Questionnaire: Use of placebo-medication for treating depression. 1. Explanation about the Placebo Treatment for Depression

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1 Questionnaire: Use of placebo-medication for treating depression We are conducting a research study aimed at examining the position of the subjects towards different treatment options for depression. In the first part of the questionnaire you will receive an explanation about the placebo effect, and its effectiveness as a treatment against depression, in comparison to standard anti-depressive medication (Prozac, Seroxat, Recital for example). The second part will be examining your personal stance regarding treatment of depression with placebo medication. The questionnaire will be completed anonymously, without providing any identifying information, and data will be stored in a secure place as required. Please, take a few minutes to fill the questionnaire. 1. Explanation about the Placebo Treatment for Depression Placebo effect refers to all the situations where the patient's expectations for improvement contribute to the actual benefit of the treatment. Every medication can influence through two mechanisms: 1. Specific mechanism - which is attributed to the drug s biological mechanism. 2. A non-specific mechanism similar to that of the placebo effect, where the subject s expectations of the drug improve his medical condition. Scientific research indicates that the placebo effect is mediated by brain mechanisms, with clear involvement of different regions of the brain and neurotransmitters. In fact, the placebo effect is an example of a self-healing mechanism of the body. Comprehensive reviews of medical literature show that placebo medication (vitamin or salt pill) is in many cases an effective treatment for depression, provided that the patient is convinced that he is taking an effective medication. In fact, every study that examines the effectiveness of an anti - depressant is required by the Federal Drug Administration to prove its effectiveness and advantage over a placebo medication. In recent years the leading medical journals have published studies which show that the efficiency of placebo treatment for mild to moderate depression is similar to that of standard anti-depressant medications. In addition, while a large portion of patients treated with anti - depressants will develop side effects, a relatively

2 negligible percentage of patients receiving placebo medication will suffer from side effects. In practice, one in five people will experience one or more depressive episodes during their life. Today, treatment of depression with a placebo is not part of the doctor's "tool box". The main reason is not lack of effectiveness of placebo, but the fact that provision of effective placebo treatment requires concealment of information about the drugs biological mechanism of action from the patient. The reason is that revealing the mechanism of the placebo reduces the patient's expectation to better his condition, neutralizing a significant portion of the placebo effect. In terms of medical ethics, patients must express consent to any treatment given to them. The value of the patients "autonomy" requires the doctor to provide him with all the relevant information about the medication that the he is receiving. In the case of placebo medication, whole consent is not possible, so the treatment is not used by physicians. On the other hand, conventional ethics deny the patient of his right to "not know". Today, the patient can not choose to take the placebo medication without knowing what its biological mechanism is. Thus, in effect, he is denied of an opportunity to receive convenient treatment, without side effects and that is effective against depression. 2. Questionnaire to be completed individually This part should be completed only if the explanation of part 1 was understood 1. Sex: A. Male B. Female 2. Age: 3. Marital Status: A. Married B. Divorced C. Widow/er D. Single 4. Occupation: A. Student B. Self Employed C. Employee D. Unemployed E. Other 5. Education one has or seeking: A. Grade school B. High school C. College Degree D. Graduate degree E. Doctorate 6. Do you use alcohol regularly?

3 7. Do you use illicit drugs regularly? 8. Your last follow up with a family doctor or specialist was within the: A. last week B. last month C. last year D. last two years E. last five years 9. The most recent time I took any sort of prescribed medication (paracetamol, anti - inflammatory, antibiotics, etc.) was within the: A. last week B. last month C. last year D. last two years E. last three years 10. Do you suffer from any chronic disease (diabetes, FMF, thyroid hormone deficiency, etc.)? 11. Do you suffer from any psychiatric illness? 12. Have you suffered in the past or present an episode of depression? 13. Have any of your relatives ever suffered an episode of depression? 14. Have you ever been treated with anti-depressants (Prozac, Recital, Seroxat, for example)? 15. If you have ever before been treated with an anti - depressant, to what extent do you attribute to it the improvement in your condition? A. Very little B. Little C. Moderately D. Much E. Very Much 16. If you suffer from depression in the future - would you agree to receive treatment with a placebo? 17. If you suffer from depression in the future would you agree to receive treatment with placebo as the first choice? (before any anti-depressant medication) 18. If you suffer from depression in the future - would you agree to receive treatment with a placebo only after failure of treatment with an anti - depressant? 19. If you suffer from depression in the future - would you be willing to waive knowledge of the

4 biological mechanism of the drug that you take (to not know whether it is an anti-depressant or a placebo)? 20. Would you agree to drug treatment with a placebo (proven effective) for a different medical problem that you currently suffer from? (blood pressure, migraines, back pain, irritable bowel)? * The following questions relate to medication prescribed to you by a doctor: 21 In how many instances does the doctor discuss with you the biological mechanism of a medication? 22 In how many instances did you check for yourself (internet, books) the biological mechanism of a medication? 23 In how many instances did you take a medication without knowledge of its mechanism of action? 24 In how many instances does the doctor discuss with you the main side effects of a medication? 25 In how many instances did you check for yourself (internet) the main side effects of a medication? 26 In how many instances did you take a medication without knowing the main side effects? Never Rarely Sometimes Often Always

5 27 To what extent is it important to you to know the biological mechanism of a medication you are taking? 28 To what extent is it important to you to know the side effects of medication you are taking? 29 To what extent do you feel that a doctor giving a placebo to a depressed patient is deceiving him? 30 To what extent would knowing your doctor gives placebos to depressed patients influence your impression of him? 31 To what extent do you feel it is deceitful to give placebos to a depressed patient? 32 To what extent do you feel that treatment with a placebo, without knowledge of its biological mechanism, would diminish your sense of autonomy? Very little Little Somewhat Largely Very much Thank you for your cooperation!

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