Joseph M. Juran Center for Research in Supply Chain, Operations, and Quality
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1 Joseph M. Juran Center for Research in Supply Chain, Operations, and Quality Professor Kevin Linderman Academic Co-Director of Joseph M. Juran Center for Research in Supply Chain, Operations, and Quality Carlson School of Management University of Minnesota
2 Origins of the Juran Fellows Program
3 Quote from Dr. Juran This will be a place where leaders engage with scholars to shape critical questions, where new knowledge is developed, translated, and disseminated, and, above all, where Quality scholars are trained. It is my hope that, generations from now, historians will note that we helped create the Century of Quality. J.M. Juran
4 Juran Fellowship Award Application Content 1. Career information 2. Executive summary 3. Project description (up to 15 pages) 4. Short curriculum vitae (1-2 pages) 5. Letter of recommendation from a faculty advisor
5 Evaluation Criteria 1. Importance of the Problem (20% of score) 2. Connection to Existing Quality Research (20% of score) 3. Appropriate Methodology (20% of score) 4. Relevance to Scholarship and Practice (20% of score) 5. Timeline and Probability of completion (10% of score)
6 Community of Juran Fellows 6
7 Community of Juran Fellows
8 The Future From seedlings to orchards
9 Recent Juran Fellow Winners Anna Errore University of Palermo (Italy) Ujjal Kumar Mukherjee Carlson School of Management
10 Anna Errore University of Palermo (Italy) Visiting PhD student at the Carlson School of Management Definitive Screening Designs for Quality Improvement
11 Anna Errore University of Palermo, Italy (visiting PhD student at Carlson School of Management, University of Minnesota) William Li Christopher J. Nachtsheim Carlson School of Management, University of Minnesota Definitive Screening Designs and Discrete Choice Experiments for Quality Improvement
12 DOE in Business and Industry All models are wrong; some models are useful. George Box, 1978 Experiments, statistically designed or not, are a component of the learning process. How well one succeeds will be a function of adherence to the scientific method, the most rapid means for speeding the learning process. Juran, J. M., and Godfrey, A. B. (1999). Juran s quality handbook (Vol. 2). New York, McGraw Hill.
13 DOE in Business and Industry In quality applications DOE plays a fundamental role in a huge variety of situations, from design and development of new products, to product or process improvement practices. In conducting experiments one of the most challenging tasks is the design of the experimental settings. Assumptions Design Experiment Analysis
14 Screening Experiments The term `Screening Design' refers to an experimental plan that is intended to find the few significant factors from a list of many potential ones. Primary purpose is to identify significant main effects Three empirical principles Effects sparsity Effects heredity Effects hierarcy Source: Li, Xiang, Nandan Sudarsanam, and Daniel D. Frey. "Regularities in data from factorial experiments." Complexity 11.5 (2006):
15 Example Example of a Screening Experiment The reactor experiment of Box, Hunter, and Hunter (2005) 5 factors: Feed Rate (A), Catalyst (B), Stir Rate (C), Temperature (D), Concentration (E). The response is the percent reacted (y).
16 Example of a Screening Experiment The fitted equation is: y = B D 3.125E BD 5.5DE Obtained with a full factorial experimental design: 2 5 = 32 runs In practice full factorial designs are very rare, especially for screening, because the run size increases exponentially with the number of factors.
17 Purpose of this project Design efficient screening designs Linear models (quantitative response) Non-Linear models (qualitative response) Identify and refine methods for the analysis Get the right information at the minimum cost Cost Information
18 Over reliance on a single model Optimal design depends on a pre-stated model Full Factorial designs optimal for full-factorial model Screening designs assume only first-order effects active (resolution III fractional factorial, Plackett Burman designs) If higher order effects are active results may be misleading
19 Desirable design features Statistical efficiency Minimum alias (confounding) of the effects Small run sizes Cost Information
20 Definitive screening designs Jones, B., & Nachtsheim, C. J. (2011) A Class of Three-Level Designs for Definitive Screening in the Presence of Second-Order Effects, Journal of Quality Technology 43(1), ASQ Brumbaugh Award 2012 Lloyd S. Nelson
21 Definitive screening designs 2 level factors 3+2 level factors 3 level factors First paper of this project (under review) Presented at Spring Research Conference 2013 Statistics in Industry and Technology University of California Los Angeles June 20th -22nd Errore, A., Jones, B., Li, W., Nachtsheim, C. J. (under review) Two-Level Definitive Screening Designs.
22 Three-level DSDs Jones, B., & Nachtsheim, C. J. (2011) A Class of Three-Level Designs for Definitive Screening in the Presence of Second-Order Effects, Journal of Quality Technology 43(1), 1-15.
23 Three-level plus two-level DSDs Added 2-level categorical factors Two construction methods: DSD-augmented, unbiased designs Orth-augmented, orthogonal designs Jones, B., & Nachtsheim, C. J. (2013). Definitive Screening Designs with Added Two-Level Categorical Factors. Journal of quality technology, 45(2),
24 Two-level DSDs Only 2-level factors Categorical factors or too costly to pick three levels Need to correctly identify active factors Goals: Clear the estimation of the ME from the 2fi High D-efficiency in the ME model Small run size Alias = 0 Orthogonal or nearly orthogonal Min run size
25 Construction method Start random m Search exchange Judge improvements 2m m 1 m Intercept ME
26 Example Screening design with 7 factors 1. Optimize a 7x7 design 2. Foldover the 7x7 design to a 14x
27 Example comparisons with other designs 7 factors Typical design choices - Fractional Factorial Resolution III 8 runs
28 Example comparisons with other designs 7 factors Typical design choices: -PlackettBurman 12 runs
29 Example comparisons with other designs 7 factors - Margolin (1969) Weighing design D-efficiency = % Ave abs corr=
30 Example comparisons with other designs 7 factors - Two-level DSD D-efficiency = 91.65% Ave abs corr=
31 Current and future work Design Two-level DSDs (paper under review) Extension to non-linear models and discrete choice experiments (WIP) Analysis Identification and selection of the correct active terms in the analysis stage (WIP)
32 LEARNING FROM HIGH TECH INNOVATION FAILURES: APPLICATION OF BIG DATA PREDICTIVE ANALYTICS ON MEDICAL DEVICE FAILURES Ujjal Kumar Mukherjee PhD Student, Carlson School of Management, UMN Kingshuk K. Sinha Professor, Mosaic Company Professor of Corporate Responsibility Supply Chain & Operations, Carlson School of Management, UMN March 11 th, 2014
33 OVERALL RESEARCH AGENDA Understanding sources of technology failures in medical devices Technology life-cycle (age of underlying technology) Differential impact on sources: Stages of development and manufacturing Predicting device failures Failure risk estimation based on unstructured market data (user experience) Predictive analytics of Big unstructured datasets Improving precision of prediction Judgment bias in failure detection Improving usage and adoption of new technology in healthcare Context of surgical robot Field study in a large multi-specialty hospital in US Looking at doctors and surgical team learning and adoption Organizational capability building of complex and critical technology in the context of healthcare
34 INNOVATION FAILURES IN THE MEDICAL DEVICE INDUSTRY Source: FDA Database Innovation failure adds substantial cost and inconvenience to the system In the second quarter of 2012, million device units were recalled Increasing complexity of devices as well as increased speed of innovation. Failures are not desirable but are not always avoidable. Important to mitigate the impact of failures if one were to happen. Therefore, failure risk prediction is critical to ensure quality of innovation.
35 OBJECTIVES OF THE RESEARCH In this study we are using a large unstructured dataset and BIG DATA analytics to build a PREDICTIVE MODEL of failure risk of high tech innovations. Research Questions: Do field failure data provide a credible signal for early detection and prediction of innovation failure risk? (Prediction) What technology, firm or industry factors individually and in combination can improve the precision of prediction of innovation failure risk? (Precision) Do firms systematically exhibit a judgment bias in interpreting signals related to innovation failures? What factors influence the judgment bias, if present? (Consistency)
36 FAILURE PREDICTION: USING SIGNAL DETECTION THEORY Rate of adverse effects reported by users as signal of failure Under normal working conditions some adverse effect reports are likely - Noise However, systematic failures lead to abnormal adverse effect rate - Signal The idea is to monitor market reports on an ongoing basis Build predictive risk models for device failures Classify user reports into likelihood of device failures Statistically, separating the Signal from Noise is important.
37 VISUALIZING PREDICTION OUTCOME IN SIGNAL DETECTION THEORY (SDT) Predicted False True Actual False Correct Rejection Rate False Alarm Rate (FAR) True Miss Rate (MR) Hit Rate (HR) Receiver operating characteristics (ROC) curve Both are expensive to the firm Accuracy of the Prediction: Area under the curve (AUC) of the ROC curve
38 HYPOTHESES Hypothesis 1 (H1): Field failures predict innovation failure. Hypothesis 2 (H2): Field failures supplemented by factors related to design, production, supply chain, regulation and technology life cycle of the innovation reduces the prediction error of the innovation failure. Hypothesis 3A (H3A): Signal to noise ratio (in H2) is associated with systematic bias in the prediction of innovation failure. High signal to noise ratio is associated with under-reaction bias and low signal to noise ratio is associated with over-reaction bias. Hypothesis 3B (H3B): Severity of innovation failure (in H2) is associated with systematic bias in the prediction of innovation failure. High severity is associated with over-reaction bias and low severity is associated with under-reaction bias.
39 Primary Data Source DATA 1 Adverse events FDA manufacturer and user reported adverse event database (MAUDE) ~ 3 Million usable datapoints. Fairly unstructured with missing data and mis-classification (BIG DATA). ( ) 2 Recalls FDA Recall database ( ) 3 Firm level product FDA approval database, Compustat database ( ) development data 4 Industry competition FDA approval database, Compustat database ( ) 5 Manufacturing changes and Global Manufacturing at the firm level. FDA user and manufacturer facility registration database; FDA supplemental approval text files ( ). 6 Supplier information FDA user and manufacturer facility registration database; FDA supplemental approval text files ( ). 7 Device classification FDA approval database ( ) 8 Usage classification FDA approval database ( ) 9 Adverse event severity FDA / CDRH Patient reports database ~ 6 million data entries ( ). 10 Implant / non-implant FDA / CDRH device database ( ) 11 Device approval classification FDA 510(k) and PMA / PMA supplement database ( )
40 CONCLUSION FROM SEVERAL PREDICTIVE ANALYTIC MODELS ON THE DATA 1. Density of adverse effects (Measure of rate) are significant predictor of recalls. 2. Product development intensity parameters are significant predictors of recalls. 3. Supply chain changes increases recall likelihood in the short run. However, data indicates that generally firms recover from short run glitches in the long run. 4. Frequency of manufacturing process changes are significant predictors of recalls. 5. Global manufacturing significantly increases the likelihood of recalls. 6. Competitive intensity increases the likelihood of recalls. 7. Regulation type PMA has higher likelihood of recalls compared to 510K.
41 PREDICTIVE MODELING AND MODEL SELECTION Generalized Linear Mixed Models (GLMM) REGRESSION MODELS Generalized Additive Models (GAM) True Positive Rate True Positive Rate False Positive Rate False Positive Rate
42 PREDICTIVE MODELING AND MODEL SELECTION ENSEMBLE CLASS MODELS Boosting Classifier Random Forest Classifier True Positive Rate True Positive Rate False Positive Rate False Positive Rate
43 PREDICTIVE MODELING AND MODEL SELECTION Method Initial Model Sensitivity Final Model Sensitivity (AUC) (AUC) LASSO Mixed Logistic Regression 0.61 ( ) 0.81 ( ) Generalized Additive Model Cox Hazard Model Naïve Bayes Neural Network Support Vector Machine (Radial Basis Function Kernel) Boosting Random Forest 0.82 ( ) 0.95 ( ) Number of devices: 5,873, Train set size: 98,650, Test set size: 28,641 and Total sample size (n) : 127,291 Considerably high prediction accuracy.
44 FIRMS EXHIBIT SOME JUDGMENT BIAS IN DETECTING FAILURE SIGNALS Variance Mean Ratio vs. Judgment Bias Failure Judgments Severity Low High Over-reaction Over-reaction Under-reaction Variance Predictive analytic framework proposed will aid decision and judgment Aimed to mitigating some of the cognitive biases Make decision support system more data and information based Experience and human judgment can never be fully replaced but can be aided with data analytics Low High
45 CONCLUSIONS 1. We have shown that it is possible to predict innovation failures with fairly high degree of accuracy. 2. We have also been able to analyze the influence of some critical covariates in improving the accuracy of predicting innovation failure. 3. We have shown that judgment bias exists in managing innovation failure. 4. Use of data analytic decision support can help improve precision of failure detection and mitigate judgment bias to a considerable extent.
46 ACKNOWLEDGEMENTS Juran Center Dissertation Grant, 2013 Social and Business Analytic Collaboration (SOBACO), UMN Grant, 2013 American Hospital Association Grant, 2012 Dissertation Fellowship, Carlson School, UMN, 2014
47 THANK YOU
48 Juran Fellowship Award We welcome your Participation! Kevin Linderman
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