAXIS FOR SEXUAL ASSAULT SURVIVORS. Carl LeBuhn, MD
NON-OCCUPATIONAL POST EXPOSURE PROPHYLAXIS FOR SEXUAL ASSAULT SURVIVORS Carl LeBuhn, MD Post-Exposure Prophylaxis (PEP) The use of therapeutic agents to prevent infection following exposure to a pathogen
More informationUPDATE IN HIV POST-EXPOSURE PROPHYLAXIS. Weerawat Manosuthi
UPDATE IN HIV POST-EXPOSURE PROPHYLAXIS Weerawat Manosuthi Outline Case scenario of postexposure prophylaxis Risks of and how to manage postexposure prophylaxis Current PEP guideline US PHS 2013 New York
More informationAntiretroviral Treatment
Antiretroviral Treatment Michael A. Tolle, MD, MPH Heidi Schwarzwald, MD, MPH Nancy R. Calles, MSN, PNP, ACRN, MPH Objectives 1. Discuss the goals of treatment for human immunodeficiency virus (HIV) infection.
More informationThis document was made possible through the financial support of the Global Fund to fight AIDS, Tuberculosis and Malaria (GFATM).
This document was made possible through the financial support of the Global Fund to fight AIDS, Tuberculosis and Malaria (GFATM). The contents are the responsibility of the Ministry of Health and do not
More informationTreating HIV in children with tuberculosis
International AIDS Society - Industry Liaison Forum Meeting 5 March 2012 Treating HIV in children with tuberculosis Helen McIlleron, Division of Clinical Pharmacology University of Cape Town Challenges
More informationManagement of HIV and TB Co-infection in South Africa
Management of HIV and TB Co-infection in South Africa Halima Dawood Department of Medicine Case Report 39 yr old female Referred to clinic on 14/06/2006 for consideration to commence antiretroviral therapy
More informationAcute HCV was defined as (3 out of 4 within the preceding 4 months):
Christoph Boesecke, Patrick Ingiliz, Hans-Jürgen Stellbrink, Mark Nelson, Sanjay Bhagani, Marguerite Guiguet, Marc-Antoine Valantin, Thomas Reiberger, Martin Vogel, Jürgen K. Rockstroh, and the NEAT study
More informationHIV Continuum of Care Monitoring Framework 2014
HIV Continuum of Care Monitoring Framework 2014 Addendum to meeting report: Regional consultation on HIV epidemiologic information in Latin America and the Caribbean HIV Continuum of Care Monitoring Framework
More informationHIV Therapy Key Clinical Indicator (KCI)
Publication Report HIV Therapy Key Clinical Indicator (KCI) Year ending 31 December 2010 Publication date 27 September 2011 A National Statistics Publication for Scotland Contents Contents... 1 About ISD...
More informationHIV Surveillance Update
HIV Surveillance Update Presentation to: CAPUS Metro Atlanta Testing and Linking Consortium (MATLC) Presented by: Deepali Rane, MPH and Jane Kelly, MD Georgia Department of Public Health Epidemiology Date:
More informationWorld Health Organization surveys to monitor HIV drug resistance prevention and associated factors in sentinel antiretroviral treatment sites
World Health Organization surveys to monitor HIV drug resistance prevention and associated factors in sentinel antiretroviral treatment sites Michael R Jordan 1 *, Diane E Bennett 2, Silvia Bertagnolio
More informationRainfed agriculture evolution in a climate variability context of West Africa sudano- sahelian zone
Rainfed agriculture evolution in a climate variability context of West Africa sudano- sahelian zone Drissa DIALLO, Université des Sciences, des Techniques et des Technologies de Bamako (USTTB) Bruno BARBIER,
More informationDHAPP SENEGAL BACKGROUND. Country Statistics
DHAPP DEPARTMENT OF DEFENSE HIV/AIDS PREVENTION PROGRAM REDUCING THE INCIDENCE OF HIV/AIDS AMONG UNIFORMED PERSONNEL IN SELECTED AFRICAN NATIONS AND BEYOND WINNING BATTLES IN THE WAR AGAINST HIV/AIDS BACKGROUND
More informationThe Basics of Drug Resistance:
CONTACT: Lisa Rossi +1-412-641-8940 +1-412- 916-3315 (mobile) rossil@upmc.edu The Basics of Drug Resistance: QUESTIONS AND ANSWERS HIV Drug Resistance and ARV-Based Prevention 1. What is drug resistance?
More informationSafety and Efficacy of DAA + PR in HCV/HIV co-infected patients. Mark Sulkowski, MD Johns Hopkins University Baltimore Maryland USA
Safety and Efficacy of DAA + PR in HCV/HIV co-infected patients Mark Sulkowski, MD Johns Hopkins University Baltimore Maryland USA Liver disease is the second leading cause of death amongst HIV-positive
More informationResidential Course on Clinical Pharmacology of Antiretrovirals 2005 2015
Residential Course on Clinical Pharmacology of Antiretrovirals 2005 2015 Gianni Di Perri Clinica di Malattie Infettive Università degli Studi di Torino Ospedale Amedeo di Savoia This project took place
More informationBritish HIV Association (BHIVA) guidelines for the treatment of HIV-infected adults with antiretroviral therapy (2006)
r 2006 British HIV Association HIV Medicine (2006), 7, 487 503 British HIV Association (BHIVA) guidelines for the treatment of HIV-infected adults with antiretroviral therapy (2006) B Gazzard on behalf
More informationModule 7: The Role of the Nurse
Module 7: The Role of the Nurse Module Objectives To describe the dynamic role of the nurse in the holistic care of a patient receiving ARV treatment To equip nurses with a sense of importance and belief
More informationWHO/HIVRESNET HIV DRUG RESISTANCE LABORATORY STRATEGY
WHO/HIVRESNET HIV DRUG RESISTANCE LABORATORY STRATEGY JULY, 2010 1 Table of Contents Abbreviations... 4 1. WHO/HIVResNet Global HIV Drug Resistance Strategy... 5 1.1. NATIONAL HIVDR WORKING GROUP...6 1.2.
More informationACCESS TO AFFORDABLE TREATMENT FOR HIV/AIDS: THE ISSUES
ACCESS TO AFFORDABLE TREATMENT FOR HIV/AIDS: THE ISSUES AIDS Law Unit Legal Assistance Centre July, 2002 INTRODUCTION Although there is currently no cure for HIV/Aids, treatment has, however, been developed
More informationUnderstanding the HIV Care Continuum
Understanding the HIV Care Continuum Overview Recent scientific advances have shown that antiretroviral therapy (ART) not only preserves the health of people living with HIV, but also dramatically lowers
More informationManagement of HIV/HCV Co-infected Patients
Management of HIV/HCV Co-infected Patients David Wyles, MD Associate Professor of Medicine Division of Infectious Diseases University of California, San Diego San Diego, California Disclosures Grants/Research
More informationHIV and Hepatitis Co-infection. Martin Fisher Brighton and Sussex University Hospitals, UK
HIV and Hepatitis Co-infection Martin Fisher Brighton and Sussex University Hospitals, UK Useful References British HIV Association 2010 http://www.bhiva.org/documents/guidelines/hepbc/2010/ hiv_781.pdf
More informationHIV/AIDS Programme. ANTIRETROVIRAL THERAPY FOR HIV INFECTION IN ADULTS AND ADOLESCENTS: Recommendations for a public health approach.
HIV/AIDS Programme Strengthening health services to fight HIV/AIDS ANTIRETROVIRAL THERAPY FOR HIV INFECTION IN ADULTS AND ADOLESCENTS: Recommendations for a public health approach 2006 revision WHO Library
More informationOUTLINE POST EXPOSURE PROPHYLAXIS (PEP) OCCUPATIONAL RISK OF VIRAL TRANSMISSION WITH SHARP INJURY FROM INFECTED SOURCE:
Professional needle stick accidents should be dealt with within 48 hours. An ARC (Aids Reference Centre) or an emergency department must be contacted as soon as possible. OUTLINE POST EXPOSURE PROPHYLAXIS
More informationTreatment Action Campaign UNDETECTABLE HOW VIRAL LOAD MONITORING CAN IMPROVE HIV TREATMENT IN DEVELOPING COUNTRIES. www.msfaccess.
Treatment Action Campaign UNDETECTABLE HOW VIRAL LOAD MONITORING CAN IMPROVE HIV TREATMENT IN DEVELOPING COUNTRIES www.msfaccess.org Table of Contents 3 Executive Summary 4 Introduction 5 MSF HIV/AIDS
More informationRegulatory Approach in Germany and in the EU to Fixed Dose Combination Medicinal Products Using HIV/AIDS Treatment as an Example
Regulatory Approach in Germany and in the EU to Fixed Dose Combination Medicinal Products Using HIV/AIDS Treatment as an Example Prof. Dr. rer. nat. habil. Harald G. Schweim President Federal Institute
More informationHIV/AIDS Programme. ANTIRETROVIRAL THERAPY FOR HIV INFECTION IN ADULTS AND ADOLESCENTS: Recommendations for a public health approach.
HIV/AIDS Programme Strengthening health services to fight HIV/AIDS ANTIRETROVIRAL THERAPY FOR HIV INFECTION IN ADULTS AND ADOLESCENTS: Recommendations for a public health approach 2006 revision IMPORTANT:
More informationNational Antiretroviral Treatment Guidelines
National Antiretroviral Treatment Guidelines Copyright 2004 Department of Health Published by Jacana Printed by Minuteman Press ISBN: 1-919931-69-4 National Department of Health South Africa 2004 This
More informationDOI: 10.1111/hiv.12119 2014 British HIV Association HIV Medicine (2014), 15 (Suppl. 1), 1 85
DOI: 10.1111/hiv.12119 British HIV Association guidelines for the treatment of HIV-1-positive adults with antiretroviral therapy 2012 (Updated November 2013. All changed text is cast in yellow highlight.)
More informationHepatitis Update. Study 110: SVR at post-treatment week 24 (SVR24) Jürgen Rockstroh, MD. No ART EFV/TDF/FTC ART/r/TDF/FTC Total
Hepatitis Update Jürgen Rockstroh, MD Study 11: SVR at post-treatment week 24 (SVR24) Patients with Undetectable HCV RNA (Percentage) 8 7 6 5 4 3 2 1 71 No ART EFV/TDF/FTC ART/r/TDF/FTC Total 69 8 74 n/n
More informationFrequently Asked Questions
Guidelines for Testing and Treatment of Gonorrhea in Ontario, 2013 Frequently Asked Questions Table of Contents Background... 1 Treatment Recommendations... 2 Treatment of Contacts... 4 Administration
More informationThe Botswana Combination Prevention Project (BCPP)
The Botswana Combination Prevention Project (BCPP) The Next Phase of HIV Prevention in Botswana A collaboration between MoH CDC-Botswana, HSPH-BHP Presenter: M.J. Makhema NAC 4 th September 2012 Mashi
More informationDOI: 10.1111/hiv.12217 on behalf of British HIV Association. HIV Medicine (2015) ORIGINAL RESEARCH
DOI: 10.1111/hiv.12217. ORIGINAL RESEARCH Paediatric European Network for Treatment of AIDS (PENTA) guidelines for treatment of paediatric HIV-1 infection 2015: optimizing health in preparation for adult
More informationImplementation of a near real-time phylogenetic monitoring program for HIV transmission outbreaks
Implementation of a near real-time phylogenetic monitoring program for HIV transmission outbreaks Art FY Poon 1,2, Conan K Woods 1, Susan Shurgold 1, Guillaume Colley 1, Robert S Hogg 1,3, Mel Krajden
More informationCLINICAL GUIDELINES FOR THE MANAGEMENT OF HIV & AIDS IN ADULTS AND ADOLOSCENTS
CLINICAL GUIDELINES FOR THE MANAGEMENT OF HIV & AIDS IN ADULTS AND ADOLOSCENTS National Department of Health South Africa 2010 1 Table of Contents Foreword... 4 Abbreviations... 5 Introduction... 7 1.
More informationHBV screening and management in HIV-infected children and adolescents
HBV screening and management in HIV-infected children and adolescents Linda Aurpibul M.D. Research Institute for Health Sciences, Chiang Mai University 8% HIV and Hepatitis B Co-infection Among Perinatally
More informationHIV/AIDS Programme WHO HIV DRUG RESISTANCE REPORT 2012
HIV/AIDS Programme WHO HIV DRUG RESISTANCE REPORT 2012 HIV/AIDS Programme WHO HIV DRUG RESISTANCE REPORT 2012 WHO Library Cataloguing-in-Publication Data The HIV drug resistance report - 2012. 1.Anti-HIV
More informationHIV Guidelines. New Strategies.
HIV Guidelines. New Strategies. Santiago Moreno Hospital Universitario Ramón y Cajal Madrid HIV Guidelines. New Strategies. Outline HIV Guidelines What is new? New strategies Treatment as Prevention HIV
More informationLondon Therapeutic Tender Implementation: Guidance for Clinical Use. 4 th June 2014 FINAL
London Therapeutic Tender Implementation: Guidance for Clinical Use 4 th June 2014 FINAL Contents 3. General principles 4. Financial impact of therapeutic tendering for branded ARVs 5. London ARV algorithm:
More informationTuberculosis OUR MISSION THE OPPORTUNITY
Tuberculosis OUR MISSION Guided by the belief that every life has equal value, the Bill & Melinda Gates Foundation works to help all people lead healthy, productive lives. Our Global Health Program is
More informationTreatment Information Service 1 800 HIV 0440 HIV/AIDS. HIV and Its Treatment What You Should Know. 2nd edition
HIV/AIDS Treatment Information Service 1 800 HIV 0440 HIV and Its Treatment What You Should Know 2nd edition HIV/AIDS TREATMENT INFORMATION SERVICE 2nd Edition HIV and Its Treatment: What You Should Know
More informationTreatment Action Campaign UNDETECTABLE HOW VIRAL LOAD MONITORING CAN IMPROVE HIV TREATMENT IN DEVELOPING COUNTRIES. www.msfaccess.
Treatment Action Campaign UNDETECTABLE HOW VIRAL LOAD MONITORING CAN IMPROVE HIV TREATMENT IN DEVELOPING COUNTRIES www.msfaccess.org Table of Contents 3 Executive Summary 4 Introduction 5 MSF HIV/AIDS
More informationARV treatment Update 2012. Avondseminarie 18 december 2012 Eric Florence ITG, Antwerpen
ARV treatment Update 2012 Avondseminarie 18 december 2012 Eric Florence ITG, Antwerpen Three big conferences in 2012 http://retroconference.org/2012/ http://www.aids2012.org/ http://www.hiv11.com/ Current
More informationUSED SYRINGES ANALYSIS : A NEW APPROACH TO BETTER KNOW THE INJECTED DRUG USES AND USERS
USED SYRINGES ANALYSIS : A NEW APPROACH TO BETTER KNOW THE INJECTED DRUG USES AND USERS Thomas NEFAU a, Catherine DUPLESSY-GARSON a, Jean-Louis BARA a, Sara KAROLAK b, Vincent THIBAULT c,yves LEVI b a
More informationJanssen Global Public Health: HIV Medicines Access & Partnerships Program APRIL 2014. Julius Bustamante, Pajaros
Julius Bustamante, Pajaros Artwork from Hospital Audiences, Inc. (HAI), a nonprofit organization that inspires healing, growth and learning through access to the arts for the culturally underserved. Janssen
More informationThe source documentation for the procedure will need to be identified for some items that are in the protocol, but not captured on the CRFs.
6. Visit Checklists 6.1. Overview of Section 6 This section provides a template checklist for each of the required study visits. The use of visit checklists is optional. 6.2. Visit Checklists as Source
More informationHPTN 073: Black MSM Open-Label PrEP Demonstration Project
HPTN 073: Black MSM Open-Label PrEP Demonstration Project Overview HIV Epidemiology in the U.S. Overview of PrEP Overview of HPTN HPTN 061 HPTN 073 ARV Drug Resistance Conclusions Questions and Answers
More informationSix-Month Outcomes from a Medical Care Coordination Program at Safety Net HIV Clinics in Los Angeles County (LAC)
Six-Month Outcomes from a Medical Care Coordination Program at Safety Net HIV Clinics in Los Angeles County (LAC) Wendy H. Garland, MPH; Rhodri Dierst- Davies, MPH; Sonali P. Kulkarni, MD, MPH 9 th International
More informationThe Western Cape Consolidated Guidelines for HIV Treatment: Prevention of Mother- to- Child Transmission of HIV (PMTCT), Children, Adolescents and
The Western Cape Consolidated Guidelines for HIV Treatment: Prevention of Mother- to- Child Transmission of HIV (PMTCT), Children, Adolescents and Adults. 2015 (Amended Version) The Western Cape Consolidated
More informationRAPID ASSESSMENT OF PEDIATRIC HIV TREATMENT IN NIGERIA
RAPID ASSESSMENT OF PEDIATRIC HIV TREATMENT IN NIGERIA JANUARY 2013 This publication was made possible through the support of the U.S. President s Emergency Plan for AIDS Relief (PEPFAR) through the U.S.
More informationPrioritizing Second-Line Antiretroviral Drugs for Adults and Adolescents: a Public Health Approach
Prioritizing Second-Line Antiretroviral Drugs for Adults and Adolescents: a Public Health Approach Report of a WHO Working Group Meeting World Health Organization HIV Department Geneva, Switzerland 21-22
More informationTHE ANRS& research in resourcelimited settings
THE ANRS& research in resourcelimited settings \1 2 / THE ANRS& research in resourcelimited settings \3 4 4 5 6 6 7 7 8 12 The ANRS: commited to resource-limited countries and the developed world Funding
More informationSURVEILLANCE OF TRANSMITTED HIV DRUG RESISTANCE AMONG VOLUNTARY COUNSELING AND TESTING CENTERS IN GONDAR TOWN ETHIOPIA
SURVEILLANCE OF TRANSMITTED HIV DRUG RESISTANCE AMONG VOLUNTARY COUNSELING AND TESTING CENTERS IN GONDAR TOWN ETHIOPIA ETHIOPIAN PUBLIC HEALTH INSTITUTE 2014 PREFACE Ethiopia has been progressively expanding
More informationChapter 36. Media Directory. Characteristics of Viruses. Primitive Structure of Viruses. Therapy for Viral Infections. Drugs for Viral Infections
Chapter 36 Media Directory Drugs for Viral Infections Slide 23 Slide 27 Slide 29 Zidovudine Animation Saquinavir Mesylate Animation Acyclovir Animation Upper Saddle River, New Jersey 07458 All rights reserved.
More informationWelcome to the first issue of the ACACIAGUM Newsletter
ACACIAGUM Innovative Management of Acacia senegal trees to improve land productivity and Gum Arabic production in Arid and Semi Arid Sub-Saharan Africa Welcome to the first issue of the ACACIAGUM Newsletter
More informationHIV infection in injecting drug users
HIV Clinical Skills Series 4 th International Training Course Tallinn 2010 HIV infection in injecting drug users Marika Raukas West-Tallinn Central Hospital Estonia InjectionDrug Users Transmission via
More informationScreening and preventive therapy for MDR/XDR-TB exposed/infected children (and adults)
Screening and preventive therapy for MDR/XDR-TB exposed/infected children (and adults) H S Schaaf Department of Paediatrics and Child Health, and Desmond Tutu TB Centre Stellenbosch University, and Tygerberg
More informationMINISTRY OF INVESTMENT PROMOTION, PARTNERSHIPS AND THE DEVELOPMENT OF STATE TELESERVICES. Direction of Financing and Public-Private Partnerships
MINISTRY OF INVESTMENT PROMOTION, PARTNERSHIPS AND THE DEVELOPMENT OF STATE TELESERVICES Direction of Financing and Public-Private Partnerships FINANCING OF PUBLIC PRIVATE PARTNERSHIP PROJECTS FORUM SEN
More informationClinical case HIV HCV coinfection
Clinical case HIV HCV coinfection Dominique Salmon HUPC, Paris Descartes University PHC, January 2016 Disclosures Board of experts for Gilead and BMS Objectives To discuss: Results of DAA combination in
More informationMesothelioma. Information for Patients and Families. identifying and evaluating experimental
Mesothelioma CLINICAL TRIALS Information for Patients and Families identifying and evaluating experimental treatments table of contents Pg. 2... Phases of a Clinical Trial Pg. 3... Mesothelioma and Clinical
More informationHIV Reports. Antiretroviral Stewardship in a Pediatric HIV Clinic. Development, Implementation and Improved Clinical Outcomes
HIV Reports Antiretroviral Stewardship in a Pediatric HIV Clinic Development, Implementation and Improved Clinical Outcomes Alice J. Hsu, PharmD, BCPS, AQ-ID,* Asha Neptune, MA, MPH, Constants Adams, BS,
More informationPresented By: Amy Medley PhD, MPH Centers for Disease Control and Prevention
Factors Associated with Non-Adherence to Antiretroviral Therapy among Patients Attending HIV Care and Treatment Clinics in Kenya, Namibia, and Tanzania Harriet Nuwagaba-Biribonwoha, Sherri Pals, Daniel
More informationPutting. A Product Guide for Viral Load and Point-of-Care CD4 Diagnostic Tools. www.msfaccess.org
Putting HIV Treatment to the Test A Product Guide for Viral Load and Point-of-Care CD4 Diagnostic Tools www.msfaccess.org THE MSF ACCESS CAMPAIGN In 1999, on the heels of Médecins Sans Frontières (MSF)
More informationPutting. A Product Guide for Viral Load and Point-of-Care CD4 Diagnostic Tools. www.msfaccess.org
Putting HIV Treatment to the Test A Product Guide for Viral Load and Point-of-Care CD4 Diagnostic Tools www.msfaccess.org THE MSF ACCESS CAMPAIGN In 1999, on the heels of Médecins Sans Frontières (MSF)
More information