ANGELO STATE UNIVERSITY. BACHELOR of SCIENCE in NURSING NUR 4314 GENETICS AND GENOMICS. Summer JACQUELINE BROWN, MS, PhD, RN

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1 ANGELO STATE UNIVERSITY BACHELOR of SCIENCE in NURSING NUR 4314 GENETICS AND GENOMICS Summer 2014 JACQUELINE BROWN, MS, PhD, RN ANGELO STATE UNIVERSITY Department of Nursing & Rehabilitation Sciences COURSE NUMBER

2 NUR 4314 COURSE TITLE Genetics and Genomics CREDITS Three Semester Credit Hours (3-0-0) Online Class: Meets completely online using Blackboard PREREQUISITE COURSES Pathophysiology NUR 2324 CO-REQUISITES NONE PRE-REQUISITE SKILLS Accessing internet web sites, use of ASU Library resources, and proficiency with Microsoft Word and/or PowerPoint are an expectation of on-line course delivery. Computer access requirements are further delineated in the Graduate Handbook. Tutorials for ASU Library and for Blackboard are available through RamPort. The ASU Undergraduate Nursing Handbook must be reviewed before taking this course: undergraduatestudenthandbook pdf COURSE DELIVERY This is an online course offering. BROWSER COMPATIBILITY CHECK It is the student s responsibility to ensure that the browser used to access course material on his/her computer is compatible with ASU s Blackboard Learning System. Faculty reserves the right to deny additional access to course assignments lost due to compatibility issues. Students are responsible for reviewing the guidelines posted in this course regarding accessing Blackboard assignments. Problems in this area need to be discussed with faculty at the time of occurrence, either via a phone call (preferred) during posted acceptable hours for calling, or via notification during times outside those posted for calls. Be sure to perform a browser test. Select the Support tab from the Blackboard homepage ( Select Test your Browser option. FACULTY Jacqueline Brown, MS, PhD, RN Office: VIN 276 Phone: (325) Fax: (325) (preferred method of communication)

3 OFFICE HOURS Prefer Appointment/ Set up via Tuesday (3 to 4 PM) Monday, Wednesday (9:30-10:30 AM) COURSE DESCRIPTION This course provides students with a sound knowledge of genetics and genomics essential for health care providers in evaluating needs of patients and delivering of care to patients and families. The course prepares nursing students by reinforcing the basic principles of genetics while exploring new advances and discussing how these advances will affect health care. The course focuses on the relationship of genetics and genomics to health, prevention, screening, diagnostics, prognostics, selection of treatment, and monitoring of treatment effectiveness. Genomic influences on complex health problems, chromosomal and mitochondrial diseases, enzyme and collagen disorders, childhood onset disorders, adult onset disorders, psychiatric and behavioral disorders, and cancer will be covered. STUDENT LEARNING OUTCOMES Student Learning Outcome By completing all cours e requirements, students will be able to: Assessment(s) or activity(ies) validating outcome achievement: Mapping to BSN Program Outcomes/Essentials 1. Understand and integrate basic aspects of genetics and genomics to plan, coordinate patient centered care What role does the nurse play specifically in terms of complying with position statement ( Web search Reluctance Genetic Testing/summar Article/ review/when to tell and test for genetic carrier status Understanding syndromes of aneuploidy and level of care required. Care plan development for mosaicism disorders. Development of educational plan for mendelian diseases Essential 7. Implement health promotion and disease prevention strategies to provide culturally competent care.

4 Development of care plans for congenital anomalies 2. To integrate information regarding the social, ethical and legal implications of genetics and genomics with the role of a nurse as educator and patient advocate. Explore pros and cons of sharing information regarding inheritable gene for Alzheimer s and the unintended consequence of sharing this information. What are the pros and cons of savior sib approach to family planning? Article/Ethics, Evidence and Cost in Newborn Screening Explore the differences between life insurance, disability insurance and long-term insurance and the ethical implications of the omission of these types of insurance from GINA. Essential 7. Implement health promotion and disease prevention strategies to provide culturally competent care. Essential 8. Demonstrate standards of professional, ethical, and legal conduct. 3. Understand policy implications of genomic health care, newborn screening and prenatal genetics to guide nursing practice. Using a reputable, patient oriented website for congenital anomaly, provide an outline of the information that would help you build a good plan of care to guide the parents of a newly diagnosed infant. Provide rationale for information chosen. What are the pros and cons of direct to consumer testing? Use article entitled Public interest in predictive genetic testing, including direct to consumer testing, for susceptibility to major depression: Preliminary findings. Develop a group summary. Essential 3. Identify and appraise best research evidence to improve and promote quality patient outcomes. Essential 4. Utilize technology to access information, evaluate patient data, and document care. Essential 7. Implement health promotion and disease prevention strategies to provide culturally competent care. Essential 8. Demonstrate standards of professional, ethical, and legal conduct. 4. Apply concepts of obtaining family history (pedigree) and assessment of risk Students will take a family history of another student/create a three generational pedigree from the information. Build a preventive plan of care for any condition(s) for which there is potential risk. Essential 1. Integrate nursing and related theories into the delivery of safe nursing care to diverse populations.

5 5. Identify and integrate information of genomic science for the management of cancer prevention and treatment Genetic Mosaicism Linkage to Aging and Cancer Explore the internet for risk assessment tools for various types of cancers. Are the tools validated? How useful are the tools? What variables are used in the calculations? Essential 7. Implement health promotion and disease prevention strategies to provide culturally competent care. Essential 1. Integrate nursing and related theories into the delivery of safe nursing care to diverse populations. Essential 3. Identify and appraise best research evidence to improve and promote quality patient outcomes. Essential 4. Utilize technology to access information, evaluate patient data, and document care. 6. Evaluate and apply information regarding health promotion, diagnosis, prevention, and treatment of complex health problems that have significant public health importance Using the website: each group will find the trial NCT (genetics and bipolar). Discuss trial purpose, inclusion/exclusion criteria, a detailed description (in your own words) and type of research. Using the ClinicalTrials.gov website (basic search), for an assigned common, complex disease, report via summary the findings to the large group regarding clinical trials. For the assigned immunologic disorders (Rheumatoid arthritis, Type I diabetes, Addison s disease, Myasthenia gravis and Grave s disease), provide a summary regarding the immunologic basis of disease and provide information on ongoing genetic research. Develop educational plan for representative diseases representing autosomal dominant disorders, autosomal recessive disorders, X- linked recessive and dominant disorders, and mitochondrial disorders/focus is role of nurses in providing information about Mendelian disease to patients and families. Essential 3. Identify and appraise best research evidence to improve and promote quality patient outcomes. Essential 4. Utilize technology to access information, evaluate patient data, and document care. Essential 7. Implement health promotion and disease prevention strategies to provide culturally competent care.

6 7. Understand the contribution of genetics and genomics to mental health issues Discuss legal, social and ethical implications of legislation that would identify carriers of addictive genes and ban them from purchasing alcohol. Essential 7. Implement health promotion and disease prevention strategies to provide culturally competent care. Essential 8. Demonstrate standards of professional, ethical, and legal conduct. Essential 3. Identify and appraise best research evidence to improve and promote quality patient outcomes. Essential 4. Utilize technology to access information, evaluate patient data, and document care. 8. Pharmacogenomics Using the CYP450 drug interaction table located at altable.aspx: Define the terms substrate, inhibitors and inducers. Pick one interaction and describe side effects that could be manifested in the patient. Article review/paper on Pharmacogenomics and Patient Care Essential 4. Utilize technology to access information, evaluate patient data, and document care. REQUIRED TEXTS AND MATERIALS Genetics and Genomics for Nursing (Carole Kenner, Judith Lewis)-required text ISBN-13: ; 2013 OTHER REQUIRED MATERIALS Computer with MAC or Windows Operating System High Speed Internet Access Webcam (C 910 Logitech highly recommended) Logitech USB microphone headset Refer to Angelo State University s Distance Education website for further technology requirements:

7 RECOMMENDED TEXTS Sixth Edition Publication Manual of the American Psychological Association ISBN-13: TOPIC OUTLINE Section One (Back to Basics) Chapters one-four (June 2-7) Chapter One/Genetics and Genomics Chapter Two/ Basic Concepts in Genetics and Genomics Chapter Three/Family Context of Clinical Genetics Chapter Four/Meiosis and Mitosis Chapters five-eight (June 9-14)) Chapter Five/Aneuploidy Chapter Six/Mosaicism Chapter Seven/Mendelian Inheritance Chapter Eight/Genetics and Fetal Development Chapter 9-12 (June 16-21) Section Two (Ethical, Legal, Social Implications Of the Human Genome Project) Chapter Nine/Ethical, Legal and Social Implications of the Human Genome Project Chapter Ten/Prenatal Testing and Screening Chapter Eleven/Newborn Screening and Genetic Testing: Ethical Considerations Chapter Twelve/Genetic Information Nondiscrimination Act Legislation Chapter (June 23-28) Chapter 13/Family History Tool Chapter 14/Risk Assessment Section Three (Assessment/Genetics of Cancer)

8 Chapter 15/Immunogenetics Chapter 16/Cancer Genetics Section Five (Public Health Genetics) Chapter (July 7-12) Chapter 17/Impact of Environment on Health: Interaction with Genes Chapter 18/Common Diseases with Genetic Linkages Section Six (Psychiatric Disorders and Addictive Behaviors) Chapter (July 14-19) Chapter 19/Bipolar Disorder and Genetic Linkages Chapter 20/ Depression and Genetic Linkages Chapter 21/Addictive Behaviors and Genetic Linkages Chapter 22/Autism Section Seven (Special Topics/Pharmacogenomics and Aging) Chapter (July 21-31) Chapter 23/Pharmacogenetics GRADING SYSTEM Course grades will be dependent upon completing course requirements and meeting the student learning outcomes. The following grading scale is in use for this course: A = percent B = percent C = percent F = <70 percent

9 EVALUATION AND GRADES Graded activities and percent of the overall course grade: TEACHING STRATEGIES Students are expected to be active learners. It is a basic assumption of the instructor that students will be involved (beyond the materials and lectures presented in the course) discovering, processing, and applying the course information using peer-review journal articles, researching additional information and examples on the Internet, and discussing course material and clinical experiences with their peers. A Discussion Board is provided in Blackboard specifically for students ( Student Lounge ) to share websites, articles, apps, and clinical experiences relevant to the course topics. ASSIGNMENT DESCRIPTIONS Discussion Board Activities: Discussion Boards provide an avenue for synthesis of material / information. A Discussion Board is provided in this course as a way to help students process course materials, express thoughts, and engage others opinions and ideas in a healthy and productive learning environment. Students are expected to respond to all discussion board assessments using the rubric attached to the assignment. Assignments : Assignments are designed to allow student opportunity in the application of information gained through review of a multitude of resources and may be individually assigned or group assigned. Group assignments necessitate full participation of all members of the group and require the use of online submission by posted due date. Students are encouraged to seek information from group members early in the semester to accommodate individual time constraints related to their focus on the course in order to maximize efficiency in group work. Testing: Evaluation of student learning in this course may take a variety of forms, including on line assessments or individual topic mini projects. Access to exams will be through Respondus Lockdown Browser and will be video recorded via Respondus Monitor [See Other Required Materials for a list of needed equipment]. To prepare for testing using Respondus Monitor, see Respondus Monitor Help under the Resources tab for the course in blackboard. There are two practice quizzes: a) one is a Webcam test and b) a short 10 question practice quiz over ASU trivia that is not graded. These tools will be available to the student to assure accessibility. Students are highly encouraged to go through these practice quizzes in advance of taking a graded exam. This process will allow you to become familiar with the technology associated with testing and improve testing environment. Weighting of Coursework: Discussion/large group (30%) Small group projects/individual Assignments (45%) Exams (25%) GENERAL POLICIES RELATED TO THIS COURSE All students are required to follow the policies and procedures presented in the following

10 documents: Angelo State Student Handbook located on the ASU website ASU Graduate Catalog located on the ASU website and University Undergraduate Nursing Handbook, located on the Nursing website: IMPORTANT UNIVERSITY DATES June 2, Class begins July 4-Holiday June 30-July 3 Exam One/during Summer I finals week Aug 4-8 Exam Two/During Summer II finals week STUDENT RESPONSIBILITY & ATTENDANCE This class is asynchronous, meaning you do not have to be on-line at a certain time. There are readings which you will have to complete to be able to adequately participate in individual and group assessments. In order to complete this course successfully, you do have to participate in all course activities i.e. discussion boards, course projects, reflective logs, etc. Students are expected to engage in course activities and submit work by due dates and times. The hope is that students will make substantive contributions which reflect integration of assigned materials as well as any outside readings as appropriate. Scholarly contribution is an expectation. For planning purposes, this class will probably require a minimum of 6-9 study hours per week on average. COMMUNICATION Faculty will respond to and/or telephone messages within 24 hours during working hours Monday through Friday. Weekend messages may not be returned until Monday although reasonable attempt will be made to accommodate learning during this time. Written communication via Blackboard: It is an expectation of this class that you use formal writing skills giving appropriate credit to the source for your ideas. Follow APA (2010) 6 th edition (2 nd Printing or higher only) guidelines for referencing. Written communication via All private communication will be done exclusively through your ASU address. Check frequently for announcements and policy changes. ASSESSMENT SUBMISSION In this class, all assessments will be completed and submitted through Blackboard using the lockdown browser. Issues with technology arise from time to time. In the event of an issue, students must contact IT ( ) of the issue. Students must then communicate with the instructor the nature of the issue in order to allow resetting of the exam. Work completed prior to the technology issue will count toward grade and students will not be allowed to start over upon resetting. In the absence of a communication from IT, assessments/exams will not

11 be reset. Please make sure that you communicate with IT on this matter. All online examinations will be presented using a format inclusive of one question at a time viewing and no back-tracking. All questions will be timed in accordance to amount of information being requested. Generally, one to two minutes per question is applied for multiple choice questions and more time allowed for short answer questions. Examinations are not open book unless otherwise specified by the instructor. Assessments in this course are not relegated solely to on line testing but may include other means. LATE WORK OR MISSED ASSESSMENTS POLICY The course is set up on weekly modules. The week begins on Monday and ends on Saturday. Assignment due dates are shown on the calendar/schedule or posted within Blackboard. Twenty points will be deducted from final grade for every day past the due date. ACADEMIC HONESTY Academic honesty is expected on all work. Students are expected to maintain complete honesty and integrity in their online experiences. Any student found guilty of any form of dishonesty in academic work is subject of disciplinary action and possible expulsion from ASU. The Nursing Department adheres to the academic honesty statement as set forth in the Angelo State University Student Handbook ( ) The University "faculty expects all students to engage in all academic pursuits in a manner that is above reproach and to maintain complete honesty and integrity in the academic experience both in and out of the classroom setting and may initiate disciplinary proceedings against a student accused of any form of academic dishonesty, including but not limited to, cheating on an examination or other academic work, plagiarism, collusion, and the abuse of resource materials." PLAGIARISM Plagiarism at ASU is a serious topic. The Angelo State University s Honor Code gives specific details on plagiarism and what it encompasses. Plagiarism is the action or practice of taking someone else's work, idea, etc., and passing it off as one's own. Plagiarism is literary theft. In your discussions and/or your papers, it is unacceptable to copy word for word without quotation marks and the source of the quotation. We use the APA Style Manual of the American Psychological Association as a guide for all writing assignments. Quotes should be used sparingly. It is expected that you will summarize or paraphrase ideas giving appropriate credit to the source both in the body of your paper and the reference list. Papers are subject to be evaluated for originality via Bb Safe Assignment or Turnitin. Resources to help you understand this policy better are available at the ASU Writing Center STUDENTS WITH DISABILITIES 1. Angelo State University is committed to the principle that no qualified individual with a

12 disability shall, on the basis of disability, be excluded from participation in or be denied the benefits of the services, programs, or activities of the university, or be subjected to discrimination by the university, as provided by the Americans with Disabilities Act of 1990 (ADA), the Americans with Disabilities Act Amendments Act of 2008 (ADAAA), and subsequent legislation. 2. Student Contact: The Student Life Office is the designated campus department charged with the responsibility of reviewing and authorizing requests for reasonable accommodations based on a disability, and it is the student s responsibility to initiate such a request by contacting the Student Life Office, Room 112 University Center, at (325) or (325) (TDD/FAX) or by at to begin the process. Reasonable accommodations will be made for students determined to be disabled or who have documented disabilities. INCOMPLETE GRADE POLICY (OP Grading Procedures) It is policy that incomplete grades be reserved for student illness or personal misfortune. Please contact faculty if you have serious illness or a personal misfortune that would keep you from completing course work. Documentation may be required. STUDENT ABSENCE FOR OBSERVANCE OF RELIGIOUS HOLY DAYS 1. A student who intends to observe a religious holy day should make that intention known in writing to the instructor prior to the absence. Please see ASU Operating Policy COPYRIGHT POLICY Students officially enrolled in this course should make only one printed copy of the given articles and/or chapters. You are expressly prohibited from distributing or reproducing any portion of course readings in printed or electronic form without written permission from the copyright holders or publishers. SYLLABUS CHANGES The faculty member reserves the option to make changes as necessary to this syllabus and the course content. If changes become necessary during this course, the faculty will notify students of such changes by , course announcements and/or via a discussion board announcement. It is the student s responsibility to look for such communications about the course on a daily basis. COURSE EVALUATION Students are provided the opportunity, and are strongly encouraged to participate in a course evaluation at the end of the semester. Areas on the IDEA evaluation include: 1. Learning to apply course material (to improve thinking, problem solving, and decisions) 2. Developing specific skills, competencies, and points of view needed by professionals in the field most closely related to this course 3. Acquiring skills in working with others as a member of a team 4. Developing skill in expressing oneself orally or in writing

13 5. Learning how to find and use resources for answering questions or solving problems

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