Annual Meeting. Italian Association for the Study of the Pancreas (AISP) Savoia Hotel Regency

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1 XXXVI Annual Meeting October 4 th - 6 th 2012 Bologna Savoia Hotel Regency

2 With the patronage of patronages Istituto Superiore di Sanità Ordine Provinciale Medici Chirurghi SIC SIGE

3 October 4 th - 6 th 2012 Honorary President of the Congress F. Minni President of the Congress R. Pezzilli AISP Governing Board President: R. Pezzilli Secretary: G. Balzano Councilors: g. Butturini M. Cantore N. Funel M. Mutignani C. Pasquali AISP Scientific Commettee G. Balzano G. Butturini M. Cantore N. Funel M. Mutignani C. Pasquali PERSONALITY

4 organization Organizing Committee L. Calculli G. Cariani R. Casadei M. D Ambra M. C. Di Marco G. F. Di Nino G. Ercolani R. Golfieri A. M. Morselli Labate A. D. Pinna A. Pigna C. Ricci D. Santini C. Serra Secretariat GAYA Events & Communication Srl Piazza Bonomelli 4, Milano - Italia tel fax mail: web:

5 Bologna Savoia Hotel Regency October 4 th - 6 th 2012 Faculty Andriulli Angelo, S. G. Rotondo Arcidiacono P. Giorgio, Milano Astolfi Annalisa, Bologna Balzano Gianpaolo, Milano Bartolomei Mirco, Cesena Basso Daniela, Padova Benini Luigi, Verona Biasco Guido, Bologna Billi Paola, Bologna Butturini Giovanni, Verona Calculli Lucia, Bologna Cantore Maurizio, Massa Carrara Capurso Gabriele, Roma Carroccio Antonio, Palermo Cascinu Stefano, Ancona Corinaldesi Roberto, Bologna Costa Pier Lorenzo, Forlì Del Chiaro Marco, Stoccolma Delle Fave Gianfranco, Roma Di Carlo Valerio, Milano Di Sebastiano Pierluigi, S. G. Rotondo Falconi Massimo, Verona Frulloni Luca, Verona Funel Niccola, Pisa Gabbrielli Armando, Verona Giovannetti Elisa, Amsterdam Hammel Pascal, Clichy Jovine Elio, Bologna Larghi Alberto, Roma Malesci Alberto, Milano Miccoli Roberto, Pisa Minni Francesco, Bologna Mutignani Massimiliano, Milano Pasquali Claudio, Padova Pederzoli Paolo, Verona Pezzilli Raffaele, Bologna Pietrabissa Andrea, Pavia Rabitti Pier Giorgio, Napoli Reni Michele, Milano Ricci Claudio, Bologna Salvia Roberto, Verona Scarpa Aldo, Verona Testoni Pier Alberto, Milano Uomo Generoso, Napoli Vantini Italo, Verona Ventrucci Maurizio, Bologna Werner Jens, Heidelberg Zerbi Alessandro, Milano FACULTY

6 Dear Colleagues, after six years our National Meeting is coming back to Bologna, the hometown of our association. In the last few years AISP has been growning, true to its mission to promote and encourage the development of science and health in the Pancreatology field. Although the present economic difficulties, we are trying to keep a high scientific standard of our National Meeting, thanks to the companies who believe in our initiatives and which are giving enthusiastically their support. The meeting will be held at Savoia Hotel Regency, easily accessible and within walking distance from the center of this charming and historical town. There will be three days of intensive work and I hope you will find the program challenging. Hot topics will include BD-IPMN management, exocrine and endocrine pancreatic insufficiency treatment after pancreatic resections, new techniques for endoscopic diagnosis and pancreatic tumors palliation and much more. I am expecting lively discussions and I hope to revitalize relationships that are precursor for future collaborations. A warm welcome to all of you in Bologna! Raffaele Pezzilli

7 Bologna Savoia Hotel Regency October 4 th - 6 th 2012 Chairmen: P. Di Sebastiano, V. Di Carlo Thursday 4 th October VIDEO SURGERY: LAPAROSCOPIC SPLEEN- PRESERVING DISTAL PANCREATECTOMY (F. Minni) Clinical and radiological presentation (C. Ricci, L. Calculli) laparoscopy is the standard for distal pancreatectomy (A. Pietrabissa) Beyond the marketing: the actual role of laparoscopy in distal pancreatectomy (A. Zerbi) Consequences of splenectomy during distal pancreatectomy: guidelines to treat splenectomised patients (G. Uomo) AISP survey on distal pancreatectomy in Italy (G. Balzano) ORAL COMMUNICATIONS Laparoscopic Versus Open Left Pancreatectomy: Short Term Outcome and Cost-Benefit Analysis. Maria Rachele Angiolini, Gianpaolo Balzano, Nicolò Pecorelli, Riccardo Ariotti, Renato Castoldi, Paolo Baccari, Marco Braga - Unit of Pancreatic Surgery, Department of General and Specialist Surgery, IRCCS San Raffaele Hospital. Milan, Italy Distal Pancreatectomy With or Without Splenectomy: Indications, Pitfalls and Long Term Outcomes. Results of a Single Center Consecutive Series of 95 Laparoscopic Distal Pancreatectomies. PROGRAMM

8 Thursday 4 th October PROGRAMM Friday 5 th October Isacco Damoli, Giovanni Butturini, Despoina Daskalaki, Giovanni Marchegiani, Giuseppe Malleo, Alessandro Esposito, Roberto Salvia, Claudio Bassi - Surgical Unit B, Pancreas Institute, Surgical and Oncological Department, Verona University Hospital. Verona, Italy. Chairmen: R. Pezzilli, P. Pederzoli AISP TRIALS: STATE OF THE ART Neoadjuvant trial (M. Reni) IPMN trial (G. Capurso) Familial pancreatic carcinoma and Italian Registry (M. Del Chiaro) New markers for early diagnosis of pancreatic cancer (A. Scarpa) OPENING CEREMONY WELCOME BUFFET Chairmen: P. Billi, A. Andriulli ORAL COMMUNICATIONS The Inflammatory Calcium Binding Protein S100A8 and Its N-Terminal Proteolytic Fragment Interact with Transforming Growth Factor-Beta1 (TGF-b1) and Alter Akt, mtor and NF-kappa B Cancer Cell Signalling.

9 Bologna Savoia Hotel Regency October 4 th - 6 th 2012 Friday 5 th October Dania Bozzato 1, Stefania Moz 1, Andrea Padoan 1, Michele Scorzeto 2, Paola Fogar 1, Cosimo Sperti 3, Eliana Greco 1, Carlo Federico Zambon 1, Filippo Navaglia 1, Michele Pelloso 1, Elisa Rossi 1, Claudio Pasquali 3, Sergio Pedrazzoli 3, Carlo Reggiani 2, Mario Plebani 1, Daniela Basso 1 - Departments of 1 Medicine, 2 Biomedical Sciences and 3 Surgical, Oncological and Gastroenterological Sciences, University of Padua. Padua, Italy Pancreatic Cancer (PaCa)-Derived Soluble Mediators Induce Dendritic Cells (DC) to Acquire an Immunosuppressive Phenotype by Downregulating CTLA4. Elisa Gnatta 1, Paola Fogar 1, Ada Aita 1, Chiara Frasson 2, Sara Teolato 1, Monica Facco 1, Dania Bozzato 1, Eliana Greco 1, Andrea Padoan 1, Filippo Navaglia 1, Stefania Moz 1, Carlo Federico Zambon 1, Giampietro Semenzato 1, Giuseppe Basso 2, Mario Plebani 1, Daniela Basso 1-1 Department of Medicine and 2 Laboratory of Pediatric Oncohematology, Department of Woman and Child Health; University of Padua. Padua, Italy Variant AB0 Blood Group Alleles and Risk of Pancreatic Cancer: Results from the PANDoRA Consortium. Cosmeri Rizzato 1, Daniele Campa 1, Jens Werner 2, Gabriele Capurso 3, William Greenhalf 4, Renata Talar-Wojnarowska 5, Krzysztof Jamroziak 5, Raffaele Pezzilli 6, Dario Fabbri 6, Roberto Valente 3, Eithne Costello 4, Kay-Tee Khaw 7, Tim Key 8, Stefano Landi 9, John P Neoptolemos 4, Peter Bugert 10, Pavel Vodicka 11, Pavel Soucek 12, Markus W. Büchler 2, Nathalia Giese 2, Federico Canzian 1 PROGRAMM

10 Friday 5 th October PROGRAMM 1 German Cancer Research Center (DKFZ). Heidelberg, Germany. 2 University of Heidelberg. Heidelberg, Germany. 3 Sapienza University of Rome. Rome, Italy. 4 National Institute for Health Research. Liverpool, United Kingdom. 5 Medical University. Lodz, Poland. 6 Sant Orsola-Malpighi Hospital. Bologna, Italy. 7 University of Cambridge. Cambridge, United Kingdom. 8 University of Oxford. Oxford, United Kingdom. 9 University of Pisa. Pisa, Italy. 10 German Red Cross Blood Service of Baden-Württemberg-Hessen. Mannheim, Germany. 11 Academy of Science of the Czech Republic. Prague, Czech Republic. 12 National Institute of Public Health. Prague, Czech Republic Inference and Modelling of the Gemcitabine Pharmacokinetics and Resistance. Paola Lecca 1, Corrado Priami 1,2 1 The Microsoft Research-University of Trento Centre for Computational and Systems Biology. Rovereto, TN, Italy. 2 University of Trento. Trento, Italy Gα15 Potential as a Biomarker for Pancreatic Carcinoma. Giulio Innamorati 1,2, Maria Teresa Valenti 3, Luca Delle Carbonare 3, Filippo Perbellini 3, Francesco Giovinazzo 1,2, Sara Zanini 1,2, Giorgio Malpeli 4, Stefano Barbi 4, Claudio Bassi 1,2-1 Laboratory of Translational Surgery, LURM and Departments of 2 Surgery, 3 Medicine, and 4 Pathology and Diagnostic, University of Verona. Verona, Italy Gemcitabine-Ukrain Combination Affects MMP9 Expression in Primary Pancreatic Adenocarcinoma Cell Cultures (PPCCs) Lucia Botta 1, Maria Denaro 1, Alessandra Alvino 1, Elisa Giovannetti 3, Luca E Pollina 1, Vittorio Perrone 2, Nelide De Lio 2, Ugo Boggi 2, Daniela Campani 1, Niccola Funel 1

11 Bologna Savoia Hotel Regency October 4 th - 6 th 2012 Friday 5 th October 1 Division of Surgical Pathology, Department of Surgery and 2 Division of General and Transplant Surgery, Department of Oncology, University of Pisa. Pisa, Italy. 3 VU University of Amsterdam. Amsterdam, The Netherlands. Chairmen: G. Delle Fave, S. Cascinu, R. Corinaldesi SIGE-AIOM-AISP SYMPOSIUM. NEW TREATMENT IN NEUROENDOCRINE PANCREATIC NEOPLASMS MTor inhibitor (Everolimus) and multitargeted tyrosine kinase inhibitor (Sunitinib) (P. Hammel) Radio-metabolic therapy (M. Bartolomei) Surgical treatment of locally advanced or metastatic neoplasms/tumors (M. Falconi) Discussion Coffee break Chairmen: G. Butturini, A. Gabbrielli ORAL COMMUNICATIONS The New Fully Automated System For Ki67 Evaluation in Pancreatic Neuroendocrine Tumors (PNETs). Would It Be Possible to Obtain a Standard to Grade Evaluation? Niccola Funel 1, Maria Denaro 1, Pinuccia Faviana 1, Luca E Pollina 1, Nelide De Lio 2, Vittorio Perrone 2, Ugo Boggi 2, Fulvio Basolo 1, Daniela Campani 1-1 Division of Surgical Pathology, Department of Surgery, and 2 Division of General and Transplant Surgery, Department of Oncology; University of Pisa. Pisa, Italy. PROGRAMM

12 Friday 5 th October PROGRAMM WHO 2010 and WHO 2000 Classification: From a Sensitive Analysis to Reality. Claudio Ricci 1, Francesco Monari 1, Salvatore Buscemi 1, Marielda D Ambra 1, Davide Campana 2, Riccardo Panzacchi 3, Claudio Ceccarelli 3, Marcello Labombarda 1, Giovanni Taffurelli 1, Raffaele Pezzilli 2, Donatella Santini 3, Paola Tomassetti 2, Riccardo Casadei 1, Francesco Minni 1 - Departments of 1 Surgery, 2 Internal Medicine and Gastroenterology and 3 Pathology, S.Orsola-Malpighi Hospital. Bologna, Italy EUS-Guided FNA for Proliferative Rate in Pancreatic Neuroendocrine Tumors: A Single Center Experience Over a 11-Year Period Maria C. Petrone, Sabrina Testoni, Silvia Carrara, Gianpaolo Balzano, Marco Manzoni, Claudio Doglioni, Pier Alberto Testoni, Paolo G Arcidiacono - San Raffaele Scientific Institute, Vita-Salute San Raffaele University. Milan, Italy Are the New IPMN s Guideline Effective to Predict the Presence of Invasive IPM Carcinoma? A Single Center Experience. Giovanni Taffurelli 1, Marielda D Ambra 1, Carlo Alberto Pacilio 1, Salvatore Buscemi 1, Eugenia Peri 1, Francesco Monari 1, Claudio Ricci 1, Raffaele Pezzilli 2, Lucia Calculli 3, Donatella Santini 4, Riccardo Casadei 1, Francesco Minni 1 - Departments of 1 Surgery, 2 Internal Medicine and Gastroenterology, 3 Radiology, and 4 Pathology, S.Orsola-Malpighi Hospital. Bologna, Italy Three Dimensional Contrast Enhanced Ultrasonography vs. Magnetic Resonance Imaging in The Diagnosis of IPMN of the Pancreas.

13 Bologna Savoia Hotel Regency October 4 th - 6 th 2012 Friday 5 th October Carla Serra 1, Lucia Calculli 2, Andrea Imbrogno 1, Davide Fabbri 1, Fabio Ferroni 2, Alexandro Paccapelo 1, Riccardo Casadei 3, Raffaele Pezzilli 1-1 Pancreas Unit, Department of Digestive Diseases and Internal Medicine, 2 Department of Radiology and 3 Department of Surgery; Sant Orsola-Malpighi Hospital, University of Bologna. Bologna, Italy Lung Progression After Resection for Invasive Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas. Sara Caponi, Enrico Vasile, Maurizio Lucchesi, Chiara Caparello, Laura Ginocchi, Alfredo Falcone - Oncological Pole, Azienda Ospedaliero-Universitaria Pisana, Tuscan Institute of Tumors. Pisa, Italy. Chairmen: N. Funel, D. Basso SYMPOSIUM. MOLECULAR TECHNOLOGIES AND THE GENOME OF PANCREATIC DUCTAL CARCINOMA: THE PRESENT MEETS THE FUTURE New technologies for genomic analysis (A. Astolfi) the relevance of immunoistochemestry in molecular pathology. New strategies in immunoreactivity evaluations (N. Funel) CGH, mirna and copy number (E. Giovannetti) LUNCH AND POSTER ROUND (Chairmen: M. Mutignani, N. Funel, M. Cantore, G. Butturini) Chairmen: C. Pasquali, G. Biasco ORAL COMMUNICATIONS PROGRAMM

14 Friday 5 th October PROGRAMM Modified FOLFOXIRI in Advanced Pancreatic Cancer. Laura Ginocchi, Enrico Vasile, Sara Caponi, Maurizio Lucchesi, Chiara Caparello, Monica Lencioni, Sergio Ricci, Alfredo Falcone - Oncological Pole, Azienda Ospedaliero-Universitaria Pisana, Tuscan Institute of Tumors. Pisa, Italy Metastatic Site in Pancreatic Adenocarcinoma Correlates with Prognosis. Stefano Cereda 1, Carmen Belli 1, Alessia Rognone 1, Paolo Passoni 2, Najla Slim 2, Michele Carvello 3, Riccardo Ariotti 3, Gianpaolo Balzano 3, Michele Reni 1 - Departments of 1 Medical Oncology, 2 Radiotherapy and 3 Surgery, San Raffaele Scientific Institute. Milan, Italy The Value of 18FDG-PET/CT in Patients with Resectable Pancreatic Cancer: A Prospective Study. Stefano Crippa, Matteo Salgarello, Silvia Laiti, Stefano Partelli, Giuliano Barugola, Paola Castelli, Giuseppe Zamboni, Massimo Falconi - Departments of Surgery, Nuclear Medicine and Pathology, Sacro Cuore Don Calabria Hospital. Negrar, VR, Italy Frequency and Characterization of Benign Lesions in Pancreatic Specimens of Patients Operated for the Suspicion of Pancreatic Cancer Francesco Vitali 1, Torsten Hansen 2, Ralf Kiesslich 3, Stefan Heinrich 4, P. Mildenberger 5, Anisha Kumar 5, Italo Vantini 1, Luca Frulloni 1-1 Department of Medicine, University of Verona. Verona, Italy. 2 Institute of Pathology, and Departments of 3 Internal Medicine, 4 Surgery and 5 Radiology, University of Mainz. Mainz, Germany.

15 Bologna Savoia Hotel Regency October 4 th - 6 th 2012 Friday 5 th October Comparing RECIST and Choi s Criteria to Evaluate Radiological Response to Chemotherapy in Patients with Advanced Pancreatic Cancer. Silvia Vecchiarelli 1, Marina Macchini 1, Claudio Ricci 2, Marielda D Ambra 2, Riccardo Casadei 2, Lucia Calculli 3, Fabio Ferroni 3, Raffaele Pezzilli 4, Elisa Grassi 1, Francesco Minni 2, Guido Biasco 1, Mariacristina di Marco 1 - Department of 1 Oncology, 2 Surgery, 3 Radiology, and 4 Internal Medicine, Sant Orsola-Malpighi Hospital. Bologna, Italy Neoadjuvant Chemo-Radiotherapy for Patients with Borderline Resectable Pancreatic Cancer: A Meta-Analytical Evaluation of Prospective Studies. Virginia Festa 1, Angelo Andriulli 2, Maria Rosaria Valvano 2, Generoso Uomo 3,Francesco Perri 2, Salvatore Corrao 4, Maurizio Koch 1-1 Division of Gastroenterology, S.Filippo Neri Hospital. Rome, Italy. 2 Division of Gastroenterology, Casa Sollievo della Sofferenza Hospital, IRCCS. San Giovanni Rotondo, FG, Italy. 3 Department of Internal Medicine, Cardarelli Hospital. Naples, Italy. 4 Biomedical Department of Internal Medicine and Subspecialties, University of Palermo. Palermo, Italy. Chairmen: I. Vantini, M. Del Chiaro FACE TO FACE ON BRANCH-DUCT IPMN Better to observe (R. Salvia) PROGRAMM

16 Friday 5 th October Better to operate ( J. Werner) Discussion Coffee break PROGRAMM Chairmen: P. G. Arcidiacono, G. Capurso lecture: Tissue is the issue: new devices in endoscopic ultrasound (A. Larghi) Chairmen: A. Carroccio, A. Malesci BEST ORAL COMMUNICATIONS Results of an International Multidisciplinary Consultation on a New Criteria to Assess Acute Pancreatitis Severity: the Determinant-Based Classification. Generoso Uomo 1, Marco J Bruno 2, E. Patchen Dellinger 3, Christopher E. Forsmark 4, Peter Layer 5, Philippe Lévy 6, Enrique Maraví Poma 7, Maxim S. Petrov 8, Tooru Shimosegawa 9, Ajith Siriwardena 10, David C. Whitcomb 11, John A. Windsor 8-1 Naples, Italy. 2 Rotterdam, the Netherlands. 3 Seattle, WA, USA. 4 Gainesville, FL, USA. 5 Hamburg, Germany. 6 Clichy, France. 7 Pamplona, Spain. 8 Auckland, New Zealand. 9 Sendai, Japan. 10 Manchester, United Kingdom. 11 Pittsburgh, PA, USA Clinical and Translational Results of a Phase II Randomized Trial of Maintenance Sunitinib or Observation in Metastatic Pancreatic Adenocarcinoma.

17 Bologna Savoia Hotel Regency October 4 th - 6 th 2012 Friday 5 th October Carmen Belli 1, Stefano Cereda 1, Anna Novarino 2, Michele Milella 3, Alessandro Passardi 4, Giuseppe Di Lucca 5, Andrea Mambrini 6, Laura Ferrari 7, Marco Danova 8, Francesca Bergamo 9, Enrico Franceschi 10, Elisa Giovannetti 11, Bianca Rovati 8, Valentina Gallà 11, Gianpaolo Balzano 1, Riccardo Ariotti 1, Eugenio Villa 1, Michele Reni 1-1 S.Raffaele Hospital. Milan, Italy. 2 Molinette Hospital. Turin, Italy. 3 Regina Elena National Cancer Institute. Rome, Italy. 4 Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori. Meldola, FC, Italy. 5 Saronno Hospital. Saronno, VA, Italy. 6 Carrara Civic Hospital. Carrara, Italy. 7 University Hospital. Udine, Italy. 8 IRCCS Foundation San Matteo. Pavia, Italy. 9 Istituto Oncologico Veneto - IRCCS. Padua, Italy. 10 Bellaria Hospital. Bologna, Italy. 11 VU University Medical Center. Amsterdam, The Netherlands A New Method to Detect Pancreatic Ductal Adenocarcinoma by Analysis of Volatile Organic Compounds (VOCs) in Alveolar Air. Andrea Princivalle 1, Giovanni Butturini 2, Lorenzo Monasta 3, Fabio Zarantonello 2, Francesca Panzeri 2, Claudio Bassi 2, Luigi Perbellini 1-1 Department of Public Health and 2 Pancreas Institute, University of Verona. Verona, Italy. 3 Department of Statistics, IRCSS Burlo. Trieste, Italy AISP GENERAL ASSEMBLY Social Dinner PROGRAMM

18 Saturday 6 th October PROGRAMM Chairmen: P. G. Rabitti, P. L. Costa ORAL COMMUNICATIONS Evaluation of a Predictive Model for Pancreatic Fistula Based on Amylase Value in Drains: A Prospective Study on 231 Consecutive Patients. Domenico Tamburrino, Stefano Partelli, Stefano Crippa, Giuliano Barugola, Enrico Facci, Claudio Zardini, Massimo Falconi - Department of Surgery, Ospedale Sacro Cuore, Negrar, Verona Autologous Islet Transplantation to Improve Glycemic Control Following Extended Pancreatectomy: Indications and Outcome. Michele M. Carvello 1, Riccardo Ariotti 1, Rita Nano 2, Paola Maffi 2, Marco Braga 1, Carlo Staudacher 1, Cristina Gilardini 1, Lorenzo Piemonti 2, Gianpaolo Balzano 1-1 Pancreas Unit, Department of Surgery and 2 Islet Processing Facility, S. Raffaele Hospital. Milan, Italy One-Hundred and Six Robot-Assisted Pancreatectomies. Mario A Belluomini, Nelide De Lio, Stefano Signori, Vittorio G Perrone, Fabio Vistoli, Emanuele F Kauffmann, Niccolò Napoli, Ugo Boggi - Division of General and Transplant Surgery, University of Pisa. Pisa, Italy i s Enucleation Safe When the Distance Between the Tumor and the Main Pancreatic Duct Is Less Than 3 mm? Results from a Multi-Institutional Retrospective Study.

19 Bologna Savoia Hotel Regency October 4 th - 6 th 2012 Saturday 6 th October Stefano Partelli 1, Volker Fendrich 2, Stefano Crippa 1, Caroline L. Lopez l, Letizia Boninsegna 1, Kristin Dietzel 2, Detlef K Bartsch 1, Massimo Falconi 1-1 Department of Surgery, Sacro Cuore Hospital. Negrar, VR, Italy. 2 Department of Surgery, University of Marburg. Marburg, Germany Morphological Features of Pancreatic Stump, Other than Wirsung Diameter and Pancreatic Texture, Influence Pancreatic Fistula Rate After Pancreaticoduodenectomy. Cristina Ridolfi, Francesca Gavazzi, M Rachele Angiolini, Marco Madonini, Barbara Fiore, Marco Montorsi, Alessandro Zerbi - Pancreatic Surgery Division, IRCCS Humanitas Clinical Institute. Rozzano, MI, Italy Have BMI an Impact in Short- and Long-Term Outcome After Pancreaticoduodenectomies? Marco Del Chiaro, Elena Rangelova, Christoph Ansorge, John Blomberg, Ralf Segersvärd - Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet at Karolinska University Hospital. Stockholm, Sweden. Chairmen: M. Ventrucci, E. Jovine SYMPOSIUM. PANCREATIC EXOCRINE AND ENDOCRINE INSUFFICIENCY AS A CONSEQUENCE OF CANCER AND SURGERY the exocrine pancreatic insufficiency in patients with cancer (M. Cantore) PROGRAMM

20 Saturday 6 th October the exocrine pancreatic insufficiency after pancreatic and gastric resection (L. Benini) glycemic control in patients with total pancreatectomy (R. Miccoli) Discussion PROGRAMM Coffee break Chairmen: M. Mutignani, L. Frulloni FACE TO FACE ON PALLATION OF DUODENAL STENOSIS IN ADVANCED CANCER The surgeon s point of view (C. Pasquali) The endoscopist s point of view (A. Testoni) Discussion Chairmen: G. Uomo, A. Zerbi ORAL COMMUNICATIONS Is Troponin T a Useful Marker of Myocardial Damage in Acute Pancreatitis? Alessandra Barassi 1, Maria Teresa Iammarino 2, Riccardo Casadei 3, Gian Vico Melzi d Eril 1, Raffaele Pezzilli 2-1 Clinical Biochemistry Laboratory, Department of Medicine, Surgery and Dentistry, San Paolo Hospital, University of Milan. Milan, Italy. 2 Pancreas Unit, Department of Digestive Disease and Internal Medicine and 3 Department of Surgery, Sant Orsola-Malpighi Hospital, Alma Mater Studiorum - University of Bologna. Bologna, Italy.

21 Bologna Savoia Hotel Regency October 4 th - 6 th 2012 Saturday 6 th October Azathioprine in Autoimmune Pancreatitis: An Italian Experience. Antonio Amodio, Luca Frulloni, Giulia De Marchi, Francesco Vitali, Tiziana Tumelero, Armando Gabbrielli, Luigi Benini, Italo Vantini Department of Medicine, University of Verona. Verona, Italy Mild Biliary Pancreatitis: Diagnostic- Therapeutic Dilemma Continues. Francesco Lapolla, Immacolata Forlano, Alberto Fersini, Nicola Tartaglia, Antonio Ambrosi, Vincenzo Neri - General Surgery, Department of Medical and Surgical Sciences, University of Foggia. Foggia, Italy. Chairmen: R. Pezzilli, G. Balzano CONCLUSIONS AND ECM TEST, WINNERS OF THE GRANTS. PROGRAMM

22 POSTER 01- PTEN AND MIR-21 EXPRESSION IN IPMN AND PDAC Alessandra Alvino 1, Lucia Botta 1, Maria Denaro 1, Luca E Pollina 1, Vittorio Perrone 2, Nelide De Lio 2, Ugo Boggi 2, Daniela Campani 1, Niccola Funel 1, Elisa Giovannetti 3. 1 Division of Surgical Pathology, Department of Surgery, and 2 Division of General and Transplant Surgery, Department of Oncology; University of Pisa. Pisa, Italy. 3 VU University. Amsterdam, The Netherlands. poster 02- REACTIVE C PROTEIN AND WHITE BLOOD CELLS LEVELS AS EARLY PREDICTORS OF POSTOPERATIVE INFLAMMATORY COMPLICATIONS AFTER PANCREATIC SURGERY. Maria Rachele Angiolini, Francesca Gavazzi, Cristina Ridolfi, Barbara Fiore, Marco Madonini, Marco Montorsi, Alessandro Zerbi. Pancreatic Surgery Division, IRCCS Humanitas Clinical Institute. Rozzano, Milan, Italy. 03- A CASE OF UNEXPLAINED ASYMPTOMATIC PANCREA- TIC HYPERENZYMEMIA SOLVED BY ENDOSCOPIC UL- TRASOUND: ADULT ANNULAR PANCREAS. Filippo Antonini, Simona Piergallini, Valerio Belfiori, Barbara Marraccini, Massimiliano Lo Cascio, Carlo Manfredi, Giampiero Macarri. Department of Gastroenterology, A. Murri Hospital, Polytechnic University of Marche. Fermo, Italy. 04- A COMPARISON OF SURGICAL OUTCOME OF MAJOR PANCREATIC RESECTIONS: LEFT PANCREATECTOMY VERSUS PANCREATICODUODENECTOMY. Riccardo Ariotti, Nicolò Pecorelli, Giovanni Capretti, Michele Carvello, Cristina Gilardini, Renato F. Castoldi, Marco Braga, Carlo Staudacher, Gianpaolo Balzano. Pancreas Unit, Department of Surgery, IRCCS San Raffaele Hospital. Milan, Italy.

23 Bologna Savoia Hotel Regency October 4 th - 6 th HEPATOCYTE GROWTH FACTOR AND E-CADHERIN IN ACUTE PANCREATITIS. TIME COURSE AND EARLY ASSESSMENT OF DISEASE SEVERITY Alessandra Barassi 1, Massimiliano M. Corsi 2, Maria Teresa Iammarino 3, Giada Dogliotti 2, Riccardo Casadei 4, Gian Vico Melzi d Eril 1, Raffaele Pezzilli 3. 1 Clinical Biochemistry Laboratory, Department of Medicine, Surgery and Dentistry, San Paolo Hospital and 2 Department of Human Morphology and Biomedical Sciences Città Studi ; University of Milan. Milan, Italy. 3 Pancreas Unit, Department of Digestive Diseases and Internal Medicine and 4 Department of Surgery, Sant Orsola-Malpighi Hospital, University of Bologna. Bologna, Italy. 06- total ROBOTIC PANCREATICODUODENECTOMY Mario A Belluomini, Nelide De Lio, Stefano Signori, Vittorio G Perrone, Fabio Vistoli, Emanuele F Kauffmann, Niccolò Napoli, Ugo Boggi. Division of General and Transplant Surgery, University of Pisa. Pisa, Italy. 07- PANCREATIC METASTASIS FROM COLORECTAL CANCER Mario A. Belluomini, Niccolò Napoli, Emanuele F Kauffmann, Andrea Gennai, Francesca Costa, Nelide De Lio, Ugo Boggi. Division of General and Transplant Surgery, University of Pisa. Pisa, Italy. 08- CYTOLOGY AND CEA FROM CYSTIC FLUID HAVE MARGINAL UTILITY IN THE MANAGEMENT OF PANCREATIC CYSTIC NEOPLASMS. Valentina Beltrame 1, Enrico Dalla Bona 1, Lucia Moletta 1, Paolo Bocus 2, Claudio Pasquali 1, Cosimo Sperti 1. 1 Department of Surgery, Oncology, and Gastroenterology, Fourth Surgical Clinic, University of Padua; 2 Institute of Oncology of Veneto (IOV). Padua, Italy. poster

24 09- laparoscopic SURGERY FOR ENDOCRINE PANCREATIC TUMORS: EXPERIENCE OF A REFERRAL CENTER Marco Boniardi, Paola V. Sartori, Sara Andreani, Juliana Pauna, Giovanni C Ferrari, Massimiliano Mutignani, Raffaele Pugliese Department of Surgery and Department of Digestive Endoscopy, Niguarda Cà Granda Hospital. Milan, Italy. 10- the INFLAMMATORY MOLECULES S100A8 AND TGF-B1 ACTIVATE THE EPITHELIAL-MESENCHYMAL TRANSITION PROCESS IN PANCREATIC CANCER CELLS. Dania Bozzato, Francesca Simonato, Stefania Moz, Matteo Fassan, Paola Fogar, Andrea Padoan, Ambrogio Fassina, Sergio Pedrazzoli, Mario Plebani, Daniela Basso. Department of Medicine, University of Padua. Padua, Italy. poster 11- groove PANCREATITIS ASSOCIATED WITH PANCREATIC ADENOCARCINOMA AND AUTOIMMUNE PANCREATITIS. Salvatore Buscemi 1, Marielda D Ambra 1, Carlo Alberto Pacilio 1, Riccardo Panzacchi 3, Giovanni Taffurelli 1, Eugenia Peri 1, Claudio Ricci 1, Donatella Santini 3, Raffaele Pezzilli 2, Riccardo Casadei 1, Francesco Minni 1. Departments of 1 Surgery, 2 Digestive Diseases and Internal Medicine and 3 Pathology, S. Orsola-Malpighi Hospital. Bologna, Italy. 12- RESECTION MARGIN INVOLVEMENT IN PANCREATICODUODENECTOMY. A SINGLE CENTRE EXPERIENCE. Salvatore Buscemi 1, Giovanni Taffurelli 1, Marielda D Ambra 1, Francesco Monari 1, Marina Macchini 3, Claudio Ricci 1, Maria Cristina Di Marco 3, Donatella Santini 4, Raffaele Pezzilli 2, Riccardo Casadei 1, Francesco Minni 1.

25 Bologna Savoia Hotel Regency October 4 th - 6 th 2012 Departments of 1 Surgery, 2 Digestive Diseases and Internal Medicine, 3 Oncology, and 4 Pathology, S.Orsola-Malpighi Hospital. Bologna, Italy. 13- OBOTIC DISTAL PANCREATECTOMY: IS HYBRID OPERATION A VIABLE APPROACH? Giovanni Butturini, Isacco Damoli, Alessandro Esposito, Despoina Daskalaki, Giovanni Marchegiani, Roberto Salvia, Claudio Bassi. Pancreas Institute, Surgical and Oncological Department, Verona University Hospital. Verona, Italy. 14- gene-wide ASSOCIATION STUDY ON THE TERT LOCUS AND PDAC SUSCEPTIBILITY. RESULTS FROM THE PANDORA CONSORTIUM. Daniele Campa 1, Cosmeri Rizzato 1, Jens Werner 2, Gabriele Capurso 3, William Greenhalf 4, Renata Talar-Wojnarowska 5, Krzysztof Jamroziak 5, Raffaele Pezzilli 6, Andrea Imbrogno 6, Roberto Valente 3, Eithne Costello 4, Kay-Tee Khaw 7, Tim Key 8, Stefano Landi 9, John P Neoptolemos 4, Peter Bugert 10, Pavel Vodicka 11, Pavel Soucek 12, Markus W Büchler 2, Nathalia Giese 2, Federico Canzian 1. 1 German Cancer Research Center (DKFZ). Heidelberg, Germany. 2 University of Heidelberg. Heidelberg, Germany. 3 Sapienza University. Rome, Italy. 4 National Institute for Health Research. Liverpool, United Kingdom. 5 Medical University. Lodz, Poland. 6 Sant Orsola-Malpighi Hospital. Bologna, Italy. 7 University of Cambridge. Cambridge, United Kingdom. 8 University of Oxford. Oxford, United Kingdom. 9 University of Pisa. Pisa, Italy. 10 German Red Cross Blood Service. Mannheim, Germany. 11 Academy of Science of the Czech Republic. Prague, Czech Republic. 12 National Institute of Public Health. Prague, Czech Republic. poster

26 15- FECAL ELASTASE-1 IS USEFUL IN THE DETECTION OF STEATORRHEA IN PATIENTS WITH PANCREATIC DISEASES BUT NOT AFTER PANCREATIC RESECTION. Pietro Campagnola, Chiara Cristofori, Antonio Amodio, Flora Agugiaro, Rocco Micciolo, Alessandra Magro, Armando Gabbrielli,Luisa Moser, Arianna Massella, Luca Frulloni, Italo Vantini and Luigi Benini. Gastroenterology Unit and Pancreas Center, Department of Medicine, University of Verona. Verona, Italy. poster 16- DERMOID CYST OF THE PANCREAS. Daniela Campani 1, Grazia Gallippi 1, Monnalisa Granai 1, Nelide De Lio 2, Ugo Boggi 2. Units of 1 Pathology and 2 General and Transplant Surgery, University of Pisa. Pisa, Italy. 17- FIXED-DOSE RATE GEMCITABINE PLUS CAPECITABINE AS SECOND-LINE TREATMENT FOR METASTATIC PANCREATIC CANCER PATIENTS PRETREATED WITH OXALIPLATIN. Chiara Caparello, Enrico Vasile, Maurizio Lucchesi, Laura Ginocchi, Sara Caponi, Monica Lencioni, Sergio Ricci, Alfredo Falcone. Oncological Pole, Azienda Ospedaliero-Universitaria Pisana, Tuscan Institute of Tumors. Pisa, Italy. 18- CONTRIBUTION OF HLA-DBR1*03 AND DRB1*04 IN GENETIC SUSCEPTIBILY OF AUTOIMMUNE PANCREATITIS: PRELIMINARY DATA. Giulia M. Cavestro 1, Davide Martorana 2, Elisabetta Goni 1, Luca Frulloni 3, Antonio Amodio 3, Italo Vantini 3, Pier A Testoni 1.

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