Sleijfer S, Verweij J. The Price of success: cost-effectiveness of molecularly targeted agents. Clin Pharmacol Ther Feb; 85(2):

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1 2009 Sleijfer S, Verweij J. The Price of success: cost-effectiveness of molecularly targeted agents. Clin Pharmacol Ther Feb; 85(2): Strijbos MH, Landburg PP, Nur E, Teerlink T, Leebeek FW, Rijneveld AW, Biemond BJ, Sleijfer S, Gratama JW, Duits AJ, Schnog JJ; on behalf of the CURAMA study group. Circulating endothelial cells: a potential parameter of organ damage in sickle cel anemia? Blood Cells Mol Dis Jul-Aug;43(1):63-7. Epub 2009 Apr 7. Strijbos MH, Kraan J, Lamers CHJ, Sleijfer S, Gratama JW. Quantification of circulating endothelial cells by flow cytomerty. Clin Cancer Res 2009 May 15;15(10); 3640; author reply Strijbos MH, Verhoef C, Gratama JW, Sleijfer S. On the Origin of (CD105+) circulating endothelial cells. Thromb Haemost. 2009;102(2); Jager A, Verweij J, Sleijfer S. Chemotherapy: Adjuvant chemotherapy in older patients with breast cancer. Nat Rev Clin Oncol 2009 Oct; 6(10); Kuijper TM, Ruigrok-Ritstier K, Verhoef-Post M, Piersma D, Bruysters MW, Berns EM, Themmen AP. LH receptor gene expression is essentially absent in breast tumor tissue: implications for treatment. Mol Cell Endocrinol Apr 10;302(1): Epub 2009 Jan 20. Trinh XB, Tjalma WA, Vermeulen PB, Van den Eynden G, Van der Auwera I, Van Laere SJ, Helleman J, Berns EM, Dirix LY, van Dam PA. The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer. Br J Cancer Mar 24;100(6): Epub 2009 Feb 24. Kuijper A, Snijders AM, Berns EM, Kuenen-Boumeester V, van der Wall E, Albertson DG, van Diest PJ. Genomic profiling by array comparative genomic hybridization reveals novel DNA copy number changes in breast phyllodes tumours. Cell Oncol. 2009;31(1):31-9. Jansen MP, Ruigrok-Ritstier K, Dorssers LC, van Staveren IL, Look MP, Meijer-van Gelder ME, Sieuwerts AM, Helleman J, Sleijfer S, Klijn JG, Foekens JA, Berns EM. Downregulation of SIAH2, an ubiquitin E3 ligase, is associated with resistance to endocrine therapy in breast cancer. Breast Cancer Res Treat Jul;116(2): Epub 2008 Jul 16. Kok M, Linn SC, Van Laar RK, Jansen MP, van den Berg TM, Delahaye LJ, Glas AM, Peterse JL, Hauptmann M, Foekens JA, Klijn JG, Wessels LF, Van't Veer LJ, Berns EM. Comparison of gene expression profiles predicting progression in breast cancer patients treated with tamoxifen. Breast Cancer Res Treat Jan;113(2): Epub 2008 Mar 4. Meijer D, Jansen MP, Look MP, Ruigrok-Ritstier K, van Staveren IL, Sieuwerts AM, van Agthoven T, Foekens JA, Dorssers LC, Berns EM. TSC22D1 and PSAP predict clinical outcome of tamoxifen treatment in patients with recurrent breast cancer. Breast Cancer Res Treat Jan;113(2): Epub 2008 Feb 26.

2 de Boer M, van Deurzen CH, van Dijck JA, Borm GF, van Diest PJ, Adang EM, Nortier JW, Rutgers EJ, Seynaeve C, Menke-Pluymers MB, Bult P, Tjan-Heijnen VC. Micrometastases or isolated tumor cells and the outcome of breast cancer. N Engl J Med Aug 13;361(7): Milne RL, Benítez J, Nevanlinna H, Heikkinen T, Aittomäki K, Blomqvist C, Arias JI, Zamora MP, Burwinkel B, Bartram CR, Meindl A, Schmutzler RK, Cox A, Brock I, Elliott G, Reed MW, Southey MC, Smith L, Spurdle AB, Hopper JL, Couch FJ, Olson JE, Wang X, Fredericksen Z, Schürmann P, Bremer M, Hillemanns P, Dörk T, Devilee P, van Asperen CJ, Tollenaar RA, Seynaeve C, Hall P, Czene K, Liu J, Li Y, Ahmed S, Dunning AM, Maranian M, Pharoah PD, Chenevix-Trench G, Beesley J; kconfab Investigators; AOCS Group, Bogdanova NV, Antonenkova NN, Zalutsky IV, Anton-Culver H, Ziogas A, Brauch H, Justenhoven C, Ko YD, Haas S, Fasching PA, Strick R, Ekici AB, Beckmann MW, Giles GG, Severi G, Baglietto L, English DR, Fletcher O, Johnson N, dos Santos Silva I, Peto J, Turnbull C, Hines S, Renwick A, Rahman N, Nordestgaard BG, Bojesen SE, Flyger H, Kang D, Yoo KY, Noh DY, Mannermaa A, Kataja V, Kosma VM, García-Closas M, Chanock S, Lissowska J, Brinton LA, Chang-Claude J, Wang- Gohrke S, Shen CY, Wang HC, Yu JC, Chen ST, Bermisheva M, Nikolaeva T, Khusnutdinova E, Humphreys MK, Morrison J, Platte R, Easton DF; Breast Cancer Association Consortium. Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35- rs J Natl Cancer Inst Jul 15;101(14): Kriege M, Seynaeve C, Meijers-Heijboer H, Collee JM, Menke-Pluymers MB, Bartels CC, Tilanus- Linthorst MM, Blom J, Huijskens E, Jager A, van den Ouweland A, van Geel B, Hooning MJ, Brekelmans CT, Klijn JG. Sensitivity to first-line chemotherapy for metastatic breast cancer in BRCA1 and BRCA2 mutation carriers. J Clin Oncol Aug 10;27(23): Gaudet MM, Milne RL, Cox A, Camp NJ, Goode EL, Humphreys MK, Dunning AM, Morrison J, Giles GG, Severi G, Baglietto L, English DR, Couch FJ, Olson JE, Wang X, Chang-Claude J, Flesch-Janys D, Abbas S, Salazar R, Mannermaa A, Kataja V, Kosma VM, Lindblom A, Margolin S, Heikkinen T, Kämpjärvi K, Aaltonen K, Nevanlinna H, Bogdanova N, Coinac I, Schürmann P, Dörk T, Bartram CR, Schmutzler RK, Tchatchou S, Burwinkel B, Brauch H, Torres D, Hamann U, Justenhoven C, Ribas G, Arias JI, Benitez J, Bojesen SE, Nordestgaard BG, Flyger HL, Peto J, Fletcher O, Johnson N, Dos Santos Silva I, Fasching PA, Beckmann MW, Strick R, Ekici AB, Broeks A, Schmidt MK, van Leeuwen FE, Van't Veer LJ, Southey MC, Hopper JL, Apicella C, Haiman CA, Henderson BE, Le Marchand L, Kolonel LN, Kristensen V, Grenaker Alnaes G, Hunter DJ, Kraft P, Cox DG, Hankinson SE, Seynaeve C, Vreeswijk MP, Tollenaar RA, Devilee P, Chanock S, Lissowska J, Brinton L, Peplonska B, Czene K, Hall P, Li Y, Liu J, Balasubramanian S, Rafii S, Reed MW, Pooley KA, Conroy D, Baynes C, Kang D, Yoo KY, Noh DY, Ahn SH, Shen CY, Wang HC, Yu JC, Wu PE, Anton-Culver H, Ziogoas A, Egan K, Newcomb P, Titus- Ernstoff L, Trentham Dietz A, Sigurdson AJ, Alexander BH, Bhatti P, Allen-Brady K, Cannon-Albright LA, Wong J; Australian Ovarian Cancer Study Group, Chenevix-Trench G, Spurdle AB, Beesley J, Pharoah PD, Easton DF, Garcia-Closas M; Breast Cancer Association Consortium. Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev May;18(5): Tan MB, Bleiker EM, Menke-Pluymers MB, Van Gool AR, van Dooren S, Van Geel BN, Tilanus-Linthorst MM, Bartels KC, Klijn JG, Brekelmans CT, Seynaeve C. Standard psychological consultations and follow up for women at increased risk of hereditary breast cancer considering prophylactic mastectomy. Hered Cancer Clin Pract Mar 31;7(1):6. Ahmed S, Thomas G, Ghoussaini M, Healey CS, Humphreys MK, Platte R, Morrison J, Maranian M, Pooley KA, Luben R, Eccles D, Evans DG, Fletcher O, Johnson N, dos Santos Silva I, Peto J, Stratton MR, Rahman N, Jacobs K, Prentice R, Anderson GL, Rajkovic A, Curb JD, Ziegler RG, Berg CD, Buys SS, McCarty CA, Feigelson HS, Calle EE, Thun MJ, Diver WR, Bojesen S, Nordestgaard BG, Flyger H,

3 Dörk T, Schürmann P, Hillemanns P, Karstens JH, Bogdanova NV, Antonenkova NN, Zalutsky IV, Bermisheva M, Fedorova S, Khusnutdinova E; SEARCH, Kang D, Yoo KY, Noh DY, Ahn SH, Devilee P, van Asperen CJ, Tollenaar RA, Seynaeve C, Garcia-Closas M, Lissowska J, Brinton L, Peplonska B, Nevanlinna H, Heikkinen T, Aittomäki K, Blomqvist C, Hopper JL, Southey MC, Smith L, Spurdle AB, Schmidt MK, Broeks A, van Hien RR, Cornelissen S, Milne RL, Ribas G, González-Neira A, Benitez J, Schmutzler RK, Burwinkel B, Bartram CR, Meindl A, Brauch H, Justenhoven C, Hamann U; GENICA Consortium, Chang-Claude J, Hein R, Wang-Gohrke S, Lindblom A, Margolin S, Mannermaa A, Kosma VM, Kataja V, Olson JE, Wang X, Fredericksen Z, Giles GG, Severi G, Baglietto L, English DR, Hankinson SE, Cox DG, Kraft P, Vatten LJ, Hveem K, Kumle M, Sigurdson A, Doody M, Bhatti P, Alexander BH, Hooning MJ, van den Ouweland AM, Oldenburg RA, Schutte M, Hall P, Czene K, Liu J, Li Y, Cox A, Elliott G, Brock I, Reed MW, Shen CY, Yu JC, Hsu GC, Chen ST, Anton-Culver H, Ziogas A, Andrulis IL, Knight JA; kconfab; Australian Ovarian Cancer Study Group, Beesley J, Goode EL, Couch F, Chenevix-Trench G, Hoover RN, Ponder BA, Hunter DJ, Pharoah PD, Dunning AM, Chanock SJ, Easton DF. Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet May;41(5): van Dooren S, Duivenvoorden HJ, Passchier J, Bannink M, Tan MB, Oldenmenger WH, Seynaeve C, van der Rijt CC. The Distress Thermometer assessed in women at risk of developing hereditary breast cancer. Psychooncology Oct;18(10): Johnatty SE, Couch FJ, Fredericksen Z, Tarrell R, Spurdle AB, Beesley J, Chen X; kconfab Investigators; AOCS Group; Swedish BRCA1 and BRCA2 Study Collaborators, Gschwantler-Kaulich D, Singer CF, Fuerhauser C, Fink-Retter A, Domchek SM, Nathanson KL, Pankratz VS, Lindor NM, Godwin AK, Caligo MA, Hopper J, Southey MC, Giles GG, Justenhoven C, Brauch H, Hamann U, Ko YD, Heikkinen T, Aaltonen K, Aittomäki K, Blomqvist C, Nevanlinna H, Hall P, Czene K, Liu J, Peock S, Cook M, Platte R, Gareth Evans D, Lalloo F, Eeles R, Pichert G, Eccles D, Davidson R, Cole T, Cook J, Douglas F, Chu C, Hodgson S, Paterson J, Hogervorst FB, Rookus MA, Seyneave C, Wijnen J, Vreeswijk M, Ligtenberg M, van der Luijt RB, van Os TA, Gille HJ, Blok MJ; HEBON, Issacs C, Humphreys MK, McGuffog L, Healey S, Sinilnikova O, Antoniou AC, Easton DF, Chenevix-Trench G; Breast Cancer Association Consortium and Consortium of Investigators of Modifiers of BRCA1/2. No evidence that GATA3 rs SNP modifies breast cancer risk. Breast Cancer Res Treat Sep;117(2): Schilder CM, Eggens PC, Seynaeve C, Linn SC, Boogerd W, Gundy CM, Beex LV, Van Dam FS, Schagen SB. Neuropsychological functioning in postmenopausal breast cancer patients treated with tamoxifen or exemestane after AC-chemotherapy: cross-sectional findings from the neuropsychological TEAM-side study. Acta Oncol. 2009;48(1): Span PN, Sieuwerts AM, Heuvel JJ, Spyratos F, Duffy MJ, Eppenberger-Castori S, Vacher S, O'Brien K, McKiernan E, Pierce A, Vuaroqueaux V, Foekens JA, Sweep FC, Martens JW. Harmonisation of multi-centre real-time reverse-transcribed PCR results of a candidate prognostic marker in breast cancer: an EU-FP6 supported study of members of the EORTC - PathoBiology Group. Eur J Cancer Jan;45(1): Duffy MJ, Napieralski R, Martens JW, Span PN, Spyratos F, Sweep FC, Brunner N, Foekens JA, Schmitt M; EORTC PathoBiology Group. Methylated genes as new cancer biomarkers. Eur J Cancer Feb;45(3): Hartmann O, Spyratos F, Harbeck N, Dietrich D, Fassbender A, Schmitt M, Eppenberger-Castori S, Vuaroqueaux V, Lerebours F, Welzel K, Maier S, Plum A, Niemann S, Foekens JA, Lesche R, Martens JW.

4 DNA methylation markers predict outcome in node-positive, estrogen receptor-positive breast cancer with adjuvant anthracycline-based chemotherapy. Clin Cancer Res Jan 1;15(1): Sieuwerts AM, Kraan J, Bolt J, van der Spoel P, Elstrodt F, Schutte M, Martens JW, Gratama JW, Sleijfer S, Foekens JA. Anti-epithelial cell adhesion molecule antibodies and the detection of circulating normal-like breast tumor cells. J Natl Cancer Inst Jan 7;101(1): van Agthoven T, Sieuwerts AM, Meijer-van Gelder ME, Look MP, Smid M, Veldscholte J, Sleijfer S, Foekens JA, Dorssers LC. Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance. J Clin Oncol Feb 1;27(4): Creighton CJ, Kent Osborne C, van de Vijver MJ, Foekens JA, Klijn JG, Horlings HM, Nuyten D, Wang Y, Zhang Y, Chamness GC, Hilsenbeck SG, Lee AV, Schiff R. Molecular profiles of progesterone receptor loss in human breast tumors. Breast Cancer Res Treat Mar;114(2): Zhang Y, Martens JW, Yu JX, Jiang J, Sieuwerts AM, Smid M, Klijn JG, Wang Y, Foekens JA. Copy Number Alterations that Predict Metastatic Capability of Human Breast Cancer. Cancer Res May 1;69(9): Umar A, Kang H, Timmermans AM, Look MP, Meijer-van Gelder ME, den Bakker MA, Jaitly N, Martens JW, Luider TM, Foekens JA, Pasa-Tolic L. Identification of a putative protein profile associating with tamoxifen therapy-resistance in breast cancer. Mol Cell Proteomics Jun;8(6): Martens JW, Margossian AL, Schmitt M, Foekens J, Harbeck N. DNA methylation asa biomarker in breast cancer. Future Oncol Oct;5(8): Stephens PJ, McBride DJ, Lin ML, Varela I, Pleasance ED, Simpson JT, Stebbings LA, Leroy C, Edkins S, Mudie LJ, Greenman CD, Jia M, Latimer C, Teague JW, Lau KW, Burton J, Quail MA, Swerdlow H, Churcher C, Natrajan R, Sieuwerts AM, Martens JW, Silver DP, Langerød A, Russnes HE, Foekens JA, Reis-Filho JS, van 't Veer L, Richardson AL, Børresen-Dale AL, Campbell PJ, Futreal PA, Stratton MR. Complex landscapes of somatic rearrangement in human breast cancer genomes. Nature Dec 24;462(7276): Ng SS, Mahmoudi T, Danenberg E, Bejaoui I, de Lau W, Korswagen HC, Schutte M, Clevers H. Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade. J Biol Chem Dec 18;284(51): Sieuwerts AM, Kraan J, Bolt-de Vries J, van der Spoel P, Mostert B, Martens JW, Gratama JW, Sleijfer S, Foekens JA. Molecular characterization of circulating tumor cells in large quantities of contaminating leukocytes by a multiplex real-time PCR. Breast Cancer Res Treat Dec;118(3): Van Agthoven T, Sieuwerts A, Meijer D, Meijer-van Gelder M, Van Agthoven T, Sarwari R, Sleijfer S, Foekens J, Dorssers L.

5 Selective recruitment of breast cancer anti-estrogen resistance genes and relevance for breast cancer progression and tamoxifen therapy response. Endocr Relat Cancer Dec 4. Van Agthoven T, Sieuwerts AM, Veldscholte J, Meijer-van Gelder ME, Smid M, Brinkman A, den Dekker AT, Leroy IM, van Ijcken WF, Sleijfer S, Foekens JA, Dorssers LC. CITED2 and NCOR2 in anti-oestrogen resistance and progression of breast cancer. Br J Cancer Dec 1;101(11): Wasielewski M, Riaz M, Vermeulen J, van den Ouweland A, Labrijn-Marks I, Olmer R, van der Spaa L, Klijn JG, Meijers-Heijboer H, Dooijes D, Schutte M. Association of rare MSH6 variants with familial breast cancer. Breast Cancer Res Treat Nov 19. Hollestelle A, Schutte M. Comment Re: MDA-MB-435 and M14 cell lines: identical but not M14 Melanoma? Cancer Res Oct 1;69(19):7893. Schmitt M, Foekens JA. Circulating tumor cells in blood of primary breast cancer patients assessed by a novel RT-PCR test kit and comparison with status of bone marrow-disseminated tumor cells. Breast Cancer Res. 2009;11(5):109. Hsieh SM, Look MP, Sieuwerts AM, Foekens JA, Hunter KW. Distinct inherited metastasis susceptibility exists for different breast cancer subtypes: a prognosis study. Breast Cancer Res. 2009;11(5):R75. Hollestelle A, Elstrodt F, Timmermans M, Sieuwerts AM, Klijn JG, Foekens JA, den Bakker MA, Schutte M. Four human breast cancer cell lines with biallelic inactivating alpha-catenin gene mutations. Breast Cancer Res Treat Sep 18. Toussaint J, Sieuwerts AM, Haibe-Kains B, Desmedt C, Rouas G, Harris AL, Larsimont D, Piccart M, Foekens JA, Durbecq V, Sotiriou C. Improvement of the clinical applicability of the Genomic Grade Index through a qrt-pcr test performed on frozen and formalin-fixed paraffin-embedded tissues. BMC Genomics Sep 10;10:424 Schrohl AS, Look MP, Meijer-van Gelder ME, Foekens JA, Brünner N. Tumor tissue levels of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) and outcome following adjuvant chemotherapy in premenopausal lymph node-positive breast cancer patients: A retrospective study. BMC Cancer Sep 10;9:322. Klintman M, Ornbjerg Würtz S, Christensen IJ, Bræmer Hertel P, Fernö M, Malmberg M, Mouridsen H, Cold F, Schrohl AS, Foekens JA, Malmström P, Brünner N. Association between tumor tissue TIMP-1 levels and objective response to first-line chemotherapy in metastatic breast cancer. Breast Cancer Res Treat Aug 4. Mostert B, Sleijfer S, Foekens JA, Gratama JW. Circulating tumor cells (CTCs): detection methods and their clinical relevance in breast cancer. Cancer Treat Rev Aug;35(5): Alles CM, Gardiner-Garden M, Nott DJ, Wang Y, Foekens JA, Sutherland RL, Musgrove EA, Ormandy J. Meta-analysis and gene enrichment relative to ER status reveal elevated activity of MYC and E2F in the basal breast cancer subgroup.

6 PloS One 4: e4710 (2009). Wasielweski M, den Bakker MA, Meijer-van gelder ME, van den Ouweland A, Portengen H, Klijn JGM, Meijers-Heijboer H, Foekens JA, Schutte M. CEK21100delC associates with male breast cancer in the Netherlands. Breast Cancer Res Treatm 116: (2009). Zhang Y, Sieuwerts AM, Mc Greevy M, Casey G, Cufer T, Paradiso A, Harbeck N, Span P, Hicks DG, Crowe J, Tubbs RR, Budd GT, Lyons J, Sweep CGJ, Schmitt M, Schittulli F, Golouh R, Talantov D, Wang Y, Foekens JA. The 76-Gene signature defines high-risk patients that benefit from adjuvant tamoxifen therapy. Breast Cancer Res Treatm 116: (2009). Bos PD, Zhang XHF, nadal C, Shu W, Gomis RR, Nguyen D, Minn AJ, van de Vijver MJ, Gerald W, Foekens JA, Massagué J. Genes that mediate breast cancer metastasis through the blood-brain barrier. Nature 459: (2009). Zhang XHF, Wang Q, Gerals W, Smid M, Foekens JA, Massagué J. Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell 16: (2009). Kreike B, Halfwerk H, Amstrong N, Bult P, Foekens JA, Veltkamp SC, Nuyten D, Bartelink H, van de Vijver MJ. Local recurrence after breast-conserving therapy in relation to gene expression patterns in large series of patients. Clin Cancer Res 15: (2009). Riaz M, Elstrodt F, Hollestelle A, Dehghan A, Klijn JG, Schutte M. Low-risk susceptibility alleles in 40 human breast cancer cell lines. BMC Cancer Jul 16;9:236. Wasielewski M, Hanifi-Moghaddam P, Hollestelle A, Merajver SD, van den Ouweland A, Klijn JG, Ethier SP, Schutte M. Deleterious CHEK2 1100delC and L303X mutants identified among 38 human breast cancer cell lines. Breast Cancer Res Treat Jan;113(2): Buiting H, Van Delden J, Onwuteaka-Philipsen B, Rietjens J, Rurup M, Van Tol D, Gevers J, Van der Maas P, Van der Heide A. Reporting of euthanasia and physician-assisted suicide in the Netherlands: descriptive study. BMC Med Ethics 2009; 27: Rietjens JA, Van Tol DG, Schermer M, Van der Heide A. Judgement of suffering in the case of a euthanasia request in the Netherlands. J Med Ethics 2009; 35: Rietjens JA, Buiting HM, Pasman HR, Van der Maas PJ, Van Delden JJ, Van der Heide A. Deciding about continuous deep sedation: physicians perspective: a focus group study. Palliative Med 2009; 23: Van Dooren S, Van Veluw H, Van Zuylen L, Rietjens J, Passchier J, Van der Rijt CCD Exploration of concerns of relatives during continuous palliative sedation of their family members with cancer. J Pain Symptom Manage 2009; 38: Oldenmenger WH, Sillevis Smitt PAE, Van Dooren S, Stoter G, Van der Rijt CCD.

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10 Ray-Coquard I, Cropet C, Van Glabbeke M, Sebban C, Le Cesne A, Judson I, Tredan O, Verweij J, Biron P, Inthibar L, Guastalla J-P, Bachelot T, Perol D, Chabaud S, Hogendoorn P, Cassier P, Dufresne A and Blay J-Y, on behalf of the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Lymphopenia as a prognostic factor for overall survival in advanced carcinomas, sarcomas and lymphomas. Cancer Res 69: , 2009 Romeo S, Debiec-Rychter M, Van Glabbeke M, Van Paassen H, Comite P, Van Eijk R, Oosting J, Verweij J, Terrier P, Schneider U, Sciot R, Blay J-Y and Hogendoorn PCW, on behalf of the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Cell cycle/apoptosis molecule expression correlates with imatinib response in patients with advanced gastrointestinal stromal tumors. Clin Cancer Res 15: , 2009 Baird RD, Clarke P, Planting A, Kitzen J, Reade S, Reid A, Lyndsey W, Lazaro LL, De las Heras B, Judson IR, Pico C, Kaye SB, Eskens F, Workman P, De Bono JS, Verweij J Phase I safety, pharmacokinetic nad pharmacogenomic trial of ES-285, a novel marine cytotoxic agent administered as an infusion over 24h every 21 days in patients with solid tumours. Mol Cancer Ther 6: , 2009 Casali PG, Jost L, Sleijfer S, Verweij J, Blay J-Y on behalf of the ESMO Guidelines Working Group: Soft tissue sarcomas: ESMO Clinical Recommendations for diagnosis, treatment and follow-up Ann Oncol 20: , 2009 Sleijfer S, Ray-Coquard I, Papai Z, Le Cesne A, Scurr M, Schöffski P, Collin F, Pandite L, Marreaud S, De Brauwer A, Van Glabbeke M, Verweij J, Blay J-Y: Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group (EORTC study 62043) J Clin Oncol 27: , 2009 Verweij J: Soft tissue sarcoma trials: one size no longer fits all J Clin Oncol 27: , 2009 Le Cesne A, Van Glabbeke M, Verweij J, Casali P, Findlay M,, Reichardt P, Issels R, Judson I, Schoffski P, Leyvraz S, Bui B, Hogendoorn P, Sciot R, Blay JY: Absence of progression as assessed by Response Evaluation Criteria in Solid Tumors predicts survival in advanced GI stromacel tumors treated with imatinib mesylate: The intergroup EORTC-ISG-AGITG phase III trial J Clin Oncol 27: , 2009 DePrimo SE., Huang X, Blackstein ME, Garrett CR, Harmon CS, Schoffski P, Shah MH Verweij J, Baum CM, Demetri GD: Circulating levels of soluble KIT serve as a biomarker for clinical outcome in Gastrointestinal stromal tumor patients receiving sunitinib following imatinib failure. Clinical Cancer Research 15: , 2009 Jager A, Verweij J, Sleijfer S: Adjuvant chemotherapy in older breast cancer patients Nat Rev Clin Oncol 6: , 2009 Hamberg P, Verweij J

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