PROGRAM. 43 rd Annual Meeting German Society for Immunology 43. Jahrestagung der Deutschen Gesellschaft für Immunologie (DGfI)

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1 43 rd Annual Meeting German Society for Immunology 43. Jahrestagung der Deutschen Gesellschaft für Immunologie (DGfI) September 2013 Mainz Peter Pulkowski PROGRAM

2 44 th Annual Meeting German Society for Immunology Chairs Prof. Dr. Gunther Hartmann Institute of Clinical Chemistry and Clinical Pharmacology September 2014 WORLD CONFERENCE CENTER BONN and Prof. Dr. Christian Kurts Institutes of Molecular Medicine and Experimental Immunology Rheinische Friedrich-Wilhelms-University Sigmund-Freud-Straße Bonn (DE) Symposia Antigen cross-presentation Inflammasome Nucleic acid immune sensing Sessions Allergy and autoimmunity Barrier immunity B cells and antibodies Cancer and inflammation Cell migration, communication and signaling Emerging topics Immune responses to infections Translational and clinical immunology Young immunologists Information and registration at

3 Table of contents Organization and Imprint... 4 Welcome Note of the Conference Chairs... 6 Key of Workshops and Abstract Topics... 7 Invitation to the General Assembly of the DGfI... 8 General Information Map of Public Transport, Campus Plan General Tips for Authors and Presenters Program Overview Wednesday, 11 September Thursday, 12 September Friday, 13 September Saturday, 14 September Satellite Symposium Joint Symposium DGfI-AKTI in association with DGI Symposium DGfI-AKTuI Scientific Program Wednesday, 11 September Thursday, 12 September Friday, 13 September Saturday, 14 September Poster Sessions Poster Session 1 Thursday, 12 September Poster Session 2 Thursday, 12 September Poster Session 3 Friday, 13 September Poster Session 4 Friday, 13 September Sponsors Exhibitors Plan of Exhibition Area Philosophicum Media Cooperations Social Program Index of Chairs, Invited Speakers and Presenting Abstract Authors

4 Organization and Imprint Venue University of Mainz Muschel, Philosophicum, ReWi Saarstrasse Mainz (DE) Date September 2013 Conference Website Organiser German Society for Immunology e. V. (DGfI) Conference Chairs Prof. Dr. Ari Waisman University Medical Center Mainz Institute of Molecular Medicine Hochhaus am Augustusplatz Obere Zahlbacher Strasse Mainz (DE) Prof. Dr. Hansjörg Schild University Medical Center Mainz Institute for Immunology Langenbeckstrasse Mainz (DE) Conference Organisation and Industrial Exhibition Conventus Congressmanagement & Marketing GmbH Nadia Al-Hamadi Carl-Pulfrich-Strasse Jena (DE) Phone Fax Nadia.Al-Hamadi@conventus.de Design/Layout Layout design.de Print Circulation Editorial Deadline 30 August

5 Special prepublication offer: CHF 90. / EUR 75. / USD Angiogenesis, Lymphangiogenesis and Clinical Implications Coming soon! Editors: Gianni Marone and Francescopaolo Granata (Naples) Articles in this book deal with the emerging, intriguing possibility that immune cells are both a source and a target of angiogenic and lymphangiogenic factors. This volume will be of broad interest to scientists interested in vascular biology, to basic and clinical immunologists, to oncologists and to specialists in allergic and immune disorders. Angiogenesis, Lymphangiogenesis and Clinical Implications (Chemical Immunology and Allergy, Vol. 99) Editors: Marone, G.; Granata, F. (Naples) approx. 200 p., hard cover, 2013 Special prepublication price: CHF 90. / EUR 75. / USD Prices subject to change EUR price for Germany, USD price for USA only ISBN (hard cover) The easiest way to order: Use the promotional code KI13273P Tentative Contents History of Research on Angiogenesis: D. Ribatti Immune Cells as Source and Target of Angio genic and Lymphangiogenic Factors: G. Marone, S. Loffredo, R.I. Staiano, F. Granata, A. Genovese Neuropilins: Role in Signalling, Angiogenesis and Disease: Zachary, I. Class 3 Semaphorin in Angiogenesis and Lymphangiogenesis: F. Bussolino, E. Giraudo, G. Serini Angiogenic and Anti-Angiogenic Chemokines: S. Sozzani, D. Bosisio, V. Salvi, V. Gagliostro Role of upa/upar in the Modulation of Angio genesis: N. Montuori, P. Ragno Neutrophil-Derived Cytokines Involved in Physiological and Pathological Angiogenesis: A. Cassatella, C. Tecchio The Roles of Eosinophils in the Modulation of Angiogenesis: H. Nissim, B. Efraim, F. Levi-Schaffer Treg Cells, Leptin and Angiogenesis: G. Matarese, V. Pucino, V. de Rosa, C. Proccacini Angiogenesis as a Therapeutic Target for Obesity and Metabolic Diseases: Y. Cao Angiogenesis in Multiple Myeloma: A. Vacca, R. Ria, A. Reale, D. Ribatti Angiogenesis Inhibitors in the Treatment of Prostate Cancer: B.A. Adesunloye, F.H. Karzai, W. L. Dahut Therapeutic Perspectives in Vascular Remodelling in Asthma and COPD: D. Olivieri, A. Chetta KI

6 Welcome Note of the Conference Chairs Dear colleagues and friends, On behalf of the board of the German Society for Immunology (DGfI) we are delighted to invite you to participate in our 43 rd Annual Meeting to be held in Mainz, Germany from September The conference will take place on the University s campus and bring together about students and professionals from academia, industry and government organisations. During main symposia and plenary sessions, an international and national delegation of renowned scientists, will present and discuss the stated main topics of basic and translational immunological research Tolerance, T cell plasticity (transcriptional regulation of immune cells), APC/T-cell interaction, Signaling, Pattern recognition, Controlling immune responses, Autoimmunity, B cells, Immune organogenesis, Innate effector cells, Tumor immunology, Gut (mucosal immunity). The lovely city of Mainz will certainly provide the perfect frame for an unforgettable event. We hope to see you all in September 2013 in Mainz! Yours Conference Chairs Ari Waisman Hansjörg Schild 6

7 Key of Workshops and Abstract Topics Workshop/abstract topic Abstract ID Pages Adhesion Molecules Autoimmunity ff. B Cells ff. Clinical Immunology, Immunodeficiencies, Reproduction Immunology ff. Complement and Fc Receptors f. Dendritic Cells ff. Effector Function of T Cells ff. Granulozytes, Mast Cells, Immune Response in the Skin , ff. Infection Immunology , , ff., 81 ff., 89 ff. Lymphocyte Activation ff. Macrophages ff. Mechanism of Tolerance induced by T Cells f. Mucosal Immunology ff. NK, Gamma Delta, NK T Cells f. Signal Crosstalk, Signaltransduction, Calcium Signaling ff. T helper Cell Differentiation ff. Transplantation Immunology ff. Tumor Immunology , ff. Vaccination and Immune Memory ff. Veterinary Immunology

8 Invitation to the General Assembly of the DGfI Thursday, 12 September 2013, University Mainz N01/Muschel Dear Members of the German Society for Immunology, on behalf of the DGfI board we invite you to our 2013 General Members Assembly. Please find the agenda below. Agenda TOP 1 Approval of the agenda TOP 2 Approval of the minutes of the last general assembly of 07 September 2012 (see members area) TOP 3 Report of the President Overview over DGfI activities 2012/2013/2014 TOP 4 Report of the General Secretary Development of member statistics Financial report (Annual accounts 2012) Travel grants Central office TOP 5 TOP 6 TOP 7 TOP 8 TOP 9 TOP 10 TOP 11 TOP 12 Discharge of the board Academy of Immunology (Education Committee) Spring School Autumn School School of Translational Immunology Consultant Immunologist of the DGfI Appointment of the commission Consultant Immunologist Activities of the study groups Upcoming meetings DGfI Annual Meeting 2013 Mainz DGfI Annual Meeting 2014 Bonn ECI2015 Vienna DGfI Annual Meeting years DGfI in 2017 ICI2019 Berlin DGfI bid Public outreach activities Update Immunology in Germany Project Immunology for Everyone Awards of the DGfI Umbrella organisations vbio IUIS AOB We are looking forward to your participation. With kind regards, Prof. Dr. Carsten Watzl Secretary General 8

9 Weitere Informationen finden Sie unter Wer träumt nicht von einer Innovation mit raschem Wirkeintritt und Langzeiteffekt? Direkt aus dem Porsche Entwicklungszentrum in Weissach: der neue Panamera S E-Hybrid, weltweit erster Plug-in-Hybrid in der Luxusklasse. Kraftstoffverbrauch (in l/100 km) kombiniert 3,1; CO 2 -Emissionen 71 g/km; Stromverbrauch 16,2 kwh/100 km Innovation_148x210_Viszeral_Medizinkongress.indd :59 89

10 General Information Registration Fees Conference fee (all days) Member DGfI Regular Member DGfI Student* Non member Regular Non member Student* 320 EUR 120 EUR 400 EUR 150 EUR Day ticket fees 12 Sep Sep Sep Member DGfI Regular 120 EUR 120 EUR 85 EUR Member DGfI Student* 50 EUR 50 EUR 30 EUR Non member Regular 150 EUR 150 EUR 130 EUR Non member Student* 60 EUR 60 EUR 40 EUR Social Program Welcome Reception, 11 September 2013 regular and student* incl. Welcome Reception, 11 September 2013 accompanying person 15 EUR Social Evening, 13 September 2013 fully booked * Please provide proof of status via at registration@conventus.de or via fax and quote DGfI. General terms and conditions Please find our general terms and conditions on the conference website List of Attendants Please remember to sign the list of attendants (with barcode, if required or applicable) which is at the Check-In. Certificate of Attendance Certificates of attendance are available on your last day of the conference at the Check-In. Education Credits and Certification The 43 rd Annual Meeting German Society for Immunology (DGfI) is certified with 18 CME points (category B) by the Landesärztekammer Rheinland-Pfalz. Scientific Program Thursday, 12 September CME points category B Friday, 13 September CME points category B Saturday, 14 September CME points category B For certification all attendants are required to daily sign the certification list near the Check-In. 10

11 General Information Opening Hours Wednesday Thursday Friday Saturday Check-In hrs hrs hrs hrs Media Check-In hrs hrs hrs hrs Industrial Exhibition hrs hrs hrs hrs Abstract Volume The abstracts of the DGfI meeting are published on a USB flash drive. Participants receive it at the Check-In free of charge. Prior to the conference all abstracts will also be available online on Internet There are computers with internet access available at the Internet Lounge sponsored by Dr. Ing. h. c. F. Porsche AG. Wireless internet will also be accessible free of charge. The code will be handed out at the Check-In. Poster Prizes The five best posters will be awarded with 500 EUR. The awards will be presented after the last plenary sessions on Saturday, 14 September, 2013 from hrs. All potential awardees will be informed on time and are kindly asked to attend. The prizes are sponsored by: Research Center for Immunology (FZI) PeproTech GmbH R&D Systems GmbH FZI Forschungs- Zentrum Immunologie Evaluation Please turn in your completed and legible evaluation form to the Info Desk or Check-In on the last day. We are looking forward to your active participation and constructive criticism. Catering During the coffee breaks, industrial exhibition free coffee, tea, water and snacks will be provided at the points marked Catering on the ground and first floor of the Philosophicum (see page 115). During lunch breaks coffee, tea and water is served free of charge at the indicated areas. Furthermore lunch is served during the breaks. Alternatively you have the option to have lunch on campus in the canteen (Mensa; hrs) or several cafeterias, serving warm dishes for reasonable prices. Please note, that the canteen only accepts cash at Theke 4. (follow the signs on site). For a better orientation, please have a look at page

12 General Information Cloakroom The cloakroom is in the fi rst fl oor of the Philosophicum (costs: 50 cent per piece). Local Transport The easiest way to reach the Mainz University is to take one of the following bus lines from Mainz main station ( Hauptbahnhof ) Line 6 (direction Marienborn ) Line 6A (direction Bretzenheim/Gutenberg-Center ) Line 54 (direction Lerchenberg/Brucknerstraße ) Please get out at following bus stops Universität (main entrance, Forum universitatis) Friedrich-von-Pfeiffer-Weg (Philosophicum) Ackermannweg (main car entrance) Every participant receives a free ticket for the public transport in Mainz for the entire period of the conference (11 14 September 2013). Participants who registered and paid until 21 August, 2013, received the namebadge and ticket for local transport prior to the conference via mail. Participants registering and paying later that 21 August, 2013, will receive the documents directly at the Check-In. The ticket is valid for all lines in the RMV-tariff area 65 (including Mainz and Wiesbaden plus following parts of the town: Zornheim, Wackernheim, Walluf, Wallgau, Hochheim, Bischofsheim and Ginsheim-Gustavsburg). For schedule information please have a look at Parking The University Campus offers several area for parking. Please leave, clearly visible, a fl yer of the DGfI conference in the front window of your vehicle. Flyers are available at the Check-In in the Philosophicum. 12

13 in Germany Celebrating the occasion of the 43 rd Annual Meeting of the German Society for Immunology (DGfI), September 2013, International Immunology has compiled a special article collection highlighting work published recently by German researchers in the journal. Differential regulation of marginal zone and follicular B cell responses by CD83 Melanie Uhde, Svenja Kuehl, Ulricke Richardt et al. Advance Access DOI /intimm/dxt021 Mast cell-derived mediators promote murine neutrophil effector functions Fatma Doener, Anastasija Michel, Sebastian Reuter, et al. Advance Access DOI /intimm/dxt019 Abrogation of IL-4 receptor-α-dependent alternatively activated macrophages is sufficient to confer resistance against pulmonary cryptococcosis despite an ongoing Th2 response Uwe Müller, Werner Stenzel, Daniel Piehler, et al. Advance Access DOI /intimm/dxt003 Histamine 4 receptor plays an important role in auto-antibody-induced arthritis Elisa Nent, David Frommholz, Mieczyslaw Gajda, et al. Volume 25 Issue 7 (2013) Vav1 regulates MHCII expression in murine resting and activated B cells Bettina Jux, Andrea Staratschek-Jox, Josef M. Penninger, et al. Volume 25 Issue 5 (2013) Targeting the antigen encoded by adenoviral vectors to the DEC205 receptor modulates the cellular and humoral immune response Matthias Tenbusch, Godwin Nchinda, Michael Storcksdieck Genannt Bonsmann, et al. Volume 25 Issue 4 (2013) In the presence of IL-21 human cord blood T cells differentiate to IL-10-producing Th1 but not Th17 or Th2 cells Aysefa Doganci, Julia Birkholz, Stephan Gehring, et al. Volume 25 Issue 3 (2013) Trafficking of regulatory T cells in the intestinal immune system Oliver Pabst Volume 25 Issue 3 (2013) Establishment of the reversible peptidemajor histocompatibility complex (pmhc) class I Histamer technology: tool for visualization and selection of functionally active antigen-specific CD8 T lymphocytes Sabine Tischer, Till Kaireit, Constança Figueiredo, et al. Volume 24 Issue 9 (2012) HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells Clarissa Anni Wild, Christoph Bergmann, Günter Fritz, et al. Volume 24 Issue 8 (2012) Visit us online to read the articles for FREE at: INTIMM_German.indd 1 7/25/13 9:32 AM 12 13

14 General Information Map of Public Transport Alte Lokhalle Fr.-v.-Pfeiffer-Weg Universität Ackermannweg/FH 14

15 66. Jahrestagung der Deutschen Gesellschaft für Hygiene und Mikrobiologie (DGHM) und Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM) JOINT MEETING Fotolia/digi dresden SEPTEMBER/OKTOBER 2014 DRESDEN Kongresspräsidenten Prof. Dr. Gerold Barth und Prof. Dr. Volkhard Kempf

16 City Center General Information Campus Plan Forum Universitatis Bus stop Fr.-v.-Pfeiffer-Weg Bus stop Fr.-v.-Pfeiffer-Weg Bus stop Universität Bus stop Universität Important Points Johannes Gutenberg University Mainz Bus stop Ackermannweg University Mainz 16

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18 General Tips for Authors and Presenters Submitting Your Presentation Please prepare your presentation in 4:3 aspect ratio. A presentation notebook with a PDF reader and MS Office PowerPoint 2007 will be provided. The use of personal notebooks is possible a technical supervisor will help you. Please provide an adapter for VGA if necessary. A notebook, presenter and laser pointer are available at the speaker s podium in the lecture hall. Media Check-In The media check-in is located on the first floor of the Philosophicum and is sponsored by Dr. Ing. h. c. F. Porsche AG. Please submit your presentation on the day before your presentation, but no later than 2 hours before your presentation. You will have the possibility to view and edit your presentation on-site. For submission, please use a USB flash drive which should not be protected with software. Time allotment Invited speaker presentations have been fixed to 25+5 minutes for discussion. The length of an oral abstract presentation is 10+5 minutes for discussion. To ensure the smooth running of the entire program, all speakers are requested to adhere to their allocated speaking time. The session chairs are encouraged to inform the speaker of any delays. Poster Sessions The poster sessions are scheduled on Thursday, 12 September 2013 and Friday, 13 September 2013 from hrs and from hrs. The following poster presentations will be held during the sessions: Poster Session 1 Thursday, 12 September 2013 ( hrs) 1 50 Autoimmunity 1+2 (see pages 64 ff.) B Cells (see pages 68 ff.) Infection Immunology 1 (see pages 70 ff.) Lymphocyte Activation 1+2 (see pages 72 ff.) Signal Crosstalk, Signaltransduction, Calcium Signaling (see pages 75 ff.) Poster Session 2 Thursday, 12 September 2013 ( hrs) Dendritic Cells 1+2 (see pages 77 ff.) Infection Immunology 2 (see pages 81 ff.) Mucosal Immunology 1+2 (see pages 83 ff.) T helper Cell Differentiation (see pages 86 ff.) 18

19 General Tips for Authors and Presenters Poster Session 3 Friday, 13 September 2013 ( hrs) Adhesion Molecules (see page 88) Complement and Fc Receptors (see pages 88 f.) Infection Immunology 3 (see pages 89 ff.) Mechanism of Tolerance Induced by T Cells (see pages 91 f.) Transplantation Immunology (see pages 92 ff.) , 581 Tumor Immunology (see pages 94 ff.) Vaccination and Immune Memory (see pages 97 ff.) Poster Session 4 Friday, 13 September 2013 ( hrs) Clinical Immunology, Immunodeficiencies, Reproduction Immunology (see pages 100 ff.) Effector Function of T Cells (see pages 103 ff.) , Granulocytes, Mast Cells, Immune Response in the Skin (see pages 105 f.) Macrophages 1+2 (see pages 106 ff.) NK, Gamma Delta, NK T Cells (see pages 109 f.) Veterinary Immunology (see page 110) Posters should be DIN A0 (84.1 cm x cm). Poster pin boards are 120cm x 150cm. They are only to be used with the designated pins. Pin boards will be numbered. Keep in mind It is recommended to all poster authors to hang their posters on the dates and times stated below. Presenting authors are kindly asked to attend to their poster during the assigned session. Poster Session 1: Wednesday, 11 September from hrs until Thursday, 12 September hrs Poster Session 2: Wednesday, 11 September from hrs until Thursday, 12 September hrs Poster Session 3: Friday, 13 September from hrs until Saturday, 14 September hrs Poster Session 4: Friday, 13 September from hrs until Saturday, 14 September hrs Posters should be removed no later than hrs on 14 September, Posters will not be redirected

20 Program Overview Wednesday, 11 September 2013 ReWi Philosophicum R1 P10 P11 Foyer 12:30 15:45 Joint Symposium German Society for Immunology/Working Group Transplant Immunology (DGfI AKTI) and the German Society for Immunogenetics (DGI) 12:00 15:45 Symposium German Society for Immunology/Working Group Tumor Immunology (DGfI-AKTuI) p. 25 p :00 18:00 DGfI President s Symposium 18:00 19:00 Opening Ceremony p :00 21:00 Welcome Reception p. 117 Key Main Symposium Plenary Session Workshop Poster Session Sessions of the DGfI Industrial Symposium Social Program 20

21 Muschel Program Overview Thursday, 12 September 2013 Philosophicum N01 N02 N03 P2 P10 P11 08:30 10:00 Tolerance Please note that the symposium takes place in the ReWi, Room R1. Industrial exhibition and coffee break (Philosophicum) p :30 12:00 10:30 12:00 10:30 12:00 10:30 12:00 10:30 12:00 10:30 12:00 Infection Immunology 1 Autoimmunity 1 B Cells Lymphocyte Activation 1 Mucosal Immunology 1 Signal Crosstalk, Signaltransduction, Calcium Signaling p. 30 p. 31 p. 32 p. 33 p. 34 p. 35 Industrial exhibition and lunch break (Philosophicum) 12:00 13:00 12:00 13:00 13:00 14:30 13:00 14:30 13:00 14:30 B Cells Signalling Controlling Immune Responses Bio Rad Laboratories Ltd Nanostring Technologies Europe LTD p. 36 p. 36 p. 36 p. 37 p :30 16:00 Poster Session 1 (Philosophicum) Autoimmunity 1+2 B Cells Infection Immunology 1 Lymphocyte Activation 1+2 Signal Crosstalk Signaltransduction, Calcium Signalling p. 64 ff. 16:00 17:30 16:00 17:30 16:00 17:30 16:00 17:30 16:00 17:30 16:00 17:30 Autoimmunity 2 Dendritic Cells 1 Mucosal Immunology 2 T helper Cell Differentiation Macrophages 1 Lymphocyte Activation 2 p. 38 p. 39 p. 40 p. 41 p. 42 p :30 19:00 Poster Session 2 (Philosophicum) Dendritic Cells 1+2 Infection Immunology 2 Mucosal Immunology 1+2 T helper Cell Differentiation 19:00 20:00 General Assembly of the DGfI p. 77 ff. p

22 Program Overview Friday, 13 September 2013 Muschel Philosophicum N01 N02 N03 P2 P10 P11 08:30 10:00 APC/T Cell Interaction Please note that the symposium takes place in the ReWi, Room R1. Industrial exhibition and coffee break (Philosophicum) p :30 12:00 10:30 12:00 10:30 12:00 10:30 12:00 10:30 12:00 10:30 12:00 Transplantation Tumor Escape and Dendritic Cells 2 Immunology Tumor Micromillieu Mechanism of Tolerance Induced by T Cells CIMT: Antibodies and their Targets in Cancer Therapy Vaccination and Immune Memory p. 44 p. 45 p. 46 p. 47 p. 48 p. 49 Industrial exhibition and lunch break (Philosophicum) 12:00 13:00 12:00 13:00 12:00 13:00 13:00 14:30 13:00 14:30 13:00 14:30 Autoimmunity Immune Pattern Recognition Organogenesis Hiss Diagnostics GmbH pluriselect GmbH Lunch Seminar DFG and EJI p. 49 p. 50 Lunch Seminar Molecular Imaging in Immunology p. 50 p. 51 p. 51 p :30 16:00 Poster Session 3 (Philosophicum) Complement and Fc Receptors Infection Immunology 3 Mechanism of Tolerance induced by T Cells Transplantation Immunology Tumor Immunology Vaccination and Immune Memory p. 88 ff. 16:00 17:30 16:00 17:30 16:00 17:30 16:00 17:30 16:00 17:30 Infection Effector Function of CIMT: Therapeutic Clinical NK, Gamma Delta, Immunology 2 T Cells Tumor Vaccination Immunology NK T Cells p. 52 p. 53 p. 54 p. 55 p :30 19:00 Poster Session 4 (Philosophicum) Clinical immunology, Immunodefi ciencies, Reproduction Immunology Effector Function of T Cells Granulozytes, Mast Cells, Immune Response in the Skin Macrophages 1+2 NK, Gamma Delta, NK T Cells Veterinary Immunology 19:00 23:00 Social Evening Alte Lokhalle p. 100 ff. p

23 Muschel Philosophicum N01 N02 N03 P10 P11 08:30 10:00 T Cell Plasticity (Transcriptional Regulation of Immune Cells) Please note that the symposium takes place in the ReWi, Room R1. Program Overview Saturday, 14 September 2013 Industrial exhibition and coffee break (Philosophicum) p :30 12:00 10:30 12:00 10:30 12:00 10:30 12:00 10:30 12:00 Infection Macrophages 2 Complement and Fc Immunology 3 Receptors Clinical Immunology, Immunodeficiencies, Reproduction Immunology Granulozytes, Mast Cells, Immune Response in the Skin p. 58 p. 59 p. 60 p. 61 p. 62 Industrial exhibition and lunch break (Philosophicum) 12:30 14:00 12:30 14:00 12:30 14:00 Innate Effector Cells CIMT: New Concepts in Gut (Mucosal Immunity) Cancer Immunotherapy p. 63 p. 63 p :00 15:30 Awards, Poster Prizes and Closing Remarks Key Main Symposium Plenary Session Workshop Poster Session Sessions of the DGfI Industrial Symposium Social Program 22 23

24 Satellite Symposium Joint Symposium DGfI-AKTI (Transplant Immunology) in association with DGI German Society for Immunology/Working Group Transplant Immunology (DGfI-AKTI) in association with the German Society for Immunogenetics (DGI) New concepts to establish and monitor individualized therapy protocols in allograft recipients Not every patient has the same immune status when he receives an organ allograft and not every patient requires the same amount of immunosuppressive drugs after transplantation. Therefore, the establishment of immunomodulatory therapies which are guided by patient-specific conditions is a major goal in transplantation medicine. New concepts of individualized therapies have recently been developed, based on research in the fields of Transplantation Immunology and Immunogenetics. Experts from both fields will contribute to the scientific discussion on the significance of individualized therapy in transplantation and give an overview on the current status. The joint symposium is addressed to basic scientists, translational researchers, and physicians interested in applied aspects of transplantation biology/immunology. The topics presented will focus on patient monitoring to assess the individual risk for rejection/infection and the development of tolerance after transplantation. Furthermore, new strategies will be discussed to achieve donor-specific nonreactivity/tolerance in clinical organ transplantation by means of cellular therapy Monitoring Aspects P10/Philosophicum Chairs Caner Süsal (Heidelberg), Reinhard Schwinzer (Hannover) Biomarkers for tolerance/rejection Birgit Sawitzki (Berlin) Pre- and posttransplant antibody monitoring in heart transplantation Teresa Kauke (Munich) An integrative algorithm for the successful transplantation of highly immunized kidney transplant recipients Caner Süsal (Heidelberg) Assessment of donor-specific adaptation in kidney grafted patients Reinhard Schwinzer (Hannover) Coffee break 24

25 Satellite Symposium Joint Symposium DGfI-AKTI (Transplant Immunology) in association with DGI Cellular Therapy and Risk Factors P10/Philosophicum Chairs Caner Süsal (Heidelberg), Reinhard Schwinzer (Hannover) Immunomodulation using regulatory macrophages James Hutchinson (Regensburg) Treg in organ transplantation Elmar Jäckel (Hannover) Mesenchymal stem cells for therapy Marc Dahlke (Regensburg) Differential immunogenicity of HLA antigen epitopes Nils Lachmann (Berlin) Complement in organ transplantation Michael Kirschfink (Heidelberg) 24 25

26 Satellite Symposium Symposium DGfI-AKTuI (Tumor Immunology) Tumor Immunology P11/Philosophicum Chairs Barbara Seliger (Halle/Saale), Michael Bachmann (Dresden) Welcome and Introduction Elfriede Noessner (Munich) Engineered mesenchymal stem cells as a therapeutic modality for the treatment of solid tumors Peter Nelson (Munich) From single to universal BiTEs and CARs for individual Immunotherapy the past, presence and future Michael Bachmann (Dresden) Combinatorial antigen recognition by dual CAR T cells for use in adoptive cell therapy Tobias Riet, Astrid Holzinger (Cologne) Intratumoral T cells in a spontaneous lymphoma model Tanja Riedel (Munich) Break Imiquimod and resiquimod efficiently improve the immunestimulatory properties of human 6-sulfo LacNAc dendritic cells Rebecca Wehner (Dresden) Role of micrornas in the regulation of HLA class I abnormalities in tumor cells Barbara Seliger (Halle/Saale) Dysfunction of lymphocytes infiltrating human renal cell carcinoma displays anergic features and reveals diacylglycerol kinase and the ERK pathway as targets for therapeutic intervention Elfriede Noessner (Munich) RIG-I initiated innate immune signaling in melanoma cells enhance their sensitivity towards T cells, but not NK cells Lina Spaan (Essen) Concluding remarks Michael Bachmann (Dresden) 26

27 Research tools for the most demanding immunology experiments Antibody arrays: HTP platform to profile protein expression Cytokines: Active proteins with low endotoxin levels and batch to batch consistency Flow cytometry validated monoclonals: Wide coverage of both surface and intracellular targets SimpleStep ELISA: Single wash sandwich ELISA kit Just mix, wash and read Discover more at abcam.com 262_13_JH 26 27

28 Scientific Program Wednesday, 11 September DGfI President s Symposium R1/ReWi Chairs Dieter Kabelitz (Kiel), Jürgen Wienands (Göttingen) Welcome Hans-Martin Jäck (Erlangen) Key Note 1 Retroelements in autoimmunity Matthias Wabl (San Francisco, CA/US) IS 1 IS 2 IS 3 IS 4 IS 5 Hans-Hench Awardee Separation from self explains failure of circulating T-cells to respond to the CD28 superagonist TGN1412 Paula Romer-Roche (Würzburg) Herbert-Fischer Awardee Microglia emerge from erythromyeloid precursors via Pu.1 - and Irf8-dependent pathways Katrin Kierdorf (Freiburg) Otto-Westphal Awardee prize is sponsored by Dr. Ing. h. c. F. Porsche AG Aryl hydrocarbon receptor signaling controls organogenesis of intestinal lymphoid follicles Elina Kiss (Freiburg) Fritz-and-Ursula Melchers Awardee Thymus autonomous T cell development Vera Martins (Ulm) Georges-Köhler Awardee prize is sponsored by Dr. Ing. h. c. F. Porsche AG Lipid oxidation at the interface of innate and adaptive immunity Gerhard Krönke (Erlangen) IS 6 Key Note 2 Sein und Dasein in B cell development Fritz Melchers (Berlin) Opening Ceremony from Welcome Reception (see page 117) Philosophicum 28