CURRICULUM VITAE. Personal Details. Surname: Isik. First Name: Ahmet. Akademic title/ position: Professor of Medicine

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1 CURRICULUM VITAE Personal Details Surname: Isik First Name: Ahmet Akademic title/ position: Professor of Medicine Key Qualifications: Internal Medicine Specialist and Romatologist Research Interest: International Experience/Collaborations: Contact Details: Work Address: Name of Hospital: Firat Universitesi Hastanesi Street: Universite Mahallesi Town: Elazig Country: Turkey Post Code: Phone/Fax: (2004) / drahmetisik@hotmail.com Date of Birth: : Place and Country of Birth:. Banaz-Uşak-Turkey Country of Citizenship: The Republic of Turkey Country of Training: Turkey First Language: Turkish Languages: English

2 Akademic Details Faculty/University ( name and address) Ataturk University Faculty of Medicine- Erzurum-Turkey Date of Graduation: 1970 Postgraduate Training: ( Name and address of Center and Supervisor [s] in charge of Training) 1-Firat University Faculty of Medicine, Department of Internal Medicine-Elazig-Turkey 2-Ege University Faculty of Medicine, Department of Rheumatology-Izmir-Turkey SUPERVISOR IN CHARGE OF TRAINING: From To Title of thesis: 1-Acute Effects of Major Calsium Antagonists (niphidipine, veraphamil, diltiasem) on Left Ventricule Functions in Patients with Systemic Hypertension and Normotensive Persons (Thesis of internal medicine) 2- Autoantibodies to Pancreas in Patients with Rheumatoid Arthritis with and without Sjögren Syndrome (Thesis of rheumatology) Accreditation: (Name, number and date of certificate issued by Universty, Medical Association or Government Body) 1-Firat University Faculty of Medicine, Department of Internal Medicine-Elazig-Turkey 2-Ege University Faculty of Medicine, Department of Rheumatology Academic Experience: Associated prof. Firat University Faculty of Medicine, Department of Internal Medicine 1997 Prof. Firat University Faculty of Medicine, Department of Internal Medicine 2006 Memberships: Society for Research and Education in Rheumatology of Turkey

3 International Publications 1. Günal A Đ, Işık A, Çeliker H, Eren O, Çelebi H, Günal S, Lüleci C Short Term Reduction of Left Ventricular Mass in Primary Hypertrophic Cardiomyopathy by Octreotid Injections. Hearth. 76: , Karaca I, Aydin K, Yavuzkir M, Ilkay E, Akbulut M, Isik A, Arslan N Predictive value of C-reactive protein in patients with unstable angina pectoris undergoing coronary artery stent implantation. Journal of International Medical Research 33 (4): JUL-AUG A. Isik, SS Koca, B Ustundag, H Celik, A Yıldırım Paraoxonase and arylesterase levels in rheumatoid arthritis Clin Rheumatol (2007) 26: A Isik, SS Koca, A Ozturk, O Mermi Anxiety and depression in patients with rheumatoid arthritis Clin Rheumatol (2007) 26: Karaca I, Coskun N, Yavuzkır M, Đlkay E, Daglı N, Işık A, Balin M, Akbulut M, Arslan N Effect of diltiazem and metoprolol on left atrial appendix functions in patients with nonvalvular chronic atrial fibrillation Anadolu Kardiyol Derg 2007; 7: Decreased total antioxidant response and increased oxidative stress in Behcet's disease Isik A, Koca SS, Ustundag B, Selek S. Tohoku Journal of Experimental Medicine 2007, Volume: 212 Issue: 2 Pages: B-type natriuretic peptide level in the diagnosis of asymptomatic diastolic dysfunction Karaca I, Gülcü E, Yavuzkir M, Dağli N, Ilkay E, Ozbay Y, Işik A, Arslan N. Anadolu Kardiyoloji Dergisi-The Anatolian Journal of Cardiology 2007, Volume: 7 Issue: 3 Pages: Effect of ongoing inflammation in rheumatoid arthritis on P-wave dispersion Yavuzkir M, Ozturk A, Dagli N, Koca S, Karaca I, Balin M, Işik A. Journal of International Medical Research 2007, Volume: 35 Pages: Anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis and Behcet's disease Koca SS, Akbulut H, Dag S, Artas H, Isik A. Tohoku Journal of Experimental Medicine 2007, Volume: 213 Pages: Effectiveness of etanercept in bleomycin-induced experimental scleroderma Koca SS, Isik A, Ozercan IH, Ustundag B, Evren B, Metin K. Rheumatology 2008, Volume: 47 Issue: 2 Pages: Serum pro-hepcidin levels in rheumatoid arthritis and systemic lupus erythematosus Koca SS, Isik A, Ustundag B, Metin K, Aksoy K. Inflammation. 2008, Volume: 31 Issue: 3 Pages:

4 12. Hepatoprotective effect of infliximab, an anti-tnf-alpha agent, on carbon tetrachlorideinduced hepatic fibrosis Bahcecioglu IH, Koca SS, Poyrazoglu OK, Yalniz M, Ozercan IH, Ustundag B, Sahin K, Dagli AF, Isik A. Inflammation. 2008, Volume: 31 Issue: 4 Pages: Ghrelin and obestatin levels in rheumatoid arthritis. Koca SS, Ozgen M, Aydin S, Dag S, Evren B, Isik A. Inflammation Oct;31(5): Serum prohepcidin level in Behçet s disease Koca SS, Ateş O, Üstündağ B, Çeliker Ü,Özgen M, Isik A. Turkiye Klinikleri J Med Sci 2008;28: Isik A, SS Koca Necrotizing fasciitis resulting from Streptococcus pneumoniae in recently diagnosed systemic lupus erythematosus case: a case report Clin Rheumatol (2007) 26: Yildirim A, Isik A, Koca S Subclavian artery pseudoaneurysm in Behcet s disease Clin Rheumatol (2007) 26: Isik A, Koca SS Osteoporosis associated with gyrate atrophy: a case report Doc Ophthalmol (2006) 113: Central retinal artery occlusion in an ANCA negative Churg-Strauss syndrome patient. Türkçüoğlu P, Isik A, Deniz N, Turgut B, Kan EK. Int Ophthalmol Dec;27(6): Presentations at International Scientific Meetings 1. Cemal Lüleci, Necip Aytuğ, Ahmet Işık, Nadi Arslan, Masis Perk. Doppler evaluation of atrial function of mitral flow after cardioversion from atrial fibrillation. Advences in Doppler Echocardiography. (Ed) Niksa Drinkovic and Anthony N. DeMaria, Zagreb, 1990, p Cemal Lüleci, Ahmet Işık, Hüseyin Çeliker, Ali Demir, Erhan Alaşehirli, Nadi Arslan. The acute effects of major calcium antagonists on left ventricular diastolic functions of hypertensive patients. 2nd International Conference on Cardiac Doppler-Echo and Color Flow Imaging. Dubrovnik, Yugoslavia. May 27-31, Cemal Lüleci, Ali Demir, Hüseyin Çeliker, Nadi Arslan, Ahmet Işık, Sedat Demir, Çiğdem Gökçe. Doppler echocardiographic evaluation of left ventricular diastolic functions in patients with essential hypertension with and without a fourth heart sound. 2nd International Conference on Cardiac Doppler-Echo and Color Flow Imaging. Dubrovnik, Yugoslavia May 27-31, 1990.

5 4 Cemal Lüleci, Ahmet Işık, Ali Demir, Hüseyin Çeliker, Mustafa Taşçı, Nadi Arslan. The acute effects of major calcium antagonists on aortic flow properties of hypertensive patients. 2nd International Conference on Cardiac Doppler-Eko and Color Flow Imaging. Dubrovnik, Yugoslavia. May 27-31, Cemal Lüleci, Ali Demir, Ahmet Işık, Hüseyin Çeliker, Nadi Arslan, Çiğdem Gökçe, Sedat Demir. Doppler ecbocardiographic evaluation of the effect of the presence of a fourth heart sound on left atrial systolic time intervals in hypertensive patients. 2nd International Conference on Cardiac Doppler-Echo and Color Flow Imaging. Dubrovnik, Yugoslavia. May 27-31, C Lüleci, S Demir, A Işık. Doppler Echocardiographic Investigations of Atrial Flow Contributions to The Cardiac Output by Increasing The Ventricular Rate in Patients Having Complete Atrioventricular Block with Artificial Ventricular Pacemakers. Kharkov/Ukraine 203, G Keser, F Oksel, V Đnal, H Koçanaoğulları, K Aksu, Y Kabasakal, A Işık, G Gümüşdiş, E Doğanavşargil. Serum Prolactin Levels in Behçet s Disease. 11th EULAR Symposium. Geneva, Switzerland. 5-8 September, (EULAR, Supplement No:2, Vol 27, 1998.) 8. Y Kabasakal, K Aksu, F Oksel, G Keser, V Đnal, H Koçanaoğulları, A Sin, A Işık, E Doğanavşargil. Antineutrophil Cytoplasmic Antibodies in Systemic Lupus Erythematosus. The Prevalance and Relation with Clinical Findings ACR Annual Scientific Meeting. Boston, Massachusetts. November 13-17, Arthritis & Rheumatism. Volume 42, No.9 (Supplement) September Işık A, Tunç E, Kitapçıoğlu G, Koçanaoğulları H, Đnal V, Doğanavşargil E, gümüşdiş G. Frequency of Autoantibodies Targeting Pancreas in Rheumatoid arthritis with and without Secondary Sjögren s Syndrome Annual European Congres of Rheumatology. Prague, Czech Republic June, Annals of the Rheumatic Diseases. Abstracts, June Aksu K, Öder GA, Kabasakal Y, Keser G, Đnal V, Işık A, Çetinkalp S, Doğanavşargil E. Incidence of pancreatic Autoantibodies in Primary Sjögren Syndrome Annual European Congres of Rheumatology. Prague, Czech Republic June, Annals of the Rheumatic Diseases. Abstracts, June I Karaca, E Gülcü, M Yavuzkır, E Đlkay, Y Özbay, A Işık, MN Dağlı, ĐN Arslan B-Type Natriuretic Peptide and the Diagnosis of Diastolic Disfunction in Hypertensive Patients Third Mediterranean Meeting on Hypertension and Atherosclerosis. Antalya-Turkey. Abstracts, April, PP 17 B12. Isik A, Koca SS Frequency of anemia and hepcidin level in Behcet s disease Arthritis and Rheumatism 54 (9): S760-S760 Suppl. S Sep 2006

6 13. Antioxidant status and oxidative stress in patients with behcet's disease Isik A, Koca S, Evren B, Ustundag B, Selek S Annual European Congress of Rheumatology (EULAR), Barcelona, June 2007 (OP0081/p76) Annals of the Rheumatic Disease Volume: 66 Pages: Published: The therapeutic roles of etanercept and thalidomide in bleomycin induced experimental scleroderma Isik A, Koca S, Evren B, Ustundag B, Ozercan I, Metin K Annual European Congress of Rheumatology (EULAR), Barcelona, June 2007 (P0279/p ) Annals of the Rheumatic Disease Volume: 66 Pages: Published: Does hepcidin take role on anemia in rheumatoid arthritis? Isik A, Koca S,Metin K, Ustundag B, Dag S Annual European Congress of Rheumatology (EULAR), Barcelona, June 2007 (P0256/p ) Annals of the Rheumatic Disease Volume: 66 Pages: Published: Prevalence and significance of MEFV gene mutations in a cohort of patient with rheumatoid arthritis Koca S, Etem E, Isik B, Yuce H, Dag S, Ozgen M, Isik A Annual European Congress of Rheumatology (EULAR), Paris, June 2008 (P0025/p145) 17. Decreased ghrelin and increased obestatin in rheumatoid arthritis Koca S, Ozgen M, Aydin S, Dag S, Isik A Annual European Congress of Rheumatology (EULAR), Paris, June 2008 (P0004/p289)