Caring for Oncology Patients:

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1 : Tips and Tools for Managing Targeted Therapy Side Effects ehandbook These independent CME/CE activities are supported by educational grants from Genentech Bio

2 Side Effects ehandbook Table of Contents INTRODUCTION TO TARGETED THERAPIES FOR SOLID TUMORS...CHAPTER 1 EGFR INHIBITORS...CHAPTER 2 VEGF INHIBITORS...CHAPTER 3 HER2 INHIBITORS...CHAPTER 4 KIT INHIBITORS...CHAPTER 5 MTOR INHIBITORS...CHAPTER 6 MULTIPLE TYROSINE KINASE INHIBITORS...CHAPTER 7 THE CYTOCHROME P450 SYSTEM...APPENDIX

3 An Ongoing CME/CE Curriculum PLEASE NOTE: As required by the ACCME, all participants must read the information below before proceeding to this activity. Introducing Caring for : Side effects from the newer targeted therapies pose a whole new set of challenges to oncologists, nurses, and pharmacists. Management of these side effects is critical and can enable patients to remain on optimal treatment regimens, diminishing the need for dose reductions or treatment interruptions. The Caring for : Side Effects ehandbook is a comprehensive online resource designed to inform, support, and guide clinicians regarding prompt and proper management of the array of adverse events seen with these newer drugs. With seven informative chapters on topics including EGFR inhibitors, anti-vegf, anti- HER2, and KIT inhibitors as well as a comprehensive appendix on the CYP450 enzyme system and common drug interactions the ehandbook provides practical strategies to identify, monitor, and manage the side effects associated with targeted therapies in solid tumors. Each chapter is available as a downloadable PDF that can be printed or viewed on screen. In addition to numerous practical tips and strategies for managing side effects, the chapters also contain active hyperlinks to current prescribing information, ongoing clinical trials, and other valuable resources. Available for CME/CE: Release Date: October 15, Termination Date: October 15, Estimated time for completion of this activity: 3.00 hours. CME/CE Instructions: To obtain CME/CE credit for this activity: 1. Read the carefully. 2. Achieve a passing score on the posttest. 3. Complete/submit the posttest and evaluation. 4. Instantly access and print out your certificate. There is no fee for this activity. Caring for : ii

4 Chair Theresa W. Gillespie, BA, BSN, MA, PhD, RN Assistant Professor Department of Surgery Associate Director Winship Cancer Institute Emory University Atlanta, Georgia Faculty Pamela H. Carney, BSN Clinical Research Specialist Cancer Information Program Vanderbilt Ingram Cancer Center Nashville, Tennessee Teresa J. Knoop, MSN, RN, AOCN Clinical Nurse Specialist Cancer Information Program Vanderbilt Ingram Cancer Center Nashville, Tennessee Caring for : iii

5 Target Audience Oncologists, oncology nurses, pharmacists, and other clinicians who specialize in caring for oncology patients on a day-to-day basis. Program Goal The goal of this CME/CE activity is to examine current and emerging strategies for treating, monitoring, and managing side effects in cancer patients on targeted agents. Learning Objectives Monitor for side effects of targeted therapies in patients with solid tumors to recognize them at onset Implement strategies to minimize and prevent side effects of targeted therapies in patients with solid tumors to maintain quality of life and optimal dosages Manage side effects of targeted therapies in patients with solid tumors to limit impact on quality of life, morbidity, and mortality CME Information: Physicians Statement of Accreditation Projects In Knowledge is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Credit Designation Projects In Knowledge designates this educational activity for a maximum of 3 AMA PRA Category 1 Credits. Physicians should only claim credit commensurate with the extent of their participation in the activity. CE Information: Pharmacists Projects In Knowledge is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education. This program has been planned and implemented in accordance with the ACPE Criteria for Quality and Interpretive Guidelines. The activity is worth up to 3.0 contact hours (.3 CEUs). The ACPE Universal Program Number assigned to this activity is H01-P. Contract for Mutual Responsibility in CME/CE Projects In Knowledge has developed the contract to demonstrate our commitment to providing the highest quality professional education to clinicians, and to help clinicians set educational goals to challenge and enhance their learning experience. Disclosure Information The Disclosure Policy of Projects In Knowledge requires that presenters comply with the Standards for Commercial Support. All faculty are required to disclose any personal interest or relationship they Caring for : iv

6 or their spouse/partner have with the supporters of this activity or any commercial interest that is discussed in their presentation. Any discussions of unlabeled/unapproved uses of drugs or devices will also be disclosed in the course materials. For complete prescribing information on the products discussed during this CME/CE activity, please see your current Physicians' Desk Reference (PDR). Pamela H. Carney, BSN, has disclosed no significant relationships. Theresa W. Gillespie, BA, BSN, MA, PhD, RN, has indicated that she has no real or apparent conflicts of interest to report. Teresa J. Knoop, MSN, RN, AOCN, is a consultant for Amgen Inc; is on the speakers bureau for Amgen Inc and Bristol-Myers Squibb; and is on the advisory board of Bristol-Myers Squibb. Peer Reviewer has disclosed no significant relationships. Projects In Knowledge s staff members have disclosed no significant relationships. Conflicts of interest are thoroughly vetted by the Executive Committee of Projects In Knowledge. All conflicts are resolved prior to the beginning of each activity by the Trust In Knowledge peer review process. The opinions expressed in this activity are those of the faculty and do not necessarily reflect those of Projects In Knowledge. This CME/CE activity is provided by Projects In Knowledge solely as an educational service. Specific patient care decisions are the responsibility of the clinician caring for the patient. This independent CME/CE activity is supported by an educational grant from Genentech Bio. Projects In Knowledge is a registered trademark of Projects In Knowledge, Inc Caring for : v

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