Table 1 Comparison of the prices of the 10 best-selling prescription drugs in America with prices in Canada, Great Britain, Australia and Mexico.
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1 Table 1 Comparison of the prices of the 10 best-selling prescription drugs in America with prices in Canada, Great Britain, Australia and Mexico. Drug Condition U.S.A Canada Great Britain Australia Mexico Prilosec Heartburn/Ulcer $3.31 $1.47 $1.67 $1.29 $0.99 Prozac Depression $2.27 $1.07 $1.08 $0.82 $0.79 Lipitor High cholesterol $2.54 $1.34 $1.67 $1.32 $3.60 Prevacid Ulcer $3.13 $1.34 $0.82 $0.83 $1.18 Epogen Anemia $23.40 $21.44 $27.48 $29.24 N/A Zocor High cholesterol $3.16 $1.47 $1.73 $1.75 $3.66 Zoloft Depression $1.98 $1.07 $0.95 $0.84 $1.96 Zyprexa Mood Disorder $5.27 $3.39 $2.86 $2.63 N/A Claritin Allergies $1.96 $1.11 $0.41 $0.48 $0.92 Paxil Depression $2.22 $1.13 $1.70 $0.82 $1.83 Source: USA Today November 10, 1999 based on data from IMS Health: drugstore.com; Ontario Ministry of Health; November Monthly Index of Medical Specialties, Haymarket Medical Ltd., London; Australia Health Insurance Commission; Farmacia Rio Grande
2
3 Table 2 Ranitidine (Zantac) Source: Dr. K Balasubramaniam. "Retail Prices in the Asia-Pacific Region" HAI News, No. 86; December Published by Health Action International Country Dose Manufacturer Brand Name/Generic Price* Australia 150 mg/100 tab Glaxo Zantac $20 Bangladesh 150 mg/100 tab - generic $5 Bangladesh 150 mg/100 tab Glaxo Zantac $33 Belgium 150 mg/100 tab Glaxo Zantac $128 Canada 150 mg/100 tab - generic $31 Canada 150 mg/100 tab Glaxo Zantac $81 Colombia 150 mg/100 tab - generic $44 Colombia 150 mg/100 tab Glaxo Zantac $47 Finland 150 mg/100 tab Glaxo Zantac $156 Germany 150 mg/100 tab - generic $67 Germany 150 mg/100 tab Glaxo Zantac $149 Greece 150 mg/100 tab Glaxo 1 $71 Hong Kong 150 mg/100 tab Glaxo Zantac $119 India 150 mg/100 tab - generic $3 India 150 mg/100 tab Glaxo Zantac $3 Indonesia 150 mg/100 tab Glaxo Zantac $150 Italy 150 mg/100 tab Glaxo Zantac $77 Malaysia 150 mg/100 tab Glaxo Zantac $86 Mexico 150 mg/100 tab - generic $18 Mexico 150 mg/100 tab Glaxo Zantac $57 Nepal 150 mg/100 tab - generic $3 Nepal 150 mg/100 tab Glaxo Zantac $3 Netherlands 150 mg/100 tab Glaxo Zantac $131 New Zealand 150 mg/100 tab Glaxo Zantac $52 Pakistan 150 mg/100 tab - generic $14 Pakistan 150 mg/100 tab Glaxo Zantac $39 Philippines 150 mg/100 tab Glaxo 1 $95 Sri Lanka 150 mg/100 tab Glaxo Zantac $63 Switzerland 150 mg/100 tab Glaxo Zantac $284 Thailand 150 mg/100 tab - generic $20-40 Thailand 150 mg/100 tab Glaxo 1 $ UK 150 mg/100 tab Glaxo 1 $73 US 150 mg/100 tab Glaxo Zantac $169 Western Samoa 150 mg/100 tab - generic $28 Western Samoa 150 mg/100 tab Glaxo Zantac $71 Zimbabwe 150 mg/100 tab Glaxo 1 $87
4 Table 3 Amoxicillin (Amoxicillin, Amoxil, Trimox) Source: Dr. K Balasubramaniam. "Retail Prices in the Asia-Pacific Region" HAI News, No. 86; December Published by Health Action International Country Dose Manufacturer Brand Name/Generic Price* Australia 250 mg/100 tab - generic $37 Australia 250 mg/100 tab SmithKline Beecham Amoxil $40 Bangladesh 250 mg/100 tab - generic $6-9 Belgium 250 mg/100 tab Canada 250 mg/100 tab - generic $8 Canada 250 mg/100 tab SmithKline Beecham Amoxil $14 China 150 mg/100 tab ~ ~ ~ Colombia 250 mg/100 tab - generic $27 Colombia 250 mg/100 tab SmithKline Beecham Amoxil $37 Finland 250 mg/100 tab - generic $86 France 250 mg/100 tab - generic $39 France 250 mg/100 tab SmithKline Beecham Amoxil $37 Germany 250 mg/100 tab - generic $60 Greece 250 mg/100 tab Hong Kong 250 mg/100 tab India 250 mg/100 tab - generic $9 India 250 mg/100 tab SmithKline Beecham Amoxil $10 Indonesia 250 mg/100 tab - generic $10 Indonesia 250 mg/100 tab SmithKline Beecham Amoxil $40 Italy 250 mg/100 tab - genericl $16 Latvia 250 mg/100 tab ~ generic $8 Latvia 250 mg/100 tab SmithKline Beecham Amoxil $18 Malaysia 250 mg/100 tab - genericl $16 Malaysia 250 mg/100 tab SmithKline Beecham Amoxil $34 Mexico 250 mg/100 tab Nepal 250 mg/100 tab - generic $8 Nepal 250 mg/100 tab SmithKline Beecham Amoxil $10 Netherlands 250 mg/100 tab - generic $22 Netherlands 250 mg/100 tab SmithKline Beecham Amoxil $40 New Zealand 250 mg/100 tab - generic $22 New Zealand 250 mg/100 tab SmithKline Beecham Amoxil $22 Pakistan 250 mg/100 tab - generic $5 Pakistan 250 mg/100 tab SmithKline Beecham Amoxil $8 Phillipines 250 mg/100 tab - generic $22 Phillipines 250 mg/100 tab SmithKline Beecham Amoxil $29 Sri Lanka 250 mg/100 tab - generic $4 Sri Lanka 250 mg/100 tab SmithKline Beecham Amoxil $24 Switzerland 250 mg/100 tab - generic $104 Tanzania 150 mg/100 tab ~ ~ ~ Thailand 250 mg/100 tab - generic $5-24 Thailand 250 mg/100 tab SmithKline Beecham Amoxil $17-26 UK 250 mg/100 tab generic $7 UK 250 mg/100 tab SmithKline Beecham Amoxil $27 US 250 mg/100 tab - generic $20 US 250 mg/100 tab SmithKline Beecham Amoxil $36 US 250 mg/100 tab Apothecon Trimox $24
5 Western Samoa 250 mg/100 tab - generic $11 Western Samoa 250 mg/100 tab SmithKline Beecham Amoxil $30 Zimbabwe 250 mg/100 tab - generic $10 Zimbabwe 250 mg/100 tab SmithKline Beecham Amoxil $24
6 Table 5 Retail Pharmacy Price Markups on Generic Drugs Source: December 31, 1998, Elyse Tanouye, "Price Markups on Generics Can Top Brand-Name Drugs," Wall Street Journal. Generic drug/brand name Treatment Dosage No. of pills Generic manuf's Generic retail Brandname retail Acyclovir/Zovirax Antiviral drug 400 mg tablet 44 $7.22 $61.64 $98.12 Cimetidine/Tagamet Ulcer drug 400 mg tablet Captopril/Capoten High blood pressure 25 mg tablet Glipizide/Glucotrol Diabetes 10 mg tablet Diazepam/Valium Antianxiety drug 5 mg tablet Haloperidol/Haldol Antipsychotic 5 mg tablet Diltiazem/Cardizem Angina (chest pain) 60 mg tablet Alprazolam/Xanax Antianxiety drug 0.5 mg tablet Atenolol/Tenormin High blood pressure 50 mg tablet Note: prices and pill quantities are based on the average retail prescriptions from Scott-Levin Source of data: Mylan document; Scott-Levin; WSJ research
7 Table 6 Competitive prices for active ingredients for four HIV drugs Period AZT D4T 3TC Nevirapine ,000 10,000 10, ,000 5,000 7, ,500 5,000 7, ,000 2,000 5, ,500 2,000 2, , ,500 Table 7 Number of patients referenced in FDA NDA Industry Government only sponsored or Sponsored Co-sponsored Total Nucleoside Analogue Reverse Transcriptase Inhibitors (NARTI) ,259 Protease Inhibitors (PI) 1, ,109 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI) ,310 Mean, 14 drugs ,216
8
9 Table 8 Cost of Trials referenced in FDA NDA Fourteen HIV antiretroviral drugs (millions of US dollars) Out of Pocket Industry only Industry plus $3k $10k NARTI $ 1.2 $ 4.1 $ 3.8 $12.6 PI $ 3.2 $10.5 $ 3.3 $11.1 NNRTI $ 2.8 $ 9.3 $ 3.9 $13.1 Mean for 14 drugs $ 2.3 $ 7.5 $ 3.7 $12.2 Adjusted for Risk of Failures, at $3k $10k NARTI $ 2.6 $ 9.0 $ 8.4 $27.7 PI $ 7.0 $23.1 $ 7.3 $24.4 NNRTI $ 6.2 $20.5 $ 8.6 $28.8 Mean for 14 drugs $ 5.1 $16.5 $ 8.1 $26.8
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