We make research data intelligible

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1 Photo: SciLifeLab/Mikael Wallerstedt We make research data intelligible Teamwork. The strong bioinformatics environment at SciLifeLab enables co-workers to benefit from each other s expertise and together offer high quality support to the scientific community. Today, in-depth knowledge about bioinformatics is essential to most life science research. Te huge amount of data that researchers gather needs to be interpreted to become meaningful. At SciLifeLab, a Swedish center for molecular biosciences, we have created a research environment where bioinformatics is one of our key investments. Te SciLifeLab center combines frontline technical expertise with advanced knowledge of translational medicine and molecular bioscience. Researchers from all of Sweden can use both the technology and the know-how that is available at the center. In order to advance the bioinformatics expertise in the whole research community, SciLifeLab also organizes courses on advanced level. Åsa Björklund is a single-cell transcriptomics expert at the SciLifeLab Bioinformatics platform. Her group makes their expertise available to the research community by placing senior bioinformaticians in diferent research groups for a specifed time. Te best part about working as a bioinformatician at SciLifeLab is the opportunity to be involved in a variety of high profle projects with novel technologies and interesting biological questions, said Åsa Björklund. Alongside our Bioinformatics platform, many of our other platforms employ bioinformaticians. Among them is the National Genomics Infrastructure (NGI), which is responsible for the majority of SciLifeLab s sequencing services. Te NGI bioinformaticians are essential to us in many aspects, said Professor Ann-Christine Syvänen at the National Genomics Infrastructure. Tey advice our users when we start a new project, analyze the data, and plan strategically for future needs in terms of storage and computational capacity. In order to ensure high quality services our bioinformaticians also develop sofware, many of which are open source.

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4 AAAS Marion Milligan Mason Award for Women in the Chemical Sciences Marion Milligan Mason was a chemist and a proud AAAS member. Her will provided for the creation of a fund with a $2.2 million bequest to support research by early-career women in the chemical sciences. AAAS is grateful for philanthropic gifs like Dr. Mason s bequest, which make it possible for us to support promising scientists early in their careers. The online application site will open November 16, 2015 Proposals are due on or before March 1, 2016 Congratulations to the 2015 Recipients ALISON FOUT Assistant Professor of Chemistry University of Illinois at Urbana-Champaign Nitrite Reduction in a Non-Heme System: Evidence for an Alternative Mechanism KATHERINE MACKEY Assistant Professor, Department of Earth System Science University of California Irvine Aerosol Trace Metal Chemistry in a Changing Ocean Awards will be announced on or before January 2017 Apply today! KRISTIN PARENT Assistant Professor of Biochemistry and Molecular Biology Michigan State University Cryo-electron tomography of large and challenging biological specimens LUISA WHITTAKER-BROOKS Assistant Professor of Chemistry The University of Utah Exploration of scalable polymer-metal for thermoelectric applications

5 Produced by the Science/AAAS Custom Publishing Office LIFE SCIENCE TECHNOLOGIES NEW PRODUCTS: MICROSCOPY Linear Motor Microscope Stages The HLD117 series of linear stages for inverted research microscopes sets new standards for convenience and top performance. The HLD117 linear stages conventional stepper motor, ball-screw based motorized stages. The HLD117 track, driving the x- and y- stage plates over precision bearing guides, providing near frictionless, ultrasmooth movement. This method of movement allows a wide range of scanning speeds (1 µm/sec up to 300 mm/sec) to be achieved, making these stages suitable for a vast range of applications from rapid screening to detailed imaging. Superb repeatability (±1.15 µm), high resolution (±0.05 µm), and exceptional accuracy (0.045 µm/mm of travel) along with 50 nm encoders as standard, make the HLD117 an excellent choice for advanced imaging techniques. Built for performance with unmatched acceleration rates and speeds, the HLD117 provides constant speeds with extremely low velocity ripple. For info: TERS Instrumentation Tip-enhanced Raman scattering (TERS) is a technique that provides molecular information on the nanometer scale through the combination of a Raman spectrometer and a scanning probe microscope. TERS has been hampered by extremely long acquisition times (measured in hours) required for collection of reasonable pixel density, and is seen by the research community as a AIST- NT all the instrumentation concerns and bring TERS as an analytical method to a completely new level. The XploRA Nano platform in the upright and side setup stands on a mm optical table), fully instrumentation is robust, compact, and easy to use. It is currently available for chemical imaging at the nanoscale level for realworld applications. For info: cellfrap Imaging Platform Enabling the easy addition of photomanipulation techniques to imaging platforms, deck system for the popular ìopen source conceptî IX83 and IX73 microscopes. The highly accu- tion with various evaluation options for data presentation needs. Unlike conven- - tion-limited laser spot for high-intensity and precise positioning of the bleaching re- ensures that photomanipulation reaches and shape of the bleaching region, and enables control of the bleaching area with extreme accuracy. Driven by the Olympus achieves an unrivaled short switchover time of only 200 µs between bleach and postbleach acquisition, ensuring detection of the most valuable initial sample response after stimulation. Olympus For info: +49-(0) Scanning Electron Microscope scanning electron microscope is now features 91 beams working in parallel and increases the throughput of the The unrivaled net acquisition speed of more than 2 terapixels per hour enables large-scale experiments such as the imaging of cubic millimeters of brain tissue at nanometer resolution for the analysis of neural circuits. For research work conducted as part of numerous brain initiatives, this will speed up the ability to map whole areas of the brain to help understand the neuronal demonstrates that the Zeiss multibeam technology is scalable and will satisfy as well, for example in semiconductor and 506 are designed for continual Zeiss For info: Atomic Force Microscope The Keysight 9500 atomic force mi- integrates new software, a new highbandwidth digital controller, and a stateof-the-art mechanical design to provide unrivaled scan rates of up to 2 sec/frame ( pixels). The ultrafast scan rates of the 9500 are made possible by is controlled through NanoNavigator, a powerful new imaging and analysis software package from Keysight. In addition NanoNavigator software lets researchers save time by using the new Auto Drive feature, which automatically and optimal- cal user interface, as it guides users step-by-step through system setup and operation via intuitive, eye-catching visuals. For ultimate convenience, the NanoNavigator mobile app for smartphones and being performed by the Keysight Technologies For info: Electronically submit your new product description or product literature information! Go to for more information. Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availability of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier. SCIENCE sciencemag.org/products 20 NOVEMBER 2015 VOL 350 ISSUE

6 Join AAAS. Get instant access to Science. Support all of the sciences. When you subscribe to Science, you become part of the American Association for the Advancement of Science (AAAS), a nonprofit community of more than 100,000 members worldwide who believe in the power of science to make the world a better place. AAAS is hard at work promoting science in government, schools, and in the public commons around the globe. AAAS s award-winning journal Science offers the top peer-reviewed research across multiple disciplines. With your subscription, you'll get: ß 51 weeks of home delivery of Science ß Instant online retrieval of every Science article ever published, dating back to 1880 ß Full access to the Science mobile site and apps ß Career advice, webinars, blogs and fascinating features exclusively for AAAS members ß Members-only newsletters, and much more With increasing public skepticism about science and public funding for research more uncertain than ever our work has never been more important. Join hands with us today! Visit promo.aaas.org/joinaaas. Together, we can make a difference.

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