The Realisation of Research

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1 Working with UCL Business in The Realisation of Research CNS technologies Dr Abbie Watts Senior Business Manager Biopharm UCL Business PLC

2 Working with UCL Business in CNS technologies Introduction to UCL and UCL Business PLC CNS and Neuroscience at UCL Case Study: Canbex from the UCLB perspective

3 An Introduction to UCL.. Founded in 1826, full scope University with a history of inclusion (race class religion gender). Located in the heart of London s bio-center. Recent survey put UCL 4th in the global rankings (QS World University Rankings)

4 An Introduction to UCL Business PLC Most universities have a Technology Transfer office UCLB is a wholly owned subsidiary of UCL that owns IP from: UCL, Moorfields, GOSH, RFH and UCLH, LSP. UCLB is a commercial entity: Financially self-sufficient 55 Employees and commercial board. Part of UCL Enterprise

5 Leveraging our intellectual property Company Formation Licensing Licensing Licensing Industry Partnership Proof of Concept Funds Research Grant Patent Filings Translational Grant Funding Data / know-how / Regulatory Exclusivity / ODD Industry Funding Funding Identify & Protect IP Idea Proof of Concept Preclinical Development Clinical Development New Therapy A Therapeutic Development Timeline

6 CNS and Neuroscience at UCL The Realisation of Research

7 UCL is Europe s research powerhouse in neuroscience Ranked first in Europe, second in the world for neuroscience and behaviour* More than twice as many publications and citations as any other European institution* UCL Neuroscience researchers generate over 30% of the country s contribution to the most highly cited publications in neuroscience. Strengths neuroimaging and clinical neurology. *Thomson ISI Essential Science Indicators

8 CNS and Neuroscience at UCL UCL Faculty of Brain Sciences UCL Institute of Neurology at Queens Square UCL Institute of Ophthalmology UCL Ear Institute UCL Division of Psychology & Language Sciences UCL Institute of Cognitive Neuroscience UCL Mental Health Sciences Unit The Research Department of Neuroscience, Physiology and Pharmacology (NPP) UCL s basic neuroscience community Highest research ranking of 5A* In SLIMS Faculty The Realisation of Research

9 The UCL Neuroscience Domain brings together all UCL neuroscientists to tackle the most important questions about how the nervous system works. We seek to make fundamental discoveries about brain function and behaviour, to teach and train the next generation of scientists and clinicians, and to transform our ability to diagnose and treat neurological and psychiatric disorders. The Realisation of Research

10 Sainsbury Wellcome Centre for Neural Circuits and Behaviour The Sainsbury Wellcome Centre represents a partnership between the Gatsby Charitable Foundation and the Wellcome Trust to establish a new Research Centre in Neural Circuits and Behaviour. The Realisation of Research

11 The Realisation of Research

12 Case Study: Canbex Therapeutics Ltd from UCLB s perspective. Formed in 2005, by UCLB UCL academics Prof David Baker (Institute of Neurology) and Prof David Selwood (WIBR) Series of compounds that relieved the symptoms of Spasticity in Multiple Sclerosis Seed funding from the Bloomsbury BioSeed Fund (BBSF) and The Wellcome Trust and Esperante and UCLB.

13 Key was the relationship between Prof Gavin Giovannoni An MS Clinician who knew what was needed - an anti-spastic without the psychotropic effects of cannabis to treat MS patients (QMUL and Barts) Prof David Selwood A medicinal chemist who designed a series of analogues of anandamide, endogenous ligand of the cannabinoid receptors CB1 and CB2. Prof David Baker An MS researcher now at QMUL who has the gold standard model for MS and could test the series after an initial screen for activity. The Realisation of Research

14 What Canbex gained from UCLB Virtual company with low burn rate Plugging into the expertise and infrastructure of UCLB and UCL Project management support and Business Manager support Legal support Company formation documentation Funding round documentation MTAs CDAs Intellectual Property support services IT support, meeting rooms, conference calling, plasma screens

15 Access to top academics - global network Grant writing strength and academic validation National MS Society Fast Forward The Wellcome Trust 1.6 million plus a partnered amount UCLB put up part of partnered amount CEO and Chairman - Merck Serono Ventures and TSB The Realisation of Research

16 Over to Keith Powell, Canbex chairman. The Realisation of Research

17 Contact us UCL Business PLC The Network Building 97 Tottenham Court Road London W1T 4TP Tel: Web:

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