Marcel Arnold, MD Neurology University of Bern, Switzerland Phone

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1 Organizing Committee Marcel Arnold, MD Neurology Phone Caspar Brekenfeld, MD Neuroradiology Phone Jan Gralla, MD, M.Sc Neuroradiology Phone Andreas Raabe, MD Neurosurgery Phone Michael Reinert, MD Neurosurgery Phone Luca Regli, MD Neurosurgery University Medical Center, Utrecht, The Netherlands Phone Gerhard Schroth, MD Neuroradiology Phone Faculty Marcel Arnold, MD Neurology, Joachim Berkefeld, MD Neuroradiology, University of Frankfurt, Germany Caspar Brekenfeld, MD Neuroradiology, Mihai Constantinescu, MD Plastic Surgery, Uinversity of Bern, Switzerland Dai-Do Do, MD Angiolology, Jan Gralla, MD Neuroradiology,

2 Faculty (continued) Daniel Hänggi, MD Neurosurgery, Heinrich Heine University, Düsseldorf, Germany Sepideh Armin Hanjani, MD Neurosurgery, University of Illinois, Chicago, USA Nadia Khan, MD Neurosurgery, Stanford University, Medical Center, Stanford CA, USA Catharina Klijn, MD PhD Neurology, University Medical Center, Utrecht, The Netherlands Dominique Kuhlen, MD Neurosurgery, Rüdiger von Kummer, MD Neuroradiolgy, University of Dresden, Germany Pasquale Mordasini, MD Neuroradiology, Jaques Moret, MD Neuroradiology, Foundation Rothschild Hospital Paris, France Peter Nakaji, MD Barrow Neurosurgical Associates, Phoenix, USA Andreas Raabe, MD Neurosurgery, Luca Regli, MD PhD Neurosurgery, University Medical Center, Utrecht, The Netherlands Michael Reinert, MD Neurosurgery, Gerhard Schroth, MD Neuroradiology, Philippe Schucht, MD Neurosurgery, Hans Jakob Steiger, MD Neurosurgery, Lucie Thibault, MD Boston Scientific, USA Albert van der Zwan, MD Neurosurgery, University Medical Center, Utrecht, The Netherlands Stephan G. Wetzel, MD Neuroradiology, University of Basel, Switzerland Martin Wiesmann, MD Neuroradiology, Helios Kliniken Schwerin, Germany

3 Topics and Venue Hands-on Microsurgical Training and Endovascular Stroke Treatment Course October 14 th 17 th 2009 Endovascular Stroke Treatment Course October 15 th 16 th 2009 Inselspital Bern, Institute of Pathology Murtenstrasse 31, CH-3010 Bern Local map: Wednesday, 14 th October 2009 Afternoon 1.00 p.m. Institute of Pathology at the Course start and welcome of the «microsurgical participants» Microsurgery hands-on: part I receipt of personal microinstrument set microsuture technique and in-vitro training device animal handling and anesthesia Demonstration hands-on: part I developments in anastomosis techniques ELANA technique and clinical application in vitro-training station End of the course 6.00 p.m.

4 Thursday, 15 th October 2009 Morning 8.00 a.m. Institute of Pathology at the Theory section: microsurgical and endosvacular participants Course start and welcome of the «endovascular participants» Theory part I: cerebrovascular physiology (8.05 a.m 9.15 a.m) cerebrovascular hemodynamics and brain metabolism online monitoring techniques (CBF, brain tissue oxygenation, NEARS ) state of the art and new developments in vascular imagin balloon test occlusion Coffee break and booth visit 30 minutes Theory part II: revascularization techniques (9.45 a.m p.m) extracranial cerebral revascularization: carotid stenosis: the gold standard endovascular: stenting of supraaortic extracranial arteries in particular carotid artery stenosis microsurgery: carotid endarterectomy intracranial cerebral revascularization: EC-IC bypass for carotid artery occlusion endovascular: intracranial stents microsurgery: microanastomosis: high-flow bypass low-flow bypass techniques for optimal vessel harvesting anti-platelet and anticoagulation in revascularization procedures physiology of anticoagulation and antiplatelet treatment round table (endovascular and microsurgery) Lunch (provided) p.m p.m.

5 Thursday, 15 th October 2009 Afternoon 1.30 p.m. Microsurgery hands-on: part II hands-on microvascular training in-vivo (rat): end-to-end carotid artery end-to-side carotid artery-jugular vein essentials in microsurgical training: tricks of the trade C-Port xa in-vitro training station in-vivo application of cardica C-Port xa Endovascular hands-on: part I hands-on endovascular training: thromboembolectomy devices stents protection devices in-vivo endovascular training: pig model Demonstration: part II cadaver dissection: carotid endarterectomy demonstration sutureless end-to-end anastomosis in the pig femoral artery End of the course 5.30 p.m. Evening Special Event (Dinner) 7.30 p.m. organized by Aesculap Akademie, Switzerland Dinner for participants and faculty. Meeting point at 7.30 p.m. at Restaurant zum Äusseren Stand Zeughausgasse 17, CH-3011 Bern

6 Friday, 16 th October 2009 Morning 8.00 a.m. Institute of Pathology at the Theory section: microsurgical and endosvacular participants Theory part III: clinical decision making (8.00 a.m 9.45 a.m) revascularization in moyamoya disease clinical decision giant aneurysms bypass endovascular reconstruction with stents and flow diverter case presentations (attendees are invited to present cases) endovascular microsurgical combined microsurgical / endovascular Coffee break and booth visit 30 minutes Theory part IV: stroke treatment (10.20 a.m a.m) organization and work flow of a stroke unit intraarterial thrombolysis: technique and results mechanical thrombectomy: approaches and devices Theory part V: research and future developments (11.00 a.m a.m) cerebral revascularization from past to future new sutureless anastomosis techniques laser and electromagentic tissue soldering stereolithographic models for advanced neurosurgical planning in EC-IC bypass surgery for complex giant aneurysm evaluation of collateral flow in acute vessel occlusion Roundtable: faculty Lunch (provided) a.m p.m.

7 Friday, 16 th October 2009 Afternoon 1.00 p.m. Microsurgery hands-on: part III hands-on microvascular training in-vivo (rat): end-to-side carotid artery-jugular vein end-to-end femoral artery microsurgery: permeability test of a microanastomosis Endovascular hands-on: part II hands-on endovascular training: thromboembolectomy devices stents protection devices in-vivo endovascular training: pig model certification endovascular participants End of the course for endovascular participants Demonstration: part III cadaver dissection: high-flow and low-flow EC-IC bypass End of the course 6.00 p.m. Saturday, 17 th October 2009 Morning 8.00 a.m. Institute of Pathology at the Hands-on section: microsurgical participants Microsurgery hands-on: part IV hands-on endovascular training for microsurgeons: thromboembolectomy devices stents protection devices In-vivo endovascular training: pig model certification microsurgery participants End of the course 1.00 p.m.

8 Terms and Conditions Registration fee Hands-on Microsurgical Training and Endovascular Stroke Treatment Course October 14 th 17 th 2009 Registration fee CHF or Euro Endovascular Stroke Treatment Course October 15 th 16 th 2009 Registration fee CHF or Euro Evening Special Event (Dinner) organized by Aesculap Akademie October 15 th 2009 Registration fee CHF or Euro Number of participants is limited to maximum 60 for the hands-on training (first-registered basis): Max. 30 participants for the microsurgery sessions Max. 30 participants for the endovascular sessions The hands-on microsurgical training and the endovascular training addresses neurosurgeons and neuroradiologists. The registration fee for participants includes: Course documentation, lunch, refreshments and for the hands-on course also all laboratory material and animals. Endorsed and accredited by the European Association of Neurosurgeons, Swiss Society for Neurosurgery, Swiss Society for Neurology and Swiss Society for Neuroradiology (CME). You will receive the confirmation together with the invoice. The registration fee must be paid at least 4 weeks before the course starts. Participants cancelling their registration 4 weeks before the course will receive a full refund. The general business conditions of B. Braun Medical AG pertain. Aesculap Akademie Cornelia Kost-Fuchs B. Braun Medical AG Seesatz, CH-6204 Sempach Phone Fax info@aesculap-akademie.ch Internet