Transplantation of unrelated donor umbilical cord blood in 102 pa...

Transcription

1 1 of 5 18-Dec-06 10:06 PM SEARCH: Prepublished online as a Blood First Edition Paper on June 7, 2002; DOI /blood Advanced Previous Article Table of Contents Next Article Blood, 1 September 2002, Vol. 100, No. 5, pp CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival John E. Wagner, Juliet N. Barker, Todd E. DeFor, K. Scott Baker, Bruce R. Blazar, Cindy Eide, Anne Goldman, John Kersey, William Krivit, Margaret L. MacMillan, Paul J. Orchard, Charles Peters, Daniel J. Weisdorf, Norma K. C. Ramsay, and Stella M. Davies From the Blood and Marrow Transplant Program of the Departments of Pediatrics and Medicine and the Biostatistical Support Group, University of Minnesota Cancer Center and School of Medicine, Minneapolis. The potential benefits of unrelated donor marrow transplantation are offset by the immunologic complications of graft-versus-host disease (GVHD) and infection. Full Text Full Text (PDF) This Article All Versions of this Article: v1 100/5/1611 most recent Alert me when this article is Alert me if a correction is p Citation Map Services this article to a friend Similar articles in this journ Similar articles in PubMed Alert me to new issues of th Download to citation manag Cited by other online article Rights and Permissions Google Scholar Articles by Wagner, J. E. Articles by Davies, S. M. Articles citing this Article PubMed Citation PubMed Articles by Wagner, J. E. Articles by Davies, S. M. Related Collections Transplantation Clinical Trials and Observat Therefore, we used cryopreserved umbilical cord blood (UCB) as a strategy to reduce th GVHD and treatment-related mortality (TRM) and improve survival. Data on 102 patients age 7.4 years) who received transplantsbetween 1994 and 2001 for the treatment of ma (n = 65; 68% were high-risk patients) and nonmalignant (n = 37) diseaseswere evaluate Log-rank tests and Cox regression analyses were used to determine the effects of variou demographic, graft-related, and treatment factors on engraftment, GVHD, TRM, relapse, survival. As of October 15, 2001, the median follow-up was 2.7years (range, ). In of neutrophil and platelet engraftment were 0.88 (CI, ) and 0.65 (CI, ), respectively. Notably, incidences of severe acute and chronicgvhd were 0.11 (CI, 0.05 and 0.10 (CI, ), respectively.at 1 year after transplantation, proportions of TRM survival were 0.30 (CI, ) and 0.58 (CI, ), respectively.in Cox regressio analyses, CD34 cell dose was the one factor consistently identified as significantly assoc

2 2 of 5 18-Dec-06 10:06 PM with rate of engraftment, TRM, and survival. Despite the low incidence of GVHD, the prop patients with leukemia relapse at 2 yearswas 0.17 (CI, ) and 0.45 (CI, patients with standard and high-risk disease, respectively. There is ahigh probability of s recipients of UCB grafts that are disparate in no more than 2 human leukocyte antigens when the grafts contain at least CD34 + cells per kilogram of recipient's body w Therefore, graft selection should be based principally on CD34 cell dose when multiple exist with an HLA disparity of 2 orless by The American Society of Hematology. This article has been cited by other articles: (Search Google for Other Citing Articles) S. Terakura, E. Azuma, M. Murata, T. Kumamoto, M. Hirayama, M. Yaza Naoe, and K. Kato Engraftment Rate and Kinetics Following Umbilical Cord Blood Transplantation Is Critically Affected by CD34+ Progenitor Cell D and CD8+ T-Cell Dose Complementary. Blood (ASH Annual Meeting Abstracts), November 16, 2006; 108(11): [Abstract] [PDF] K. M. Pastos, W. B. Slayton, L. M. Rimsza, L. Young, and M. C. Sola-Vis Differential effects of recombinant thrombopoietin and bone ma stromal-conditioned media on neonatal versus adult megakaryo Blood, November 15, 2006; 108(10): L. M. Calvi Hematopoietic-Osteoblastic Interactions in the Hematopoietic St Niche IBMS BoneKEy, May 1, 2006; 3(5): N. S. Majhail, D. J. Weisdorf, J. E. Wagner, T. E. Defor, C. G. Brunstein, J. Burns Comparable results of umbilical cord blood and HLA-matched sib donor hematopoietic stem cell transplantation after reduced-inte preparative regimen for advanced Hodgkin lymphoma Blood, May 1, 2006; 107(9): E. A. Copelan Hematopoietic stem-cell transplantation. N. Engl. J. Med., April 27, 2006; 354(17): [Full Text] [PDF]

3 3 of 5 18-Dec-06 10:06 PM K. Li, C. K. Y. Chuen, S. M. Lee, P. Law, T. F. Fok, P. C. Ng, C. K. Li, D. A. Merzouk, H. Salari, G. J.-S. Gu, and P. M. P. Yuen Small Peptide Analogue of SDF-1{alpha} Supports Survival of Co Blood CD34+ Cells in Synergy with Other Cytokines and Enhance Ex Vivo Expansion and Engraftment into Nonobese Diabetic/Sev Combined Immunodeficient Mice Stem Cells, January 1, 2006; 24(1): C. J. Fraser, B. A. Hirsch, V. Dayton, M. H. Creer, J. P. Neglia, J. E. Wag and K. S. Baker First report of donor cell-derived acute leukemia as a complicati umbilical cord blood transplantation Blood, December 15, 2005; 106(13): W. B. Slayton, D. A. Wainman, X. M. Li, Z. Hu, A. Jotwani, C. R. Cogle, Walker, R. C. Fisher, J. R. Wingard, E. W. Scott, and M. C. Sola Developmental Differences in Megakaryocyte Maturation Are Determined by the Microenvironment Stem Cells, September 1, 2005; 23(9): S. J. Lee New approaches for preventing and treating chronic graft-versu disease Blood, June 1, 2005; 105(11): K. K. Ballen New trends in umbilical cord blood transplantation Blood, May 15, 2005; 105(10): R. Bornstein, A. I. Flores, M. A. Montalban, M. J. del Rey, J. de la Serna Gilsanz A Modified Cord Blood Collection Method Achieves Sufficient Cell for Transplantation in Most Adult Patients Stem Cells, March 1, 2005; 23(3): L. De Felice, C. Tatarelli, M. G. Mascolo, C. Gregorj, F. Agostini, R. Fiorin Gelmetti, S. Pascale, F. Padula, M. T. Petrucci, W. Arcese, and C. Nervi Histone Deacetylase Inhibitor Valproic Acid Enhances the Cytokine-Induced Expansion of Human Hematopoietic Stem Cell Cancer Res., February 15, 2005; 65(4): J. N. Barker, D. J. Weisdorf, T. E. DeFor, B. R. Blazar, P. B. McGlave, J. Miller, C. M. Verfaillie, and J. E. Wagner Transplantation of 2 partially HLA-matched umbilical cord blood to enhance engraftment in adults with hematologic malignancy Blood, February 1, 2005; 105(3):

4 4 of 5 18-Dec-06 10:06 PM W. Tse and M. J. Laughlin Umbilical Cord Blood Transplantation: A New Alternative Option Hematology, January 1, 2005; 2005(1): S. Takahashi, T. Iseki, J. Ooi, A. Tomonari, K. Takasugi, Y. Shimohakam Yamada, K. Uchimaru, A. Tojo, N. Shirafuji, H. Kodo, K. Tani, T. Takaha Yamaguchi, and S. Asano Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients hematologic malignancies Blood, December 1, 2004; 104(12): V. Rocha, M. Labopin, G. Sanz, W. Arcese, R. Schwerdtfeger, A. Bosi, N Jacobsen, T. Ruutu, M. de Lima, J. Finke, F. Frassoni, E. Gluckman, and Acute Leukemia Working Party of European Blood Transplants of Umbilical-Cord Blood or Bone Marrow from Unrela Donors in Adults with Acute Leukemia N. Engl. J. Med., November 25, 2004; 351(22): B. Vandekerckhove, I. Van haute, N. Lootens, C. De Buck, L. Verdegem De Steene, S. De Smet, and D. Craeye Selection of Cord Blood Units Based on CD34+ Cells for Storage Blood Bank. Blood (ASH Annual Meeting Abstracts), November 16, 2004; 104(11): [Abstract] S. Miyakoshi, K. Yuji, M. Kami, E. Kusumi, Y. Kishi, K. Kobayashi, N. Mu T. Hamaki, S.-W. Kim, J.-i. Ueyama, S.-i. Mori, S.-i. Morinaga, Y. Muto, Masuo, M. Kanemaru, T. Hayashi, Y. Takaue, and S. Taniguchi Successful Engraftment After Reduced-Intensity Umbilical Cord Transplantation for Adult Patients with Advanced Hematological Diseases Clin. Cancer Res., June 1, 2004; 10(11): N. J. Chao, S. G. Emerson, and K. I. Weinberg Stem Cell Transplantation (Cord Blood Transplants) Hematology, January 1, 2004; 2004(1): G. Michel, V. Rocha, S. Chevret, W. Arcese, K.-W. Chan, A. Filipovich, T Takahashi, M. Vowels, J. Ortega, P. Bordigoni, P. J. Shaw, I. Yaniv, A. M P. Pimentel, F. Fagioli, A. Verdeguer, J. P. Jouet, B. Diez, E. Ferreira, R. Pasquini, J. Rosenthal, E. Sievers, C. Messina, A. P. Iori, F. Garnier, I. I F. Locatelli, and E. Gluckman Unrelated cord blood transplantation for childhood acute myeloi leukemia: a Eurocord Group analysis Blood, December 15, 2003; 102(13):

5 5 of 5 18-Dec-06 10:06 PM J. N. Barker, D. J. Weisdorf, T. E. DeFor, B. R. Blazar, J. S. Miller, and J Wagner Rapid and complete donor chimerism in adult recipients of unrel donor umbilical cord blood transplantation after reduced-intensi conditioning Blood, September 1, 2003; 102(5): S. S. Grewal, J. N. Barker, S. M. Davies, and J. E. Wagner Unrelated donor hematopoietic cell transplantation: marrow or umbilical cord blood? Blood, June 1, 2003; 101(11): [Full Text] [PDF] Blood Online is supported in part by Genentech BioOncology and Biogen Idec Copyright 2002 by American Society of Hematology Online ISSN: