Wädenswil. Karin Kovar & Tobias Merseburger University of Applied Sciences Zurich, Waedenswil

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1 Wädenswil Karin Kovar & Tobias Merseburger University of Applied Sciences Zurich, Waedenswil 1

2 Wädenswil Zurich 2 Wädenswil 3 Winterthur 2

3 outline NEW department of Life Sciences (ZHAW, UAS Zurich) building an international research network Abteilung Biotechnologie (UAS Waedenswil) reflecting on the future & lessons learned discussion 3

4 Department Life Sciences, ZHAW Hochschule Wädenswil biotechnology chemistry facility management food technology natural resources sciences 4

5 Abteilung Biotechnology Fachabteilung Biotechnologie Tobias Merseburger Pharma Bioprocesses Biology Pharmazietechnik Vera Luginbühl Rahel Gröflin Claudia Ghisleni Phytopharmazie Beat Meier Daniela Spriano Qualität / Steriltechnik Tobias Merseburger Ulrike Hahnemann Umweltbiotechnologie Urs Baier Sebastian Baum Britta Hölzel Hans Rudolf Zweifel Benjamin Reinhard Bioverfahrenstechnik Dieter Eibl Sören Werner Senad Lisica Sebastian Rothe Zellkulturtechnik Regine Eibl Tizian Demont Lidija Lisica Ramona Mettler Bioprozessinformatik Mark Jaeggi Roland Fehlmann Daniel Hans Bioprozesstechnik Karin Kovar Sabine Ammann Petr Hyka David Langenegger Verena Looser Robert Lovchik Chemie / Analytik Jürg Müller David Critchley Roger Müller Molekularbiologie Martin Sievers Priska Keller Cyrill Tanner Giovanna Spielmann-Prada Andreas Stein Tobias Wermelinger Radka Strnadova Martin Lauber Zellbiologie Angelika Viviani Jenny Eggenschwiler Leopold von Balthazar 5

6 Bioprocess Technology Biotechnology Fachabteilung Biotechnologie Tobias Merseburger Pharma Bioprocesses Biology Pharmazietechnik Vera Luginbühl Rahel Gröflin Claudia Ghisleni Phytopharmazie Beat Meier Daniela Spriano Qualität / Steriltechnik Tobias Merseburger Ulrike Hahnemann Umweltbiotechnologie Urs Baier Sebastian Baum Britta Hölzel Hans Rudolf Zweifel Benjamin Reinhard Bioverfahrenstechnik Dieter Eibl Sören Werner Senad Lisica Sebastian Rothe Zellkulturtechnik Regine Eibl Tizian Demont Lidija Lisica Ramona Mettler Bioprozessinformatik Mark Jaeggi Roland Fehlmann Daniel Hans Bioprozesstechnik Karin Kovar Sabine Ammann Petr Hyka David Langenegger Verena Looser Robert Lovchik Chemie / Analytik Jürg Müller David Critchley Roger Müller Molekularbiologie Martin Sievers Priska Keller Cyrill Tanner Giovanna Spielmann-Prada Andreas Stein Tobias Wermelinger Radka Strnadova Martin Lauber Zellbiologie Angelika Viviani Jenny Eggenschwiler Leopold von Balthazar 6

7 Wädenswil... from serving industry to an international research network 7

8 building an international research network outline applied (industrial) research Czech-Swiss cooperation prospects of an European network 8

9 outline applied (industrial) research - prerequisites and why? - services for white biotechnology - budget models and fundraising 9

10 equipment 10

11 equipment Bioprocess Technology 11

12 investments in infrastructure key of success For each successful acquisition of a project with a turn-over of about CHF, an up to CHF investment in infrastructure was made. 12

13 applied research applied R&D 13

14 white (industrial) biotechnology white (industrial) biotechnology 14

15 contract manufacturing not available! 15

16 patent & know-how 16

17 budget models 50% CTI (university) 50% industry salaries only 10-30% cash 20% virtual materials, travel expenses, etc. salaries industry 17

18 advanced process technology KTI co [g/kg] time [h] 18

19 process capability KTI * 18 product ch process control (5.2 %) change of feed profile (31.9 %) process control (7.1 %) feed groups Gruppe * problem identified 19

20 benefit of the improvement KTI product before improvement 26% before 1 2 production change 20

21 starting point Swiss-Czech cooperation 1 relevance for industry 2 shared interests BSE protein recombinant non-kosher 3 (personal/private relations) 4 governmental funds 5 spin-off or PR activities bovine porcine 21

22 outline Swiss-Czech cooperation - LONZA Ltd. worldwide - concentration and consolidation - types of international activities 22

23 worldwide activities Lonza Ltd. R&D sales office production site headquarter 23

24 Swiss-Czech cooperation Lonza Ltd. 24

25 Prague 25

26 1844 swiss cheese dairy 1890,1935&1992/99 Nestlé s.r.o & history Roche of s.r.o. Czech-Swiss Lonza Biotech cooperation s.r.o. food 1970 immigration biotech s.r.o mobility Bata Schuh AG 1919 Ota Sik 1970 economist Raphael Kubelik 1973 conductor Vladimir Prelog 1975 Nobel Price 26

27 cooperation 1999 with Lonza R&D Conference, Visp , 2002, 2005 & 2008 KTI st project Eureka E! /8 KTI & projects

28 ca Euro - cash benefit KTI industry KTI LSPP-LS KTI LSPP-LS governmental funding cash from industry 160 contribution industry 10 3 Euro time (h) E!

29 collateral activities Czech-Swiss cooperation R&D projects student/teacher exchange scientific symposia 4 e-learning 29

30 exchange students 2002/2003 Markus Züger 1970 Petr Hyka 2003/2004 & Radka Strnadová 2003-open end 2004/2005 Manuel Egger 1990 Petra Horová 2004/ Sandro Dilettoso Martina Skodová 2006/

31 next

32 small European projects bioprocess technology 32

33 outline prospects of an European network - elearning - (interested) partners - project focussing & synergies - means of international recognition 33

34 means of quality assurance elearning As a consequence of continuing trend of rising student numbers, the quality of instruction is put at risk, since the number of teachers, financial subsidies, and the physical space in laboratories remain practically unchanged. 34

35 new release January

36 sustainability model financial sustainability ***a part of the benefits of industrial consulting is redirected to the advantage of elearning. The presentation tools developed are also utilised to communicate research results more professionally. Consequently, we are more successful in acquiring industry projects and *** 36

37 funding cooperation 37

38

39 international projects bioprocess technology ESA Space Biology ETHZ et al. new Uni Ghent, B, Uni Boku & FHcampus Wien, A and ICT Prague, CZ KTI LSPP-LS ICT Prague & Lonza s.r.o, CZ & Lonza AG, CH KTI LSPP-LS GlycoVaxyn AG. Wädenswil CH KTI LSPP-LS Lonza AG, Visp CH E! 3415 ICT Prague & Lonza s.r.o, Kourim CZ & Lonza AG, Visp CH SVC 3025 EAWAG, ETH, Uni Bern & Zurich & Basel & Dortmund Creatools KTI FHS Biospectra AG & Lonza AG & IMSV Uni Bern SVC EAWAG, ETH, HS-T Zurich KTI Biospectra AG, Schlieren CH 39

40 BLSS (European Space Agency) 40

41 lessons learned What type of research field do we want to conduct and what degree of engagement can we realistically afford? 41

42 project partners bioprocess technology 1 Ghent University, B 2 UAS & BOKU Vienna, A 3 Inst. of Chem. Techn. Prague, CZ 4 Technical University Prague, CZ 5 Technical University Graz, A 6 Lonza Biotech s.r.o. Kourim, CZ 7 Dept. BCI, Uni Dortmund, D 8 EAWAG, Duebendorf, CH 9 Space Biology Group, ETH Zurich, CH 10 Biozentrum, University Basel, CH 11 ISMV University Bern, CH 12 Inst. of Education, Uni Zurich, CH 13 GlycoVaxyn AG, Zurich, CH 14 EMPA St. Gallen, CH 15 Inst. of Inorg. Chemistry, Uni Zurich, CH 16 Lonza AG, Visp, CH , ,12,13,

43 education research further education 43

44 Looser et al Biotech. Bioeng. 92:

45 Lista Innovationspreis

46 fundraising 46

47 long-term strategy sustainability Sustainable = able to continue over a (long) period of time. 47

48 efficiency sustainability Sustainable = causing little or no damage to the environment and therefore able to continue for a long time = efficient use of resources 48

49 ...since 1999 ar&d is a passion... lessons learned 49

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