آشنايي دانشجويان با اصول و مباني دانش ايمونولوژی و چگونگي کاربرد آن برای شناخت پیشگیری تشویص و

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1 )برای يک جلسه از درس برای مثال 2 ساعت از کالس درس در يک هفته( دانشکده: پیراپزشکي گروه آموزشي: علوم آزمايشگاهي مقطع و رشتهی تحصیلي:کارشناسي ناپیوسته نام درس: ايمونولوژی زمان برگزاری کالس: روز: کي تعداد دانشجويان: تعداد واحد: 2 شنبه ساعت: 810 نوع واحد: نظری پیش نیاز: ندارد مکان برگزاری: کالس B 22 نفر مسئول درس: خانم قره گزلو مدرسین )به ترتیب حروف الفبا(: خانم قره گزلو و دکتر ناصری شرح درس: )لطفا شرح دهید( ايمني شناسي از دروس اصلي رشته علوم آزمايشگاهي است و هدف اين درس آشنايي با سیستم دفاعي بدن شامل ارگانها سلولها و مولکولهای دخیل در اين سیستم و نیز میانکنش اين عناصر در سالمتي و بیماری مي باشد. اين درس روشهای کنترل بیماری در انسان و راههای مقابله بدن با عوامل عفوني را شرح مي دهد. همچنین به راههای ورود عوامل بیماريزا به بدن شناخت عوامل موثر بر مقاومت بدن و واکسیناسیون مي پردازد. ايمونولوژی پیوند اعضا بیماريهای خودايمني نقص ايمني ايمني تومورها از ديگر موضوعات مورد بحث در اين درس است. هدف کلي: )همان هدف بینابیني طرح دوره است ) آشنايي دانشجويان با اصول و مباني دانش ايمونولوژی و چگونگي کاربرد آن برای شناخت پیشگیری تشویص و درمان بیماريها. 1

2 اهداف رفتاری جلسه اول: در پایان درس از فراگیر انتظار می رود : Innate Immunity Phagocytosis ایمنی ذاتی را توضیح دهد و تفاوت آن را با ایمنی اکتسابی ذکر نماید. راههاي ورود عامل خارجی به بدن را توضیح دهد. موانع طبیعی و سدهاي فیزیكی بدن را شرح دهد. خصوصیات هر کدام از سدهاي فیزیكی بدن را شرح دهد. وظایف پاسخ هاي ایمنی بدن را شرح دهد. فاگو سیتوز را شرح دهد و مراحل آن را لیست نماید جدول زمانبندی ارائهی مطالب جلسه 1 ایمنی ذاتی محل هاي ورود میكروارگانیسمها به بدن /سدهاي آناتومیكی / مكانیكی / شیمیایی / هومورال و سلولی در مقابل میكروبها سخنرانی تعاملی پرسش و پاسخ کوئیز از درس جلسه پرسش و پاسخ درس فاگوسیتوز تعریف بیگانه خواري انواع سلولهاي بیگانه خوار مراحل فاگوسیتوز التهاب 15 دقیقه جمع بندي مطالب و پرسش و پاسخ 2

3 اهداف رفتاری جلسه چهارم Maturation of T cells : مراحل بلوغ سلولهاي T را را ذکر نماید. اهمیت Pre T cell receptor را شرح دهد. مولكولهاي سطح یک سلول T بالغ را فهرست کند.. اجزاي تشكیل دهنده T cell receptor complex را با رسم شكل توضیح دهد. اهمیت T cell receptor complex را ذکر نماید. مولكولهاي costimulatory سلول T را توضیح دهد. جدول زمانبندی ارائهی مطالب جلسه 4 سخنرانی تعاملی پرسش و پاسخ Pro T cell/ pre T cell/ Immature T cell / mature T cell نقش تیموس در ایجاد گنجینه سلولی اصلی در مسیر اصلی T مراحل تكامل سلول T سلولهاي کوئیز از درس جلسه پرسش و پاسخ درس T و T گاما دلتا Pro TCR / T Cell CoReceptor / T cell costimulatory molecules T Cell Receptor Complex / T cell surface molecules 15 دقیقه جمع بندي مطالب و پرسش و پاسخ 3

4 Maturation of Bcell s اهداف رفتاری جلسه پنجم : در پایان درس از فراگیر انتظار می رود:: مراحل بلوغ سلولهاي B را را ذکر نماید. اهمیت Preرا B cell receptor شرح دهد. مولكولهاي سطح یک سلول B بالغ را فهرست کند.. اجزاي تشكیل دهنده cell receptor complex را توضیح دهد. اهمیت B cell receptor complex را شرح دهد. ساز مان یابی ژنی گیرنده لنفوست B را در هر مر حله تكاملی را شرح دهد. باز آرایی ژنی را در لنفوسیت هاي B در هر مرحله تكاملی شرح دهد. تغییرات در تکامل سلولهای B از روی مارکرها را تشویص داده و توضیح دهد. جلسه 5 جدول زمانبندی ارائهی مطالب 40 دقیقه بلوغ سلولهاي B در مغز استخوان Pro B cell/ pre B cell/ Immature B cell / mature B cell سخنرانی تعاملی پرسش و پاسخ کوئیز از درس جلسه پرسش و پاسخ درس B cell receptor & co receptor/ costimulatory باز آرایی ژنی در B Cell Receptor Complex / B cell surface molecules ساز مان یابی ژنی گیرنده 40 دقیقه 15 دقیقه 15 دقیقه لنفوستB جمع بندي مطالب و پرسش و پاسخ لنفوسیت هاي B در هر مرحله تكاملی.تغییرات در تکامل سلولهای B از روی مارکرها 4

5 اهداف رفتاری جلسه هفتم: T cell Activation در پایان درس از فراگیر انتظار می رود: ویژگی آنتی ژن هاي قابل شناسایی توسط لنفوسیت هاي T را توضیح دهد. APCs و نقش آنها در پاسخ هاي ایمنی را شرح دهد. ویژگی ها و عملكرد APCs را ذکر نماید. نحوه پردازش آنتی ژن هاي با ماهیت اگزوژنی را شرح دهد. نحوه پردازش آنتی ژن هاي سیتوزولی را توضیح دهد. نحوه ونتیجه فعال شدن سلولهاي + CD4 را با سلولهاي + CD4 مقایسه نماید. جدول زمانبندی ارائهی مطالب جلسه 7 سخنرانی تعاملی پرسش و پاسخ تعریف آنتی زن اگزوژن / نحوه پردازش و عرضه آنتی ژن اگزوژن / فعال شدن سلولهاي + CD4 و ترشح سایتوکاین نحوه پردازش آنتی ژن هاي با ماهیت اگزوژن یا وزیكولی کوئیز از درس جلسه پرسش و پاسخ درس و درانتهاي جلسه نحوه پردازش آنتی ژن هاي تعریف آنتی زن اندوژن یا سیتوزولی اندوژن / نحوه پردازش و عرضه آنتی ژن اندوژن / فعال شدن سلولهاي + CD8 و نحوه کشتن سلولی 15 دقیقه جمع بندي مطالب و پرسش و پاسخ 5

6 اهداف رفتاری جلسه هشتم: B cell Activation يا ضمن توضیح انواع لنفوسیت ه Bاي تفاوت آنها را لیست نماید. تفاوت آنتی ژنهاي آنتی ژن هاي مستقل ازT و وابسته به Tرا لیست نماید. نحوه فعال شدن لنفوسیت ه Bاي توسط آنتی ژن هاي مستقل از T را توضیح دهد نحوه فعال شدن لنفوسیت ه Bاي توسط آنتی ژن هاي وابسته به Tرا توضیح دهد نقش سلول ه Tاي در تولید آنتی بادي بوسیله سلول ه Bاي را بیان نماید پیامده فعال شدن لنفوسیت ه Bاي را شرح دهد تولید سلول خاطره و پالسماسل را توضیح دهد. پاسخ اولیه و ثانویه را با هم مقایسه نماید. جدول زمانبندی ارائهی مطالب جلسه 8 سخنرانی تعاملی پرسش و پاسخ 45 دقیقه شناسایی آنتی ژنهاي مستقل از سلول T نوع آنتی ژن / نوع سلول / کالس انتی بادي و نوع پاسخ / پالسماسل کوئیز از درس جلسه پرسش و پاسخ درس شناسایی آنتی ژنهاي وابسته نوع آنتی ژن / نوع به سلول T سلول / کالس انتی بادي و نوع پاسخ/ و سلول خاطره اي/ پاسخ اولیه و ثانویه 15 دقیقه جمع بندي مطالب و پرسش و پاسخ 6

7 اهداف رفتاری جلسه نهم: Cytokines سایتوکاین هارا تعریف و طبقه بندي کند ویژگی سایتوکاین ها را توضیح دهد سایتوکاین هاي ایمنی ذاتی را نام ببرد. منابع اصلی تولید و عملكرد سایتوکاین هاي ایمنی ذاتی را شرح دهد سایتوکاین هاي ایمنی اداپتیو را نام ببرد. منابع اصلی تولید و عملكرد سایتوکاین هاي ایمنی اداپتیو را شرح دهد سایتوکاین هاي مربوط به خون سازي را نام ببرد. منابع اصلی تولید و عملكرد سایتوکاین هاي مربوط به خون سازي را شرح دهد جدول زمانبندی ارائهی مطالب جلسه 9 سخنرانی تعاملی پرسش و پاسخ * با استفاده از وسایل کمک آموزشی وایت بورد تعریف و خصوصیات سایتوکاین ها مشخصات فیزیكو شیمیایی سایتوکاینها ریداندنسی/ پلیوتروپیسم/ سینرژیسم/ آنتاگونیسم / گیرنده هاي سایتوکاینها کوئیز از درس جلسه پرسش و پاسخ درس ویدئو پروژکتور پاور پوئنت 45 دقیقه طبقه بندي سایتوکاین ها سایتوکاین هاي ایمنی ذاتی/ سایتوکاین هاي ایمنی اداپتیو/ سایتوکاین هاي مربوط به خون سازي/ تنظیم هاي سایتوکاین کننده ایمنی 15 دقیقه جمع بندي مطالب و پرسش و پاسخ 7

8 اهداف رفتاری جلسه دوازدهم: Tolerance ین تولرانس را تعریف نماید. علل ایجاد تحمل و فعال نشدن سیستم ایم بر علیه ملكولهاي خود را شرح دهد. ضمن شرح تولرانس مرکزي و محیطی آن دو را با هم مقایسه نماید. مكانیزمهاي ایجاد تولرانس مرکزي در سطح سلولهاي B و T را توضیح دهد. مكانیزمهاي ایجاد تولرانس محیطی در سطح سلولهاي B و T را توضیح دهد. جدول زمانبندی ارائهی مطالب جلسه 12 سخنرانی تعاملی پرسش و پاسخ تعریف و انواع تولرانس تولرانس مرکزي و تولرانس محیطی کوئیز از درس جلسه پرسش و پاسخ درس 20 دقیقه 30 دقیقه تولرانس در سلولهايB تولرانس مرکزي و محیطی در سطح سلولهايB / مكانیسماي ایجاد و اهمیت ان 30 دقیقه تولرانس در سلولهايT تولرانس مرکزي و محیطی در سطح سلولهايT / مكانیسم هاي ایجاد و اهمیت ان 15 دقیقه جمع بندي مطالب و پرسش و پاسخ 8

9 اهداف رفتاری جلسه سیزدهم: Autoimmunity علل شكست تولرانس را شرح دهد مكانیسم ه يا را تعریف نماید بروز بیماریه يا کند. را بیان بیماریه يا را طبقه بندي نماید. تشخیص و درمان ایمونولوژیكی بیماریه يا را شرح دهد جدول زمانبندی ارائهی مطالب جلسه 13 سخنرانی تعاملی پرسش و پاسخ تعریف/ مكانیسم هاي شكست اتوتولرانس/عوامل مستعد کننده بروز خودایمنی کوئیز از درس جلسه پرسش و پاسخ درس 20 دقیقه بیماریه يا بیماریهاي سیستمیک و 40 دقیقه اختصاصی ارگان/ مكانیسمهاي اسیب بافتی ناشی از فعال شدن سیستم ایمنی/ توضیح برخی بیماریهاي شایع خودایمنی 30 دقیقه تشخیص و درمان تشخیص ها و درمانهاي ایمونولوژیكی ایمونولوژیكی 10 دقیقه جمع بندي مطالب و پرسش و پاسخ 9

10 اهداف رفتاری جلسه شانزدهم: Immunodeficiency نقص ایمنی را تعریف کند علل ایجاد انواع نقص ایمنی ( اولیه و ثانویه( را نام ببرد. بیماریهاي نقص ایمنی را طبقه بندي کند بیماریهاي نقص ایمنی هومورال را توضیح دهد شرح دهد بیماریهاي نقص ایمنی سلولی را بیماریهاي نقص ایمنی بیگانه خواري را توضیح دهد کاربرد تست هاي ایمونولوژیكی تشخیص نقص ایمنی را ذکر نماید روشهاي درمان ایمونولوژیكی نقص ایمنی را شرح دهند. جدول زمانبندی ارائهی مطالب جلسه 16 سخنرانی تعاملی پرسش و پاسخ بورد 15 دقیقه نقص ایمنی تعریف نقص ایمنی / نقص ایمنی اولیه و ثانویه و عوامل موثر در ایجاد نقص ایمنی/ کوئیز از درس جلسه پرسش و پاسخ درس ویدئو پروژکتور 30 دقیقه نقص ایمنی هایپوگاماگلوبولینمیاي هومورال مادرزادي/بروتون/ نقص ایمنی IgA وهایپرIgM / تشخیص و درمان ایمونولوژیكی نقص ایمنی سندروم دي جرج/ نقصهاي عملكردي/ 30 دقیقه سلولی تشخیص و درمان ایمونولوژیكی نقص ایمنی نقص فاگوسیتوز و کموتاکسی/ بیماري 25 دقیقه بیگانه خواري گرانولوماتوز مزمن/ /LAD تشخیص و درمان ایمونولوژیكی 10 دقیقه جمع بندي مطالب و پرسش و پاسخ 10

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