Status and perspective of emission imaging techniques for ion beam therapy in Lyon

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1 14th International Conference on Nuclear Reaction Mechanisms, Varenna 18th June 2015 Status and perspective of emission imaging techniques for ion beam therapy in Lyon on behalf of the CAS-PHABIO group of IPNL Lyon 1 University and CNRS/IN2P3, France

2 Rationale for ion therapy and range verification Present Reduced integral dose (factor ~3) Healthy Tissues Paganetti AAPM 2012 Tumor Target Tumor volume Organ at risk Future Reduction of safety margins (dose escalations; higher cure rate) Use of new irradiation fields (use of sharp distal penumbra of Braggpeaks) Tang et. al. Med.Phys

3 How do we reduce range uncertainties? In-vivo range verification PET Prompt gamma cameras Increasing accuracy in range prediction Ion CT 3

4 Prompt gamma 4

5 Prompt gamma based range verification Projectile Nucleons and clusters Projectile fragment Fireball Target Prompt gamma Target fragment 75, 95 MeV/u 12C ions on PMMA 160 MeV protons on PMMA TOF background discrimination BP position BP position BP position ENVISION collaboration: Dauvergne et al (IPNL Lyon), Prieels et al (IBA) 5

6 Collimated cameras in Lyon 6

7 Prompt gamma profiles: TOF influence 7

8 Multislit collimator in Lyon 8

9 Multislit collimator in Lyon 9

10 Compton camera in Lyon 10

11 Gamma cameras in Lyon: Hodoscope 11

12 Compton camera in Lyon: Scatter detector 12

13 Gamma cameras in Lyon: Absorber 13

14 IVI 14

15 Interaction vertex imaging (IVI) Projectile Projectile fragment Fireball Target Nucleons and clusters Target fragment Secondary charged particles (e.g, proton) Dauvergne et al 2009 AQUA Project: G4 simulations

16 IVI in Lyon: Detectors 16

17 IVI in Lyon: Set-ups 17

18 IVI in Lyon: Measurements (GSI) 18

19 IVI in Lyon: Measurements (GSI) 19

20 IVI in Lyon: MC/Measurements (HIT) R. Rescigno et al, ICTR-PHE

21 Summary Imaging range verification Hardware development Monte Carlo simulations 21

22 Thank you

23 Backup

24 Prompt gammas CAS-Phabio IPN-Lyon Multi-slit Prompt-gamma camera p 160 MeV on PMMA PG without TOF PG with TOF Diff with/without TOF Compton camera Roellinghoff et.al. Phys. Med. Biol. 59 (2014) Monte Carlo as a tool for feasibility and detector design studies Detection set-up characterization and optimization in clinical conditions Clinical validation of real time range verification

25 Monte Carlo validation 3 p 160 MeV on MLFC p 160 MeV on PMMA 2 Smeets et al., PMB 57 (2012) Rinaldi et al., PMB 56 (2011), Ferrari, Rinaldi et al., in preparation 25

26 Range resolution with prompt gammas 1-sigma of a distributions of fall-off positions Roellinghoff et.al. Phys. Med. Biol. 59 (2014) - 1 mm precision with 2E+09 protons, TOF selection and small detector (4 cm high) for an homogeneous target - Increase of the solid angle by a factor 10: Millimetric precision on a pencil beam basis - For distal spots ~2x108 protons/spot

27 IVI techniques Single-proton imaging (SP-IVI) Intersection of a secondary-proton trajectory with the incident-ion trajectory Double-proton imaging (DP-IVI) Intersection of 2 secondary-proton trajectories Detectors Tracker (CMOS) + beam hodoscope (in coincidence) Courtesy of E. Testa 27

28 IVI perspectives In-beam tests with CMOS detectors: GANIL (95 MeV/u) HIT ( MeV/u) QAPIVI project (IPNL+IPHC) Courtesy of E. Testa

29 IVI perspectives Henriquet et.al. PMB Gwosch et.al. PMB

30 How to measure prompt gamma Collimated camera single and multislit Common device: Hodoscope Ray (IPN Lyon) Hardware - array of scintillating fibres (1x1 mm2) - 2 prototypes: 2x32 and 2x128 fibres - time resolution 1 ns - goal: count rates up to 108 1/s Compton camera electronic collimation Ray (IPN Lyon) Electronics - development of ASIC - new version with DLL timing Krimmer and De Rydt (IPN Lyon)

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