Anthony and Accounts. 2 Heathgate Place Agincourt Road Hampstead London NW3 2NU

Transcription

1 Anthony NolaN Annual Report and Accounts 2 Heathgate Place Agincourt Road Hampstead London NW3 2NU

2 Anthony NolaN Annual Report and Accounts 2 Heathgate Place Agincourt Road Hampstead London NW3 2NU years of lifesaving stories 40 years ago, in 1974, something incredible was born. A register of potential bone marrow donors was created by Anthony Nolan s mother, Shirley, in the hope of finding a cure for the lifethreatening blood disorder her son had been born with. In 2014 Anthony s legacy lives on. Every day we match incredible individuals willing to donate their blood stem cells to people with blood cancer who desperately need lifesaving transplants. And, every day, wonderful stories begin when a stranger does something amazing to save the life of someone they ve never met. A 40th anniversary is not only a good time to celebrate what we ve achieved: it s also a great time to reassess the way in which we work, how we reach people, and how we can maximise the impact of our lifesaving work.

3 England And Wales Charity Registration Number Scotland Charity Registration Number SC Company Registration Number Board of Trustees Chairman Simon Dyson MBE* Trustees Fran Burke Lionel Cashin Professor John Goldman (died 24 December 2013) Peter Harrison Ian Krieger* David Noon Dr Colin Rickard* Professor K Michael Spyer Paul Stanley* Brian Turner CBE Karin Swann (resigned 25 March 2014) * Audit Committee member Medical Director Professor Charles Craddock Senior Management Team Anthony NolaN Annual Report and Accounts Chief Executive Henny Braund Communications & Marketing Director Richard Davidson Finance & Resources Director Jonathan Bell Fundraising Director Catherine Miles IT Director Andrew Broadbent Operations Director Nicola Alderson Commercial Director Timothy Fox Bioinformatics Director Professor Steven Marsh Scientific Director Professor J Alejandro Madrigal Laboratory Director Dr Katy Latham Chief Medical Officer Dr Bronwen Shaw Auditor & Accountants Baker Tilly UK Audit LLP 25 Farringdon Street, London EC4A 4AB Bankers Barclays Bank plc 1 Churchill Place London E14 5HP Solicitors Bates, Wells and Braithwaite 2-6 Cannon Street London EC4M 6YH Table Of Contents 1 Statement From The Chairman And Chief Executive TRUSTEES REPORT 5 Why We Are Here 7 How We Operate Strategic Report 13 The Story So Far 23 Where We Are Going And How We Will Get There 27 The Financial Review 31 Our Finances Independent Auditor s Report Consolidated Statement Of Financial Activities Parent Charity Only Statement Of Financial Activities Consolidated And Charity Balance Sheets Consolidated Cash Flow Statement Financial Statements Notes To The Financial Statements Registered Office Royal Free Hospital Pond Street Hampstead London NW3 2QG Administrative Address 2 Heathgate Place Agincourt Road Hampstead London NW3 2NU Photography by Stephen Pennells

4 19-74 January 1974 Shirley Nolan sets up the Anthony Nolan register I believe that Anthony represented much more than the struggle to establish a bone marrow transplant programme in Britain. He represents the rights of the individual in our society, especially those of our children, and their basic human right of a chance to lead a normal, healthy life. Shirley Nolan Shirley Nolan s cause, from humble beginnings 40 years ago, grew to form an organisation that saves lives in a way few others can claim to do. We now have over 500,000 donors on our register. That s half a million people who could save the life of someone with blood cancer. Chairman & Chief Executive Statement

5 We have a long road ahead but I look to the day when no child dies like my son, waiting for a donor to save him. Shirley Nolan Statement From The Chairman And Chief Executive 40 years ago this year a register of potential bone marrow donors was created by Anthony Nolan s mother, Shirley, in the hope of finding a cure for the life-threatening blood disorder her son had been born with. In 2014 Anthony s legacy lives on. It has been an amazing four decades for the charity, and we are tremendously proud of what we have achieved. We have led the way with the world s first bone marrow register; saliva testing for people joining the register; world-class research into stem cell matching; and the setting up of the UK s first dedicated cord blood bank. The last ten years have seen consistent and constant financial growth, and crucially, the number of donors we have identified for transplants has tripled. But we are not ones to rest on our laurels and, in the last, we have done more, broken new ground and saved even more lives, with the result that our work is more in demand than it has ever been. We have reached many memorable milestones. In December we reached and passed 500,000 donors on our register. And in this financial year we facilitated 1,240 lifesaving transplants. 1 2

6 There have also been many incredible personal stories. Victoria Rathmill became the youngest person in the world to donate her bone marrow to a stranger, at just 17 years of age. There was also the inspiring story of two-year-old Gaurav Bains, who was diagnosed with the rare blood disorder, Monosomy 7 Syndrome. His family launched an appeal for donors and we saw a 1,200% increase in Asian people applying to join our bone marrow register online. Then we heard the great news in December that a matching donor had been found and Gaurav was able to have a transplant. These inspiring stories of lifesavers and the people whose lives they saved are what we, as a charity, strive to achieve. However we simply couldn t be there for those people without the doctors, nurses and scientists we work with in hospitals, as well as our partners in the NHS and other organisations, doing incredible work to save lives. I d like to meet him or her one day. If they write a letter to me I d be happy to write one back, but if they don t that s OK. I just hope they re getting better, I just hope that I ve helped that s the most important thing. Victoria Rathmill This year the Department of Health confirmed the next stage of their funding for our ongoing partnership with NHSBT, guaranteeing a further 4 million in funding to support our work. We were also successful in a bid for the Government s Regional Growth Fund scheme, gaining 1.7m that allowed us to open three new cord collection centres and a second processing shift at our bank in Nottingham. Our first Post-Transplant Nurse Specialist will shortly begin work and we were also awarded a grant by the Wolfson Foundation towards the cost of our two new liquid handling instruments, Hamilton Robots. We know all of our lifesaving would not be possible without our fantastic supporters who helped us raise an amazing 8.2m and to say thank you we launched our first ever Supporter Awards. We would also like to thank the patients who inspire our work, the selfless donors and, of course, our wonderful staff and volunteers. Finally, we d like to take this opportunity to remember the life of Professor John Goldman, who sadly passed away last year, aged 75. As our Medical Director and later a Trustee, John was a leading figure in the global fight against blood cancer and his work transformed the lives of hundreds of thousands of patients worldwide. John s remarkable vision will continue to drive our work at Anthony Nolan. We will continue to endeavour to help every single person in need of a transplant find a good matching donor, have a successful transplant and then have a good quality of life. That was Shirley Nolan s dream 40 years ago when she set up our charity, and we will not rest until it has been achieved. Chairman, Simon Dyson, MBE Chief Executive, Henny Braund 3 4

7 The Big Campaign A Round Table campaign signs up 100,000 donors in six weeks. Our long relationship, which continues today, has raised millions of pounds to support Anthony Nolan s lifesaving work and found thousands of donors. Anthony Nolan is incredibly fortunate to have had such constant support from the Round Table throughout its 40 year history. Tablers have been with us every step of the way and I have no doubt that Anthony Nolan would not be here today without the Round Table. Simon Dyson, Chairman 40 years on, we have inspiring individuals and groups from around the country helping to sign up thousands of donors. Last year, for example, following an appeal by the family of two-year-old Gaurav Bains, who was diagnosed with a rare blood disorder, we saw a 1,200% increase in Asian people applying to join our register online. Why We Are Here

8 Trustees Report Why We Are Here At Anthony Nolan we exist to help save the lives of people with blood cancer who need a blood stem cell or bone marrow transplant. We are a pioneering charity that saves the lives of people with blood cancers such as leukaemia, myeloma or lymphoma and other serious blood disorders. For 40 years we have matched remarkable individuals willing to donate their blood stem cells to people who desperately need lifesaving transplants. Our objectives are to: provide relief, treatment or cures for people with blood cancer or similar immunological deficiencies, diseases or conditions provide information to help people with blood cancer It s fair to say that I always feel lucky to be here. I was never supposed to live past two but luckily, after finding an unrelated donor, I did. Nowadays, thanks to the work of Anthony Nolan and improved treatments, survival of conditions like chronic granulomatous disease is far more likely. Simon Bostic carry out research into the causes, diagnosis and treatment of blood cancer advance research into improving blood stem cell transplantation and to publish the useful results of such research. Despite what we have achieved in our 40 years, we know we need to do even more. Every 20 minutes in the UK, someone is diagnosed with a blood cancer. Many people in need of a transplant die because a suitable match can t be found in time to help them. That is why we launched an ambitious new strategic plan, all under one vision: To save the lives of everyone who needs a stem cell transplant To make sure we realise our vision, we set ourselves four strategic aims: Find a donor for every patient who needs one Improve the quality of life of patients who have had a transplant Put customers in the transplant community at the heart of what we do Provide the right people, environment and funding to maximise our impact Our vision is to help make sure every single person in need of a transplant can be found a successful match and has a good quality of life after their transplant. It s a big goal but, as we move into the future, we are taking steps to make sure we get closer to achieving it. How will we do this? In broad terms, we will: ensure patients get the best possible match, survive the transplant and have a good quality of life, post-transplant serve our customers in the transplant centres and hospitals, making sure we provide them with the right match for the right patient at the right time carry out research that helps patients in areas such as matching, tissue typing and post-transplant treatment harness the power of our supporters to raise funds and to spread the word about our lifesaving work recruit donors and support all those who go through the donation process work with partners on policy, research and campaigning to drive innovation and improve the lives of patients We know these are ambitious aims. But we have already begun to achieve them. 5 6

9 The launch of our student group, Marrow In 1998 James Kustow was inspired to organise a donor recruitment clinic at Nottingham University after his friend was diagnosed with leukaemia. Following the success of that single event, James went on to found Marrow, an award-winning medical student-run organisation that recruits students to our register. In 2014 Marrow is now a 44-strong network of student groups who this year broke records yet again. They signed up an astonishing 11,606 potential lifesavers across 321 events and raised an amazing 117,000. How We Operate

10 How We Operate Organisational Structure Anthony Nolan is a registered charity and a company limited by guarantee, not having share capital. Every member undertakes to contribute an amount not exceeding 1 to the assets of the charity in the event of the charity being wound-up during the period of their membership, or within one year thereafter. The members are the Trustees and Directors of the charity. The charity s governing document is in the form of a memorandum and articles association dated 6 March My condition is genetic so I want to be a world-leading geneticist. Then I can invent a cure that s really easy for all people who have CGD. Alex Hannard The overall strategic direction of the charity is determined by the Trustees, who meet formally at least four times each year. The Trustees are responsible for planning and policy-making for Anthony Nolan and, accordingly, all key decisions are referred to and taken by the Board of Trustees. The day-to-day management of Anthony Nolan is entrusted to the Chief Executive and the senior management team, who have delegated authority from the Board to administer the affairs of the charity. The Chief Executive and senior management team are invited to the Trustees meetings, and provide them with regular reports on the work of Anthony Nolan. The Trustees have taken the Charity Commission s general guidance on public benefit (contained within the guidance publication Charities and Public Benefit) and specific guidance on public benefit (contained within the guidance publication Public Benefit and Fee-Charging) into consideration in preparing their statements on public benefit contained within this Trustees annual report. Senior Management Team Anthony Nolan s senior management team meets on a regular basis, and departmental meetings are held throughout the year. Employees Policy For Disabled Persons Anthony Nolan operates a clear policy of equal opportunity for people with disabilities, which is communicated to all staff in our staff handbook. Anthony Nolan makes a specific commitment to employing people with disabilities wherever and whenever possible. Our policies reflect our desire to treat disabled persons fairly in all aspects of recruitment and employment and we have committed ourselves to providing assistance in career progression and training. We welcome ideas for making our facilities more user-friendly for the benefit of staff with disabilities. Employee Information The senior management team regularly provides information to employees through the publication of a quarterly magazine distributed to staff, through all-staff briefings held twice a year, as well as through weekly s from the Chief Executive to all staff and a variety of other communications. Regular consultations are held with staff through Anthony Nolan s Staff Forum, at which representatives from Human Resources are always present, to enable us to take employees views into account. Employee views are also sought on a variety of issues through web-based surveys 7 8

11 as well as Anthony Nolan s participation in the Sunday Times 100 Best Companies survey. Presentations by members of the commercial and finance teams to the organisation s senior and divisional staff help to create a common awareness of the financial and economic factors affecting Anthony Nolan s performance. Sub-Committees An Audit Committee, chaired by Ian Krieger, is a formal sub-committee of the Board of Trustees. The Chief Executive and the Finance & Resources Director are invited to attend the meetings. I think when you re diagnosed with cancer you ve got two options: you beat it or you let it beat you. And I think what got me and Paula through the transplant was Ryan himself. He never once complained, he just got on with it. Stuart, Ryan s dad Anthony Nolan Trading The charity owns 100% of the issued share capital of Anthony Nolan Trading Limited (ANTL). This subsidiary plays a crucial role in fundraising on behalf of the charity and the principal activity of ANTL is to carry on the trading operations of the group with a view to raising funds. This is achieved through advertising, selling merchandise, fundraising events and exploiting intellectual and similar rights held by the parent charity. Recruitment, Appointment, Election, Induction And Training Of Trustees Recruitment And Appointment Appointment to the Board of Trustees is by invitation after the needs of the charity and the range of suitable candidates are considered by the Trustees. The number of Trustees is not subject to a maximum, but must be three or greater. Election The Trustees retire from the Board by rotation every three years with the option of re-election. The Trustees aim to ensure that the composition of the Board contains individuals with suitable backgrounds and experience to contribute positively to the governance of Anthony Nolan. Since the members of Anthony Nolan are the Trustees and Directors, election and re-election is determined by the current Board in all cases. Induction And Training The work of Anthony Nolan involves continuously advancing scientific and medical processes of stem cell transplants. To keep Trustees aware of the charity s operations on both a national and international level, sessions are arranged to update them on facets of Anthony Nolan s work, either during Trustees meetings or away days. Presentations by outside advisers relating to specific governance issues are organised as appropriate. The induction of a new Trustee is tailored to the individual concerned. It does, however, always include the provision of key documents and information relating to Anthony Nolan, a guided tour of the charity s operations, an introduction to key staff, and an outline the duties and responsibilities of being a trustee and director. Declaration Of Interests Each financial year, all Trustees complete a Declaration of Interests form and new Trustees complete a Fit & Proper Person Declaration, as recommended by HMRC. The Declaration of Interests registers are included in the year end examination by our auditors. 9 10

12 Professional Indemnity Insurance The charity has taken out an insurance policy that provides professional indemnity insurance cover for the Trustees. The cost of this insurance for the period was 1,421 (2011/13 2,166). Risk And Corporate Governance Matters The Trustees have made an assessment of the risks to which Anthony Nolan is exposed, especially those related to business, operations and finance. They have put in place a review and reporting procedure to manage and reduce those identified risks. The key risks faced by Anthony Nolan include income continuity (which is dependent in part on NHS policy); any changes in clinical practice which adversely affect the place of unrelated donors in transplant activity and cash flow, particularly from NHS hospital trusts. This year we were successful in a bid for the Government s Regional Growth Fund scheme, allowing us to open three new cord collection centres, two in Nottingham and one in Manchester, and add a second processing shift at our bank in Nottingham. Procedures are in place to review risks on a regular basis. The actions that might need to be taken have also been considered, and are monitored and formally reassessed by the Trustees annually. Trustees And Directors Responsibilities In The Preparation Of Financial Statements The Trustees (who are also the directors of Anthony Nolan for the purposes of company law) are responsible for preparing the Trustees annual report and the financial statements in accordance with applicable law and United Kingdom Accounting Standards (United Kingdom Generally Accepted Accounting Practice). Company law requires the Trustees to prepare financial statements for each financial year which give a true and fair view of the state of affairs of the charitable company and the group as at the balance sheet date, and of the incoming resources and application of resources, including the income and expenditure for the charitable group, for that period. In preparing those financial statements, the Trustees are required to: select suitable accounting policies and then apply them consistently observe the methods and principles in the Charities SORP make judgements and estimates that are reasonable and prudent state whether the applicable UK Accounting Standards have been followed subject to any material departures disclosed and explained in the financial statements; and prepare the financial statements on the going concern basis unless it is inappropriate to presume that the charitable company will continue in business. The Trustees are responsible for keeping proper accounting records, which disclose with reasonable accuracy at any time the financial position of the charitable group, and enable them to ensure that the financial statements comply with the requirements of The Companies Act 2006, The Charities Act 2011, The Charities and Investment (Scotland) Act 2005 and The Charities Accounts (Scotland) Regulations They are also responsible for safeguarding the assets of the charitable company, and hence for taking reasonable steps for the prevention and detection of fraud and other irregularities. The Trustees are responsible for the maintenance and integrity of the corporate and financial information on the charitable company s website. Legislation in the United Kingdom governing the preparation and dissemination of financial statements may differ from legislation in other jurisdictions

13 The 2,500th person is provided with a lifesaving transplant The year 2000 saw Anthony Nolan reach many milestones. We provided our 2,500th person with a lifesaving transplant; our income was more than 10 million for the first time, and Shirley Nolan was awarded an OBE. 14 years later and we continue to see constant and increased growth, both financially and in the number of transplants we provide. In 2014 we provided 1,240 transplants that s over 12,000 transplants since 1974 and our work is more vital and in demand than ever. The Story So Far

14 This year we recruited 49,241 new potential donors. This meant we reached and passed the milestone of 500,000 donors on our register. That s half a million people who could save the life of someone with blood cancer. Strategic Report The Story So Far When Shirley Nolan set up a register of potential bone marrow donors, she had a dream that every single person in need of a transplant would be able to find a successful match and have a good quality of life after their transplant. Every year we re getting closer to achieving that. In the last 12 months, through innovative and pioneering work and the passion and dedication of our staff, supporters and volunteers we have made great strides in achieving the four aims which we set out two years ago

15 Aim One Find A Donor For Every Patient Who Needs One Right now, almost 1,800 people in the UK 37,000 worldwide are waiting for that vital match. Over the past, we have worked hard to change that statistic and we re making matches right around the world: We have helped facilitate 1,240 lifesaving transplants. We ran 1,796 new searches for UK patients, an 8% increase on the previous year. The number of Confirmatory Typing requests for UK patients from Anthony Nolan donors was 1,746, a 13% increase on the previous year. We shipped 1,041 during this period, a 21% increase on the previous year. We recruited 49,241 new potential donors. This meant we reached and passed the milestone of 500,000 donors on our register. That s half a million people who could save the life of someone with blood cancer. People signed up in huge numbers online and at each of the 528 events that took place. October 2013 saw the first anniversary of our change in joining policy to recruit those between the ages of 16 and 30. During the last financial year, 2, year-olds and 3, year-olds joined our register. Importantly, the change in joining policy change has reduced the average age of a new donor to the register from 29 to 21. Research has shown that younger donors offer patients the best chance of life, and this makes sure that more donors than ever in the ideal age range are available to hospitals. Following the change to our joining policy, our youngest ever donor was found. Victoria Rathmill was only 17 but entered the record books as the youngest unrelated donor to donate lifesaving stem cells. Following an appeal by the family of two-year-old Gaurav Bains from Birmingham, who was diagnosed with the rare blood disorder Monosomy 7 syndrome in July 2013, we saw a 1,200% increase in Asian people applying to join our register online. And in December we heard the great news that he had found a match and had a transplant. Marrow, our 44-strong network of student groups, broke records yet again, signing up an astonishing 11,606 potential lifesavers across 321 events and raising an amazing 117,000. Following an appeal by the family of Charlie Craig from Cookstown, a two-year-old battling leukaemia, the number of people from Northern Ireland signing up to our bone marrow register increased by over 2,000%. The Department of Health guaranteed a further 2m in funding to support our cord blood programmes and adult donor recruitment. We were successful in a bid for the Government s Regional Growth Fund scheme, gaining 1.7m to be invested over 18 months, allowing us to open three new cord collection centres - two in Nottingham and one in Manchester - and add a second processing shift at our bank in Nottingham. The Policy and Public Affairs team also raised the profile of the R&Be programme among MPs. We did this with Seema Malhotra MP, who tabled a Ten Minute Rule Bill calling for compulsory education for year-olds on blood, organ and bone marrow donation. Seema also tabled an Early Day Motion, which 67 MPs signed, also calling for compulsory education for year olds on blood, organ and bone marrow donation. We worked with the late Paul Goggins MP to raise awareness of the need for a cord blood collection centre in Manchester. Paul helped establish a relationship with Central Manchester University Hospitals Trust, which led to the set up of a cord blood collection centre. Our Reach the Six campaign, which focused on the 6% of the UK population who are Asian and urging them to join our register, won the Social and Charitable Campaign Award at the Asian Media Awards. The campaign saw 4,964 Asian donors join our register. At Leicester Royal Infirmary and Leicester General Hospital baby Alexander s cord blood was the 5,000th to be collected in Leicester since the cord collection centres opened in October Through our pioneering education scheme, Register and Be a Lifesaver, we spoke to 33,833 young people aged at 473 presentations about the life-changing difference they can make by donating their stem cells

16 Aim Two Improve The Quality Of Life Of Patients Who Have Had A Transplant We know that unfortunately around 50% of patients who have had a transplant die in the short-term: so we need to focus on improving the quality of life of all of our patients before, during and after a transplant. We have done a lot of work in this area including developing our support for, and engagement with, patients. This work has been wellreceived by patients, their families and transplant centres and we are keen to develop it. We have secured funding for one Anthony Nolan Nurse Specialist for three years (with plans for two more). They will work in transplant centres and be dedicated to improving the experience of transplant patients, particularly life after transplant. There has been greater alignment of the UK Registries (Anthony Nolan, NHS Blood and Transplant, Welsh Bone Marrow Donor Registry) from 1 September 2013, providing UK transplant centres with a single point of contact for the facilitation and provision of donors. Delete Blood Cancer UK also recruits potential donors to the Anthony Nolan and NHS Stem Cell Registry. The patient experience team launched the Day Zero cards for adults and children. Every person who receives a transplant will get this card on the day they receive their cells from an unrelated donor. The card celebrates day zero - or their second birthday - and lets them know about Anthony Nolan, how we can help and the support we can offer. A person s tissue type is defined by the characteristics of six genes, collectively known as the human leukocyte antigen (HLA) genes. These HLA genes that define our tissue type are very variable, but a successful stem cell transplant all depends on finding the right HLA match. This year we increased our Patient/Donor Panel, adding over 200 pairs to the human leukocyte antigen (HLA) database and sample repository. We have also increased the number of HLA (1,743) and Killer cell Immunoglobulin-like Receptors (KIR) (62) sequences submitted to the IMGT /HLA and IPD-KIR Databases meaning there is a greater chance we will find lifesaving matches. Visits to all transplant centres started in 2013 and will continue in 2014, allowing us to cement existing relationships and develop a better informed understanding of bone marrow transplants and the teams that deliver the clinical services. We ve worked with over 60 patients and families who have directly influenced our work. One of the highlights of this was working with 17 parents from all over the UK to write A Parent s Guide to the Transplant Journey the only support of its kind in the UK. The book will be shared with paediatric transplant centres, helping them to support parents at this difficult time. This initiative is a direct result of feedback received via our recently established parent panel. We created our patient and family Facebook page which now has nearly 500 followers. Our animation about having a transplant has been viewed over 1,000 times in three months on YouTube, and we have distributed over 500 copies of the written guide in that time. We launched an online Transplant Community for people to share their experiences with others. We have over 150 users signed up, with nearly 3,000 page views in three months. The Policy and Public Affairs team launched the A Roadmap for Recovery campaign, which calls for an end to the postcode lottery currently seen in post-transplant care. We worked with 2020health, a think tank, to research the report that informs the campaign. The report made 13 recommendations, which would ensure all post-transplant patients receive equal access to a comprehensive service to manage the physical and mental health complications they could experience after a transplant. We took the campaign to the political party conferences. We were invited to become a member of the Clinical Reference Group on Blood and Marrow Transplantations - the formal advisory group to NHS England on priorities to improve health and care related to bone marrow transplant

17 Aim Three Put Our Customers Transplant Centres, Clinicians At The Heart Of What We Do. We know that in order to provide the best possible service for hospitals and their patients, we must understand their needs and ensure that they are met. And here is how we have been making sure we provide a first-class service: The first Anthony Nolan Clinical Retreat was held in September 2013 and brought together 25 of the UK s leading bone marrow transplant clinicians. We had a hugely positive response to the event s agenda and format which allowed us to deliver a successful meeting with a further one planned for We were awarded 260,000 towards our two new liquid handling instruments, Hamilton Robots from the Garfield Weston Foundation and the Wolfson Foundation. Staff from our Laboratories, Research and Operations divisions attended the annual conference of the European Federation for Immunogenetics (EFI) in Maastricht. Prof Steve Marsh and Dr Katy Latham were invited to attend a Key Opinion Leaders Workshop on Next Generation Sequencing; James Robinson was an invited speaker at a masterclass session on HLA Data Resources and Dr Esteban Arrieta presented two of his scientific posters. The World Marrow Donor Association (WMDA) conducted its first full on-site visit of Anthony Nolan and we were awarded full WMDA accreditation. Prior to this we were a WMDA qualified registry, but this full accreditation gives us greater international recognition and assures our external customers that we follow robust practices and meet recognised standards. It was announced that over 9,000 HLA alleles have been identified in individuals from all over the world. Many have only been reported in single individuals and most likely are rare alleles. Thanks to our work with the National Marrow Donor Program, the latest version of the Common and Well-Documented (CWD) alleles catalogue is now available to download. It allows scientists performing tissue typing at medium resolution to understand which alleles are likely to be present in an individual and so avoid the time consuming and costly process of excluding rare alleles. We have published papers in some of the most prestigious scientific journals in the world, helping to improve the outcome of bone marrow transplantation. Since 2012, our research scientists have published 56 papers in 17 journals. Dr Robert Lown and Dr Bronwen Shaw s paper, Beating the odds: factors implicated in the speed and availability of unrelated haematopoietic cell donor provision, received the highest number of citations of all papers published in that year

18 Aim Four Provide The Right People, Environment And Funding To Maximise Our Impact. We know that to save as many lives as possible, we must have the best staff, the right environment and the necessary resources. And we have been working hard to make these happen: Fundraising income has continued to grow. Our gross fundraising income reached 8.4m, from 10m in the previous 18 month period. Net income from fundraising reached 2.8m. We increased our pool of regular givers to over 32,000, donating vital, consistent funds which enable us to grow our work and plan for the future. Over 1,500 people ran, cycled, trekked or parachuted for us, raising over 1.1m in the process. As official charity of the 2014 Virgin Money London Marathon we successfully recruited a team of over 500 runners, over 70% of whom had a personal link to Anthony Nolan. Our partnership with Virgin Money beat all targets to raise over 144,000. Over 1,200 individuals and groups in the community raised over 1m by doing street collections, cake sales at work, holding quiz nights and being sponsored to do the things they love. The family and friends of Lucas Ruddy, a three-year-old from London who received a successful transplant via Anthony Nolan, raised over 123,000 by cycling from Land s End to John O Groats. There are now 45 volunteer couriers including eight new volunteers recruited since last year. In 2013 there were 885 courier trips, 839 of which were covered by volunteer couriers. Over 1,000 volunteers have worked with our Register Development team through the year to recruit donors at events and to deliver Register and Be a Lifesaver presentations. We have seven active London donor visitors (five of whom are also couriers) and one active Sheffield visitor, with additional volunteers currently being recruited. We started using volunteer donor visitors in June 2013 and since August an average of 60% of donor visits have been carried out by volunteers, saving the time of office staff and in January/February 2014 this increased to over 90% of visits covered by volunteers. We created a new Commercial division and developed the first Anthony Nolan commercial strategy. We established commercial relationships with partners such as The National Marrow Donor Program, NHSBT and Delete Blood Cancer UK (DKMS). We implemented business to business customer relationship software and developed our UK and international market intelligence. We were ranked number 89 in the Sunday Times Best Not-for-Profit Organisation to work for survey. We launched a partnership with Trinity Mirror which began with the publication in The Mirror of the story of Simon Bostic, who had the first ever bone marrow transplant from an unrelated donor. The collaboration, which links with our 40th anniversary year, will see content run in the Mirror and across a number of its regional titles, as well as engaging staff and readers to raise vital funds

19 The UK s first dedicated cord blood bank is set up We set up the UK s first dedicated cord blood bank. This allows mothers to safely donate the blood from their umbilical cord and placenta after they give birth. Cord blood is rich in stem cells, which we use for lifesaving transplants. I almost wasn t aware of the cord donation it was all done in the room, calmly, quietly and with no fuss. I was busy getting to know my gorgeous son Toby. Catriona Finlayson, Toby s Mother In 2014 Leicester Royal Infirmary and Leicester General Hospital celebrated their 5,000th cord blood collection. Baby Alexander s cord blood was the 5,000th cord blood to be collected in Leicester since the cord collection centres opened in October Where We Are Going And How We Will Get There

20 Right from the offset you re mentally and physically drained so you re limited in what you can do. But I m a go get em kind of person and I couldn t sit on my backside for very long. I found myself walking and running as soon as I possibly could. Johnny Pearson Where We Are Going And How We Will Get There Here s To The Next 40 Years Pioneering spirit is something that has always marked Anthony Nolan out. And, though our 40th anniversary is a good time to reflect on what we have achieved, this same spirit will continue to be at the heart of our work as we push forward to do even more. We have achieved some incredible things and made great strides to ensure we are closer than we ever have been to realising our goal of saving the lives of everyone who needs a stem cell transplant. We know there is still a long way to go, but we are sure the next 40 years will be even more successful. Of course, with so much happening beyond our walls, there will be challenges. The science behind transplants; the international market for stem cells and Government investment in stem cell transplantation are just some of the areas which have seen dramatic change. In order to keep achieving more and more each year, we must change with them. And we are confident in our plans for the future

21 My football club, Crystal Palace, was the one place I found I could come and forget about my cancer. For 90 whole minutes, my focus was here. Chris Lewis Raising Our Game: More Transplants, More Lives Saved And Improved Support We are now two years into our three year plan so we need to start preparing for a new three-year strategy. We have identified 12 priorities for the next year to enable us to deliver our goals. Our current strategy is to focus on providing the best quality donors as we know that this will have the best outcomes for blood cancer patients. However, to be able to afford this in the long term we must find cheaper ways of providing this quality and amend our operating model to capitalise on commercial opportunities. Third Generation Sequencing We know that others in our field have introduced or have plans to introduce next generation sequencing, enabling faster, cheaper typing on a bigger scale than previously possible. Our plan is to leapfrog them and move to the stage beyond this: third generation sequencing. Third generation sequencing means typing at the highest possible level of resolution and doing so faster and at lower cost than we do now. We believe it will provide us with a vital competitive advantage. We have also recently restructured our register development and donor recruitment teams which will mean that we are recruiting more, and better, potential donors. Through the introduction of third generation sequencing and better recruitment, alongside investment in our IT infrastructure, we will be able to facilitate more transplants than ever before (our target is 1,450 in the coming year compared to around 1,240 in 2013/14). Financially we aim to grow again next year: in 2014/15 the Fundraising team will grow income to over 5.5m net, double the net income of the 2008/09 financial period. We have also made huge strides in our supporter development work over the last few years but we still have some way to go to make sure that our supporters understand the many ways whether that s fundraising, campaigning, volunteering or another way they can get involved with us to save lives. Our Work And Our Staff We also need to recruit and develop great staff and ensure that we have the best management information to support our decision-making. To help us do this we have looked to the future by launching our organisational values Passionate, Patient-Focused, Accountable, Innovative and Improving Everyday which will run through all the work we do and will be embodied by every member of staff. These are the tools we will use to succeed in our ambitions. By focusing on our strengths we will build a sustainable organisation, which can continue to save lives for at least another 40 years

22 The World s Youngest Donor In 2012 the world s millionth stem cell transplant took place something that was unimaginable when Shirley started her campaign. The same year, we became the first register in the world to start recruiting 16-year-olds. It was Victoria Rathmill who, in 2013, became the world s youngest ever stem cell donor aged just 17. It was an immediate decision. I had the opportunity to save someone s life, I didn t have to think about it. I wasn t expecting it, and I was a little scared but I was excited for what it meant. Victoria Rathmill The Financial Review

23 The Financial Review During the previous reporting period, the Trustees decided to change the year-end to March from September to align with suppliers and customers and last year we produced financial statements covering a period of 18 months. The current set of financial statements covers a period of to March 2014 and all financial comparisons are between the most recent period of and the previous period of 18 months. I want to be able to travel and get out there and do things, just as I would have done before the diagnosis. And I m sure that will happen. I m half-way there now and I feel good. Jim Whittall During the past Anthony Nolan s income reached 45m (from 58m in the previous 18-month period, or 39m on an annualised basis). The main reason for the underlying increase is that a greater number of transplants being carried out both worldwide and in the UK has increased demand for stem cells from unrelated donors. In the past we helped facilitate 1,240 lifesaving transplants. Income from the provision of donors exceeded 35m (from 47m in the previous 18-month period, or 31m on an annualised basis), representing underlying growth of 14%. Many donors continue to be drawn from the world s largest registries in Germany and the USA and Anthony Nolan has added over 49,000 new potential donors to our register during the past to help meet growing demand domestically. Meanwhile, greater alignment of the UK registers (Anthony Nolan, NHS Blood and Transplant, Welsh Bone Marrow Donor Registry) from September 2013 now provides UK transplant centres with a single point of contact for the facilitation of the provision of donors. Fundraising income has continued to grow. Total income from fundraising exceeded 8.2m compared to 10m in the previous 18-month period. We extended our investment in individual giving and now have over 32,000 supporters providing regular and predictable income. This investment means that net voluntary income was 2.8m compared to 4.3m in the previous period, or 2.9m on an annualised basis. Our cost base continues to benefit from improvements in procurement and the periodic review of major costs. Donor provision costs were 34m (compared to 43m in the previous 18-month period, or 29m on an annualised basis). This underlying increase largely reflects the higher volume of transplant activity. We have also expanded and accelerated our cord collection activity which has been enabled by the Department of Health, the Regional Growth Fund and the investment of our own resources. During the past we collected our 5,000th cord, which will again contribute to meeting the demand for stem cells. Anthony Nolan s other main charitable activities education and awareness and research have also increased. We spent 4.2m on these two areas in the last compared to 5.2m in the previous 18-month period, or 3.4m on an annualised basis. This reflects our stronger support for patients and the start of a three-year project on T-cell research funded by the European Union

24 Our governance costs have remained broadly unchanged ( 267,000 compared to 431,000 in the previous 18-month period, or 290,000 on an annualised basis), though are likely to increase in the year ahead when we plan to refresh our strategy. Our support costs, which help all of our work, have remained steady at 12% of income, reflecting our concern to control costs as we grow. We have continued to invest in improving our core IT systems to improve access to our register and reduce the time taken to search for potential donors. This complex work is expected to be completed during the 2014/15 financial year. I will never forget Professor Goldman agreeing to let me have kids before the transplant. I thank God every day - not that I am here, but that I fought and fought to have these boys. Fran Burke Cash flow is an important part of our financial management and planning. Growing organisations often experience a growth in debtors and Anthony Nolan is no exception. Nevertheless, cash levels during the period have fallen only slightly, from 5.4m to 4.6m. Changes in the practice of some hospitals has made the process of settling payments more challenging but we continue to work closely with transplant centres and overseas registers to ensure that the payment process can be as smooth as possible. In the year ahead we will invest in the introduction of third generation sequencing and our IT infrastructure which will mean being able to type to the highest possible level of resolution and do so faster and at lower unit cost than we do now. This, together with changes to our register development and donor recruitment teams, will help us to facilitate more transplants than ever before. Reserves Policy Anthony Nolan s policy with regard to reserves is to make suitable investment in the on-going development of the charity, while maintaining adequate funds to deal with current and medium-term needs and having the necessary provision to deal with unforeseen circumstances. Free reserves at the year-end, excluding fixed assets, designated funds and restricted funds, amounted to 3.3m compared to 4.0m in the previous year. The Trustees have determined that the optimal level for free reserves is 6m and that in the medium term free reserves should be managed to reach this level to deal with the following: Requirements for a reasonable level of working capital, taking into account our growth. Period of time required to downsize the charity operations if necessary to respond to any downturn in income streams or reduced demand for donors. Period of time to re-establish income streams. The Trustees have plans in place to deliver surpluses over the next few years to reach the desired level of reserves. The appropriate level of reserves of the charity will continue to be reviewed regularly. Auditor Baker Tilly UK Audit LLP has indicated its willingness to continue in office. Statement As To Disclosure Of Information To Auditor The Trustees who were in office on the date of approval of these financial statements have confirmed as far as they are aware, that there is no relevant audit information of which the auditor is unaware. Each of the Trustees have confirmed that they have taken all the steps that they ought to have taken as Trustees in order to make themselves aware of any relevant audit information and to establish that it has been communicated to the auditor. Funds Held As Custodian Although the charity maintains restricted funds to deal with incoming resources that are earmarked for a particular purpose by donors, sponsors, and other funds, Anthony Nolan does not currently hold, and the Trustees do not intend that it will in the future hold, any funds as custodian for any third party. The Trustees Annual Report is approved by order of the Board of Trustees and the Strategic Report (included therein) is approved by the Board of Trustees in their capacity as the directors at a meeting on 3 July 2014 and signed on their behalf by: Chairman, Simon Dyson, MBE Date 3/7/

25 Today, our register has more than 500,000 potential donors on it As we celebrate 40 fantastic years our work is as in demand as it ever was, and changes lives every day. Here s to the next 40 years. Our Finances

26 Independent Auditor s Report To The Trustees And Members Of Anthony Nolan We have audited the group and parent charitable company s financial statements of Anthony Nolan ( the financial statements ) for the year ended 31 March 2014 on pages 33 to 60. The financial reporting framework that has been applied in their preparation is applicable law and United Kingdom Accounting Standards (United Kingdom Generally Accepted Accounting Practice). This report is made exclusively to the members, as a body, in accordance with Chapter 3 of Part 16 of the Companies Act 2006, and to the charitable company s trustees, as a body, in accordance with section 44(1)(c) of the Charities and Trustee Investment (Scotland) Act 2005 and regulation 10 of the Charities Accounts (Scotland) Regulations 2006 (as amended) and the Charities Act Our audit work has been undertaken so that we might state to the members and the charitable company s trustees those matters we are required to state to them in an auditor s report and for no other purpose. To the fullest extent permitted by law, we do not accept or assume responsibility to anyone other than the charitable company, its members as a body, and its trustees as a body, for our audit work, for this report, or for the opinions we have formed. I worked out what my coping mechanisms were and, for me, it was about accepting what was in my control and what wasn t. I found myself watching Grand Designs and I was fascinated plus it became an evening ritual that I could control. As soon as I was in recovery, I started looking for houses to renovate. Paul Golding Respective Responsibilities Of Trustees And Auditor As explained more fully in the Statement of Trustees responsibilities set out on page 22 the trustees (who are also the directors of the charitable company for the purposes of company law) are responsible for the preparation of the financial statements and for being satisfied that they give a true and fair view. We have been appointed auditors under section 44(1)(c) of the Charities and Trustee Investment (Scotland) Act 2005, section 151 of the Charities Act 2011 and under the Companies Act 2006 and report in accordance with regulations made under those Acts. Our responsibility is to audit and express an opinion on the financial statements in accordance with applicable law and International Standards on Auditing (UK and Ireland). Those standards require us to comply with the Auditing Practices Board s (APB s) Ethical Standards for Auditors. Scope Of The Audit Of The Financial Statements A description of the scope of an audit of financial statements is provided on the Financial Reporting Council s website at Opinion On Financial Statements In our opinion the financial statements: - give a true and fair view of the state of the group s and the parent charitable company s affairs as at 31 March 2014; and of the group s and the parent charitable company s incoming resources and application of resources, including their income and expenditure, for the year then ended; - have been properly prepared in accordance with United Kingdom Generally Accepted Accounting Practice; and - have been prepared in accordance with the Companies Act 2006, the Charities Act 2011, the Charities and Trustee Investment (Scotland) Act 2005 and regulations 6 and 8 of the Charities Accounts (Scotland) Regulations 2006 (as amended). Opinion On Other Matter Prescribed By The Companies Act 2006 In our opinion the information given in the Strategic Report and the Trustees Annual Report for the financial year for which the financial statements are prepared is consistent with the financial statements. Matters On Which We Are Required To Report By Exception We have nothing to report in respect of the following matters where the Companies Act 2006, the Charities Act 2011 and the Charities Accounts (Scotland) Regulations 2006 (as amended) requires us to report to you if, in our opinion: the parent charitable company has not kept sufficient, proper and adequate accounting records, or returns adequate for our audit have not been received from branches not visited by us; or the parent charitable company financial statements are not in agreement with the accounting records and returns; or certain disclosures of trustees remuneration specified by law are not made; or we have not received all the information and explanations we require for our audit Nicholas Sladden FCA DChA (Senior Statutory Auditor) For and on behalf of BAKER TILLY UK AUDIT LLP, Statutory Auditor Chartered Accountants 25 Farringdon Street London EC4A 4AB BAKER TILLY UK AUDIT LLP is eligible to act as an auditor in terms of section 1212 of the Companies Act