DRUG DESIGN AND DEVELOPMENT CENTRE (DDDC) M. S. Ramaiah University of Applied Sciences
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1 DRUG DESIGN AND DEVELOPMENT CENTRE (DDDC) 1
2 Dr. Sarasija Suresh Dr. S. Bharath Dr. R. Deveswaran Dr. Anita Murali Dr. J. Anbu Dr. Harish Kumar D.R Dr. R. S. R. Murthy Dr. S. N. Yoganarasimhan Dr. V. Madhavan 2
3 Need for Drug Design and Development Centre To develop delivery systems through state of the art technologies for improvement of clinical efficacy of new and existing drugs. Major area of pharmaceutical research benefit to patient As an alternative for time consuming and expensive new drug discovery Unmet need in India for R & D in advanced drug delivery research 3
4 Global Drug Research in Pharmaceutical Sciences 10.3% 18.2% 40.9% 30.6% 4
5 Drug Delivery Systems in Therapy Products Extended release Ciprofloxacin Mylan, USA Company Long-acting Insulin Novo-Nordisk, Denmark Transdermal systems Nitroglycerin- NITRO-DUR Merck, Germany Transiderm-Nitro patches Novartis, Switzerland 5
6 Drug Delivery Research Centers In India NIPERs ICT, Mumbai Research Centers in India Sree Chitra Institute of Medical Sciences Few UNIVERSITY DEPARTMENTS CDRI, Lucknow Although research in pharmaceutical sciences is conducted, dedicated research on advanced drug delivery is not undertaken 6
7 Why MSRUAS? The Drug Design and Development Centre at MSRUAS is a dedicated centre for advanced drug delivery research: Expertise in drug delivery technologies Interdisciplinary team Potential for Bench to Bedside research 7
8 Drug Design and Delivery Centre Vision To develop safe & efficacious drug products for patient benefit Mission Conduct research and development by combining scientific innovations with business and through collaboration 8
9 Aim Drug Design and Delivery Centre To create a Centre of Excellence in Pharmaceutical Research Objectives To develop new and novel technologies including nanomedicine with enhanced efficacy by way of sponsored research To establish industry-institute interaction to undertake research projects and for translating research into products To foster collaboration with institutions in India and abroad in the area of advanced drug delivery and to understand impact at molecular and genomic levels 9
10 Areas of Expertise Available Bioavailability Improvement Tablets Mathematical modeling IVIVC TECHNOLOGIES Increase in plasma half life Injections Improved drug efficasy Inhalation Immediate action Mouth dissolving tablets 10
11 Facilities, Faculty of Pharmacy Development of Conventional Products Tablets, capsules, injections and Topical products Evaluation In vitro & In Vivo characterization & evaluation In Vivo Studies Pharmacokinetic & Pharmacodynamic studies Target drug delivery using Nanotechnology 11
12 Facilities Envisaged 12
13 13
14 Proposal for Undertake product development with Industrial Partners Initiate sponsored research Undertake sponsored research & Establishment of state of art facilities for advanced research in delivery systems Road Map Evaluation Studies- in vivo and at molecular level Publications Presentation Sponsored research with national and international agencies Patents Publications Establish Centre of Excellence in Advanced Pharmaceutical Research
15 15
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