MALDI-MS Product overview 1 Company Instrument Benchtop (j/n)

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1 MALDI-MS Product overview 1 Voyager TM DE- PRO ja ja <20 ppm () 2x96, 100, 384, 400 well, 337 nm N2 DE TM, Time-ion selection, PSD, Collision-induced dissociation (CID) Voyager TM DE- (s)str ja <5 ppm () 2x96, 100, 384, 400 well, 337 nm N2 (optie Nd-YAG) DE TM, Time-ion selection, PSD, CID, high sensitivity Detector 4700, MALDI- TOFTOF; Proteomics Discovery System TM ja <2 ppm () 2x96, 100, 384, 400, 1536 well, membrane/gel, Weefsel target, hydrofobic masks, Opti- Solid State 355 nm, 200 Hz laser DE TM, accurate Timed-ion selection, real MS/MS, hoog resolutie MS/MS, High sensitivity Detector, Unattended Automated High Throughput with RDA TM (Result Dependent Analysis), Oracle data management, GPS TM (Global Proteome Server), diverse sample prep. robots Windows 2000/XP, BioMarker Discovery, PTM analyses, Abs. en Rel. Quantificatie analyses, Global Proteome Server, RDA, Imaging MS, LC-MALDI, LIMS 4800 Plus, MALDI- TOFTOF; Proteomics Discovery System TM ja <2 ppm () 2x96, 100, 384, 400, 1536 well, membrane/gel, Weefsel target, hydrofobic masks, Opti- Solid State 355 nm, 200 Hz OptiBeam laser DE TM, accurate Timed-ion selection, real MS/MS, hoog resolutie MS/MS, High sensitivity Detector, Unattended Automated High Throughput with RDA TM (Result Dependent Analysis), Oracle data management, GPS TM (Global Proteome Server), diverse sample prep. robots Windows 2000/XP, BioMarker Discovery, PTM analyses, Abs. en Rel. Quantificatie analyses, ProteinPilot, Markerview, RDA, Imaging MS, LC-MALDI, cicat, itraq, SILAC, LIMS QSTAR Elite quadrupoolvluchtijd hybride ja <5 ppm 2x96, 100, 384, 400 well,, Cyphergen-source TEMPO MALDI spot robot, LC PROTEINPILOT met PARAGON, Packings Probot, MS-MS met ANALYST (Windows2000/XP), Add on hoog-resolutie in MS2. Met LINAC tools: IDA (Information Dependent (PULSAR)TM botsingscel. Acquisition) anauwkeurigheid <5 ppm, differentiele expressie studies, hoge automatisatie graad uitbreidbaar met prep. Robot, SELDI-analysis, Opti-TOF

2 MALDI-MS Product overview 2 microflex LT yes linear only 105. < 75 Target size exactly ¼ of industry standard microtiter plates Various 96-spot targets available Compatible with Bruker Daltonics, sample preparation robotics Patented AnchorChip techlogy for fast, automated data acquisition, increased sequence coverage and fold sensitivity increase 20Hz N 2 laser Gridless design of ion source with improved Pulsed Ion Extraction (PIE TM ). Ultrastable power supplies for TOF analyzer, detector and ion source. especially well integrated with Clinprotools software for biomarker discovery, Getools for DNA SNP getyping and DNA QC applications plus an unique and innvative Biotyper module for identification of microorganisms is available. microflex yes 105 linear or 196. Linear: < 50 : < 15 ppm Target size exactly ¼ of industry standard microtiter plates Various 96-spot targets available Compatible with Bruker Daltonics, sample preparation robotics Patented AnchorChip techlogy for fast, automated data acquisition, increased sequence coverage and fold sensitivity increase Nitrogen laser with up to 20 Hz repetition rate >15000 resolution microscout TM Ion Source with state-of-the-art pulsed ion extraction Optional MS/MS capability (PSD) Service features Remote on-line service capability Extended self diagstics Fully integrated in the powerful CompassTM suite Highly intuitive GUI for simple instrument and workflow control Smooth data transfer to peripherals and library search engines Optional Compass security pack for regulated environments Linear and high-resolution TOF analyzer Powerful Compass software suite Fully integrated in PROTEINEER, CLINPROT and GENOLINK system solutions. Supplementary IQ, OQ-PV procedures available MALDi molecular imager optional, 120 linear < 20 slide adapter for 2 glass slides with conductive coating to be used in MALDI imaging of tissue 200 Hz solid state new imageprep robot for tissue (incl new preparation with <50 micrometer SMARTbeam) with droplets and high spectral quality. software controlled spot sizes between 10 and 200 microns Fleximaging (tissue imaging) as part of the clinprot solution package for Biomarker Analysis. ClassImaging multivariate statistics for classification of several images.

3 MALDI-MS Product overview 3 Autoflex III 120 linear or 215. Linear: < 20 : < 5 ppm, and Twister improved sensitivity. 200 Hz solid state resolution >20,000 () (incl SMARTbeam Gridless design, DE, PSD, ISD, ) CID, HIMAS detector, improved sensitivity, Twister robot (automated analysis of up to 30,000 samples/day) Proteir Spotpicker Robot, Proteir Digest & Preparation Robot, Barcode reader, SPR(Biacore)- MS, (na)lc-maldi Mascot/Profound search, (proteins), RapiDevo (devo Proteomics), Getools (SNP getyping), imaging), Biotyper (microorganisms) Autoflex III TOF/TOF 120 linear or Uncompromi sed linear performance Linear: < 20 : <5 ppm, and Twister improved sensitivity. 200 Hz solid state same as Autoflex TOF, with LIFT (incl SMARTbeam TOF/TOF and CID MS/MS ) options. TOF performance uncompromised when TOF/TOF switched off.t3-sequencing of intact proteins possible, broad massrange resolution PAN. Mascot/Profound search, (proteins), WARP-LC (protein quantitation), RapiDevo (devo Proteomics), Getools (SNP getyping), imaging), Biotyper (microorganisms). Ultraflex III TOF/TOF Uncompromi sed linear performance Linear: < 15 : < 3 Paramic mass range calibration, and Twister improved sensitivity (<200amol) 200 Hz solid state same as Ultraflex TOF, with LIFT- (incl SMARTbeam II TOF/TOF MS/MS options. TOF ) performance uncompromised when TOF/TOF switched off. T3- sequencing of intact proteins possible. Broad massrange resolution PAN. Mascot/Profound search, (proteins), WARP-LC (protein quantitation), RapiDevo (devo Proteomics), Getools (SNP getyping), imaging), Biotyper (microorganisms).

4 MALDI-MS Product overview 4 IonSpec/Va rian ProMALDI FTMS (7.0 Tesla magnet) n.a. (ICR cel) < 2 ppm, AB 4700 plates 1 ppm (interne standaard, andere standaardisatie Maldi target plates ) optiol 15-8,500 mass range MS/MS opties: ECD, IRMPD, simultane ECD/IRMPD Omega 2XP (Windows XP), PeakHunter, de vo sequencing IonSpec/Va rian ProMALDI FTMS (9.4 Tesla magnet) n.a. (ICR cel) < 2 ppm, AB 4700 plates 1 ppm (interne standaard, andere standaardisatie Maldi target plates ) optiol 15-18,000 mass range MS/MS opties: ECD, IRMPD, simultane ECD/IRMPD Omega 2XP (Windows XP), PeakHunter, de vo sequencing MaldiisoTOF ja j < 20 ppm AB 4700 plates standaard - Analyser Pro(Windows XP) PerkinElmer Benelux protof 2000 MALDI O- TOF Spectromet er N Y < 5 Range to 300,000 Da 96 to 1536 well reusable stainless steel or singleuse MALDI chip target plates Up to 100 Hz MALDI laser with TOFWorks software. Discriminatory extended life (> 200 million analysis of MS spectra performed by using pulses); Fmol sensitivity with >4 PG600 Biomarker Discovery Software. orders dynamic range; Orthogonal PrOTOF anf PG600 are part of TOF with Collisional Cooling; Dual PerkinElmer Biomarker Discovery Platform Processor system controller; Fully called BioXPRESSION. integrated software platform Shimadzu Benelux AXIMA-QIT (Quadrupol e Ion Trap- TOF) 337 nm N2 Ion Trap, MS n,variable CID control, precursor Ion selection resolution >1000,special adaptors for chiptechlogy, mass resl >6000 Shimadzu Benelux Axima - TOF² Shimadzu Benelux AXIMA- CFR plus Shimadzu Benelux AXIMA- CFR <10 ppm with IC 96, 384 and nm N2 MS/MS, range kda, resolution > 20,000 Precursor ion selection resolution > nm N2 Seamless PSD, Robotic Sample Processor, CID,Resolution>20,000,special adaptor for chip techlgie 337 nm N2 Seamless PSD, Robotic Sample Processor, Resolution>10,000 Shimadzu Benelux AXIMA- LNR Liniar flight tube, 1,2m <50 ppm with IC 96, 384 and nm N2 Seamless PSD, Robotic SampleProcessor, Resolution>4000

5 MALDI-MS Product overview 5 Waters, Micromass techlogies Maldi-Micro- yes yes 10 ppm, internal calibation 96 of 384 positives, user definable plates 337 nm N2 TLF; standard Parallel PSD ( PSD, without parent ion selection!) Lynx 4.0 (Windows XP of Windows 2000), Lynx is CFR 21 part 11 complaint.; various integrated links to Microbelynx, Proteinlynx Global server.) Waters, Micromass techlogies MALDI-Q- TOF Premier yes < 3 ppm 96 of 384 positives, user definable plates 337 nm N2 Parent ion resolulion. Accurate mass MS and MS/MS, Lynx 4.0 (Windows XP of Windows 2000), Lynx is CFR 21 part 11 complaint.; various integrated links to Microbelynx, Proteinlynx Global server.)

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