Plenary Lectures NOVEL AND NEW CONCEPT TO INCREASE OXYGEN TRANSFER IN BIOREACTORS D.I.C. Wang and B. Olle

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1 Content Plenary Lectures NOVEL AND NEW CONCEPT TO INCREASE OXYGEN TRANSFER IN BIOREACTORS D.I.C. Wang and B. Olle NATIONAL PATENTING AND LEGAL ASPECTS IN INDIA COMPARED WITH EUROPE AND USA ONES Amarjit Singh 1 13 Regulations and Patenting INTELLECTUAL PROPERTY IN BIO-TECHNOLOGY: RELEVANCE AND STRATEGY IN THE PHARMACEUTICAL INDUSTRY C. Noeske-Jungblut and A. Bertucco TECHNOLOGY VALUATION FOR BIOTECHNOLOGY: TECHNIQUES FOR VALUATION OF INTELLECTUAL PROPERTY A. Ranaulo, D. Napolitano, L. Iavarone and M. Iacobelli Biofinance BIO-INCUBATION: A PRIVAT/PUBLIC PARTNERSHIP BASED APPROACH 37 F. Conicella, A. Baldi and K. Romani DOING BUSINESS GLOBALLY: CROSS-BORDER FINANCING AND MARKET OPPORTUNITIES P. Barbanti 43 Metabolic Engineering TOWARD A BETTER UNDERSTANDING OF WHY AND HOW ANTIBIOTIC BIOSYNTHESIS IS BEING TRIGGERED IN STREPTOMCES? A. Smirnov, C. Esnault, A. Nowacka-Mazurek, C. Martel, E. Darbon-Rongere, H. Chouayekh, S. Ghorbel, N. Shikura, N. Seghezzi and M.J. Virolle GENETIC ENGINEERING OF ESCHERICHIA COLI TO ENHANCE BIOLOGICAL PRODUCTION OF VANILLIN FROM FERULIC ACID F. Luziatelli and M. Ruzzi SMALL ANIMAL IMAGING FACILITY:A METABOLIC AND STRUCTURAL IMAGING CENTER R. Grassi, C. Cavaliere, M. Corona, B. Andria, M.A. Di Pasquale, S. Cozzolino and A. Rotondo

2 Process Engineering THE ROLE OF SINGULARITY POINTS IN THE DYNAMICS OF A CHEMOSTAT A. Cammarota, M. Miccio and M. Poletto HETEROLOGOUS PROTEIN PRODUCTION BY YEAST IN AERATED FED-BATCH CULTURES: RELEVANCE OF THE HOST STRAIN VIABILITY V. Romano, L. Paciello, P. Parascandola, V. Palermo, C. Mazzoni, C. Falcone and E. De Alteriis ULTRASOUND EXTRACTION OF ACTIVE PRINCIPLES WITH HYPOGLYCEMIC ACTIVITY FROM MEDICINAL PLANTS A. Alupului and V. Lavric EXPERIMENTAL AND SIMULATION ANALYSIS OF MEMBRANE ADSORBERS USED FOR THE PRIMARY CAPTURE STEP IN ANTIBODY MANUFACTURING C. Boi, S. Dimartino and G.C. Sarti ASSESSMENT OF THE KINETICS OF PHENOL BIOCONVERSION BY PSUDOMONAS SP. OX1 G. Olivieri, M.E. Russo, A. Di Donato, A. Marzocchella and P. Salatino NOVEL EXPRESSION SYSTEMS FOR RECOMBINANT PROTEIN PRODUCTION AT LOW TEMPERATURES M. Giuliani, E. Parrilli, M.L. Tutino, G. Sannia and G. Marino PROTOPLAST FUSION TECHNOLOGY AND ITS BIOTECHNOLOGICAL APPLICATIONS N. Verma, M. Bansal and V. Kumar UNSTRUCTURED MODELS FOR BATCH CULTURES OF LACTOBACILLUS HELVETICUS A. Bouguettoucha, B. Balannec, S. Nacef and A. Amrane USE OF A MATHEMATICAL MODEL TO INVESTIGATE THE INFLUENCE OF NITROGEN CONSUMPTION ON PH DURING FERMENTATION H. Akin, C. Brandam, X.M. Meyer and P. Strehaiano MATHEMATICALL MODELLING ASPECTS OF TRICHODERMA REESEI SYSTEM: A REVIEW N. Verma, M. Bansal and V. Kumar NON-LOCAL PHENOMENA UNDER HEAT AND MASS TRANSFER IN THE HIGH RATE PROCESSES A. Muratov, A. Brener and O. Balabekov

3 Bio-Products IMPROVEMENTS IN PHA PRODUCTION, CONTROL AND APPLICATIONS N. Berezina, O. Talon and L. Paternostre INTERLOCKING OF PRIMARY AND SECONDARY METABOLISM IN ANTIBIOTIC-PRODUCING ACTINOMYCETES E. Stegmann, B. Hadatsch, C. Kittel, O. Puk, R. Menges, R. Suessmuth and W. Wohlleben A NEW FORMULA (BG z1) FOR MORE EFFICIENT DELIVERY OF B. thuringensis var. israelensis ENDOTOXINS AGAINST MOSQUITO S LARVAE S. Dell'Aversana, L. Tranchino, V. Di Grazia, G. Mele, G. Lacertosa, A. Petrozza and F. Cellini SACCHAROTHRIX ALGERIENSIS, A NEW ANTIBIOTIC PRODUCER: INVESTIGATIONS ON ITS SECONDARY METABOLISM C. Strub, C. Brandam, X.M. Meyer and A. Lebrihi EFFECT OF INULIN SUPLEMENTATION OF MILK TO PREPARE FERMENTED BIOMILKS R. Oliveira, P. Perego, A. Converti and M. Oliveira BIOCONVERSION OF FERULIC ACID OBTAINED FROM WHEAT BRAN INTO VANILLIN L. Sciubba, D. Di Gioia, L. Setti, M. Ruzzi and F. Fava SHELF STABILITY OF LUTEIN FROM MARIGOLD (TAGETES ERECTA L.) FLOWERS IN VEGETABLE OILS R. Lavecchia and A. Zuorro EFFECT OF THE CARBON AND NITROGEN SOURCES ON BIOSURFACTANT PRODUCTION BY PSEUDOMONAS FLUORESCENS BIOSURFACTANT CHARACTERIZATION A. Yataghene, M. Abouseoud, R. Maachi and A. Amrane FRUCTOOLIGOSACCHARIDES PRODUCTION FROM SUCROSE BY ASPERGILLUS SP. N74 IMMOBILIZED IN CALCIUM ALGINATE O. Sanchez, F. Guio, D. Garcia, N. Algecira, E. Silva and L. Caicedo COMPARATIVE BATCH GROWTH STUDIES OF PURE LACTOBACILLUS STRAINS AND THEIR CO-CULTURE IN SYNTHETIC MEDIUM WITH DIFFERENT NEUTRALIZING AGENTS M. Ghosh and U. Ghosh

4 Biofuels BIOFUELS:DREAM OR REALITY. ENTHALPIC, EXERGETIC AND SOCIOECONOMICAL ANALYSIS L. Zanderighi CONTINUOUS PRODUCTION OF BIODIESEL USING A MICROTUBE REACTOR G. Guan, K. Kusakabe, K. Moriyama and N. Sakurai CONTINUOUS BIOETHANOL AND BIOGAS PRODUCTION FROM FOOD PROCESSING WASTE M. Zanette, M. Torresendi, D. Bolzonella, F. Fatone and F. Cecchi FUNGAL BIOMASS-BASED PRODUCTION OF LIPIDS FOR BIODIESEL SYNTHESIS A. D'Urso, R. Bubbico, M. Scarsella and M. Bravi PRODUCTION OF HYDROGEN BY WASTEWATER SLUDGE USING ANAEROBIC FERMENTATION IN A PILOT SCALE REACTOR B. La Licata, A. Scaletta, F. Sagnelli, T. Tommasi, P. Zitella and B. Ruggeri A STUDY ON THE BIOCHEMICAL REACTION ENGINEERING OF BIODIESEL PRODUCTION A. Gallifuoco, L. Cantarella, A. Spera, I Venti and M. Cantarella ASSESSMENT OF KINETICS OF BUTANOL PRODUCTION BY CLOSTRIDIUM ACETOBUTYLICUM F. Napoli, G. Olivieri, A. Marzocchella and P. Salatino PRODUCTION OF 2,3-BUTANEDIOL BY BACILLUS STEAROTHERMOPHILUS: FERMENTATION AND METABOLIC PATHWAY P.P. Giovannini, M. Mantovani, A. Medici and P. Pedrini GLYCEROL FERMENTATION TO 1,3-PROPANEDIOL BY KLEBSIELLA OXYTOCA NRRL B-199: STUDY OF THE INHIBITION OF THE FINAL PRODUCTS OF BOTH THE OXYDATIVE AND THE REDUCTIVE ROUTES C. Galdeano, G. Salguero, V.E. Santos, M. Zazo, J.L. Garcia and F. Garcia-Ochoa STUDY ON REACTION PARAMETERS IN LIPASE-CATALYZED METHANOLYSIS OF PLANT OIL M. Hajar, F. Vahabzadeh and S. Shokrollahzadeh

5 Industrial Enzymes ENHANCEMENT OF LYCOPENE EXTRACTION FROM TOMATO PEELS BY ENZYMATIC TREATMENT R. Lavecchia and A. Zuorro WATER CONTACT ANGLE AND FTIR STUDY OF THE SURFACE MODIFICATION OF PET BY LIPOLYTIC ENZYME I. Donelli, P. Taddei, V.A. Nierstrasz and G. Freddi LACCASE-CATALYSED AZODYE SYNTHESIS 315 M. Trovaslet, E. Enaud, A. Bazes, C. Jolivalt, F. Van Hove and S. Vanhulle NICOTINIC ACID BIOPRODUCTION IN UF-MEMBRANE REACTOR VIA NITRILE HYDRATASE-AMIDASE CATALYZED REACTIONS M. Cantarella, L. Cantarella, A. Gallifuoco, A. Malandra, A. Spera and L. Martínková IMMOBILIZATION-STABILIZATION OF CANDIDA ANTARCTICA LIPASE B IN AGAROSE-GLYOXYL AND AGAROSE-OCTYL: DEACTIVATION KINETICS C. Belver, J.J. Tamayo, L. Molinero, M. Ladero, B.C.C. Pessela, J.M. Guisán and F. Garcia-Ochoa EVALUATION OF ORANGE PEEL AND GREEN SOYBEAN AS A SUBSTRATE FOR THE PRODUCTION OF α-galactosidase BY A SOIL ISOLATED ASPERGILLUS ORYZAE IN SOLID STATE FERMENTATION D. Alvarez and O. Sanchez EVALUATION OF DRYING TECHNIQUES MEASURING PROTEOLYTIC ACTIVITY OF PAPAIN OBTAINED FROM UNRIPE FRUIT AND SKIN JUICE A. Puig, I. Gil and O. Sanchez BIO-EXTRACTION OF OLIVE OIL: IMPROVEMENT OF QUALITY AND EXTRACTION OUTPUTS B. Aliakbarian, D. De Faveri, A.A. Casazza, R. Oliveira, M. Oliveira, A. Converti and P. Perego CHIRAL AROMATIC ALCOHOLS PRODUCTION BY THERMOPHILIC NADH-DEPENDENT CARBONYL REDUCTASE A. Pennacchio, B. Pucci, F. Secundo, F. La Cara, M. Rossi and C.A. Raia

6 Health Care Biotechnologies ALBUMIN-BOUND TOXIN REMOVAL IN LIVER SUPPORT DEVICES: CASE STUDY OF TRYPTOPHAN ADSORPTION AND DIALYSIS M.C. Annesini, V. Piemonte and L. Turchetti OPTIMISATION STUDIES ON MULTIPLE ELICITOR ADDITION IN MICROBIAL SYSTEMS: P. CHRYSOGENUM AND B. LICHENIFORMIS R. Nair, T. Murphy, I. Roy, A. Harrop, K. Dixon and T. Keshavarz OPTIMIZATION OF CAPSAICIN ACYLASE PRODUCTION FROM STREPTOMYCES MOBARAENSIS IN BENCH-TOP REACTOR S. Crognale, P. Barghini, P. Di Matteo, F. Federici and M. Ruzzi THE MINI BIOARTIFICIALIVER: A CELLULAR BIOSENSOR IN THE DRUG DEVELOPMENT PROCESS B. Andria, A. Bracco, E. Alimenti, C. Attanasio, A. Tammaro, S. Scala, RAFM Chamuleau and F. Calise FURTHER STUDIES ON NUCLEOPEPTIDES WITH DABA-BASED BACKBONE G. Roviello, D. Musumeci, E.M. Bucci, M. Castiglione, C. Pedone, E. Benedetti, R. Sapio and M. Valente EXPERIMENTAL MODELS IN LARGE SIZE ANIMALS FOR DEVICES IN VASCULAR PATHOLOGIES A. Pantaleo, L. Di Tommaso, M. Monaco, S. Castaldo, D. Di Napoli, P. De Marinis, S. Cozzolino and G. Iannelli Environmental Biotechnology MODEL INVESTIGATION OF FUNGAL ACTIVITY ON A SYNTHETIC BIORECALCITRANT WASTEWATER A. D'Urso, D. Gapes and M. Bravi STUDY ON LABORATORY REACTORS FOR BIODEGRADATION OF TEXTILE DYES BY IMMOBILIZED WHITE-ROT FUNGI MYCELIUM J. Pocedic, P. Hasal and C. Novotny USE OF ENZYMES IN THE PRE-TREATMENT OF COTTON 423 K. Opwis, D. Knittel and E. Schollmeyer PSEUDOMONAS AERUGINOSA GROWTH IN MICROWAVE IRRADIATED ENVIRONMENT R. Carta and F. Desogus MEMBRANE FILTRATION OF SURFACE WATER FOR THE REMOVAL OF HUMIC SUBSTANCES M. Prisciandaro, A Salladini and D. Barba

7 BIOFILTRATION OF TCE VAPOURS IN A MIXED COMPOST-INERT CARRIER TRICKLE BED L. Della Vedova, I. Colussi, A. Cortesi and V. Gallo HIGH-RATE ANAEROBIC-AEROBIC BIOLOGICAL TREATMENT OF A WASTEWATER FROM A FISCHER-TROPSCH PROCESS M. Beccari, M. Majone, D. Dionisi, A. Donadio, E.N. Daddario and R. Sbardellati OPTIMIZATION OF A DESULFURIZATING BIOCATALYST BY COMBINING CELLS OF DIFFERENT CELL AGE OF PSEUDOMONAS PUTIDA CECT5279 J. Calzada, S. Heras, J. Carbajo, A. Alcon, V.E. Santos, J.L. Garcia and F. Garcia-Ochoa REDUCTIVE DECHLORINATION OF WEATHERED PCBS IN THE MARINE SEDIMENTS OF BRENTELLA CANAL OF VENICE LAGOON G. Zanaroli, A. Negroni, A. Balloi, D. Daffonchio and F. Fava BIOSORPTION OF AQUEOUS CHROMIUM VI BY LIVING MYCELIUM OF PHANEROCHAETE CHRYSOSPORIUM M. Nikazar, L. Davarpanah and F. Vahabzadeh BIOREMEDIATION OF OLIVE OIL MILL WASTEWATERS BY FUNGAL (T. VIRIDE, STRAIN 8/90) SEQUENCING BATCH REACTOR A. D'Urso, D. Gapes and M. Bravi KINETIC MODELING OF BIOSORPTION OF HEAVY METALS BY LOOFA-SPONGE IMMOBILIZED PHANEROCHAETE CHRYSOSPORIUM FROM AQUEOUS SOLUTION M. Nikazar, P. Namiranian and F. Vahabzadeh SUSTAINABLE DECONTAMINATION OF AN ACTUAL SITE AGED PCB POLLUTED SOIL BY A BIOSURFACTANT-BASED WASHING FOLLOWED BY A PHOTOCATALYTIC TREATMENT D. Todaro, F. Occulti, G. Camera Roda and F. Fava POTENTIAL OF MICROBIAL SPECIES IN BIODEGRADATION OF VOLATILE ORGANIC COMPOUNDS FROM WATERS L. Jecu, A. Gheorghe, F. Popea, A. Rosu, A. Stoica and M. Stroescu BIOLOGICAL CONTROL OF PHYTOPATHOGEN MICROORGANISMS WITH ANTAGONIST BACTERIA A. Gheorghe, L. Jecu, A. Voicu, F. Popea, A. Rosu and A. Roseanu EVALUATION OF M-NITROPHENOL AND P-NITROPHENOL DEGRADATION WITH BIOLOGICAL ACTIVATED CARBON BY IMMOBILIZATION OF PSEUDOMONA PUTIDA ATCC E. Escobar, J.C. Moreno, M.D.P. Perez and O. Sanchez