COMPETITION FOR 90 POST-DOC TWO YEARS FELLOWSHIPS TYPE A, FOR A COLLABORATION TO RESEARCH ACTIVITIES THE RECTOR

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1 COMPETITION FOR 0 POST-DOC TWO YEARS FELLOWSHIPS TYPE A, FOR A COLLABORATION TO RESEARCH ACTIVITIES THE RECTOR CONSIDERING May th 1 no. 16; CONSIDERING Statuto of Università degli Studi di Milano, issued by Rector s Decree on May 2 th 16 and following modifications; CONSIDERING art. 1, paragraph 6 of December 2 th 1 no. 44 that establishes the institution of fellowships for collaboration to research activities; CONSIDERING Decreto Ministeriale February th 1 that establishes the amount of the fellowship and the criteria of assessment; CONSIDERING Decreto Ministeriale February 26 th 2004 no. 4 which establishes the minimum and maximum amount of the fellowships; CONSIDERING Regulations concerning fellowships for a collaboration to research activities issued by Rector s decree n. 261 on April 1 st 200 as from art. 1 paragraph 6 of no. 44/, in particular art. 2 of the Regulations which rules the institution of fellowships to be charged to University budget; AS AS 0 new fellowships have been financed in 200 within approval of the University budget on November 24 th 200; Senato Accademico on April 21 st 200 divided 0 Fellowships for collaboration to research activity among the scientific areas established in University and decided the criteria of assessment of research projects, qualifications and scientificprofessional curriculum of the candidate; AS on June 3 rd 200 a Rector s Decree established the Commissione di Garanzia approved by Senato Accademico on May th 200; CONSIDERING on June 4 th 200 CARSTT established the scientific areas concerning which the candidates must sit for an interview, according to what established by art. 2, paragraph of the Regulations mentioned above; CONSIDERING candidates resident abroad for at least one year do not have to sit for the interview, if placed in the ranking in useful position; ORDAINS Art. 1 - As from Decreto del Ministero dell Università e della Ricerca Scientifica e Tecnologica on February th 1 issued in enforcement of art. 1, paragraph 6, 44/1 and of art. 2 of Regulations concerning fellowships for a collaboration to research activities issued by Rector s Decree no. 261 on April 1 st 200, University of Milan has launched a competition by qualifications and interview to award 0 fellowships for a collaboration to research activities restricted to doctorate graduates or graduated in medicine and surgery, holding a diploma in the specialty area of medicine (medical), with appropriate scientific production, lasting two years and divided among the scientific areas established at the University of Milan, as follows: 1

2 SCIENTIFIC AREA N. FELLOW-SHIPS INTERVIEW YES/NO LANGUAGE REQUIRED FOR THE PROJECT 1. Mathematics 3 NO English; in case, Italian 2. Physics 4 YES English; in case, Italian 3. Chemistry YES English; in case, Italian 4. Geology 2 YES English; in case, Italian. YES English; in case, Italian 6. Information Sciences 4 YES English; in case, Italian. 1 YES English; in case, Italian. 6 YES English; in case, Italian. YES English; in case, Italian. Pharmaceutical and pharmacological Sciences YES English; in case, Italian. NO Italian; in case, English. history, philology,. History, Philosophy, Pedagogy, Psychology 6 YES Italian and English YES Italian; in case, English 14. Economics and statistics 3 NO English; in case, Italian 1. Political Sciences and Sociology 3 YES Italian and English TOTAL FELLOWSHIPS YEAR Art. 2 REQUIREMENTS AND INCOMPATIBILITIES All those who have achieved a PhD and graduated in medicine and surgery, holding a diploma in the specialty area of medicine (medical), together with an appropriate scientific production and a scientific and professional curriculum vitae suitable for research activity can take part in this competition. Candidates must send the application form and the description of a research project to be developed with reference to only one subject among those established in Enclosure 1), in one or both languages specified in the chart. Absence of criminal prosecution is required. Those who have been already awarded fellowships within the limits established by the laws in force (eight years or four if the fellow has been awarded a PhD grant) cannot participate in the selection. If the fellow has 2

3 been awarded a PhD grant for less than four years, the fellowship can be awarded up to a total duration of eight years between fellowship and PhD grant. Staff employed in Universities and in the other bodies as from art. 1, paragraph 6, 44/ can participate in the selection: in case of awarding the fellowship, the fellow must resign. Fellows awarded other grants can participate but must renounce other grants in case of winning the fellowship. Civil Servants can be awarded the fellowship but must be put on leave without salary in the administration they work for, according to the laws in force. The qualifications must be held within the deadline established for the presentation of the application form, except for what established for the PhD degree, according to art. 2 paragraph of Regulations, which can be achieved within the date of stipulation of the individual contract. Art. 3 - APPLICATION FORM AND DEADLINE The candidates must fill in the application form available on-line at Candidates having already the access to the Unimi will have to connect to this web-site: This does not substitute the paper form which must be sent to the University. After filling in the application form candidates will print a file containing the main personal information and will send it to Magnifico Rettore dell Università degli Studi di Milano. The applicant must bring it directly to Ufficio Archivio e Protocollo of Università degli Studi di Milano Via Festa del Perdono,, 202 Milano- Italy, or send it by registered letter with return coupon attached ( in this case the stamp and date of the post office will be considered) within 16/0/200: otherwise he/she will be excluded from the competition. The Administration is not responsible if communications get lost because the address written by the candidate is not correct or a change of address has been communicated lately or not communicated by the candidate or because of mistakes in delivery due to third parties, chance or force majeure. Application forms without signature or incomplete or sent after the deadline established will not be accepted. Forms on-line must contain the following information: - RESEARCH PROJECT CONCERNING ONE SUBJECT AMONG THOSE ESTABLISHED BY THIS COMPETITION; - DEGREE AND FINAL MARK; - PHD THESIS (ALSO IN TEMPORARY VERSION IF NOT DISCUSSED YET); - SPECIALIZATION DEGREES AND MARKS; - SCIENTIFIC PUBLICATIONS AND QUALIFICATIONS WITH ALL REFERENCES USEFUL FOR A CORRECT IDENTIFICATION; - SCHOLARSHIPS AND/OR RESEARCH CONTRACTS, ATTENDANCE OF POST-GRADUATE COURSES, RESEARCH ACTIVITY IN ITALY AND/OR ABROAD, FELLOWSHIPS, SCIENTIFIC-PROFESSIONAL CONTRACTS AND APPOINTMENTS, PARTICIPATION IN CONGRESSES, PATENTS; - OTHER QUALIFICATIONS PROPERLY CERTIFIED. 3

4 The Administration could ask the candidates to bring or send the whole documentation of the publications specified in the list. Art. 4 - ASSESSMENT Application forms will be assessed by Commissione di Garanzia, made up of five members selected among professors in this University, which will take advantage of at least two external experts (for each application or for applications concerning the same subject). The list of examiners is established by CARSTT and approved by Rector s decree. Each examiner can use up to points, to be divided as follows: - assessment of the candidate up to 6 points - assessment of the project up to 6 points The evaluation criteria for candidates scientific qualifications and scientific-professional curriculum are the following: - degree mark ; - PhD thesis; - specialization degrees and marks; - attendance of post-graduate courses; - research activity in Italy; - research activity abroad; - fellowships, scientific-professional contracts and appointments; - participation in scientific congresses; - scientific publications and qualification; - monographic publications and chapters in books; - patents. Evaluation criteria for research projects are the following: - relevance of the project to the subject suggested by the Department; - originality of the research suggested; - updating of the project with reference to knowledge acquired; - appropriate bibliographic reference; - potential achievement of the project in the space and time available; - relevance of results potentially achievable. In case of incomplete or insubstantial evaluation and in case of discrepancy between two evaluations, superior of equal to 6 points, Commissione di Garanzia will ask for a third assessment. Commissione di Garanzia forms a ranking for each area related to the posts, with reference to marks given by the examiners. The result of the assessment of the project and of the scientific qualifications of each candidate will be posted up and published on the University web-site. Candidates who have not earned at least points from at least two examiners are excluded from the ranking. Candidates living abroad for at least one year (to prove with proper certification) who occupy a useful position 4

5 in the ranking within posts available can be directly appointed among winners. Candidates in the ranking and placed in position equal to the number of fellowships available for the area concerned increased of 0%, to round up to the next integer, can take part in the interview, if established by this competition. The interview, which takes place with a Commission established by the Rector and suggested by Commissione di garanzia and made up of a member of Commissione di garanzia, who is the president, of the president or other member of Comitato d area and, as third member, of Director of the Department concerned or of a delegate, will take place according to the schedule enclosed. The Commission in charge of the interview can use up to 3 points for each candidate. The candidates who have to sit for the interview will be called by at the address communicated by the candidate in the application form; in case of absence, candidates will be automatically excluded from the final ranking. Commissione di garanzia, at the end of the assessment of the candidate, the research project and the interview, will publish the result of the assessment for each candidate and will form a ranking for each area, with reference to the marks earned. Assessment must end within six months since the transmission, to the referees, of the themes and the related projects. The results of the assessment will be formalized by Rector s Decree and published in University web-site. If marks, gained in the same scientific area, end in a tie, the fellowship will be assigned to the younger candidate. Art. FELLOWSHIP AWARDING The Rector will communicate, by registered letter at the address in the application form, the awarding of the fellowship to the winners. Within the deadline mentioned in the communication, the winner must send to the Rector the acceptance declaration required by the Administration, otherwise he/she will loose the post; afterwards he/she will be called to stipulate a contract. The contract conditions are ruled by Regulations concerning fellowships for collaboration to research activity of University of Milan. The fellowship implies the achievement of the research project suggested by the candidate, under the supervision of the Scientist-in-charge and at the related structure. The Scientist-in-charge and the candidate will agree on the activities related to the research project which will be carried out during the fellowship and that will be verified periodically, according to modes established by the individual contract. The awarding of the fellowship does not imply employed work and does not give rights to employment by Universities. Fellows can participate in the University in commissions for examinations as experts in a specific subject and collaborate to tutoring activities. The fellowship cannot be added to grants or other types of aid, except for those established for integration of stays abroad, neither with other contracts of collaboration nor with income coming from free lance activities

6 performed with continuity. Extra-university activities as speaker in seminars, conferences or publishing activities and a limited activity of self-employed work are compatible with the fellowship, upon written communication and in agreement with the scientist-in-charge and upon the condition that such activity is declared compatible by the Structure where the fellow performs research activity and does not imply interest conflicts with the research activity performed for the University. Self-employed work cannot exceed the income limits established by Consiglio di Amministrazione equal to a gross yearly amount of Euros, with exclusion of remuneration coming from copyright. Art. 6 - REMUNERATION The yearly gross amount of the fellowship is of 16.,00 Euros. The amount does not include expenses for industrial accident insurance and public liability insurance which are charged to the University. The amount is tax free (Irpef exempt) according to art. 4 of August th 14 no. 46 and subjected, for what concerns social insurance, to rules as from art. 2, paragraph 26 and following of August th 1 no. 33. The amount is paid in monthly postponed instalments. Art. ACCEPTANCE AND SIGNING OF THE CONTRACT Declarations and certifications of acceptance sent by registered letter with reply coupon attached within fifteen days (the stamp and date of the post office will be considered) since the communication by the Rector or brought directly to the appropriate office will be taken into account. Personal facts and qualities self-attested by the winner of the competition will be checked properly by the University, also by sample, in order to verify their truth. The winners will be called to stipulate the contract of collaboration to research activity, which will start from the first day of the month following the signature. For non-ec subjects the fellowship will start after having obtained the visa for self-employed work and the actual beginning of the research activity. Art. LOSS OF THE RIGHT TO THE FELLOWSHIP AND CANCELLATION OF THE CONTRACT If the contract is not signed within the deadline mentioned by the appropriate office or if the candidate does not achieve the PhD within the stipulation date, the winner will loose every right to the fellowship. In case of loss of the right to the fellowship or of renounce by the winners, the fellowships are made available to candidates placed usefully in the ranking. The ranking is valid for days since its approval. The winners of the fellowships who do not attain themselves to what established by this competition notice and to the Regulations mentioned above will loose every right to the fellowship by means of a Rector s Act upon written notification. During collaboration activity, if the Fellow does not carry out regularly research activity, without justified reason, or is responsible of serious and continuous malpractice, the procedure of cancellation of the contract 6

7 will be started, on request of the Scientist-in-charge. Art. REFERENCE For what is not established by this competition notice please refer to the Regulations concerning fellowships for research activity issued by Rector s Decree on April 1 st 200 no. 261 and the rules in force about the subject. Art. PERSONAL INFORMATION According to D.L. 16/03 University will commit itself to respect all confidential information provided by the candidate: all information provided will be handled only for aims connected to the selection and to the stipulation and management of relationship with University. Art. COMPETITION MANAGEMENT According to August th no. 241, the Head of Office in charge of the competition is Dr. Anna Tavano Ufficio Contratti di Formazione e Ricerca at Divisione Stipendi e Carriere del Personale Via S. Antonio n., Milano. REG. AL N DEL IL RETTORE Enrico Decleva

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9 Enclosure 1 ID subject Research project Description Scientific Area 1 BARBIERI VIALE LUCA Dipartimento di Matematica 2 BERTOLINI MASSIMO Dipartimento di Matematica 3 MANTOVANI SANDRA Dipartimento di Matematica 4 RUF BERNHARD Dipartimento di Matematica VESELY LIBOR Dipartimento di Matematica 6 BELLINI TOMMASO Dipartimento di Chimica, Biochimica e Biotecnologie Per La Medicina BERSANELLI MARCO RINALDO FEDELE Dipartimento di Fisica Sezione Fisica dei Plasmi e Astrofisica BRACCO ANGELA Dipartimento di Fisica Sezione Fisica del Nucleo BROGLIA RICARDO AMERICO Dipartimento di Fisica Sezione Fisica del Nucleo CARACCIOLO SERGIO Dipartimento di Fisica Sezione Fisica Teorica Motivic Homotopy and Motives Elliptic curves, modular forms, L-functions Internal categorical methods in homotopical, (nonabelian) homological, universal algebra. Nonlinear analysis and partial differential equations Infinite-dimensional convexity Experimental study of biological soft matter, complex fluids and systems of biomedical relevance Experimental Cosmology: Data analysis of the PLANCK mission and new technological developments Nuclear structure and reaction studies of exotic nuclei and their astrophysical applications Physics of Biological Systems Field theory and strings: fundamental interactions and critical phenomena Motivic cohomology, mixed motives, n-motives and triangulated motives with respect to problems and conjectures in algebraic K-theory and arithmetic geometry such as Deligne conjectures, Bloch-Beilinson conjectures and Tate's conjecture. 1. Construction of rational points on elliptic curves, abelian varieties, algebraic varieties. 2. Iwasawa theory and p-adic L-functions. 3. Arithmetic theory of modular forms. Subject: internal structures and internal constructions (such as internal crossed modules and internal actions) for homotopy, (non-abelian) homology and categorical aspects of universal algebra in homological and semiabelian categories. Nonlinear elliptic and degenerate elliptic quations: - existence, non-existence and multiplicity of solutions - variational methods; non-compactness and concentration fenomena - qualitative properties of solutions; symmetrisation methods Convex sets and support properties. Infinite-dimensional polytopes in Banach spaces. Best approximation and Chebyshev centers in Banach spaces. The research focuses on the study of supramolecular organization. The study could combine different techniques: scattering of light, neutrons or x-rays; microscopy; calorimetry; fluorescence; magnetic resonance; numerical simulation. Possibilities: A) Analysis of data from the PLANCK satellite and future CMB experiments B) Study of possible commercial applications of microwave technologies we developed for CMB observations See The nuclear physics is within experiments or theory. Experiments are on nuclear structure far from stability or astrophysics nuclear reactions. Theoretical Developments use many-body techniques. See 1) Study of protein folding with simplified models; 2) Study of physical models for genetic expression and of hydrodynamics in colloids to describe the motion of cilia and flagella in microorganisms. String and field theory are essential tools both in theoretical high-energy physics to describe fundamental interaction as in the description of lower energy collective phenomena, to understand critical behaviour. 1 Mathematics 1 Mathematics 1 Mathematics 1 Mathematics 1 Mathematics 2 Physics 2 Physics 2 Physics 2 Physics 2 Physics

10 GAMBARINI GRAZIA Dipartimento di Fisica Sezione Fisica Medica LASCIALFARI ALESSANDRO Dipartimento di Scienze Molecolari Applicate ai Biosistemi MERONI EMANUELA Dipartimento di Fisica Sezione Fisica delle Particelle Elementari 14 POZZOLI ROBERTO Dipartimento di Fisica Sezione Fisica dei Plasmi e Astrofisica Ionizing radiation: study and development of methods of interest for dosimetry and radiobiology Study of spin dynamics and quantum effects in magnetic nanostructures Experimental physics of Particle, Astroparticle and Solar Neutrino Collective phenomena in complex plasmas or in ultracold atoms Development of innovative methods involving ionizing radiation (photon, neutrons, ions) aimed at issues in the fields of radiotherapy, radioprotection and cellular damage. The activity is both experimental and computational. We will investigate the local spin dynamics and quantum effects at low temperature in magnetic nanostructures, by means of magnetization, magnetic susceptibility and Magnetic Resonance experimental techniques. Data Analysis: ATLAS: Higgs physics, Supersymmetry, top; BaBar: bottomonium spectroscopy, new physics at Y(3S); Borexino: solar neutrinos with 200 kev energy threshold; Auger: ultra-high energy cosmic rays - Turbulence and coherent structures in complex and non-neutral plasmas: experiments and theory. - Superradiance and subradiance generation in ultracold atoms. See 2 Physics 2 Physics 2 Physics 2 Physics 1 BASSOLI ANGELA Dipartimento di Scienze Molecolari Agroalimentari 16 BERNARDI ANNA Dipartimento di Chimica Organica e Industriale 1 GENNARI CESARE MARIO ARTURO Dipartimento di Chimica Organica e Industriale 1 MUSSINI PATRIZIA ROMANA Dipartimento di Chimica Fisica ed Elettrochimica 1 PRATI LAURA Dipartimento di Chimica Inorganica, Metallorganica e Analitica 20 ROBERTO DOMINIQUE MARIE Dipartimento di Chimica Inorganica, Metallorganica e Analitica TRP bioactive compounds from foodplants Design and synthesis of oligosaccharide mimics Discovery of new enantioselective catalysts using combinatorial strategies Molecular electrochemistry and electrocatalysis: mechanisms, materials, applications Renewable valorisation by catalytic processes Synthesis of new organometallic photosensitizers for application in photovoltaic solar cells Compounds active on TRP receptors involved in chemical sensing and gustation from food plants. Synthesis, SARs, modelling, bioactivity assays with cloned receptors, sensory evaluation; agrifood, gastronomy and pharmaceutical applications. The field of glycomimetics has been reviewed recently. See for instance: Imberty et al. Chem. Eur. J. 200, 40 and Murphy P. V. Eur. J. Org. Chem. 200, 41 The field of combinatorial catalysis has been recently reviewed by M. T. Reetz in Angew. Chem. Int. Ed. 200, 4, On this subject, an EC Marie Curie contract is presently active Electron transfers in complex systems, involving catalytic electrodes and/or complex molecular structures (conjugation, multiple redox centers...); mechanisms and applications to electroanalysis and development of functional materials Synthesis and use of catalytic systems in renewable transformation for fine and bulk chemicals. Evaluation of catalytic tests and long-term use of catalytic systems Design, synthesis and characterization of - new ruthenium complexes as efficient photosensitizers for Graetzel cells. - novel organometallic complexes and/or polymers as active components for bulk heterojunction solar cells. 21 Novel synthetic methodologies for the synthesis of Foremost targets: reduced synthetic steps, low production of waste products, high 3 3 Chemistry 3 Chemistry 3 Chemistry 3 Chemistry 3 Chemistry 3 Chemistry

11 ROSSI ELISABETTA Dipartimento di Scienze Molecolari Applicate ai Biosistemi 22 SIRONI ANGELO AGOSTINO DANIELE Dipartimento di Chimica Strutturale e Stereochimica Inorganica 23 TANTARDINI GIAN FRANCO Dipartimento di Chimica Fisica ed Elettrochimica 24 DE CAPITANI LUISA Dipartimento di Scienze della Terra "Ardito Desio" 2 ERBA ELISABETTA Dipartimento di Scienze della Terra "Ardito Desio" 26 GIUDICI MAURO Dipartimento di Scienze della Terra Sezione di Geofisica 2 PELFINI MANUELA Dipartimento di Scienze della Terra "Ardito Desio" 2 TINTORI ANDREA Dipartimento di Scienze della Terra "Ardito Desio" 2 BARAJON ISABELLA Dipartimento di Morfologia Umana e Scienze Biomediche Citta' Studi 30 BELTRAME MONICA DANIELA Dipartimento di Scienze Biomolecolari e Biotecnologie 31 BERRUTI GIOVANNA Dipartimento di Biologia heterocyclic and hetero(poly)cyclic systems. structural behaviour of porous MOF as a function of pressure, temperature and different guests Theoretical Studies of Interactions and Reactions at Gas-Surface Interfaces Environmental problems in areas contaminated by metals: prevention, risk mitigation and remediation CALCAREOUS PHYTOPLANKTON EVOLUTION AND THE CARBONATE SYSTEM IN THE JURASSIC-CRETACEOUS OCEANS Multidisciplinary characterization of alluvial aquifers at different scales Changes in climate related geomorphological processes and climatic trend in glacialized environments Fossil Vertebrate Faunas: systematic, paleoecology and paleobiogeography. Expression of Toll-like receptors during the development of the peripheral nervous system Zebrafish as a model for vertebrate development & human disease: roles of SOX transcription factors Molecular mechanisms and intracellular trafficking events in male germ cell differentiation structural flexibility. Theoretical and practical development of: domino reactions, multicomponent reactions, click reactions, cycloadditions, and catalysis. We plan to study, by high pressure (1-0 Bars) XRPD, the structural modifications of porous Metal Organic Frameworks induced by the absorption of small molecules (H2O, CO2, CH4, C2H2, H2, CO, Xe?) at different temperatures and pressures The molecule-solid surface interactions are investigated by means of ab initio and Fisrt Principles methods, and the dynamics of physi- and chemi-sorption, diffiusion, reaction and desorption are classically and quantum mechanically simulated. Feasible researches according to academic grant and scientific instruments of Department are here proposed as: geochemical hazard maps acquisition, quantitative approach to hazard evaluation, definition of areas responsible for contamination HIGH-RESOLUTION QUANTITATIVE ANALYSES OF JURASSIC-CRETACEOUS CALCAREOUS NANNOFLORAS FOR RECONSTRUCTIONS OF THEIR EVOLUTIONARY HISTORY AND BIOCALCIFICATION RELATIVE TO CHANGES IN pco2 AS WELL AS OCEAN FERTILITY, CHEMISTRY AND STRUCTURE. From hydrostratigraphy to numerical models of water flow in the aquifer groups of the Quaternary Lombardy alluvial plain: integrating geophysical and geological methods for efficient mathematical modelling Analysing climate change effects on high mountain environments since the LIA. Studying changes in magnitude and rates of glacial and slope processes by dendroclimate and geomorphological methods on Alpine and extra Alpine environments The candidate should consider the use of mostly newly collected material from fossil vertebrate levels in order to describe the taxa and to use the assemblages for paleoenvironmental and paleogeographic restorations as well as for biostratigraphy The nervous system and the immune system share a common repertoire of molecules. The project aims at characterizing the expression of innate immunity receptors of the Toll-like family during the development of the murine peripheral nervous system. SOX proteins play key roles in embryonic development and in human diseases, such as the HLT syndrome linked to mutations in SOX1. Using zebrafish as a model system, we study SoxF genes (Sox, 1, 1) in cardiovascular/lymphatic development. The research is addressed to mechanisms of signal transduction mediated by small G-proteins (organization of cell architecture, junctional dynamic, cytokinesis) and to vesicular sorting, ubiquitin-dependent, of proteins during cell differentiation 32 Structural Discovery Methods in "Reverse X-ray crystallography, biochem and biophysical methods are applied to the study Chemistry 3 Chemistry 3 Chemistry 4 Geology 4 Geology 4 Geology 4 Geology 4 Geology

12 BOLOGNESI MARTINO Dipartimento di Scienze Biomolecolari e Biotecnologie 33 CANDIA MARIA DANIELA Dipartimento di Biologia 34 CIUFFREDA PIERANGELA Dipartimento di Scienze Precliniche Lita Vialba 3 DE BIASI SILVIA Dipartimento di Scienze Biomolecolari e Biotecnologie 36 DE GIULI MORGHEN CARLO Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica 3 DEHO' GIOVANNI Dipartimento di Scienze Biomolecolari e Biotecnologie 3 DONETTI ELENA BIANCA Dipartimento di Morfologia Umana e Scienze Biomediche Citta' Studi 3 GALLINA ANDREA Dipartimento di Medicina, Chirurgia e Odontoiatria 40 IAMETTI STEFANIA Dipartimento di Scienze Molecolari Agroalimentari 41 MINETTI ALBERTO ENRICO Dipartimento di Fisiologia Umana 42 MORONI ANNA Dipartimento di Biologia Vaccinology" Autotomy and regeneration: key-role of dynamic connective tissues in animal models Endocannabinoids and related acylethanolamides: a role in metabolic diseases ALTERATIONS OF THE LYSOSOME-AUTOPHAGOSOME PATHWAY IN MODELS OF MOTONEURON DISEASE Arbovirus retargeting as an alternative strategy eradicate latent cellular HIV reservoirs Novel molecular targets for the devolpment of new antibacterial drugs Morphological analysis of chronic cigarette smoke effects on human oral mucosa. Virus-host interaction mechanisms during HIV-1 and cytomegalovirus infection INTERACTOMICS STUDIES ON COFACTOR- SINTHESIZING MULTIPROTEIN MACHINERIES Physiology and Biomechanics of Locomotion with Human Powered Vehicles Engineering transport protein functions of selected cell-surface protein domains from bacterial pathogens, to relate 3D protein structures with their antigenic properties in the context of vaccine development. Autotomy and regeneration phenomena of tissues and organs are explored in appropriate animal models in the light of the dynamic properties of connective tissues, with a wide applied potential for biomaterial science. The goal of this research is to set up an analytical method to identify and quantify acylethanolamides in biological samples from healthy subjects and patie with metabolic diseases. Aim of the project is to localize at cellular and subcellular level alterations in the expression of molecular markers of the intracellular lysosome-autophagosome proteolytic pathway in models of motor neuron disease HIV causes AIDS by permanently integrate its proviral DNA into the host genome. To eradicate these viral reservoir we will engineer a chimeric Arbovirus able to selectively penetrate and kill cells expressing gp0 HIV env latently-infected by HIV. Novel molecular targets essential for bacterial cell survival, pathogenicity or biofilm formation will be characterized in different model bacteria. Inhibitory molecules will be designed or screened for as new drug leads A morphological analysis of the cigarette smoke effects on human oral mucosa will be performed on bioptic fragments obtained from young chronic smoker and non smoker volunteers. Epithelial proliferation, adhesion, and differentiation will be studied. Specific research aims are defining: the virological and immunological parameters predictive of HIV patient response to HAART; the role of cytomegalovirus (CMV)- encoded virokines in CMV entry and sedation of the innate immune response. Use of proteins immobilized on magnetic nanoparticles for assessing the role of protein-protein interactions in activity and regulation of cofactor-assembling machineries Human powered vehicles and other passive tools overcome evolutionary determined musculo-skeletal limits, by linking the biological engine (muscles) to actuators (gears and mechanisms) suitable to different environments (ground, water, air, gravity) The focus is on applying protein-engineering protocols to transmembrane transport systems. We alter protein function for the purposes of changing protein interaction specificities and catalytic function and the goal is the production of biosensors. 43 Analysis of the mechanisms responsible for neuronal We will investigate the neurodegenerative mechanisms in two motor neuron

13 POLETTI ANGELO Dipartimento di Endocrinologia, Fisiopatologia e Biologia Applicata 44 RIZZO ANGELA MARIA Dipartimento di Scienze Molecolari Applicate ai Biosistemi 4 RUMIO CRISTIANO Dipartimento di Morfologia Umana e Scienze Biomediche Citta' Studi 46 SAINO NICOLA Dipartimento di Biologia 4 SAMAJA MICHELE Dipartimento di Medicina, Chirurgia e Odontoiatria 4 SANTANIELLO ENZO Dipartimento di Medicina, Chirurgia e Odontoiatria 4 SICCARDI ANTONIO Dipartimento di Biologia e Genetica Per Le Scienze Mediche 0 SONNINO SANDRO Dipartimento di Chimica, Biochimica e Biotecnologie Per La Medicina 1 SPADA ALBERTO Dipartimento di Biologia 2 TONELLI CHIARA Dipartimento di Scienze Biomolecolari e Biotecnologie 3 VEICSTEINAS ARSENIO Sezione del Dipartimento di Scienze Dello Sport, Nutrizione e Salute death in motor neuron diseases EFFECTS OF LONG CHAIN PUFAS OMEGA-3 INCORPORATION IN CELL MEMBRANE MICRODOMAINS OF HUMAN BREAST CAN Study of mucosal immunity and its modulation via interaction with glucose transporters Reproductive adaptations in vertebrates: the evolutionary ecology of 'maternal effects' Role of hypoxia and microcirculation in tumorigenesis in vivo Design of compounds for in vivo imaging of the expression of reporter genes in animal models Construction of rmva expressing membrane IgE adjuvant in vaccines against tumors and pathogens Sphingolipids in the regulation of signal transduction Biodiversity and its variations by human activity Identification and analysis of guard cell specific genes to modulate plant response to drought Muscle stretching in sport and rehabilitation: Basic mechanisms and functional implications diseases: the amyotrophic lateral sclerosis (ALS) and the spinobulbar muscular atrophy (SBMA). In particular, we will analyse possible alteration of axonal functions The aim of the study is the evaluation of cell growth after treatment with PUFA omega-3 in two cell lines of human adenocarcinoma with different expression of ER receptor, and to analyze the alteration of composition and function of lipids rafts. We aim to evaluate the use of glucose transporters as novel pharmacological targets to induce antinflammatory effects in inflammation-based pathologies involving the gut and the lung, based on recent studies showing the immuneregulatory role of SGLT1 Consequences of maternal effects mediated by breeding habitat, egg quality (concentration of hormones, antioxidants) and post-natal environment for offspring development, physiology and socio-sexual behaviour in birds. Sex-related maternal effects Development of experimental murine models for the study of the molecular mechanisms that control the growth of solid tumors, with particular concern to those related to tissue hypoxia and microcirculatory factors The research is concerned with the design of new compounds for monitoring the gene reporter expression in transgenic animals by means of imaging techniques based on bioluminescence, magnetic resonance, gamma ray or positron emission (PET, SPECT). The interaction between IgE and FceRI receptors favours anti-tumor vaccination in murine and "humanized" models 1)Construction of rmva expressing membrane IgE 2)Analisys of IgE-driven immune response 3)Extension to infectivological models The theme address the study of signal transduction regulated by sphingolipids in its biochemical, metabolic, molecular and cellular aspects. Studiare attraverso marcatori molecolari: 1) la variabilita genetica delle sottospecie domestica e selvatica di Vitis vinifera 2) loro demografia 3) origini e periodo di domesticazione 4) relazioni genetiche tra le specie selvatiche del genere Vitis Aim of the proposed of the research is the identification through molecular and generic screening in model plant system, of genes involved in the regulation of stomatal movemnet to enhance drought tolerance and water use efficiency in crops The aim of the study is dual: a) to study the stretching-induced changes in the single muscle fibre and muscle-tendon unit; and b) to assess the effects of stretching on physical performance in sport and rehabilitation.

14 4 BORGHESE NUNZIO ALBERTO Dipartimento di Scienze Dell'Informazione CAMPADELLI PAOLA Dipartimento di Scienze Dell'Informazione 6 DAMIANI ERNESTO Dipartimento di Tecnologie Dell'Informazione DAMIANI MARIA LUISA Dipartimento di Informatica e Comunicazione DE CINDIO FIORELLA Dipartimento di Informatica e Comunicazione MARINI DANIELE Dipartimento di Informatica e Comunicazione 60 ORNAGHI MARIO Dipartimento di Scienze Dell'Informazione 61 PAVESI GIULIO Dipartimento di Scienze Biomolecolari e Biotecnologie 62 PIURI VINCENZO Dipartimento di Tecnologie Dell'Informazione 63 PRINI GIANFRANCO Dipartimento di Informatica e Comunicazione 64 SAMARATI PIERANGELA Dipartimento di Tecnologie Computational models of cognitive processes Development of automatic image analysis techniques Information technologies and methodologies for service-oriented applications Multi-granular representation of moving objects trajectories Models, methods and tools for participation in webbased social machines Color appearance algorithms and models, and advanced application in digital imaging and CG Logical techniques in formal specification and verification Development and Application of Bioinformatic Tools for the Analysis of ChIP-Seq and RIP-Seq Data Information technologies and methodologies for industrial applications A workbench for the integrated study of manuscripts Technologies and methodologies for security and privacy in computer systems and networks Development of connectionist models of Human cognitive functions (e.g. reading, memory, motor control,...), to test hypotheses on the processes involved and to generate predictions to be verified through ad-hoc behavioral experiments. Applications requiring automatic image analysis techniques are becoming more and more demanding. Therefore, development of innovative and efficient methods for classification, clustering, pattern recognition, and statistical inference are required. The activity will address cross-cutting concerns permeating service-oriented computing. (i) Semantics-aware service design/composition. (ii) Compliance/QoS, encompassing functional/non-functional attributes and the service's business sustainability. Specification and prototyping of a data model for the representation of moving objects trajectories at multiple semantic, spatial and temporal granularities. The research aims at conceptualizing online social interaction environments (virtual communities,blogs, ocial networks) and the ICT tools that support them, for developing an online environment that integrates them with online deliberation features The research will deal with the perceptive non-linearities within digital imaging or CG pipeline, through the examination of different color appearance algorithms and models, proposed by the CIE or based on spatial color models. Logical methods for the specification and validation of (Object Oriented) systems 1. Automated reasoning/model checking 2. Specification languages and lightweight formal techniques based on model generation from specifications The researcher will be in charge of the analysis of ChIP-Seq and RIP-Seq data, produced in cooperation with other groups. Also, he/she will be involved in basic research on the development and testing of novel bioinformatic tools for these tasks. Innovation in modelling, monitoring, control, signal/image processing, electronic design, and optimization, with information technologies for industrial, environmental, medical, bioinformatic, logistic, decision-support, and electronic applications The workbench shall support the integrated study of different manuscripted copies of the same opus, aimed at the production of critical editions, with integrated annotations and apparatus info, and with the automatic generation of the stemma codicum. Techniques and methodologies for security, privacy, and data protection; access control policies, models and systems; network and information system security; formal models and methods for security. 6 Information Sciences 6 Information Sciences 6 Information Sciences 6 Information Sciences 6 Information Sciences 6 Information Sciences 6 Information Sciences 6 Information Sciences 6 Information Sciences 6 Information Sciences 6 Information Sciences 14

15 Dell'Informazione 6 VALENTINI GIORGIO Dipartimento di Scienze Dell'Informazione 66 AGUS GIOVANNI BATTISTA Dipartimento di Scienze Chirurgiche Specialistiche 6 ALAMANNI FRANCESCO Dipartimento di Scienze Cardiovascolari 6 BA GABRIELLA Dipartimento di Scienze Cliniche "Luigi Sacco" 6 BALOTTA CLAUDIA Dipartimento di Scienze Cliniche "Luigi Sacco" 0 BERTAZZI PIETRO ALBERTO Dipartimento di Medicina del Lavoro "Clinica del Lavoro L.Devoto" 1 BIANCHI PORRO GABRIELE Dipartimento di Scienze Cliniche "Luigi Sacco" 2 BLASI FRANCESCO BRUNO ARTURO Dipartimento Toraco Polmonare e Cardiocircolatorio 3 BOLIS GIORGIO Dipartimento di Scienze Materno- Infantili 4 BOSARI SILVANO Dipartimento di Medicina, Chirurgia e Odontoiatria BRANCACCIO DIEGO Dipartimento di Medicina, Chirurgia e Machine learning methods for the integration of heterogeneous biomolecular data sources CVI TREATMENT PERFORMED ON AN OUTPATIENT BASIS. TRENDS FROM DIFFERENT MODELS OF ENDOVENOUS LASER-ELT New diagnostic-therapeutic approaches in the mitral valve prolapse Integrated treatment of Panic disorder: long term outcome evaluation model EVOLUTION OF RESISTANCE IN HIV-1 INFECTED PATIENTS TREATED WITH SECOND GENERATION HAART Functional and molecular mechanisms of environmental toxicants and human health interactions POTENTIAL PROGRESSION OF NON-EROSIVE GASTROESOPHAGEAL REFLUX DISEASE: CLINICAL AND MOLECULAR FEATURE CLINICAL FAILURE AND CARDIOVASCULAR EVENTS IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA PROGNOSTIC FACTORS IN RECURRENT OVARY TUMOR: GENE AND PROTEIC EXPRESSION, IN PARTICULAR OF GHRELIN Development of tissue cultures for pre-clinical assessment of pharmacological agents 1. Development of ensemble and kernel based methods for the integration of multiple sources of data. 2. Application to relevant problems in bioinformatics and biomedicine: gene function prediction and biomolecular characterization of diseases. Patients with bilateral saphenous varicose veins (duplex marking for haemodinamic patterns) treated with ELT diode 0 and 140 in two session in different legs (1- mounth interval) and setting (day-surgery/office) with standard procedure (IEWG) This research aims at the clinical application of new methods for the support to mitral valve repair surgery, based on the utilization of advanced technologies in trans-thoracic and trans-esophageal real-time 3D ecocardiographic imaging. Aim of the research will be structured and use an evaluation model to study the efficacy of integrated treatment for panic disorder, with psychopharmacological and psychotheratic approaches, which could analyzes the long term outcome variables. The evaluation of virological and clinical efficacy of new antiretroviral regimens, either in first line or salvage regimens, requires the development of resistance assays for new viral targets (HIV-1 env gene and integrase region). The aim of this study is to identify the associations between environmental exposures and epigenetic changes (eg. DNA methylation and histones), through multidisciplinary approaches that include clinical, biochemical, molecular and cellular studies. RELATIONSHIP BETWEEN PROGRESSION TO ESOPHAGITIS AND SEVERITY OF ACID VS NON-ACID REFLUX AS MEASURED BY ESOPHAGEAL ph-impedance MONITORING, AND INFLAMMATORY MARKERS, IN PATIENTS WITH NON-EROSIVE REFLUX DISEASE (NERD) DURING FOLLOW-UP OF MONTHS Clinical failure is one of the most relevant outcomes in patients with communityacquired pneumonia. Cardiac events were identified as triggers of clinical failures. Study of the expression of the genes involved in recurrent ovary tumor using microarray, real-time PCR detection and immunohistochemistry. In particular, the possible prognostic role of ghrelin and its pathway, will be evaluated. Novel technologies for the establishment of tissue and/or organotypic cultures. Application of tissue cultures as a pre-clinical platform for the evaluation of pharmacological agents. 6 Information Sciences 1

16 Odontoiatria 6 CAIRO GAETANO Dipartimento di Morfologia Umana e Scienze Biomediche Citta' Studi CALVANESE ERNESTO Dipartimento di Scienze Giuridiche Ecclesiasticistiche, Filosofico- Sociologiche e Penalistiche "Cesare Beccaria" CANEVINI MARIA PAOLA Dipartimento di Medicina, Chirurgia e Odontoiatria CAPITANI ERMINIO GIUSEPPE Dipartimento di Medicina, Chirurgia e Odontoiatria 0 CARANDENTE FRANCA Sezione del Dipartimento di Scienze Dello Sport, Nutrizione e Salute 1 CARRASSI ANTONIO MICHELE Dipartimento di Medicina, Chirurgia e Odontoiatria 2 CATTANEO MARCO NATALE Dipartimento di Medicina, Chirurgia e Odontoiatria 3 CELOTTI FABIO MARIA Dipartimento di Endocrinologia, Fisiopatologia e Biologia Applicata 4 CETIN IRENE Dipartimento di Scienze Cliniche "Luigi Sacco" COMI PAOLA PIERA MARIA Dipartimento di Medicina, Chirurgia e Odontoiatria Molecular basis of the interaction between oxygen homeostasis and iron metabolism The social danger of the foreigner and the choices of criminal policy in the present society. Neurophysiology of motor patterns in epilepsy and sleep. Cognitive, relational and behavioural aspects of dementing diseases ROLE OF PHYSICAL ACTIVITY IN THE PERIPHERAL SENSITIVITY TO GLUCOCORTICOIDS Local treatments of oral inflammatory diseases: absorption and systemic effects Variability in the response to antiplatelet agents in paztients with coronary artery disease Epigenetic effects of endocrine disruptors (ED) on the development of reproductive pathologies Placental oxygenation and transport in normal and intrauterine growth restricted (IUGR) pregnancies Study of cancer-related signaling pathways addressed to improving therapy and prognosis. Both O2 and iron control Hypoxia-inducible factor1 (HIF1), the regulator of O2 homeostasis. In turn, HIF-1 regulates several genes of iron metabolism. Our aim is to characterize this interaction and its pathological relevance at the molecular level Overview of law interventions regarding immigration in the last years. Statistic Analysis of crimes committed by immigrants. Media representation of the phenomenon. Relation between perceived and real social danger of the foreigner Investigation of neural pathwyas underlying complex stereotyped motor actions: comparison of neural patterns in physiological and pathological paroxystic activity. The study of dementia should take into account cognitive aspects and social interrelations. We aim at proposing a new evaluation tool devoted to this dimension. Physical exercise probably is capable of modulating peripheral sensitivity to cortisol, determining the activation of the enzymatic processes implicated, on the level of tissue, in the conversion of cortisol into cortisone and vice-versa. Our aim is to investigate absorption and cinetic of some drus, particularry of steroids used for chronic inflammatory mucosal conditions. The results could emprove prescriptions of such drugs. Aim of the study is to investigate gentic and environmental factors that may influence the response to antiplatelet agents in patients with coronary artery disease, using highly specific tests for these drugs. The ed effects on the DNA methylation status, on the hystonic modification and on the enzymes involved in these processes will be studied to assess the epigenetic mechanisms involved in the reproductive system development and diseases Placental amino acid and iron transporters will be studied in fetal and maternal diseases. Gene and protein expression and regulation will be related to oxygen, iron and transferrin levels, mitochondrial content and function in fetus and placenta Investigation into the role that signaling pathways deregulated in cancer play in tumorigenesis, neoplastic progression and associated clinical problems in order to identify potential therapeutic targets and prognostic markers. 16

17 6 COMI GIACOMO PIETRO Dipartimento di Scienze Neurologiche CONTE DARIO Dipartimento di Scienze Mediche COSTA GIOVANNI Dipartimento di Medicina del Lavoro "Clinica del Lavoro L.Devoto" CUGNO MASSIMO Dipartimento di Medicina Interna 0 CUSI DANIELE MARIA Dipartimento di Scienze e Tecnologie Biomediche 1 DELLA BELLA SILVIA ANGELA MARIA Dipartimento di Scienze e Tecnologie Biomediche 2 ESPOSITO SUSANNA Dipartimento di Scienze Materno- Infantili 3 FERRERO MARIA ELENA Dipartimento di Morfologia Umana e Scienze Biomediche Citta' Studi 4 FINELLI PALMA Dipartimento di Biologia e Genetica Per Le Scienze Mediche FIORENTINI CESARE Dipartimento di Scienze Cardiovascolari 6 FIORILLI AMELIA Dipartimento di Chimica, Biochimica e Biotecnologie Per La Medicina Molecular basis, ethiopatogenesis and new therapeutic approaches for neurodegenerative diseases. TNF alfa inhibition in the modulation of mucosal immunity in IBD Sleepiness at work and safety: electrophysiological and clinical study in shiftworkers and drivers Activation of blood coagulation in autoimmune skin disorders: local and systemic implications Genetics of complex diseases Dendritic cells and B lymphocytes in the development of new-generation anti-infective vaccines STUDY OF GENETIC POLYMORPHISMS WITH THE AIM OF IDENTIFYING NEW PREVENTIVE STRATEGIES OF INFLUENZA Mechanisms involved in neovasculature development and in vasculature normalization Genomic architecture and predisposition to complex diseases 3D echocardiography study of the right ventricle. Nutraceuticals. From foods to nutrients: biochemical characterization, mechanism and biological role Analysis of the pathogenetic molecular mechanisms (from a genomic, ribonomic, proteomic perspective) of neurodegenerative diseases for the development of new therapeutic strategies for these diseases for which no effective therapy is available. Evaluation of mucosal cytokine levels in intestinal biopsies from patients with IBD undergoing treatment with anti-tnf alfa antibodies. Evaluation of colonic lamina propria lymphocyte and dendritic cell functional polarization In the 24-hours Society sleep deficit and sleepiness are more and more common with consequent impairment of performance efficiency and safety. The aim of the project is to study sleepiness at work on shift/night workers and professional drivers Study of local and systemic coagulation in patients with autoimmune skin diseases, using immunoenzymatic and immunohistochemical methods as well as molecular biology techniques (reverse transcriptase-pcr and in situ hybridization). Identification of genes involved in complex cardiovascular and neuropsychiatric diseases with microarray genome wide analyses (SNPs, CNVs, gene expression e methylation) and 'next generation sequencing', with a translation in the clinical practice. Characterization of the responses of human dendritic cells and B lymphocytes upon in vitro stimulation with bacterial antigens involved in immune escape, for the development of new-generation vaccines. To evaluate whether the severity of influenza and the immunogenicity of influenza vaccination are related to polymorphisms of toll-like receptors, the genes located on the axis of the response to infections, and class II histocompatibility antigen. Therapeutic approaches, aiming at modulating vessel formation, based on: studies of mechanisms involved in the "angiogenic switch" and their regulation in vitro; histological analysis of vascular architecture in selected pathologies in vivo. The genomes can differ with respect to the copy number of thousands of loci, implying a different inter individual gene expression. By genomic architecture study it may be possible to identify numeric variants, often common, which could be involved in the development of complex diseases. This study is aimed at the assessment of both feasibility and reproducibility of the new 3D system in the evaluation of volume and function of the right ventricle in normal and pathological patients The present study aims to establish potential application of food derive d peptides, able to complex metals such calcium and zinc, in bone repair and remodeling defects, leading to the comprehension of their biomolecular mechanisms and potential uses EFFICACY OF NEW ANTIVIRAL REGIMENS IN HIV- To optimize the treatment of HIV-1/HBV coinfection, based upon the availability 1

18 GALLI MASSIMO Dipartimento di Scienze Cliniche "Luigi Sacco" LARIZZA LIDIA Dipartimento di Medicina, Chirurgia e Odontoiatria LUCIGNANI GIOVANNI Dipartimento di Scienze e Tecnologie Biomediche 0 MAGRINI FABIO Dipartimento Toraco Polmonare e Cardiocircolatorio 1 MANTOVANI ALBERTO Dipartimento di Medicina Traslazionale 2 MERONI PIERLUIGI Dipartimento di Medicina Interna Sezione Granelli 3 MORACE GIULIA Dipartimento di Sanita' Pubblica Microbiologia Virologia 4 NERI ANTONINO Dipartimento di Scienze Mediche PAYVANDI FLORA Dipartimento di Medicina Interna 6 PODDA MAURO Dipartimento di Medicina Traslazionale RATIGLIA ROBERTO Dipartimento di Scienze Chirurgiche Specialistiche 1/HBV COINFECTED PATIENTS Epigenetic alterations in rare genetic diseases IN VIVO MULTIMODAL MOLECULAR AND CELLULAR IMAGING The 24h R-R interval and blood pressure relation in ambulatory monitoring in hypertensive subjects Role of the microenvironment in gastroenterologic tumor progression MicroRNA PROFILES AND FUNCTIONS IN VASCULOPATHIES Biomolecular and pharmacological studies of pathogen-pathogen and pathogen-host interactions Identification novel clinical and molecular markers in the diagnosis and prognosis of lymphoprolifer Biological effects of the therapy with monoclonal antibodies in patients affected by TTP Study of autoantigen changes leading to the loss of tolerance in autoimmune disease Ocular surface inflammation and autoimmune diseases: pathogenesis, clinic and therapy. of new active drugs, an accurate monitoring of viral replication and the detection of mutations associated to resistance in polymerase genes of both viruses are required. A few genes responsible for malformation syndromes exert a role in the epigenetic regulation of gene expression. Dysregulated effects primed by mutations of these master genes can be highlighted by targeted analysis of imprinted regions. Development of methods for in vivo assessment of cellular and sub-cellular molecular processes, function and trafficking of cell populations in animal models by nuclear-based, optical and magnetic resonance imaging methods. The distribution on the Cartesian space of the variables obtained by 24h blood pressure monitoring gives information about individual autonomic control, thus may help classifying untreated hypertensive patients and choosing pharmacological treatment The project must be focused on the role of the inflammatory milieu and leukocyte infiltrate in tumor biology (immune response deviation, tumor angiogenesis, metastatization), and must be characterized by an innovatively and translational approach MicroRNAs (mirnas) controll gene expression at a post-transcriptional level in a redundant/pleiotropic manner. The project will evaluate mirna profile/function in vasculopathies mediated by pathogenic effectors of the innate and adaptive immunity. Analysis of gene expression, biomolecular identification and functional assays to study the surface proteins involved in the interactions of microbial pathogens with other microbes or host cells In an era of increasing treatment options and improved biologic understanding of pathophysiology of lymphoproliferative disorders determining therapy for patients has become increasingly complex and confusing Evaluation of ADAMTS activity, titer of the anti-adamts autoantibodies, lymphocytes B depletion and regeneration with the clinical response after monoclonal antibodies treatment of patients with autoimmune thrombotic thrombocytopenic purpura. Identification of post-translational and post-apoptotic changes of autoantigens in cells targeted by the autoimmune injury in humans and animal models: cross-talk with autoreactive immune cells and autoantibodies Ocular surface inflammation is a common finding in several autoimmune diseases. Nowadays some pathogenetic aspects are still unknown and their comprehension may have relevant implications in treatments. 1

19 ROVIARO GIAN CARLO Dipartimento di Scienze Chirurgiche SILANI VINCENZO Dipartimento di Scienze Neurologiche 0 SPADA ANNAMARIA Dipartimento di Scienze Mediche 1 TORTORANO ANNA MARIA Dipartimento di Sanita' Pubblica Microbiologia Virologia 1 ZANETTI ALESSANDRO REMO Dipartimento di Sanita' Pubblica Microbiologia Virologia 3 ACUTIS MARCO Dipartimento di Produzione Vegetale 4 ADANI FABRIZIO Dipartimento di Produzione Vegetale BANTERLE ALESSANDRO Dipartimento di Economia e Politica Agraria Agro-Alimentare e Ambientale 6 BIANCO PIERO ATTILIO Dipartimento di Produzione Vegetale CASIRAGHI ERNESTINA Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche COLOMBO MARIO Dipartimento di Protezione dei Sistemi Agroalimentare e Urbano e Valorizzazione delle Biodiversita' CORTESI PAOLO Dipartimento di Protezione dei Human stem cells as a model for neurodegeneration EPIDEMIOLOGICAL SURVEILLANCE OF HEALTHCARE- ASSOCIATED INFECTIONS Surveillance and control of viral infections seriously impacting on Public Health Monitoring and optimisation of nutrient management in arable crops Organic matter recalcitrance: a "nano-scale" approach. Relationships among resources, strategies and performances of agri-food small and medium enterprises Innovative strategies for the control of phytoplasmal diseases of grapevine Application of innovative methods for food quality prediction and for studying food modifications du Biodiversity in rice-fields and in wetlands, epidemiology and control of emerging fungal plant pathogens inducing cankers on trees The project will explore how human stem cells can be used as in vitro models of neurodegenerative diseases and how they can be used to develop theraputic approaches for these diseases. Study of the relationship between chronic inflammation, autoimmunity and tumorigenesis; consequences and effects of fetal cell microchimerism; study of specific microrna; correlation between genetic alterations and clinical features of the tumors Active prospective survey of invasive fungal infections to assess the burden and secular trends to identify potential changes in new at risk patient groups and emerging pathogens Implementation of HELICS protocol in ICUs The following research areas will be investigated: molecular evolution of potentially pandemic influenza viruses; virological monitoring of human antipapillomavirus vaccination; strategies for preventing congenital cytomegalovirus infection Particularly in livestock farms, nitrogen management is complicated, because predicting and measuring its dynamics in the soil-crop system is difficult. Reliable diagnostic methods are needed for on-farm application in real time. The project aims to describe from a mechanistic point of view, processes leading to the organic matter conservation in soil. The research aims to analyse the resources of agri-food SMEs which are relevant to improve competitiveness and intends to assess through empirical analysis the effect of the entrepreneurial choices on performance. In silico and in vivo analyses for identifying phytoplasmal proteins involved in the plants-insect interaction. Use of viral vectors for the expression of bacteriocines in plants. Development of innovative strategies for phytoplasmal disease control Innovative methods (NIR and MIR spectroscopy, NIR hyperspectral imaging, image analysis and e-nose), combined with chemometric strategies for food quality prediction and for studying food modifications during food processing and storage. The research activity will focus on rice-fields as agro-ecosystems with different degree of naturalness and a comparison with wetlands, to emphasize the relation between rice-fields under different management practices and ecosystem biodiversity. Among the emerging diseases causing bark cankers on trees, the research proposal will focus on biology and epidemiology of a fungal pathogen with the aim to develop management strategy, preferably biological control 1

20 Sistemi Agroalimentare e Urbano e Valorizzazione delle Biodiversita' 0 DAFFONCHIO DANIELE GIUSEPPE Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche 1 FOSCHINO ROBERTO CARMINE Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche 2 GANDOLFI CLAUDIO Dipartimento di Ingegneria Agraria 3 MANNINO SAVERIO Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche 4 MAZZETTO FABRIZIO Dipartimento di Ingegneria Agraria MORA DIEGO Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche 6 PIERGIOVANNI LUCIANO Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche PRETOLANI ROBERTO Dipartimento di Economia e Politica Agraria Agro-Alimentare e Ambientale PROVOLO GIORGIO MARIO Dipartimento di Ingegneria Agraria SCIENZA ATTILIO Dipartimento di Produzione Vegetale 0 TAMBONE FULVIA Dipartimento di Produzione Vegetale Understanding the mechanisms of microbial colonization of stone New analytical strategies for the evaluation of microbiological safety and quality in foods Uncertainty sources in unsaturated zone models Food Bionanotechnology Development of crop monitoring technologies for farm information systems CONFRONTING THE CLINICAL RELEVANCE OF BIOCIDE INDUCED ANTIBIOTIC RESISTANCE IN FOOD BACTERIA Innovative food packaging products and processes in the technological of bio-based materials The agricultural commodity markets: effects of recent international economic scenarios Strategies and practical solutions to reduce pollution caused by nitrates from agricultural sources Physiological responses and induction of resistance mechanisms to abiotic stresses in grape. Bio-molecules from biomasses for technology applications Study of the dynamics of microbial communities pioneer of colonisation of stone substrates, processes that sustain the deterioration of cultural heritage stone surfaces, and the mechanisms leading to soil fertility. The evaluation and design of the microbiological safety and quality in foods requires the development of new analytical strategies to rapidly and efficiently control bacterial pathogens and/or hygienic indicators and/or quality markers. Address one or more of the sources of uncertainty for the case of distributed models of the soil unsaturated zone: inaccuracy of the input timeseries; approximations in the formulation and solution of model equations; parameters uncertainty The aim of the present research is to develop nanostructured materials to be used in the food sector as packaging materials, process and product coadjuvants and as support for the design of nano-bio-sensors for quality control. Development of proximal sensing tools (ground sensing), with integration of signals both from optical and laser-scanner sensors, for evaluating and recording into farm databases crop phyto-sanitary states. GRAS microorganisms commonly used in the food processes may represent a reservoir of potential biocide and biocide/antibiotic resistances transferable by horizontal gene transfer to spoilage and/or pathogenic microorganisms. After adequate chemical and enzymatic modification and in various combination, protein, starch and cellulosic bio-polymers will be used to produce innovative, safe, inexpensive and effective food packaging materials. The candidate should focus his/her project analysing the causes and the nature of the high price volatility of agricultural commodities by the use of econometric tools in the framework of price transmission theory and transport costs. Development of an expert system, based on databases and simulation models, for the identification of alternatives of animal manure management and processing, at farm and catchment level, to reduce the environmental impact of livestock farming. Study of the mechanisms involved in the responses to water and saline stress in different rootstocks selected for their resistance considering the relationships with the scion and the effects on characteristics of the berries. The project aims to obtain bio-macromolecules from biomasses for technology purpose, tanks to surfactant and electron shuttle properties. 1 Alternative protein sources in feeding of poultry, Effect of inclusion in the diet of different protein alternative feedstuffs derived 20

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