PhD School of Molecular Metabolism and Danish Cardiovascular Research Academy

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1 PhD School of Molecular Metabolism and Danish Cardiovascular Research Academy PhD Course on Molecular Mechanisms in the Metabolic Syndrome - 3 ECTS Time: 29 October 1 November 2007 Place: Trinity Hotel and Conference Center A/S, Fredericia, Denmark Topics: - Basic molecular and pathophysiological aspects of insulin resistance - Multiphase consequences of insulin resistance and hyperinsulinaemia - Biochemical role of obesity - The basic biochemistry of the atheromatous vascular disease - Development of and the disordered kinetics of the dislipidaemia in vascular disease - Pathophysiology of hypertension and its relationship to the development of the syndrome - Biochemical and metabolic impact of glucose intolerance - The clinical and the therapeutic implications arising out of the above pretentions will be stressed throughout the course. Prerequisites: PhD candidates in Diabetes, Endocrinology, Cardiology and Higher Physician training, as a postgraduate segment towards their PhD degree. Registration: Registration form can be found at and must be forwarded to the Secretariat of the PhD School of Molecular Metabolism no later than 7 September 2007 Price: 7,000 DKK. PhD and pre-graduate medical students free of charge. Further information: (B2) or Tel

2 PhD School of Molecular Metabolism and Danish Cardiovascular Research Academy PhD Course: Molecular Mechanisms in the Metabolic Syndrome 29 October (Monday) 1 November (Thursday) 2007 Programme DAY 1: Monday 29 October a.m. Registration and refreshments a.m. Welcome & Intro HBN SESSION I THE METABOLIC SYNDROME Chair person: Henning Beck-Nielsen a.m. The Metabolic Syndrome (MS): Definition, clinical features and metabolic costs in HBN a.m. Discussion Workshop: a.m. Insulin resistance what is it and how do we measure it? A. The Clamp technique (including indirect calorimetry, glucose turnover measurements, glucose processing invivo and muscle biopsy procedure) ( and ) B. Surrogate measurements: Fasting plasma insulin, HOMA, QUIKY, etc. ( and ) JEH/OHN

3 p.m. Lunch p.m. The normal glucose and fat metabolism NF/JK p.m. Discussion p.m. Molecular/Biochemical basis of insulin resistance. KH p.m. Discussion p.m. Mitochondrial function and insulin resistance MM p.m. Discussion p.m. Coffee/tea break SESSION II EPIDEMIOLOGY OF MS; GENOME AND MS; THE LIVER AND MS; SKELETAL MUSCLE AND MS Chair person: Kurt Højlund p.m. The liver and its role in the metabolic syndrome OHN p.m. Discussion p.m. Non-alcoholic fatty liver (NAFL) and insulin resistance HYJ p.m. Discussion 7.00 p.m. Dinner

4 DAY 2: Tuesday 30 October 2007 Chair person: Bjørn Richelsen a.m. The epidemiology of the metabolic syndrome KBJ a.m. Discussion a.m. The genome and the metabolic syndrome TH a.m. Discussion a.m. Coffee/tea break a.m. Obesity and its role in the development of the MS. BR a.m. Discussion The adipocytokines (Leptin, adiponectin, TNFalpha) BR Discussion p.m. Lunch SESSION III THE ROLE OF EXERCISE Chair person: Jørgen Wojtaszewski p.m. The role of skeletal muscle in the metabolic syndrome KH p.m. Discussion p.m. The signalling cascade for energy supply in exercising skeletal muscle of normal and insulin resistant subjects. JW

5 p.m. Discussion p.m. Exercise as medicine FD p.m. Discussion p.m. Coffee/tea break SESSION IV FFA AND PPARS Chair person: Susanne Mandrup p.m. I. The PPAR system in fat metabolism. SM p.m. Discussion p.m. II. The PPAR system a clinicopathological perspective. HBN p.m. Discussion 7.00 p.m. - Dinner

6 DAY 3: Wednesday 31 October 2007 SESSION V ENDOTHELIAL FUNCTION Chair person: Christian Torp Pedersen a.m. Lipoprotein lipase (LPL) and lipid turnover the importance of LPL to the metabolic syndrome and cardiovascular diseases FLH a.m. Discussion a.m. Interleukin-6 inflammation, insulin resistance and exercise: its role in the metabolic syndrome BK a.m. Discussion a.m. Coffee/tea break a.m. Endothelial function and the metabolic syndrome CRM a.m. Discussion Endothelial function and cardiovascular disease CTP Discussion p.m. Lunch SESSION VI DYSLIPIDAEMIA Chair person: Børge Nordestgaard p.m. I. Dyslipidaemia lipid turnover and its implication for insulin resistance. BN p.m. Discussion

7 p.m. II. Dyslipidaemia implications for the development of atherosis and vascular disease. BN p.m. Discussion p.m. Metabolic syndrome in the cardiovascular clinic PH p.m. Discussion p.m. Coffee/tea break p.m. Evidence based management of dyslipidaemia in the metabolic syndrome: How relevant are targets to outcomes? HSH p.m. Discussion p.m. The prenatal/intrauterine environment in the development of the metabolic syndrome and arteriosclerosis PP p.m. Discussion 7.00 p.m. - Dinner

8 DAY 4: Thursday 1 November 2007 SESSION VII HYPERTENSION AND MS Chair person: Henning Beck-Nielsen a.m. Hypertension and the metabolic syndrome CB a.m. Discussion a.m. PCOS and the MS insulin resistance and dyslipidaemia DG a.m. Discussion a.m. Coffee/tea break Workshop/seminar Newer techniques in defining the dysmetabolic signalling cascades in the metabolic syndrome: 1) Proteomics 2) Transcriptomics 3) Lipidomics 4) Bioinformatics ML QT JK SB Questions to the entire course curriculum HBN Sandwiches and Farewell HBN

9 FACULTY Henning Beck-Nielsen (HBN) Course leader Sten Christensen (SC) Course leader Christian Berne (CB) Knut Borch-Johnsen (KBJ) Søren Brunak (SB) Flemming Dela (FD) Nils Færgeman (NF) Dorte Glintborg (DG) of Medicine Dept. of Endocrinology Dept. of Pharmacology University of Copenhagen Endocrinology and Diabetes section The Uppsala Academic Hospital SWEDEN Chief physician Steno Diabetes Center Copenhagen Biocentrum Technical University of Denmark Kgs. Lyngby DMSc Dept. of Medical Physiology Panum Institute University of Copenhagen Associate Dept. of Biochemistry and Molecular Biology University of Southern Denmark MD, PhD Dept. of Endocrinology Kolding Hospital

10 Henrik Steen Hansen (HSH) Torben Hansen (TH) Per Hildebrandt (PH) Jan Erik Henriksen (JEH) Finn Lund Henriksen (FLH) Ole Hother-Nielsen (OHN) Kurt Højlund (KH) Bente Klarlund (BK) Associate professor, MD, DMSc Dept. of Cardiology MD Steno Diabetes Center Copenhagen Head of department, Chief physician, DMSc Clinical Research Unit, Dept. of Cardiology and Endocrinology E Frederiksberg Hospital MD, PhD Dept. of Endocrinology MD, PhD Dept. of Cardiology DMSc Dept. of Endocrinology MD, PhD Dept. of Endocrinology Muscle Research Centre Rigshospitalet Copenhagen

11 Jens Knudsen (JK) Martin Larsen (ML) Christian Rask Madsen (CRM) Susanne Mandrup (SM) Martin Mogensen (MM) Børge Nordestgaard (BN) Christian Torp Pedersen (CTP) Pernille Poulsen (PP) Dept. of Biochemistry and Molecular Biology University of Southern Denmark Research professor, PhD Dept. of Biochemistry and Molecular Biology University of Southern Denmark Research Fellow Harvard Medical School Joslin Diabetes Center Boston USA Associate professor Dept. of Biochemistry and Molecular Biology University of Southern Denmark, Odense MSc, PhD student Institute of Sports Science and Biomechanics University of Southern Denmark Department of Clinical Biochemistry Herlev County Hospital Clinic of Cardiology Y Bispebjerg Hospital Post.doc. Steno Diabetes Center, Gentofte

12 Bjørn Richelsen (BR) Qihua Tan (QT) Jørgen Wojtaszewski (JW) Hannelei Yki-Järvinen (HYJ) Dept. of Medical Endocrinology Aarhus University Hospital Assistant professor Human MicroArray Center Associate professor August Krogh Institute University of Copenhagen Department of Medicine University of Helsinki FINLAND Course secretariat: PhD School of Molecular Metabolism Research secretary Tine Christensen Dept. of Endocrinology Kloevervaenget 6, Odense C Denmark Tel Fax Web site: - (B2) Place: Trinity Hotel and Conference A/S, Gl. Færgevej 30, Snoghøj, Fredericia, Denmark Tel

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