10/15/2012. Innovation, Translation, Impact. Quentin Pankhurst

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1 Innovation, Translation, Impact Quentin Pankhurst A cross-faculty consortium for the promotion of innovative and translational research in medical technologies Medical Technologies Used to diagnose, monitor or treat medical conditions -from syringes & bandages to orthopaedic implants & pacemakers Principal intended action not pharmacological, immunological or metabolic but it may be assisted in its function by such means 1

2 The influence of medical technologies far outweigh their cost (only 4% of total healthcare expenditure): UK: Operating & other costs Pharmaceuticals Medical devices Between 1980 & 2000 medtech reduced hospital stays by 56% and dramatically cut costs (study by The Value Group, 2004). 2

3 Bringing together UCL s expertise inacademic and clinical R&D to create aworld-class research centre for biomedical engineering Goal to be a fast and cost-effective deliverer of patient benefit byharnessing the power of university-based innovation andexperimental medicine Supporting translational activities Education, collaboration, industry Support of PIs at the experimental medicine stage Support of students through an Enterprise Academy & taught courses on MedTech Entrepreneurship UCL Expertise UCL Biomedical Engineering leads the UK in most-highly-cited publications (13% NIHR Survey, 2011) Across UCL there are more than 150 PIs in more than 35 departments, centres & institutes, active in medtech Population Health Sciences 11 Medical Sciences 41 Engineering 39 MAPS 21 Brain Sciences Life Sciences

4 Gastroenterology & Nutrition Ear Institute Eastman Dental Speech, Hearing & Urology Institute Phonetics Mechanical Engineering Cardiology Chemistry Biochemical Engineering School of Pharmacy Mathematics Medical Physics & Bioengineering CHIME Centre for Medical Image Computing Computer Science Neuroscience, Physiology & Pharmacology Electronic & Electrical Engineering RNTNE Institute of Neurology Civil, Environmental & Geomatic Engineering Royal Free Hospital Institute of Child Health Chemical Engineering Institute of Ophthalmology Institute of Hepatology Structural & Molecular Biology Pathology Institute of Sport, Exercise & Health Cell & Developmental Biology Oncology Medicine London Centre for Nanotechnology Physics & Astronomy Laboratory of Molecular Cell Biology National Medical Laser Centre Institute of Child Health Institute of Orthopaedics& Musculoskeletal Science UCL Interaction Centre UCL Expertise UCL Biomedical Engineering leads the UK in most-highly-cited publications (13% NIHR Survey, 2011) Across UCL there are more than 150 PIs in more than 35 departments, centres & institutes, active in medtech Expertise spans 12 thematic areas, from implants to e-health, from imaging agents to ageing & well-being.. 4

5 UCL Expertise UCL Biomedical Engineering leads the UK in most-highly-cited publications (13% NIHR Survey, 2011) Across UCL there are more than 150 PIs in more than 35 departments, centres & institutes, active in medtech Expertise spans 12 thematic areas, from implants to e-health, from imaging agents to ageing & well-being.... closely coupled to identified patient need & clinical practice via the world s largest academic health science centre UCL Partners Case Study: UCLIC UCL Interaction Centre EPSRC funded project to improve the safety of interactive (programmable) medical devices, e.g. infusion pumps Directly translatable learn more about medical devices and how people design, buy and use them 5

6 Case Study: Autonomous Functional Implants World s first successfully transplanted artificial trachea Nanocompositestents and valves Commercialisationof bypass grafts for renal access, biological glues, an implantable pump Case Study: National Medical Laser Centre An academic clinical partnership Directly translates academic research into the clinic Interventional facilities at GOSH and thenational Hospital for Neurology andneurosurgery Success in PDT and HIFU Case Study: Endomagnetics Ltd UCL spinout company Improving access to best standards of care in breast cancer management First-in-man studies at UCLH as a clinician-led investigator trial SentiMag probe & Sienna+ tracer both now CE-marked as Class IIa devices 6

7 Case Study: Stanmore Implants Worldwide Exploits research from the Institute of Orthopaedics and Musculoskeletal Science Projects range from extreme orthopaedics to minimally invasive & robotic surgery Started as a UCL spinout sold for 10M Now a world-leading custom-made implants company a provider of personalised medicine A Challenge and an Opportunity: To empower university-based innovators of MedTechR&D, and to best facilitate the successful translation fromconceptsinto products of significantpatient benefit andreal commercial value Thank you 7