Alice M. Boylan, M.D. Curriculum Vitae

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1 Alice M. Boylan, M.D. Curriculum Vitae SCHOOL ADDRESS Division of Pulmonary Department of Medicine College of Medicine 96 Jonathan Lucas Street C.S.B. Suite 812 MSC 630 Charleston SC EDUCATION Year Institution Degree Major 1979 Dickinson College B.S Temple University M.D. Medicine POSTDOCTORAL EDUCATION Year Institution Role University of California, San Francisco Research Fellow, Cardiovascular Research Institute University of California, San Francisco Fellow in Pulmonary Disease and Critical Care Dartmouth Hitchcock Medical Center, Hanover, Hew Hampshire Intern and Resident, Internal Medicine LICENSURE AND CERTIFICATION Year Description 01/1995 Licensure - SC Medical License 01/2002 Certification - Pulmonary Disease, American Board of Internal Medicine 01/2002 Certification - Critical Care Medicine, American Board of Internal Medicine 01/1988 Certification - Internal Medicine, American Board of Internal Medicine FACULTY APPOINTMENTS Year Institution Role Present Medical University of South Carolina, Medicine, Division of Pulmonary Associate Professor Present Medical University of South Carolina, Graduate Studies Associate Medical University of South Carolina, Medicine, Division of Pulmonary Assistant Professor University of California, San Francisco Assistant Professor of Medicine PROFESSIONAL SOCIETIES/ASSOCIATIONS - INTERNATIONAL American Thoracic Society Society of Critical Care Medicine International Mesothelioma Interest Group PROFESSIONAL SOCIETIES/ASSOCIATIONS - LOCAL Associate of the Graduate Faculty, College of Graduate Studies, Medical University of South Carolina Hollings Cancer Center BOOKS EDITED Page 1 / 6

2 American Review of Respiratory Cell and Molecular Biology EDITORIAL SERVICE FOR JOURNAL American Review of Respiratory Disease JOURNAL ARTICLES REVIEWED International Journal of Cancer Cancer Research Chest 2011 ISRN Pulmonology Editorial review board. EDITORIAL REVIEW BOARD ATS "Gene Express" Deputy Editor International Mesothelioma Interest Group Web Site Deputy Editor HOSPITAL COMMITTEES Year Name of Committee Role Institution Present Faculty Senate Institutional Advancement Committee Medical University of South Carolina Present Medical Executive Committee Medical University of South Carolina Present Clinical Laboratory Advisory Committee Co-Chair Medical University of South Carolina Present Strategic Planning Committee for Driving Strategy F1 Co-Leader Medical University of South Carolina Present Department of Medicine Peer Review Committee Medical University of South Carolina Present Improve Committee Medical University of South Carolina Present Faculty Senate Medical University of South Carolina Present Clinical Documentation Committee Medical University of South Carolina Present Critical Care Steering Committee Co-Chair Medical University of South Carolina Present Emergency Teams Committee Medical University of South Carolina Present Venous Access Committee Medical University of South Carolina Present Medical Acute and Critical Care Services Director Medical University Hospital Authority Critical Care Task Force Medical University of South Carolina Present Critical Care Committee Co-Chair Medical University of South Carolina Present MET/Mayday Team Committee Medical University Hospital Authority Stroke Committee Medical University of South Carolina Respiratory Therapy Quality Improvement Committee Chair Medical University Hospital Authority Present Adult and Pediatric Respiratory Therapy Director Medical University Hospital Authority Present MICU/MSICU Quality Improvement Committee Medical University Hospital Authority Critical Care Quality Improvement Committee Chair Medical University of South Carolina Infection Control Committee Ralph H Johnson VA ER Committee Medical University of South Carolina 2003 Transplant Committee Medical Univeristy of South Carolina Present Critical Care Committee Medical University of South Carolina Medical Intensive Care Unit Director Medical University Hospital Authority Present Ethics Committee Ralph H. Johnson VA Medical Center Pharmacy and Therapeutics Committee Ralph H Johnson VA Medical Center EXTERNAL GOVERNANCE OR COMMITTEES Year Name of Committee Role Institution Correlative Disease Section CALGB (Cancer and Leukemia Group B) Correlative Disease Section NIH site review Grant Review Services NIH Present Education Committee ATS Present Acute Liver Failure Study Group Page 2 / 6

3 2005 Ad hoc NIH/NCI study section Grant Review Services NIH/NCI Present Respiratory Cell Molecular Biology Planning Committee ATS Respiratory Cell Molecular Biology Nomination Committee Chairman ATS Coastal Carolina Cancer Control Program Coastal Carolina Cancer Control Program 2001 NIH study section, Lung Biology and Pathology Grant Review Services NIH Respiratory Cell Molecular Biology Program Committee Chairman ATS Lung Conference Program Committee ALA TriState 1998 American Heart Association Grant Review Services American Heart Association 1998 NIH Site Review Grant Review Services NIH TEACHING EXPERIENCE/CURRICULUM DEVELOPMENT Year Title/Description Assisted in development of a critical care lecture series for pulmonary fellows. Helped develop a multidisciplinary critical care grand rounds. Developed a critical care M and M for pulmonary. Instructor/supervising physician for 4 critical care nurse practioner students from University of South Carolina. One per year over the past 4 years Assisted in development of core lecture series for medicine residents rotating through the MICU Present Preceptor Acute Care Nurse Practioner Program, University of South Carolina, present (4 students to date) Preceptor, Physical Diagnosis Preceptor, Clinical Correlates, 3rd year students INVITED PRESENTATIONS 1. ATS 2007 Genetics of Lung Cancer, May Spanish Respiratory Society, Featured Speaker Symposium on Pleural Diseases, December, ATS 2002, the First Whole Earth Genomics Course, May Advances in Internal Medicine, 18th Annual, San Francisco, California, "Pleural effusions: an update." 5. ATS 2001 International Conference. May Malignant mesothelioma: where are we going?. 6. Tenth Charleston Pulmonary Symposium. March, "Occupational lung disease. 7. Chest 2000 Conference How to manage malignant mesothelioma in October, Chest 2000 Conference Malignant mesothelioma: new insights into the biology and current management. October, Tenth Charleston Pulmonary Symposium. March, "Asbestos pleuro-pulmonary disease. 10. ALA/ATS 1999 International Conference. April, New concepts in the diagnosis and management of diffuse malignant mesothelioma." 11. ALA/ATS 1999 International Conference. April, New insights into the biology and management of malignant mesothelioma." 12. Visiting Professor, Yale University Medical Center Dec, "Mesothelioma 1998-with special reference to advances in therapy." 13. MUSC Department of Medicine Research Grand Rounds Dec, "Molecular markers of pleural micrometastatic disease in resected NSCLC." 14. Dr. Samuel Jaffe Memorial Lecturer, Mount Sinai Medical Center. Nov, "New therapies for mesothelioma." 15. ALA/ATS 1998 International Conference. April, "Malignant mesothelioma: Diagnosis and treatment." 16. Eighth Charleston Pulmonary Symposium. March, "Critical care of the pregnant patient." 17. 3rd International Conference on Gene Regulation, Oncogenesis, AIDS. Sept, "Insights into the molecular interaction of asbestos and the mesothelial cell." 18. ALA/ATS 1997 International Conference. May, "Novel Approaches to therapy of diffuse malignant mesothelioma." 19. Seventh Charleston Pulmonary Symposium. March, "Gene therapy of inherited and acquired lung diseases." 20. Visiting Scientist, University of Washington Medical Center, Seattle, WA Dec, "Mechanisms of asbestos-induced apoptosis of pleural mesothelial cells." 21. Medical Grand Rounds, Medical University of South Carolina. November, "Update on mesothelioma." 22. Sixth Charleston Pulmonary Symposium. March, "Malignant pleural mesothelioma." 23. Visiting Scientist, Dartmouth-Hitchcock Medical Center, Hanover, NH "The role of avb5 in the internalization of crocidolite asbestos by pleural mesothelial cells." 24. Visiting Scientist, University of South Carolina, Charleston, SC. October, "The molecular interaction of asbestos and the mesothelial cell." 25. UCSF Pulmonary Research Group, 5th Annual Meeting, September "Insights into the mechanism of asbestos uptake by mesothelial cells." 26. UCSF Occupational Medicine Research Conference, March, "The role of integrins in asbestos uptake and injury." 27. Pulmonary Grand Rounds, Moffitt Hospital, June "Management of bronchopleural fistula." 28. Advances in Internal Medicine, 18th Annual, San Francisco, California, "Pleural effusions: an update." 29. Cardiovascular Research Institute, Pulmonary Biology Research Conference, "Pleural inflammation and the role of the mesothelial cell." ACCEPTED PRESENTATIONS Co-chair, Thoracic malignancies state of the art course, American Thoracic Society Co-chair, Mesothelioma and translational pleural disease, American Thoracic Society Co-chair, Pleural diseases, American Thoracic Society Co-chair, Whole earth genomics, do it yourself course, American Thoracic Society Co-chair, "research in the assemblies: year in review, American Thoracic Society Co-chair, Poster discussion Malignant mesothelioma, American Thoracic Society Page 3 / 6

4 Co-chair, Whole earth genomics course, American Thoracic Society Co-chair, "Evolving concepts in mesothelioma. Minisymposium, American Thoracic Society Co-chair, "Mouse transgeneics and knockouts as tools to define the role of cytokines in lung inflammation and fibrosis. Minisymposium, American Thoracic Society Co-chair, "research in the assemblies: year in review, American Thoracic Society Chairman, "Postgraduate Course-Molecular Biology Techniques for the Study of Lung Diseases" Co-Chair, "Pleural Malignancy", American Thoracic Society Chairman, "Postgraduate Course-Advanced Techniques in Immunology and Molecular Biology" American Thoracic Society Co-Chair, "Pathophysiology, diagnosis, and management of pleural disease" Poster discussion, American Thoracic Society Chairman, "Postgraduate Course-Advanced Molecular Biology Techniques", American Thoracic Society Co-Chair, "Pleural Disease: Clinical Insights" Poster discussion, American Thoracic Society CHAPTERS OR OTHER PARTS OF BOOK 1. Boylan AM, Broaddus VC. The pleura. In: ATS Respiratory Book. (2010). 2. Boylan AM, Broaddus VC. Tumors of the pleura. In: Textbook of Respiratory Medicine. 4 th Edition. Murray & Nadel. Philadelphia: Eleseveir, 2005, Section O. 3. Wiener-Kronish JP, Boylan AM, Broaddus VC. Pleural diseases. In: Annual Review of Pulmonary and Critical Care Medicine, Philadelphia: Hanley & Belfus, 1991, pp Boylan AM, Stulbarg MS. Pulmonary embolism. In: Emergency Medicine. M Callaham, ed. Philadelphia: BC Dekker Inc, Boylan AM, Stulbarg MS. Pulmonary embolism. In: Decision Making in Emergency Medicine. M Callaham, CW Barton, HM Schumaker, eds. Philadelphia: BC Dekker Inc, PEER-REVIEWED PUBLICATIONS 1. Adams J, Boylan AM, Cochran J. Use of renal replacement therapy in patients receiving extracorporeal membrane oxygenation ECMO is not associated with chronic renal insufficiency in patients with severe acute respiratory distress syndrome (ARDS). (submitted Intensive Care Medicine). 2. Pierce WA, Cooper-Hassig TB, Crego S, Mazur JE, Boylan AM, Uber WE. Inhaled epoprostenol vs inhaled nitric oxide for acute respiratory distress syndrome. (submitted IntensiveCare Medicine). 3. Boylan AM, Wang XF, Ko R, Watson PM, Gu L, Harpole D, Bueno R, Kelly RF, Kohman L, Kratzke R. Detection of human telomerase reverse transcriptase mrna in cells obtained by lavage of the pleura in patients with stage I/II non-small cell lung cancer: Results of CALGB Jl Thoracic Cardiovasc Surg Sep 28. pii: S (12) doi: /j.jtcvs [Epub ahead of print], PMID: , PMCID: PMC Watson P, Miller SW, Fraig M, Cole DJ, Watson DK, Boylan AM CaSm (LSm-1) Over-expression in lung cancer and mesothelioma is required for transformed phenotypes. Am J Resp Cell Mol Biol 2008: 38(6): , PMID: , PMCID: PMC Ko R, Mazur JE, Pastis NJ.,Cahng E, Sahn SA, Boylan. AM, Common problems in critically ill obstetric patients with an emphasis on pharmacotherapy. Am J Med Sci 2008: 335 (1) , PMID: Yan Y, Rubinchik S, Watson PM, Kelly JR, Fraser MM, Wood AL, Dong JY, Gillanders WE, Boylan AM, Watson DK, Cole DJ. Establishing a murine pancreatic cancer CaSm model: up-regulation of CaSm is required for the transformed phenotype of murine pancreatic adenocarcinoma. Mol Ther 2005: 11(3) , PMID: Fraser MM, Watson PM, Fraig MM, Kelley JR, Nelson PS, Boylan AM, Cole DJ, Watson DK. CaSm-mediated cellular transformation is associated with altered gene expression and messenger RNA stablity. Cancer Res 2005: 65(14): , PMID: Johnson KR, Johnson KY, Crellin HG, Ogretmen B, Boylan AM, Harley RA, Obeid LM. Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue. J Histochem Cytochem. 2005: 53(9) , PMID: Wallace MB, Block M, Hoffman BJ, Hawes RH, Silvestri G, Reed CE, Mitas M, Ravenel J,Fraig M, Miller S, Jones ET, Boylan A. Detection of telomerase expression in in mediastinal lymph nodes of patients with lung cancer. Am J Respir Crit Care Med 2003: 167(12) , PMID: Boylan AM. Mesothelioma: New concepts in the diagnosis and management. Curr Opinion Pulm Med 2000; , PMID: Robinson MB, Erle DJ, Jones DA, Shapiro S, Metzger WJ, Albelda SM, Parks WC, Boylan AM. Recent advances in molecular biology techniques and their relevance to pulmonary research. Thorax 2000: 55(4) Ogretem B, Bahadori HR, McCauley MD, Boylan AM, Green M, Safa AR. Co-ordinated overexpression of the MRP and the g-glutamylcysteine synthetase genes, but not MDR1, coorelates with doxorubicin resistance in human malignant mesothelioma cell lines. Int J Cancer 1998; Ogretem B, Bahadori HR, McCauley MD, Boylan AM, Green M, Safa AR. Lack of coorelation of MRP and g-glutamylcysteine synthetase overexpression with doxorubicin resistance due to increased apoptosis in SV40 large T-antigen transformed human mesothelial cells. Cancer Chemother Pharmacol 1998; Broaddus VC, Yang L, Scavo LM, Ernst JD, Boylan AM. Crocidolite asbestos induces apoptosis of pleural mesothelial cells: role of reactive oxygen species and poly(adp-ribosyl) polymerase. Envirn Health Perspect 1997; Broaddus VC, Yang L, Scavo LM, Ernst JD, Boylan AM. Asbestos induces apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species. J Clin Invest 1996: Boylan AM, Sheppard D, Sanan D, Broaddus VC. Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin avb5. J Clin Invest 1995; Broaddus VC, Boylan AM, Hoeffel JM, Sadick M, Chuntharapai A, Kim KJ, Hébert CA. Neutralization of interleukin-8 inhibits neutrophil influx in a rabbit model of endotoxin-induced pleurisy. J Immunol 1994; Boylan AM, Hébert CA, Sadick M, Wong WL, Hoeffel JM, Hartiala KT, Broaddus VC. Interleukin-8 is a major component of pleural liquid chemotactic activity in a rabbit model of endotoxin pleurisy. Am J Physiol 1994; 267 (Lung Cell. Mol. Physiol. 11): L137-L Boylan AM, Rüegg C, Hoeffel J, Kim KJ, Hébert CA, Pytela R, Sheppard D, Goldstein IM, Broaddus VC. Evidence of a role for mesothelial cell-derived interleukin-8 in the pathogenesis of asbestos-induced pleurisy in rabbits. J Clin Invest 1992; Broaddus VC, Hébert CA, Vitangcol RV, Hoeffel JM, Bernstein MS, Boylan AM. Interleukin-8 is a major neutrophil chemotactic factor in pleural liquid of Page 4 / 6

5 patients with empyema. Am Rev Respir Dis 1992; NON-PEER-REVIEWED PUBLICATIONS 1. Block M., Boylan AM. Mesothelioma update. Pulm Critical Update Online Pulm Crit Care Update Boylan AM. Translational applications of gene microarry studies. ATS, GeneExpress, Oct and Dec ABSTRACTS (NON-PRESENTATION) 1. Fix OK, Liou I, Karvellas C, Ganger D, Forde KA, Subramanian RM, Boylan AM, Hanje AJ, Stravits RT, Lee WM. Development and pilot of a checklist for management of acute liver failure in the intensive care unit. (accepted for presentation EASL 2013). 2. Sachs BL, Cawley PJ, Hoffecker BM, Coffman ZJ, Haynes LE, Boylan AM, Simpson KN, Sargent S, Byrne J, Srinivas P, Botham P, Scheurer DB. Photographic documentation of pressure ulcers-demonstrated improved transistion of patient care. Better clinical outcomes as measured by care quality and cost reduction. (accepted for presentation AAMC Quality Conference 2013). 3. Sachs BL, Cawley PJ, Lewis C, Floyd PJ, Shaw K,, Boylan AM, Rees C. How an academic university medical center improved quality and documentation of post-op respiratory failure (PORF) with an interprofessional team approach. (accepted for presentation AAMC Quality Conference 2013). 4. Meaburn, A, Boylan, AM, Byrne, J, Ford, DW, Nivea K, Huckabee, D, Parnell L. Improving patient care during transitions from the ICU to the general care floor via staff and family collaboration and a novel patient/family-centered transfer brochure. Crit Care Med (presented 1/2013) 5. Byrne, J MSN RN, Ford, DW MD, Meaburn, A MSN RN ANP-BC, Boylan, AM, Huckabee, DD,Zeigler, M, Hassig, T, Keevern, J, Goodwin, A, Swant, B. Impact of implementing the Awakening and Breathing Coordination, Delirium Monitoring and Management, and Early Mobility (ABCDE) bundle and Incorporating Family (F) Centered care in a Medical Intensive Care Unit: Improving outcomes A-F. Crit Care Med.(presented 1/2013) 6. Byrne J, Boylan AM, Allen MC, Formby L, Ford DW, Stockholm K, Salgado CD. Impact of an educational monitoring method for terminal cleaning in a medical intensive care unit (MICU) on rates of antibiotic resistant organisms (ARO) and healthcare-acquired infections (HAI). Am J Resp Crit Care Med (Presented 5/12). 7. Borders MK, Sofronescu A, -G, Huckabee DD, Boylan AM, Byrne J, Ford DW, Strange C, Epps JA, Schmidt CA, Washington KQ, Warren M, Zhu Y. Discrepancies in arterial PO2 (PaO2) measurements between a point of care testing (POCT) analyzer and standard laboratory analysis of samples transported via pneumatic tube system (PTS). Am J Resp Crit Care Med (Presented 5/12). 8. Adams J, Boylan AM, Cochran J. Use of renal replacement therapy in patients receiving extracorporeal membrane oxygenation ECMO is not associated with chronic renal insufficiency in patients with severe acute respiratory distress syndrome (ARDS). Am J Resp Crit Care Med (Presented 5/12). 9. Tanner NT, Watson PM, Wang JS, Boylan AM, Pastis NJ, Silvestri GA. Identification of molecular markers that indicate prognosis in lung cancer using minimally invasive endobronchial ultrasound fine needle aspiration of lymph nodes. Am J Resp Crit Care Med (presented, 5/10). 10. Watson PM, Tannner NT, Wang JS, Pastis NJ, Boylan AM, Silvestri GA. Markers of epithelial-mesenchymal transition as indicators of prognosis in lymph node aspirates from lung cancer patients. Am Assoc Canc Res (Presented 4/10). 11. Watson PM, Boylan AM, Watson D. LsM1 over-expression contributes to an increase in alternative splicing in lung cancer cells. Am Assoca Cancer Res (presented, 4/10) 12. Ko R, Gu L, Wang XF, Watson PM, Miller S, Green MR, and A Boylan,. Detection of telomerase activity in cells obtained by lavage of the pleura is not associated with worse outcome in patients with stage I/II non-small cell lung cancer. Am J Respir Crit Care Med (presented, 5/08). 13. Watson PM, Harris W, Watson DK, A Boylan.. Elevated expression of LSm1 (CaSm) in cancer is correlated with and leads to changes in expression of other LSm proteins and DCP1 and 2, contributing to altered mrna metabolism. Am Assoc Cancer Res (presented, 4/07). 14. Watson PM, Frasier MM, Kelly JR, Cole DJ, and A Boylan.. CaSm oncogene expression contributes to transformation and cellular proliferation via control of mrna stability. Am J Respir Crit Care Med (presented, 5/06). 15. Boylan AM, Watson P, Jones ET, Fraiser MM, and Watson DK. Reduced expression of the CaSm oncogene in malignant mesothelioma cells is associated with reduced proliferation and cell cycle changes in vitro, and reduced tumor growth in mice in vivo. Am J Respir Crit Care Med (accepted for presentation, 5/02) 16. Barker J, Watson P, and Boylan AM. Human small cell lung cancer cells express CXCR4 receptors and exhibit directional migration toward CXCL12/SDF- 1a. Am J Respir Crit Care Med (accepted for presentation, 5/02). 17. Watson PM, Fraser MM, Jones ET, Watson DK, and Boylan A. The CaSm oncogene is associated with cell cycle progression and transformation in malignant mesothelioma. Am Assoc Cancer Res (presented, 4/02). 18. Wallace MB, Madani n, Fickling W, Hoffman B, Hawes R, Miller S, Jones ET, and Boylan A. Detection of lymph node micrometastases by PCR for telomerase in EUS-FNA. Am Assoc Cancer Res (presented, 4/02). 19. Bahadori HR, GMR Carbone, ET Jones, A Boylan, MR Green and CV Catapano. Peroxisome proliferator-activated receptor delta (PPARD) is a novel target for therapy and prevention of non-small cell lung cancer. Am Assoc Cancer Res (presented, 4/02). 20. Jones ET, Schweinfest CW, Chapman, TS, Watson DK, Boylan AM. The CaSm oncogene is differentially expressed in malignant mesothelioma and contributes to the transformed state in a sarcomatous mesothelioma cell line. Am J Respir Crit Care Med 2001;163:A Boylan AM., ET Jones, C Reed, J Kern, D Levine, and MR Green Telomerase in pleural lavage: a potential marker for micrometastatic disease to the pleura in patients with resected non-small cell lung cancer. Am J Respir Crit Care Med 2001;163:A Bahadori HR, GMR Carbone, ET Jones, A Boylan, MR Green and CV Catapano. Expression of peroxisome proliferator-activated receptor in non-small cell lung cancers. Am Assoc Cancer Res presented Jones ET, Schweinfest CW, Chapman JM, Papas TS, Watson DK, Boylan AM. CaSm (Cancer-Associated-Sm-like) is differentially expressed in non-small cell lung cancer and contributes to the transformed state in A549 cells. Am J Respir Crit Care Med 2000; 155:A Boylan AM, Schweinfest CW, Alexander A, Chapman JM, Papas TS, Watson DK. Differential expression of three novel genes in mesothelioma cells. Fourth International Mesothelioma Conference Boylan AM, Schweinfest CW, Alexander A, Chapman JM, Papas TS, Watson DK. Differential expression of three novel genes in mesothelioma cells. Am J Respir Crit Care Med 1998; 26. Boylan AM. Yang L, Broaddus VC, Yang L Asbestos induces apoptosis of pleural mesothelial cells via reactive oxygen species. Mol Bio Cell 1997; 7S: Broaddus VC, Yang L, Boylan AM. Engagement of vitronectin receptors inhibits asbestos-induced apoptosis of pleural mesothelial cells. Am J Respir Crit Care Med 1997; 155:A14. Page 5 / 6

6 28. Broaddus VC, Yang L, Scavo LM, Ernst JD, Boylan AM. Asbestos induces apoptosis in mesothelial cells. Am J Respir Crit Care Med 1996; A Broaddus VC, Yang L, Scavo LM, Ernst JD, Boylan AM. Asbestos induces apoptosis of pleural mesothelial cells via reactive oxygen species. Envirn Health Perspect. 30. Broaddus VC, Embry MG, Boylan AM. Crocidolite asbestos coated with vitronectin inhibits mesothelial cell proliferation. Am J Respir Crit Care Med 1995; 151:A Boylan AM, Yang L, Sanan DA, Sheppard D, Broaddus VC. Pleural mesothelial cells recognize and internalize serum-coated crocidolite asbestos via a vitronectin receptor avb5. Mol Bio Cell 1995; 6S:165a. 32. Boylan AM, Hébert CA, Hoeffel, Sadick M, Broaddus VC. Neutralization of interleukin-8 (IL-8) inhibits neutrophil influx in a rabbit model of endotoxininduced pleurisy. Am J Respir Crit Care Med 1994; 149:A Broaddus VC, Sanan DA, Kim KJ, Yung RC, Sheppard D, Boylan AM. The role of vitronectin receptors in the internalization of crocidolite asbestos by pleural mesothelial cells. Am J Respir Crit Care Med 1994; 149:A Boylan AM, Hébert CA, Hoeffel JM, Broaddus VC. Interleukin-8 is an important chemotactic factor in endotoxin pleurisy in anesthetized rabbits. Am Rev Respir Dis 1993; 145:A Broaddus VC, Yung R, Sanan D, Sheppard D, Boylan AM. Attachment of crocidolite asbestos fibers to pleural mesothelial cells is mediated via integrin avb5. Mol Bio Cell 1993; 4:S:284a. 36. Boylan AM, Hoeffel JM, Rüegg C, Kim KJ, Hébert CA, Pytela R, Broaddus VC. Mesothelial cell-derived interleukin-8 is a likely mediator of asbestosinduced pleurisy in rabbits. Am Rev Respir Dis 1992; 37. Yung RC, Sheppard D, Boylan AM, Broaddus VC. Detection of message for interleukin-8 in asbestos-stimulated rabbit pleural mesothelial cells by in situ hybridization. Am Rev Respir Dis 1992; 145:A Broaddus VC, Hébert CA, Kim KJ, Hoeffel JM, Boylan AM. Interleukin-8, a major neutrophil chemotactic factor in human pleural inflammation. Am Rev Respir Dis 1992; 145:A Boylan AM, Sanan DA, Broaddus VC. Identification of intracellular asbestos fibers in mesothelial cells using fluorescence confocal microscopy. Mol Bio Cell 1992; 3:679a. 40. Boylan AM, Kim KJ, Broaddus VC. Rabbit pleural mesothelial cells stimulated with tumor necrosis factor produce neutrophil chemotactic activity which is partially blocked by an antibody to interleukin-8. Clin Res 1991; 39:72A. 41. Boylan AM, Rüegg C, Pytela R, Sheppard D, Broaddus VC. Gene expression and partial sequence of interleukin-8 in rabbit mesothelial cells stimulated with tumor necrosis factor. FASEB J 1991; 5: Broaddus VC, Hoeffel JM,Boylan AM. Inflammation caused by endotoxin, interleukin 1b and tumor necrosis factor in the rabbit pleural space. Am Rev Respir Dis 1991; 143:A766. FACULTY DEVELOPMENT Year Description 2011 Teach the Teacher Presentor: Deborah DeWaay, MD November 15, 2011 COMMUNITY SERVICE Preceptor Acute Care Nurse Practitioner Program, University of South Carolina (5 students to date) Present Medical Director Trident Technical College Respiratory Care Program Present Volunteer Our Lady of Mercy Community Outreach Volunteer MUSC Gives Back (Migrant Worker Health Care Program) Page 6 / 6

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