Yearbook Chemistry of Life - Engineering Biology

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1 Yearbook 2013 Chemistry of Life - Engineering Biology 1

2 NBV yearbook 2013 Eighteenth year of publication, June 2013 Official publication by the Netherlands Biotechnological Society, KvK Secretariat Christien Lokman Han BioCentre Postbus GL Nijmegen Tel: Editor Annika van Rosmalen Subscriptions Members and sponsors of the NBV receive this year book automatically. Others can download a free summary at Copyright Using, copying, reproducing or otherwise publication of the information in this year book is only permitted after written consent from the NBV board. 2

3 Index Sponsors 4 Preface 5 Chemistry of life Engineering Biology 6 Programme 7 Keynote speakers 8 Parallel sessions 10 Activities th Netherlands Biotechnology Congress 18 Zilveren Zandloper Awards 21 Working group activities 22 Financial report Financial report Exhibits (in Dutch) 27 About the NBV What is NBV 28 Board 28 Working groups 31 Members statistics 35 The future of NBV 38 Questionnaire NBC SBN residual cash 39 Closing words by chairman 40 Appendix Minutes of General Assembly 2012 (in Dutch) 41 List of NBV members 43 3

4 Sponsors of the NBV The board would like to thank the following sponsors very much for their financial contribution to the NBV: Applikon Biotechnology BV Finesse Solutions AG GE Healthcare GEA Westfalia Separator Nederland BV Infors Benelux BV More information on sponsorship can be found on the NBV website. 4

5 Preface Traditionally the year after a NBC, the working group day is the major networking event of the NBV. For 2013 we have decided to team up with the KNCV and therefore it is my pleasure to announce the combined meeting of the KNCV and NBV, in which we combine the KNCV Spring event and the NBV working group day. Although the meeting is in June, spring in the Netherlands was late this year and we follow nature with this name. We are happy to organise the working group day event this year with the KNCV. As they had planned an event with synthetic biology as central theme and synthetic biology is one of the working groups of the NBV, a combination of events was an obvious way forward. When this synergy also offered an even better scientific program and a significant opportunity for cost reduction of the working group day, the NBV board decided to join forces. The result is a combined meeting at the Radboud University in Nijmegen on Tuesday 25 th of June with the very interesting theme Chemistry of Life - engineering biology. As usual, the working group day serves a great way to network within the Netherlands Biotechnology Society, which is this time further extended with the presence of KNCV members with an interest in synthetic biology in the broadest sense. In addition, this event is combined with an information and company fair to also provide you access to companies active in this space. Synthetic biology has gained a lot of interest in the last years and the organising committee has put a lot of effort in putting together a very appealing program around this central theme. Many Dutch scientists, including those from the NBV working groups, will present their work and I am sure this will result in stimulating and interesting discussions. In addition, the organisers have been able to attract two international speakers for plenary sessions. I want to thank the sponsors, the organizing and program committee for making this event possible. I also want to congratulate the KNCV with their 110 th birthday. I hope you will enjoy the presentations and I wish you a successful and enjoyable meeting. Hans Preusting Chairman NBV board 5

6 Chemistry of Life Engineering Biology June 25 th, 2013 Radboud University Nijmegen, the Netherlands Organised by the Netherlands Biotechnological Society (NBV) and the Royal Netherlands Chemical Society (KNCV) Organising committee Annika van Rosmalen Christien Lokman Frans Koeman Gabrielle Donné Jan Marijnnissen Board NBV, Netherlands Biotech Industry Association Board NBV, HAN University of Applied Sciences KNCV KNCV KNCV, Radboud University Scientific committee Joost Reek Klaas Hellingwerf Bert Poolman Vitor Martins dos Santos Roel Bovenberg Jan van Hest University of Amsterdam (chair) Swammerdam Institute for Life Sciences Groningen University Wageningen University & Research DSM and Groningen University Radboud University Nijmegen Sponsors The organising committee gratefully acknowledges the financial contributions from the sponsors: Pall Life Sciences, Biowake, Hogeschool Utrecht, IPecunia Patents, Shimadzu and Zirbus Technology 6

7 Programme 8:30 Registration & coffee / Company Market 9:15 Opening & Welcome 9:30 Keynote: James Liao Exploring principles of metabolic engineering for fuels and chemicals production 10:15 KNCV Golden Medal-ceremony 10:30 Luc Brunsveld Supramolecular Chemical Biology: Interfacing supramolecular systems with proteins and cells 11:00 Coffee / tea break and Company Market 11:30 Parallel Sessions morning 13:00 Lunch and General Assemblies (ALV s) and Company Market 14:00 Parallel Sessions afternoon and Carreer Workshop 15:30 Coffee / tea break and Company Market 16:00 Lecture by Winner igem 2012 Golden Master Award and Gouden Spatel Ceremonies 16:45 Keynote: Andrew Turberfield Molecular machinery from DNA: Synthetic biology from the bottom up 17:30 Appointment of honorary members and members of merit 17:45 Drinks and Company Market 7

8 Keynote presentations Exploring Principles of Metabolic Engineering for fuels and chemicals production James C. Liao (UCLA,USA) While petroleum provides the majority of fuels and chemicals used today, the unreliable supply, the fluctuation of price, and the negative environmental impact of its use have stimulated significant interests to replace petroleum with alternative sources. Existing schemes include the use of plant biomass or algae to produce ethanol, biodiesel, and some chemicals. Despite the success of these leading processes, next-generation bio refinery should consider other options as the starting materials, manufacturing schemes, and the product itself. To accomplish these goals, synthetic pathways in cells are to be re-engineered to produce various chemicals and fuels. In this talk, we will discuss principles for re-wiring metabolic networks in living organisms, including biochemical, thermodynamic, and kinetic considerations. Dr. James C. Liao, Ralph M. Parsons Foundation Professor and Chair, Chemical and Biomolecular Engineering of UCLA, is a pioneer in Metabolic Engineering and Synthetic Biology. He received his BS degree from National Taiwan University and PhD from University of Wisconsin-Madison. After working as a research scientist at Eastman Kodak Company, Rochester, NY, he started his academic career at Texas A&M University in 1990 and moved to UCLA in He was elected Fellow of American Institute for Medical and Biological Engineering, 2002, and received numerous awards, including NSF Young Investigator Award (1992), Merck Award for Metabolic Engineering (2006), Food, Pharmaceutical, and Bioengineering Division award of American Institute of Chemical Engineers (AIChE) (2006), Charles Thom Award of the Society for Industrial Microbiology (2008), Marvin Johnson Award of American Chemical Society (2009), Alpha Chi Sigma Award of AIChE (2009), James E. Bailey Award of Society for Biological Engineering (2009), and Presidential Green Chemistry Challenge Award (2010), and the White House Champion of Change for innovations in renewable energy (2012). In 2013, he was elected as Member of National Academy of Engineering. 8

9 Molecular Machinery from DNA: Synthetic Biology from the Bottom Up Andrew J. Turberfield (Oxford, UK) DNA is a wonderful material for nanoscale construction: its self-assembly can be programmed by making use of its information-carrying capability, and its hybridization or hydrolysis can be used as to provide energy for synthetic molecular machinery. With DNA it is possible to design and build three-dimensional scaffolds, to attach molecular components to them with sub-nanometre precision and then to make them move. I shall describe our work on autonomous, biomimetic molecular motors powered by chemical fuels and the use of synthetic molecular machinery to control covalent chemical synthesis. I shall demonstrate bipedal motors whose operation depends on the coordination of the chemomechanical cycles of two separate catalytic centres and burnt bridges motors that can be programmed to navigate networks of tracks. I shall also discuss the use of kinesin motor proteins to power synthetic devices. Andrew Turberfield is one of the leaders of the rapidly developing interdisciplinary research field based on selfassembly programmed through molecular recognition. He is a Professor of Physics at Oxford University with a background is in solid state physics: he developed new spectroscopies of correlated states of 2D electrons in the fractional quantum Hall regime and, with Prof. R.G. Denning, introduced important techniques for the fabrication of microstructured photonic materials. His work on DNA self-assembly started with a sabbatical visit to Prof. B. Yurke at Bell Laboratories: together, they produced the first synthetic molecular machine made from and fuelled by DNA and demonstrated the principle of DNA hybridization catalysis. His current research includeds the study of synthetic molecular structures and machinery, including their use for the control of chemical synthesis, protein structure determination and as intracellular probes. 9

10 Parallel sessions 1) Engineering of biology: new products and synthetic cells Synthetic Biology is an emerging field at the interface of biology, chemistry and physics that focuses on foundational research and technological applications in the life sciences. The ultimate aim is to create cellular systems as simple as possible to perform specific functions, for instance, the synthesis of new drugs, the targeting and destruction of malignant cells in the body or new energy conversions. The inner workings of such a cell would be geared towards this function and be very different from known living organisms that have evolved to sustain in a given environment. To create such an artificial cell one could minimize the genome of existing forms of life ('minimal cell approach') and introduce new functions but maintain the cell s ability to grow and replicate. One step further and more complicated would be the creation of a synthetic cell from its component molecules. Such bottom-up synthesis of a cell is not only a formidable engineering challenge but will also allow us to unravel the principles of life processes in a truly fundamental way, and at the same time bring unprecedented opportunities for applications in health, biotechnology and materials. Research on the engineering of living systems as well as the assembly of a living cell from basic molecular components will be presented in this session of the symposium. Co-chairs: Roel Bovenberg, DSM (morning session) Bert Poolman, Groningen University (afternoon session) Speakers: Zohreh Nourian (Delft University of Technology) Lotteke Swier (University of Groningen) Marileen Dogterom (AMOLF) Manuel Montalbán López (University of Groningen) Philipp Savakis (University of Amsterdam) Mark van Passel (Wageningen University) 10

11 2) The yin and yang of systems- and synthetic biology Systems Biology aims to understand how higher-level properties emerge from the complex network of interactions among the many (types of) individual components of a biological system. It does so by addressing, in an integrated, quantitative manner intertwining modeling and experimentation, the mechanisms by which cellular components, organelles, cells and multicellular organisms interact in space and time. Synthetic Biology draws upon this knowledge and to build new functions, systems, and even new biological entities for an enormous range of applications. This session will explore the intertwining between systems and synthetic biology (yin and yang), and how this mutually reinforcing cycle foster discovery and developments in biotechnology. Six speakers will present their views and work on topics ranging from circuit design in plants and algae to genome engineering in yeast, model-driven catalyst design, production of chemicals and epigenetic re-programming. Co-chairs: Speakers: Vitor Martins dos Santos, Wageningen University Klaas Hellingwerf, University of Amsterdam Hans Roubos (DSM) S. Andreas Angermayr (University of Amsterdam) Christian Fleck (Wageningen University) Pernette J. Verschure (Swammerdam Institute for Life Sciences) Pascale Daran-Lapujade (Delft University of Technology) Speaker to be confirmed (Hubrecht Laboratorium) 11

12 3) Intensified processes for selective recovery of active peptides and proteins Efficient recovery of peptides and proteins in large quantities remains challenging and expensive in industrial food and biotechnology applications. Current technologies are reaching their limits with regard to throughput. The aim is to develop an efficient and costeffective separation technology for active biomolecules from complex process streams such as fermentation broths and food waste streams. The combination of affinity chromatography in combination with membrane technology could allow selective, fast and cheap processing without pressure build-up. In this session the following three topics will be discussed: A. Development of novel affinity ligands via phage/cell based display technologies for the selective absorption of specific biomolecules B. Resin-based affinity membrane development for capturing specific biomolecules C. Evaluation of mixed membrane modules as purification device Chair: Michel Eppink Speakers: Guy de Roo (Synthon Biopharmaceuticals BV, Nijmegen) Serve Kengen (Wageningen University) Willem van Berkel (Wageningen University) 12

13 4) How to start your career in Life Sciences? Which career opportunities exist for BSc, MSc or PhD students in the Life Sciences? In this workshop (young) professionals with degree in the Life Sciences tell about their current job, how they got to this position and what helped them in their careers. There is also the opportunity to meet the professionals face to face in a group speed-date. The workshop is free for BSc and MSc students. Chair: Ir. Paul Rulkens, Program manager One DSM Professionals: Dr. Marijke Westra, patent attorney V.O. Amersfoort Anneke Steegh, MSc, Lecturer Hogeschool Arnhem Nijmegen Dr. Wilbert Heijne, product application specialist, Beer (Enzyme Solutions) at DSM Food Specialties Eric Benjamins, MSc Researcher R&D Friesland/Campina Domo/PhD student University of Groningen 13

14 5) Bio-inspired self-assembled systems Nature attains exquisite control regarding the three-dimensional build-up of functional molecular assemblies via well-defined supramolecular binding motifs. Recent advances in bioconjugate chemistry and protein engineering have given researchers in the fields of chemical biology and bionanotechnology access to a wide range of these natural motifs and biomolecular building blocks. In this session both protein-protein interactions and DNA-based directed assembly will be discussed. Different examples will be presented of how a better understanding and improved synthesis of tailor made structures leads to well-defined assembled systems with added value in biocatalysis and sensing. Chair: Joost Reek Jan van Hest Speakers: Maarten Merkx (Eindhoven University of Technology) Andreas Bastian (University of Groningen) Jocelyne Vreede (University of Amsterdam) Mark van Eldijk (Radboud University Nijmegen) Kristina Djanashvili (Delft University of Technology) Melissa Koay (Twente University) 14

15 6) Samen werken aan universitair onderwijs en 20 Jaar Stichting C3 A. Samen werken aan universitair onderwijs ICAB (InnovatieCentra Academisch Bètaonderwijs) brengt docenten van universitaire opleidingen chemie en chemische technologie met elkaar in contact en beoogt good practices en onderwijsmateriaal uit te laten wisselen. Er zullen twee projecten worden gepresenteerd. Een project dat toetsmateriaal uitwisselt en gebruik maakt van een Europese vragenbank (EChemTest) voor diagnostische toetsing. En een project dat een leeromgeving heeft ontwikkeld om studenten adaptief onderwijs aan te bieden bij het leren van struikelvakken, zoals kwantumchemie. B. C3 bestaat 20 jaar! 20 jaar chemiepromotie onder jongeren. Gedurende die tijd heeft C3 tal van promotieactiviteiten en -materialen ontwikkeld, in de ijskast gestopt en uit de mottenballen gehaald: Video s, micro-chemie, de proevenwaaier, Lab Experience Days, Exactwatjezoekt!, Proef! en Proef!werk, kinderpagina s en kinderlabs. Op een interactieve manier krijgen de deelnemers van de C3-werkgroep een trip langs een memory lane met gedenkwaardige hoogtepunten. Uiteraard gaan de handen uit de mouwen en word je als deelnemer geïnspireerd en gemotiveerd om de C3-materialen in je eigen werkpraktijk in te zetten. Techniekpact wordt chemiepact: ervaar Het C3-leven live! U wordt bijgepraat door Marijn Meijer, Pauline Sloet en Remco Simonz. Zaalvoorzitter: Martin Goedhart Sprekers: Martin Goedhart (RUG) Natasa Brouwer-Zupancic (UvA) Floris Rutjes (RU) 15

16 7) Towards the engineering of life: from microbiology and biochemistry to synthetic biology The rise of biotechnology, and engineering approaches to life in general, has been the result of an on-going interaction between chemistry and biology. After Martinus Beijerinck ( ) had introduced industrial microbiology to the Polytechnic School at Delft (later Technical University Delft), his successor Albert Kluyver ( ) introduced biochemistry into the study of microbiology, thereby creating a unity of both fields that had a great international impact. After the discovery of DNA, in 1953, it was the interaction between biochemistry and molecular biology that drove the field forward. The discovery of rec-dna techniques opened the road to so-called genetic manipulation, and later to the new field of synthetic biology, culminating in the dream of the synthetic cell. These developments are a great challenge for philosophy as well. Do they produce a completely new view of nature? And do they give man the possibility to control the future of life? These ancient philosophical questions are highly relevant in the light of the most recent developments. Chair: Rob van Veen Speakers: Dr. Lesley Robertson, FBS (TU Delft) Prof. Dr. Ab van Kammen (ex-wageningen UR) Prof. Dr. Hub Zwart (RU Nijmegen) 16

17 8) Societal impact of synthetic biology for our health, food, energy and materials Synthetic biology is an exciting multidisciplinary field that emerged in the beginning of this century as an engineering science of life. It is best understood as the deliberate (re)design of biological systems and living organisms using engineering principles. The field promises many benefits, whilst at the same time raising important social and ethical issues. In this session synthetic biology and its societal implications will be introduced and the scientific and societal value of its approach will be discussed, focusing on applications in industrial biotechnology and in gene therapy. Chair: Dirk Stemerding (Rathenau Instituut) Speakers: Roel Bovenberg (DSM) Rob Hoeben (Leiden University Medical Centre) Dirk Stemerding (Rathenau Instituut) 17

18 Activities 2012 NBC-14 Biotechnology, delivering value: bridging science and business NBC-14 was held on the 16th and 17th of April 2012 and it was a great success! All participants enjoyed seven keynote lectures, many parallel sessions, and the social and interactive aspects of the conference. And as always, the Zilveren Zandloper Awards for innovation and education were awarded. A short report: The opening keynote lecture was given by Prof. Eric Claassen. He plead for more knowledge of IPR at scientists. Without IPR, no new products. For example, when a scientist thinks he has a great innovative idea, (s)he should not only check the database for publications, but also the database for patents. In his experience, lots of ideas are already in the latter database. If not, you really have an innovative idea. Furthermore, not only IPR is important if you market new knowledge, also branding and copyrights can help to protect your invention, even when the patent expires. Chair of the social and economic council Alexander Rinnooy Kan reflected on possibilities for life scientists in the biobased economy (BBE). In the BBE new high value applications are possible, such as bio-steel, woven from natural fibres that can be used for trains. In his view, the Netherlands should focus on the development of such high value applications, because these counteract the possible negative effects of the BBE, such as on the food supply and biodiversity. Hans Preusting (left) en Alexander Rinnooy Kan (right) 18

19 Matthias Reuss explained how multi-scale modelling can enhance cancer therapy. Models can help to understand how real tissues work and can thereby improve efficacy of therapy and reduce side effects. Reuss applied rigorous dynamic modelling of the central metabolism and application of metabolic control analysis to identify glycolyitic inhibitors for the treatment of cancer. However, since several normal tissues (e.g. brain tissue) depend on glucose as the main energy and carbon source, this approach has to be taken with care. Thus in the second part of the talk dealt with the fact that drugs beyond the cellular level are essential for designing individual of drug delivery concepts and allow to propose the possibility of optimized cancer treatment therapies. Although working with entrepreneurs a lot, René Wijffels stays an academic. In his research, he focuses on algae for food and fuel. In the AlgaePARC in Wageningen, he works with companies to find a solution for our need of biobased chemicals, materials and fuels. Today, the business case is still for niche markets, with high value compounds from mostly small companies. But Wijffels expects that in years, the market for algae has shifted to bulk materials and low value compounds from large companies. It can be done, but still a few technical hurdles need to be taken. Chief Innovation Officer of DSM Rob van Leen showed us how his company thinks of innovation. DSM believes in open innovation and develops itself more and more into a company selling knowledge instead of products. Collaboration is already very important for the company, as for example in the top institute BioMedical Materials where DSM develops biointeractive compounds that deliver biological for cartilage repair that stimulate the right tissue growth and disappear after use. Luuk van der Wielen explained that innovation is not possible without piloting. The University of Delft therefore developed a piloting facility for innovations in sustainable bioprocesses. For example, if you want to source sustainable biomass from Malaysia, what best to do? Dutch importers are quite critical, but for the Malaysians, sustainability is not a necessity yet. The university therefore started with knowledge transfer and the definition of opportunities for Malaysian plant owners. Without understanding the infrastructure, culture and companies in the country you work in, innovation is not possible. 19

20 According to Rob Carlson, we are experiencing a proliferation of skills and technology that is driven largely by economic demands and that will facilitate a very different mode of production than we have seen until now. As technologies like synthetic biology mature, they will enable the construction of entirely new genetic circuits and metabolic pathways, as is now being demonstrated for pharmaceuticals and biofuels. Biotechnology can produce fuels and materials at lower cost and lower environmental impact that we have seen with industrial chemistry. 20

21 Zilveren Zandloper Awards There were many nominations of excellent candidates for this year s Zilveren Zandloper Awards. The winner for the Education Award was Dr. Carla van Beuningen from Fontys Hogeschool, University of Applied Sciences, TNW. Dr. van Beuningen was nominated for high motivation in education and her successful efforts to prepare her students for employment in industry. This is shown with her directorship of ASIA (Applied Science and Engineering Consultancy) which are projects run by the students together with various companies. Dr. Kees Leenhouts from Mucosis won the Innovation Award. He worked for several years in academia at the University of Groningen and then moved to a local biotech company, BioMade. He used his discoveries and experience both from academia and industry to establish a new company, Mucosis. This company has succeeded in bringing his technology to Phase I clinical trials. Dr. Leenhouts has shown an excellent example of valorisation of scientific knowledge via a start-up company. 21

22 Activities NBV Working Groups Working Group Animal and Plant cell culture: Symposium New Initiatives in animal cell culture: Developments in stem cell cultivation On the 22 nd of November the Working Group Animal and Plant cell culture organized the Symposium "New initiatives in animal cell culture: Developments in stem cell cultivation. Animal cell culture for the production of vaccines, cell and gene therapy products, tissues and complex pharmaceutical proteins is still a rapidly growing field. Therefore some interesting speakers were invited to share their work on cultivating stem cells for different applications. Bernard Roelen from the University of Utrecht is exploring the possibilities of producing in vitro meat by generating muscle tissue from pig stem cells. Roelen has overcome many hurdles in cultivating these pig stem cells, but producing an edible piece of meat requires much more than simply collecting muscle cells, he showed the public. At Leiden University Robert Passier is working on a different future application of stem cells. He generates heart muscle cells from stem cells to heal damaged heart tissue. He transplanted the heart muscle cells in mice, which suffered from a heart attack. After four weeks, the treated mice did significantly better than the control mice. Unfortunately, this effect only lasted for a very short period of time. He now also uses these heart cells for toxicology studies for the pharmaceutical industry The controlled expansion of stem cells is crucial in the examples above. Matthieu Egloff (ATMI life sciences) showed the public a special multiplate bioreactor in which the cells can be scaled up under controlled conditions. The biggest bioreactor has a surface of 12 sq meters. Pieter van Santen (Xpand Biotechnology) is working on a disposable bioreactor for stem cells, which is currently being tested by Sanquin and Leiden University Medical Centre. Working group Green Biotechnology: Parallel session NBC - 14 The working group Green Biotechnology has organised, together with the NGI-Platform Green Synthetic Biology (PGSB), a parallel session at the NBC conference in April The title of this session was "Green-White biotech: plant metabolites produced by microbes and was introduced by the director of the PGSB. The plant kingdom represents a tremendous diversity of highly interesting phytochemicals with potentially a wide range of applications. However, often these compounds cannot be harvested in an economically viable way because plants may grow slowly, are rare, difficult to domesticate or the compounds are hard to purify. In this session, progress and opportunities were discussed to produce such phytochemicals via microbial biotechnology. Two speakers from academia, from the plant field (Wageningen UR) and from microbial biotechnology (TUD), provided presentations on developments in science and technology. Two speakers from industries, Isobionics and Fluxome, provided presentations on using these technologies to produce commercially interesting terpenes and flavonoids respectively. The session was very well visited. 22

23 Working group Product isolation en purification Symposium Freeze drying and spray drying, industrial perspective On May 23rd the symposium Freeze drying and spray drying, industrial perspective was organized in Amersfoort. Jack Nijholt from MSD Animal Health in Boxmeer presented the development and optimisation of freeze drying processes. Marc Vorage from Avebe and David Hollestelle from Nizo were invited to share their experience on spray drying technology. About 30 people, mainly from the industry, attended the symposium. Jack Nijholt presented lyophilisation for pharma products, which is a technique that is used at MSD Animal Health to stabilize live vaccine products. Although the technology is time consuming and expensive, it is used for a significant number of products, not only at MSD Animal Health but across the pharmaceutical industry. The presentation included a case study of how the lyophilization cycle time of a product has been reduced, from the start of the project until implementation of the developed lyophilization cycle in the production environment, using a lean six sigma approach. Furthermore, recent developments in freeze drying technology were highlighted and evaluated against the pressure of producing more product in the same time frame. Jack Nijholt s presentation resulted in an active discussion with the audience. Marc Vorage and David Hollestelle gave a duo presentation. David started off with a general introduction on spray drying. Marc Vorage took over to discuss the practical aspects. This included protein stability, fouling issues and predictability of nozzle performance. Special attention was paid to heat integration. Spray drying is an energy intensive process, typically 30% of the cost of the unit operation is energy consumption. As a rule of thumb only half of the energy used for heating the incoming air is subsequently used for water evaporation. The other half is lost by the (hot) vent gasses of the dryer. Polymer heat exchangers are under development to recover part of the energy from the vent-gasses to heat-up the cold incoming air. After Marc s introduction to (novel) type heat exchangers, the audience was asked to discuss in small teams the most efficient way to implement heat integration for spray driers. Some groups were asked to present their ideas to the audience. After the small work shop David introduced the Dutch Drying Institute and invited the academics and industry to actively participate in this institute. The speakers were thanked for their contribution and the discussions were lively continued during the drinks afterwards. 23

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