therapeutic targets for Richter's syndrome 2 GR Neurofunctional Alterations of Body representation in Anorexia Nervosa:

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1 Young Italian Researchers Grant Evaluation Committee - Final List with Funding Information Rank Code Title Principal Investigator Institutions Average Score Score Overall costs Funding MoH 1 GR Identification of novel prognostic factors and Silvia DEAGLIO Piemonte 6,17 8, , , therapeutic targets for Richter's syndrome 2 GR Neurofunctional Alterations of Body Cosimo Urgesi Istituto "Eugenio 6, , , representation in Anorexia Nervosa: Medea" - Neuropsychological Measures and Associazione La Nostra Famiglia Neurophysiologic Treatments 3 GR Understanding in vivo MSC-mediated Antonella Viola Istituto Clinico 6, , , , immunosuppression: scientific bases for Humanitas clinical protocols. 4 GR Idiopathic Central Hypogonadism (ICH) as MARCO BONOMI Fondazione 7,00 6,5 5 9, , , an emerging clinical problem: Investigations Istituto Auxologico on the disrupted signals underlying its Italiano pathogenesis and generation of an efficient national network for its diagnosis and management 5 GR The role of Activation Induced Deaminase in Silvestro Conticello Toscana 7,00 7,5 5, , , the onset and progression of B-cell tumours 6 GR Activation of Nuclear Bile Acid Receptor FXR Antonio Moschetta IRCCS Giovanni 7, , , , as a novel therapeutic approach to colon Paolo II cancer 7 GR MicroRNAs as novel regulators of the Stefano Pluchino Fondazione 7, , , , therapeutic plasticity of somatic STEM cells Centro San (mir-stem) Raffaele del Monte Tabor 8 GR Exploring the endocannabinoid system to Diego Centonze Fondazione Santa 7, , , face inflammatory neurodegeneration in Lucia Multiple Sclerosis 9 GR Employment, Disease Burden and Indirect Luca Neri Regione 7,50 9,5 6,5 6, , , Costs in Chronic Kidney Disease (EBICK Lombardia - study) Direzione Generale Sanità Pagina 1 di 98

2 10 GR The kidney as a sensor of risk in clinical practice: optimizing cost-effectiveness in the identification of high risk patients with primary hypertension Francesca Viazzi Liguria 7,67 6,5 5, , ,00 11 GR PARACRINE EFFECTS AND CARDIAC Massimiliano Gnecchi IRCCS 7, , , REGENERATIVE POTENTIAL OF FETAL Fondazione MESENCHYMAL STEM CELLS DERIVED Policlinico San Matteo FROM HUMAN PLACENTA 12 GR Study of cholesterol metabolism as valerio leoni FONDAZIONE 7,67 7 8,5 7, , , biomarker in Huntington disease: new IRCCS ISTITUTO insights in the pathogenesis of NEUROLOGICO "C.BESTA" neurodegeneration 13 GR Non-invasive tools for early detection of Maria Luisa Scattoni Istituto Superiore 7,83 8, , , Autism Spectrum Disorders 14 GR Analyzing the genetic architecture of Crohn's Anna Latiano Ospedale 8,00 7,5 10 6, , , disease. The International IBD Genetic Generale Consortium study Regionale "Casa Sollievo della Sofferenza" 15 GR Sonodynamic therapy: high energy shock Loredana Serpe Piemonte 8, , , waves and porphyrin compounds for treatment of solid tumors 16 GR The Role of Vascular Smooth Muscle Cell Iris Jaffe Istituto San 8,00 10,5 8, , , Mineralocorticoid Receptors in Vascular Raffaele Pisana Function and Disease 17 GR Prevention and Therapy of Hepatocellular Giovanni Sitia Fondazione 8,00 8,5 9, , , Carcinoma Centro San Raffaele del Monte Tabor 18 GR Role of cannabinoid and vanilloid receptors Silvia Marinelli Fondazione Santa 8,00 6,5 10 7, , , in the central mechanism of neuropathic pain Lucia 19 GR MyD88: A New Therapeutic Molecular Elisabetta Volpe Fondazione Santa 8,17 7, , , Target for the Treatment of Multiple Sclerosis Lucia 20 GR New therapeutical approaches to RANKLdependent cristina sobacchi Istituto Clinico 8,17 7, , , Autosomal Recessive Humanitas Osteopetrosis Pagina 2 di 98

3 21 GR Aberrant gene expression and muscular Davide Gabellini Fondazione 8,17 7, , , dystrophy: role of the epigenome in the Centro San pathogenesis and potential therapies. Raffaele del Monte Tabor 22 GR A longitudinal MRI investigation of patients with mild cognitive impairment using structural and functional techniques to identify biomarkers of diagnostic and prognostic value. Marco Bozzali Fondazione Santa Lucia 8,17 8 5, , ,00 23 GR Exploiting proteotoxic stress against plasma Simone Cenci Fondazione 8,17 7, , , cell malignancies Centro San Raffaele del Monte Tabor 24 GR Defining stem cell lineages for regenerative Giuseppe Testa Istituto Europeo di 8,33 7,5 8, , , medicine: histone methylation in neural Oncologia differentiation 25 GR Mannose Binding Lectin, a Potential New Target for Stroke Therapy: Biochemical, in Vitro and in Vivo Experimental, and Clinical Approaches to Define its Role in Ischemic Injury. Elisa Zanier Ospedale Maggiore 8,33 8,5 7 9, , ,00 26 GR Analysis of the pathogenetic mechanisms ENRICO MORO Istituto "Giannina 8, , , underlying lysosomal disorders using Gaslini" zebrafish biosensors 27 GR Innovative IDO-targeting interventions in CIRIANA ORABONA Umbria 8, , , autoimmunity 28 GR Prediction of cognitive decline in mild cognitive impairment (MCI) subjects carrying genetic risk factors based on quantitative EEG and transcranial magnetic stimulation markers Fabrizio Vecchio Associazione Oasi Maria SS. 8, , ,00 29 GR Antisense RNA-mediated gene therapy of Michela Denti Provincia 8, , , retinal dystrophies and dysfunctions. autonoma Trento 30 GR NMDA receptor modulation in early Barbara Picconi Fondazione Santa 8,50 6, , , Parkinsonism and in L-DOPA-induced Lucia dyskinesia: a new therapeutic strategy 31 GR Epigenetic regulation of transcription in Diego Pasini Istituto Europeo di 8, , , , cellular differentiation and cancer formation Oncologia Pagina 3 di 98

4 32 GR Preclinical evaluation of the NAMPT inhibitor Alessio Nencioni Liguria 8, , , FK866 for the treatment of autoimmunity and lymphoblastic leukemia 33 GR NEW IMMUNOTHERAPEUTIC Alessandro Zerbini Emilia-Romagna 8,67 9,5 9 7, , , STRATEGIES FOR HEPATOCELLULAR CARCINOMA 34 GR Targeting mutant-p53 to develop new Michelangelo Cordenonsi Veneto 8, , , prognostic and therapeutic tools for breast cancer metastasis 35 GR Secretases, myelin and neurodegenerative Carla Taveggia Fondazione 8,83 6, , , diseases Centro San Raffaele del Monte Tabor 36 GR Application of high-field structural and Maria Rocca Fondazione 8, , , , functional MRI to investigate the substrates Centro San of fatigue in multiple sclerosis and the effects Raffaele del Monte Tabor of tailored treatments. 37 GR Study of the role of S-nitrosoglutathione reductase (GSNOR) in neuronal homeostasis and its implication in Parkinson's disease etiopathogenesis Giuseppe Filomeni Istituto San Raffaele Pisana 8, , , ,00 38 GR Role of the putative oncosupppressor HIPK2 cinzia rinaldo Istituto Regina 9,00 8,5 9, , , in cytokinesis and induction of chromosomal Elena instability 39 GR In vivo screening for genes inducing neural Paolo Malatesta Istituto Nazionale 9, ,5 7, , , tumors and development of animal models per la Ricerca sul for assaying innovative therapies for gliomas Cancro 40 GR SUMF1 (Sulfatase Modifying Factor 1) maria pia cosma Campania 9,00 8,5 9 9, , , controls self-renewal and differentiation of the HSCs (hematopoietic stem cells) 41 GR Identification of molecular signatures Filippo Canducci Fondazione 9, , , associated with coronary and carotid artery Centro San atherosclerotic diseases progression and Raffaele del Monte Tabor clinical acute manifestations through the analysis of peripheral and local immunological pathogenetic determinants. Pagina 4 di 98

5 42 GR SET UP OF HIGH SENSITIVITY MUTATIONAL ASSAY TO DETECT CANCER-ASSOCIATED GENOMIC INSTABILITY USING NEXT-GENERATION SEQUENCING TECHNOLOGY Francesca Donatella Ciccarelli Istituto Europeo di Oncologia 9, ,5 8, , ,00 43 GR Polyphenol-Rich Food Consumption and Simona Costanzo Molise 9,00 7,5 9, , , Short and Long-Term Prognosis after Coronary Artery Bypass Graft Surgery 44 GR Mesenchymal Stem Cells and Cancer: Massimo Dominici Emilia-Romagna 9, , , Toward Safer Cell-Based Therapeutic Applications 45 GR UNRAVELING THE MECHANISMS OF THE ACTIVATION OF RESIDENT CARDIAC STEM CELLS: AN APPROACH TO CARDIOVASCULAR REGENERATIVE THERAPY Daniele Torella Calabria 9,00 9,5 8, , ,00 46 GR Methylome profiling and clinical correlations Barbara Banelli Istituto Nazionale 9, , , , in Neuroblastoma per la Ricerca sul Cancro 47 GR New assays for evaluation of tumorigenic potential of malignant brain tumor cancer stem cells clonal derivatives and identification of molecular targets for pharmacological interventions Yvan Torrente Ospedale Maggiore 9, , , ,00 48 GR Autophagy modulation as target to develop Paolo Pinton Emilia-Romagna 9, , , , novel pharmacological approaches for mitochondrial disorders 49 GR Designing strategies to target cancer stem cells: a study on the molecular bases of mitotic spindle coupling to polarity cues in mammalian asymmetric divisions. Marina Mapelli Istituto Europeo di Oncologia 9, , , ,00 50 GR Does rehabilitation with a 10-Hz sensory stimulation improve brain rhythms and cognitive-motor performance in neurological patients? Towards Internet-based clinical applications at subjects home Claudio Del Percio Istituto San Raffaele Pisana 9,17 9,5 8,5 9, , ,00 Pagina 5 di 98

6 51 GR Body composition and energy expenditure of Duchenne Muscolar Distrophy (DMD) patients and correlation with disease progression Alessandra Coin Veneto 9,17 5, , ,00 52 GR An innovative surveillance system for obesity Garden Tabacchi Agenzia per i 9, , , , and lifestyles in adolescents applied to the Servizi Sanitari public health service Regionali 53 GR Ubiquitin-dependent regulation of p63 and angelo peschiaroli Istituto 9, ,5 10, , , p73 in physiological and pathological Dermopatico conditions dell'immacolata ' IDI, di proprietà e gestito dalla Provincia Italiana della C.F.I.C 54 GR Hirschsprung's disease as a model of neuroimmune dysfunctions in the gut: role of RET proto-oncogene in the correct development and maintenance of microbial homeostasis Domenico Mavilio Istituto Clinico Humanitas 9, , ,00 55 GR Cystic Fibrosis as a model disease for Nicoletta Pedemonte Istituto "Giannina 9, , , protein misfolding defects Gaslini" 56 GR Promoting Recovery from stroke: INdividually filippo zappasodi Abruzzo 9, , , , enriched therapeutic intervention in Acute Phase (PRINAP) 57 GR Hematopoietic stem cell gene therapy for the Alessandra Biffi Fondazione 9, , , , treatment of rare inherited pediatric disorders Centro San Raffaele del Monte Tabor 58 GR Role of lung cancer initiating cells in Luca Roz Fondazione 9, , , prognosis and chemoresistance IRCCS Istituto Nazionale dei Tumori 59 GR ZINC SULPHATE: SAFETY AND EFFICACY Rosanna Squitti Centro San 9,67 11,5 8 9, , , IN ALZHEIMERS DISEASE PATIENTS Giovanni di Dio - TREATED WITH Fatebenefratelli ACETYLCHOLINESTERASE INHIBITORS. A PROSPECTIVE, RANDOMIZED, DOUBLE BLIND, PARALLEL, & PLACEBO- CONTROLLED PHASE II STUDY Pagina 6 di 98

7 60 GR TOWARDS AN INNOVATIVE THERAPEUTIC TREATMENT OF ECTRODACTYLY-ECTODERMAL DYSPLASIA-CLEFTING (EEC) SYNDROME USING ALLELE-SPECIFIC RNA SILENCING Enzo Di Iorio Veneto 9, , , ,00 61 GR Negative modulation of nicotinic acetylcholine receptor by PPAR-alpha as a novel therapeutic target in autosomaldominant nocturnal frontal lobe epilepsy. Miriam Melis Sardegna 10,00 8,5 9 12, , ,00 62 GR New predictors of cardiovascular disease Marcello Rattazzi Veneto 10,00 11,5 12 6, , , and their role in acute coronary syndromes 63 GR Role of BDNF in L-DOPA-induced dyskinesia Manolo Carta Sardegna 10,00 8, , , , in animal models of Parkinson s disease 64 GR Sleep related risk factors for postpartum Mauro Manconi Regione 10, , , depression Lombardia - Direzione Generale Sanità 65 GR Study of the role of pro-angiogenic factors in Rosa Bernardi Fondazione 10, , , leukemogenesis and evaluation of the Centro San effectiveness of their targeting as anti-tumor Raffaele del Monte Tabor therapy 66 GR Testing the effectiveness of a drug abuse preventive program through wastewater analysis, a novel approach to estimate drug consumption in a community Sara Castiglioni Istituto Superiore 10,00 8,5 9 12, , ,00 67 GR Reducing Parkinson's Disease DIEGO ALBANI Fondazione Don 10, , , , Neurodegeneration Using Protective Factors Carlo Gnocchi Produced by Autologous Engineered Onlus Fibroblasts 68 GR Role and clinical significance of Tie2- Michele De Palma Fondazione 10, , , , expressing monocytes and circulating Centro San endothelial cells in cancer patients Raffaele del Monte Tabor 69 GR Human Immunoagents for the Therapy of Claudia De Lorenzo Istituto Regina 10,17 12,5 9,5 8, , , Mammary Carcinoma Elena 70 GR Combined MR and PET imaging for Letterio Salvatore Politi Fondazione 10,17 13, , , monitoring stem cell therapies Centro San Raffaele del Monte Tabor Pagina 7 di 98

8 71 GR Hemodymanic brain-computer interfaces in Andrea Caria Istituto di 10,17 9, , , stroke rehabilitation Neuroriabilitazione Motoria San Camillo 72 GR Combined treatment models of borderline MONICA ZIZZA Piemonte 10,17 9 8, , , personality disorder (BPD): comparison between brief and long-term results 73 GR The Rai adaptor protein in Th17 cell differentiation, effector function and chemotaxis and in the pathogenesis of multiple sclerosis MARIA TERESA SAVINO Istituto Europeo di Oncologia 10, , , ,00 74 GR Toward personalized medicine: investigating antidepressant efficacy and the underlying molecular mechanisms in a gene by environment interaction perspective Igor Branchi Istituto Superiore 10, , , ,00 75 GR Innovative approaches to the diagnosis and PAOLA GUGLIELMELLI Toscana 10, , , , prognostication of Philadelphia-negative chronic myeloproliferative neoplasms 76 GR Role of upar in the epidermal stem cell Silvia D'Alessio Fondazione 10, , , , compartment Centro San Raffaele del Monte Tabor 77 GR Tumor suppressor targeting as a novel molecular therapy for cancer: the Bcr-Abl Hausp FoxO3a pathway in Chronic Myeloid Leukemia alessandro morotti Piemonte 10, , , ,00 78 GR Role of the inwardly rectifying potassium channel Kir4.1 in the pathogenesis of cryptogenic epileptic syndromes and encephalopathies. Federico Sicca Fondazione Stella Maris 10, , ,00 79 GR Characterization of a novel human cardiac alessandra rossini Centro 10, , , cell population suitable for clinical Cardiologico applications Monzino 80 GR MicroRNAs as molecular markers to design Lucia Ricci Vitiani Istituto Superiore 10, ,5 13, , , novel therapies for glioblastoma and colorectal cancer treatment Pagina 8 di 98

9 81 GR New insight for a therapeutical approach to alcoholism: study of toxicity, tolerance and ethanol dependence mechanisms by regulation of transcription, molecular imaging and epigenetic analysis Claudio D'Addario Emilia-Romagna 10,33 12,5 9, , ,00 82 GR Identification and functional analysis of mutations in FMR1 and FMRP-interacting genes CYFIP1 and BC200 in a large cohort of patients with idiopathic mental retardation and/or autism. FRANCESCA ZALFA Fondazione Santa Lucia 10, , ,00 83 GR Role of the innate immunity in herpes Cristina Cerboni Istituto 10, , , simplex virus (HSV)-1-related Neurologico neuropathologies. Mediterraneo Neuromed 84 GR Services for Prevention of psychotic and paolo brambilla Istituto "Eugenio 10, , , depressive EpisodeS: from genomics to Medea" - phenomics in a human/animal perspective Associazione La Nostra Famiglia 85 GR B cell in autoimmunity: from basic research elisabetta traggiai Istituto "Giannina 10, , , to diagnostic and pharmacological targets Gaslini" 86 GR Exploring induced pluripotent stem cells for Claudia Bearzi IRCCS 10, , , heart failure treatment Multimedica 87 GR Chromogranin-A and its derived peptides as predictive markers of complex ventricular arrhythmias in patients with dilated cardiomyopathy Tommaso Angelone Calabria 10, , , ,00 88 GR The power of economic policies in fighting Silvano Gallus Istituto Superiore 10,50 8 8, , , the tobacco epidemic 89 GR The IL-7/IL-7 receptor axis in T cell memory Paolo Monti Fondazione 10, , , , in type I diabetes mellitus and islet allotransplantation Raffaele del Centro San Monte Tabor 90 GR Global warming, urbanization and Simona Gabrielli Istituto 10, , , immunodeficiency: effects on the Zooprofilattico leishmaniosis transmission patterns. Sperimentale del Lazio e della Toscana Pagina 9 di 98

10 91 GR Gamma irradiation of dried fruits: evaluation Maria Cristina D'Oca Istituto 10, , , of biohazardous pollutants (pesticides and Zooprofilattico mycotoxins), of moulds and fungi reduction, Sperimentale della Sicilia and investigation on nutritional modifications 92 GR Telemonitoring intervention for elderly patients with acute decompensation of chronic heart failure treated in Hospital at Home: a randomized trial. Vittoria Tibaldi Piemonte 10, , ,00 93 GR Therapeutic application of mesenchymal AMALIA FORTE Campania 10, , , stem cells in pre-clinical models of vascular stenosis 94 GR IL-7 expression and regulation in Renata Mazzucchelli Fondazione 10,67 8 7,5 16, , , lymphopenic, physiological and pathological Centro San conditions Raffaele del Monte Tabor 95 GR The extracellular matrix protein EMILIN1 as a Carla Danussi Centro di 10,67 10,5 13, , , determinant in the pathogenesis of Riferimento lymphedema: a basis for new therapeutic Oncologico approaches 96 GR Systematic assessment of the acute and Marcella Brunetti Abruzzo 10, , , chronic effects of trauma on quality of life 97 GR A multidisciplinary approach for the discovery of a novel class of protein-protein interaction inhibitors targeting latently HIV-1 infected reservoirs. A brand new strategy for HIV-1 eradication. Maria Letizia Barreca Istituto Superiore 10,67 14,5 9 8, , ,00 98 GR RESTART OF ADULT HEPATOCYTES Anna Alisi Ospedale 10,83 7,5 14,5 10, , , THROUGH REGENERATING SIGNALS: A Pediatrico CHALLENGE FOR LIVER Bambino Gesu TRANSPLANTATION 99 GR THE DNA "METHYLOME" OF HUMAN Luca Sigalotti Centro di 10, , , , CUTANEOUS MELANOMA: PROGNOSTIC, Riferimento CLINICAL AND IMMUNOTHERAPEUTIC Oncologico IMPLICATIONS 100 GR Role of Chromatin Remodeling in Germ DAVIDE CORONA Sicilia 10, , , , Stem Cell Identity Pagina 10 di 98

11 101 GR Stem cell derived in vitro models of inherited Alessandro Pecci IRCCS 10, , , , thrombocytopenias for studying their Fondazione pathogenesis and identifying drugs for their Policlinico San Matteo therapy 102 GR The role of HIV-1 Nef in neuroaids Maria Giovanna Istituto Superiore 11,00 8,5 16 8, , , development: identification of predictive Quaranta biomarkers and novel therapeutic targets 103 GR Multispecies characterisation of animal BARBARA MANACHINI Istituto 11, , , pathogens in cattle dedicated environments Zooprofilattico Sperimentale della Sicilia 104 GR Gut microbiota, innate immune system and Melania Manco Ospedale 11,00 9,5 14, , , insulin resistance in the pathogenesis of Pediatrico obesity Bambino Gesu 105 GR Role of Arrhythmia-Susceptibility Genes in Lia Crotti IRCCS 11, ,5 7, , , Neonatal Long QT Syndrome, Sudden Infant Fondazione Death Syndrome and Intrauterine Fetal Death Policlinico San Matteo 106 GR Development of new anti-alzheimer therapies based on Rho GTPases modulator proteins governing cytoskeleton remodeling: tackling effects on cognition and unveiling changes in signaling mechanisms following inhibition/stimulation of the target proteins. Sara Travaglione Fondazione Santa Lucia 11, ,5 12, , , GR The NGR/isoDGR motif: a molecular timer Flavio Curnis Fondazione 11, , , for regulating endothelial cells adhesion to Centro San fibronectin and a tool for drug development Raffaele del Monte Tabor 108 GR Identification of PHOX2B interactors and target genes as pharmacological candidates for Congenital Central Hypoventilation Syndrome (CCHS) and screening of drugs for preventing formation or inducing degradation of PHOX2B polyalanine aggregates tiziana bachetti Istituto "Giannina Gaslini" 11,00 8,5 6 18, , , GR Identification of defects in hippocampal Helene Marie Fondazione Santa 11, , , , function in Alzheimer's mouse models and Lucia evaluation of novel rescue therapies. Pagina 11 di 98

12 110 GR New strategy against intractable epilepsy Laura Maggi Istituto 11,17 17,5 8,5 7, , , using a pharmacological and physiological Neurologico approach Mediterraneo Neuromed 111 GR A bright idea to detoxify CO poisoned patients stefania abbruzzetti Emilia-Romagna 11, , , , GR Gastrointestinal neuropathies induced by Paola Brun Istituto "Eugenio 11,17 8 7, , , neurotropic viruses as a model of Medea" - neurodegeneration Associazione La Nostra Famiglia 113 GR Modulation of ER stress as a therapeutic Maurizio D'Antonio Fondazione 11, , , , approach in hereditary neuropathies Centro San Raffaele del Monte Tabor 114 GR Dissecting the role of plasmacytoid dendritic William Vermi Istituto Clinico 11, , , , cells in human cancer Humanitas 115 GR Genes for Mental Retardation, genetic and Patrizia D'Adamo Fondazione 11, , , , functional analysis Centro San Raffaele del Monte Tabor 116 GR Evaluation of pulmonary risks from exposure Massimo Corradi Fondazione S. 11,17 13, , , to chlorination products in indoor swimming Maugeri - Clinica pools. del lavoro e della riabilitazione 117 GR How COMT Val158Met polymorphisms influence behavioral and neural nociceptive processing in placebo responders and nonresponders suffering from chronic pain. Luana Colloca Fondazione Santa Lucia 11, , , , GR C-Choline PET/CT as Image Guide for Maria Picchio Fondazione 11,17 6,5 17,5 9, , , radiotherapic treatment of prostate cancer Centro San recurrent lymphnodes Raffaele del Monte Tabor 119 GR Effectiveness, efficiency and equity of Bruno Federico Agenzia per i 11, , , regional primary care models in the care of Servizi Sanitari people with complex health and social needs Regionali 120 GR Nuovi approcci per la terapia differenziativa dei tumori solidi: i microrna / MicroRNAs: new approaches for the differentiative therapy of solid tumors Riccardo Taulli Piemonte 11,33 14,5 13 6, , ,00 Pagina 12 di 98

13 121 GR Surg2Aid: New approaches in diagnosis and Enrico Caiani Centro 11, , , support in cardiac surgery based on the Cardiologico integration of 4D echocardiographic image Monzino processing with computational modeling 122 GR Nanotechnologies in Public Health: use of Massimiliano Cuccioloni Marche 11, , , optic biosensor for the detection of pathological agents 123 GR Congenital malformations of the cerebellum: Enza Maria Valente Ospedale 11, ,5 5, , , epidemiology, genetic basis, clinical Generale correlates, diagnosis and patients' Regionale "Casa Sollievo della management Sofferenza" 124 GR Best clinical practice for heritable Michele Pasotti IRCCS 11, , , aneurysmal and dissecting diseases of the Fondazione aorta Policlinico San Matteo 125 GR EPIGENETIC BASIS OF DUCHENNE Claudia Colussi Centro 11,33 9,5 14, , , CARDIOMYOPATHY: IDENTIFICATION OF Cardiologico NOVEL THERAPEUTIC TARGETS Monzino 126 GR Restoration of virus specific T cell memory in Carolina Boni Emilia-Romagna 11,50 12, , , chronic HBV infection: implications for optimization of antiviral-therapy. 127 GR Effects of neuroactive drugs on aging and Alessandro Cellerino Centro San 11, , , , cognitive deficit Giovanni di Dio - Fatebenefratelli 128 GR Genetic Profiling for Prediction of Life- PIETRO FRANCIA Istituto 11, , , , Threatening Arrhythmias in Heart Failure Neurologico Mediterraneo Neuromed 129 GR RAS signalling dysregulation and cognitive Simone Martinelli Istituto Superiore 11, , , , functions 130 GR Adoptive Immunotherapy with Cytokine Induced Killer Cells for Solid Tumors: Biological Pre-clinical Studies and Clinical Applications Dario Sangiolo Piemonte 11, , , , GR In vitro and in vivo multidimensional study on the effects of repetitive transcranial magnetic stimulation (rtms) on cerebral ischemia: from basic mechanisms to clinical application Robert Nistico Fondazione Santa Lucia 11, , , ,00 Pagina 13 di 98

14 132 GR From behavioural counselling to Romina di Giuseppe Molise 11,50 11, , , 'personalized nutrition': a right key to prevent cardiovascular disease? 133 GR Enzimi della biosintesi degli steroli rappresentano nuovi bersagli farmacologici per inibire l'angiogenesi e la crescita tumorale/ Sterol biosynthetic pathways: new targets for anti-angiogenesis and anti-tumor therapies Enrico Giraudo Piemonte 11,50 8, , , GR Immunoglobulin G Fragment C Receptor Polymorphisms and Clinical Efficacy of Neoadjuvant Trastuzumab-Based Treatment in Patients with HER-2/neu-positive Breast Cancer Antonino Musolino Emilia-Romagna 11, , , , GR TERAPIA ANTIPERTENSIVA DI POPOLAZIONE: LA GENETICA COME STRUMENTO DI VALUTAZIONE ECONOMICA PER MIGLIORARE EFFICACIA E SOSTENIBILITA ERSILIA CIPOLLETTA Campania 11,50 20, , , GR Production of specific molecules against ion Olivia Crociani Toscana 11, , , channel based diseases: new tools for K+ channels targeting in oncology. 137 GR Therapeutical approaches for diabetes due Carlo Colombo Ospedale 11,67 8,5 14, , , to the proteotoxic effect of misfolded insulin. Pediatrico Bambino Gesu 138 GR Insulin Growth Factor-I/Oestrogen Receptors Isabella Tognarini Toscana 11,67 18,5 7 9, , , interactions in osteoblastic/osteoclastic differentiation of human adult stem cells 139 GR Brain multi-parametric magnetic resonance Giovanni Rizzo Emilia-Romagna 11,67 14,5 12, , , study of patients with vegetative and minimally conscious state 140 GR Functional neuroimaging of the chemobrain: Roberto Caldara Istituto Nazionale 11,67 10,5 8 16, , , understanding cognitive impairments Tumori following chemotherapy Fondazione G. Pascale 141 GR CONGENITAL MUSCULAR DYSTROPHIES. ADELE D'AMICO Ospedale 11, ,5 12, , , FROM DIAGNOSTIC PROTOCOLS TO Pediatrico PATHOGENETIC MECHANISMS FOR Bambino Gesu THERAPEUTIC STRATEGIES. Pagina 14 di 98