Annex 2. Current PhD theses. Divison Cognitieve Neuropsychiatry & Clinical Neuroscience

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1 Annex 2

2 Annex 2 Current PhD theses Divison Cognitieve Neuropsychiatry & Clinical Neuroscience Name Title Thesis Supervisor(s) Co-Supervisor(s) Sandra van Abeelen Psychogenic non-epileptic seizures in children. Prof. Dr. A.P. Aldenkamp Bart Ament Early problem detection and support for frail elderly: evaluation of the effects of an integrated chain of care model. Prof. Dr. G.I.J.M. Kempen Prof. Dr. F.R.J. Verhey / Dr. P.M.A. van Bilsen / Dr. M.E. de Vugt Monique Anten Contribution of chlamydia pneumonae infection to atherosclerotic cerebrovasculare disease. Prof. Dr. J. Lodder Prof. Dr. C.A. Bruggeman / Dr. A.J. van der Ven Remo Arts Tinnitus suppression by intracochlear stimulation; development of a tinnitus-implant. Prof. Dr. R.J. Stokroos / Dr. E.L.J. George Laura Baijens Surface electrical stimulation of the neck for oropharyngeal dysphagia in Parkinson s disease: therapeutic aspects and Prof. Dr. B. Kremer Dr. R. Speyer reliability of measurement. Ellen Barendse Neuronal correlates in children with Asperger disease. Prof. Dr. A.P. Aldenkamp / Dr. F. Kessels Dr. M.P.H. Hendriks Kim Beerhorst Osteoporosis as a long-term effect of antiepileptic medication. Prof. Dr. A.P. Aldenkamp / Prof. Dr. R.J. van Oostenbrugge Dr. T. Verschueren Kim Bekelaar Small Fiber Neuropathy and Pain. Prof. Dr. R.J. van Oostenbrugge Dr. C.G. Faber / Dr. I.S. Merkies Raymond van de Berg Vestibular implant. Prof. Dr. H. Kingma Prof. Dr. R.J. Stokroos René Besseling White mater tractography in Roland Epilepsy. Prof. Dr. A.P. Aldenkamp Dr. W.H. Backes Wilma van Blarikom The effect of living circumstances on the epilepsy in patients with severe epilepsy. Prof. Dr. A.P. Aldenkamp Guy Bogaarts Towards routine continuous-eeg-monitoring in the intensive care unit. Prof. Dr. W.H. Mess Lizzy Boots Prepair for Alzheimer Dementia: A self-management programme for spouses of elderly with early stage Alzheimer. Prof. Dr. F.R.J. Verhey Dr. M.E. de Vugt Zita Bouwman The development of the Wechsler Memory Scale IV. Prof. Dr. A.P. Aldenkamp / Dr. F. Kessels Dr. M.P.H. Hendriks Angela Bouwmans Early detection of Parkinson. Prof. Dr. W.H. Mess / Dr. W.E.J. Weber Ingrid Brands Psychological adjustment after brain injury. Prof. Dr. C.M. van Heugten / Prof. Dr. D. Wade Dr. S. Stapert??? Breuer Epilepsy as a model for neurodegeneration. Prof. Dr. A.P. Aldenkamp Meindert Buskermolen Behavioural impairments in children with hearing deficits. Prof. Dr. A.P. Aldenkamp Dr. J. Hoekman Frank van Bussel Functional MRI biomarkers of cognitive decrements in diabetes. Prof. Dr. J.E. Wildberger Dr. J.F.A. Jansen Mickey Chenault Psychometric measures applied to audiological rehabilitation: uncovering factors influencing the process. Prof. Dr. B. Kremer Lies Clerx Alzheimer s Disease through the MR-eye: novel diagnostic markers and the road to clinical implementation. Prof. Dr. F.R.J. Verhey Dr. P. Aalten / Dr. P.-J. Visser Fiona Cleutjens Neuropsychological functioning of COPD patient and the influence on health status, daily functioning and the Prof. Dr. E. Wouters / Prof. Dr. R.W.H.M. Ponds Dr. D.J.A. Janssen / Dr. J. Dijkstra outcome of pulmonary rehabilitation. Janine Collet SPECIMENh. Prof. Dr. F.R.J. Verhey / Prof. Dr. J.M.G.A. Schols Alieske Dam InLife: evaluation of an internet-based social support tool for caregivers of dementia patients. Prof. Dr. F.R.J. Verhey Dr. M.E. de Vugt / Dr. M.P.J. van Boxtel Joke Debruyne Auditory parameters of prelingually deafened adults in relation to their everyday functioning with a cochlear Prof. Dr. B. Kremer / Prof. Dr. R.J. Stokroos / Dr. L.J.C. Anteunis implant: an initiation to the modification of speech coding strategies. Kay Deckers Innovative Midlife Intervention for Dementia Deterrence (In-MINDD). Prof. Dr. F.R.J. Verhey Dr. M.P.J. van Boxtel Guido Dees Cochleair implants, physycomechanical effects on outcome. Prof. Dr. R.J. Stokroos / Prof. Dr. B. Kremer Elke DeVocht Key contributors to successful bimodal fitting. Prof. Dr. R.J. Stokroos / Dr. E.L.J. George Fleur van Dooren The role of pyschological variables (depression, anxiety, type D personality) in the pathogenesis of type 2 diabetes and Prof. Dr. F.R.J. Verhey Dr. M. Schram / Dr. M.P.J. van Boxtel diabetes-related microvascular complications. Tim Draak Peripheral Neuropathy Outcome Measures Standardisation (PeriNomS) Study part III. Dr. C.G. Faber Dr. I.S.J. Merkies Jan Duijvestijn Ageing and hearing loss. Prof. Dr. B. Kremer Dr. L.J.C. Anteunis Saskia Ebus Treatment of frequent epileptiform discharges; the effect on cognition. Prof. Dr. A.P. Aldenkamp / Prof. Dr. J.B.A.M. Arends Mitchel van Eeden Economic impact of stroke. Prof. Dr. C.M. van Heugten / Dr. S.M.A.A. Evers Manon Fens Structured care for chronic stroke patients. Prof. Dr. J. Metsemakers / Prof. Dr. C.M. van Heugten Dr. G. Beusmans Brechje FitzGerald e/v Dandachi Symptom validity in a clinical setting. Prof. Dr. F.R.J. Verhey / Prof. Dr. R.W.H.M. Ponds Whitney Freeze Blood-brain barrier leakage in dementia. Prof. Dr. F.R.J. Verhey Dr. S. Burgmans 50 MH&NS Annual Report 2013

3 Oliver Gerlach Parkinson Care research. Prof. Dr. M. Limburg Dr. W. Weber Nienke Gosens The role of mitochondrial dysfunction in the development of refractory epilepsy. Prof. Dr. A.P. Aldenkamp / Prof. Dr. R.J.E.M Smeets Dr. G. Hoogland Bianca de Greef From mutation to targeted therapy: a randomized trial in Nav1.7 mutations related painful small fiber neuropathy. Dr. C.G. Faber Dr. I.S.J. Merkies Nils Guinand Development of a vestibular implant for patients with bilateral vestibular function loss: 1--acute electric stimulation Prof. Dr. H. Kingma / Prof. Dr. R.J. Stokroos of the vestibular nerve, 2--candidate s quality of life assessment, 3--development of diagnostic and monitoring tools. Harm van de Haar Novel MRI biomarkers in Alzheimer s disease. Prof. Dr. F.R.J. Verhey Dr. W.H. Backes Renske Hamel Early detection and diagnosis of Alzheimer s Disease (VSB-MCI study). Prof. Dr. F.R.J. Verhey Dr. P. Aalten Ron Handels Health technology assessment of diagnostic strategies for cognitive disorders. Prof. Dr. F.R.J. Verhey / Prof. Dr. J.L. Severens Darius Henatsch Pathophysiology and alternative treatment options for chronically infected open mastoidectomy cavities. Prof. Dr. R.J. Stokroos Danny Hilkman Towards routine continuous-eeg-monitoring in the intensive care unit. Prof. Dr. W.H. Mess Janneke Hoeijmakers Small fiber neuropathy and sodium channels; a paradigm shift. Prof. Dr. R.J. van Oostenbrugge Dr. C.G. Faber/ Dr. I.S.J. Merkies Janny Hof OAE at compensated middle ear pressure. Prof. Dr. B. Kremer / Prof. Dr. R.J. Stokroos Dr. J. van Dijk / Dr. L.J.C. Anteunis Marc van Hoof The Bone-Anchored Hearing aid - investigation of the clinical outcomes of a skin-integrating implant. Prof. Dr. R.J. Stokroos Marjolein Huijts Cognitive function in patients with cerebral small vessel disease. Prof. Dr. R.J. van Oostenbrugge Dr. A.A. Duits / Dr. J.E.A. Staals Dominique IJff MR spectroscopy of neurotransmitter system in relation to cognitive side effects of antiepileptic drugs. Prof. Dr. A.P. Aldenkamp Dr. J.F.A. Jansen Willemijn Jansen Neuropsychology of cognitive decline. Prof. Dr. F.R.J. Verhey Dr. P. Aalten Stephan Jansen Imaging for the life sciences: medical imaging and movement detection to probe neuroplasticity. Prof. Dr. H. Kingma Reina de Kinderen Cost-effectiveness of ketogenic diet in chronic epilepsy. Prof. Dr. A.P. Aldenkamp / Prof. Dr. S. Evers Dr. H.J.M. Majoie Rosalie van Knippenberg An e-monitor intervention for management of daily chalenges in dementia. Prof. Dr. F.R.J. Verhey Dr. M.E. de Vugt Alexandra König The development of an integrated solution for the remote monitoring, diagnosis and support of people with Prof. Dr. Ph. Robert Prof. Dr. F.R.J. Verhey / Dr. P. Aalten dementia (project Dem@Care). Sylvie van der Kruijs Neuronal and psychophysiological correlates of dissociation in patients with psychogenic non-epileptic seizures. Prof. Dr. A.P. Aldenkamp / Prof. Dr. K. Vonck Dr. R. Lazeron Loes Leenen Self-management in patients with epilepsy. Prof. Dr. S. Evers / Prof. Dr. C.M. van Heugten Dr. H.J.M. Majoie Marjolein Legra The role of personality features on behavioral and psychological symptoms of dementia. Prof. Dr. F.R.J. Verhey Dr. B. van Alphen Annelien Mertens Endothelial progenitor cells in Alzheimer s disease. Prof. Dr. J.W. Cohen-Tervaert Prof. Dr. J. Lodder / Prof. Dr. R.J. van Oostenbrugge / Dr. J.G.M.C. Damoiseaux / Drs. E. Pijpers / Dr. M.M.G.L. Thewissen Carlota Mestres Gonzalvo Neuropsychiatric clinical rules and development of a computerized decision support system. Prof. Dr. F.R.J. Verhey Dr. P-H.M. van der Kuy Joany Millenaar Needs in Young Onset Dementia - deel II (NeedYD - II). Prof. Dr. F.R.J. Verhey / Prof. Dr. R.T.C.M. Koopmans Dr. M.E. de Vugt Anja Moonen Emotional processing and cognition in Parkinson s disease. Prof. Dr. F.R.J. Verhey Dr. A.F.G. Leentjens Veronique Moulaert Cognitive impairments following post hypoxic encephalopathy. Dr. J. Verbunt / Prof. Dr. C.M. van Heugten / Prof. Dr. D. Wade Anne-Hilde Muris Immune and disease modulating effects of vitamin D in multiple sclerosis. Prof. Dr. R.M.M. Hupperts Iris Nowak - Maes Tinnitus; assessment of quality of life & cost-effectiveness. Prof. Dr. M. Peters / Prof. Dr. B. Kremer Dr. M. Joore / Dr. L.J.C. Anteunis Mayke Oosterloo Genetic aspects for Huntington disease. Prof. Dr. R.A.C. Roos Dr. E.K. Bijlsma Janneke Peijnenborgh Cognitive rehabilitation in virtual reality. Prof. Dr. J.S.H. Vles / Prof. Dr. A.P. Aldenkamp Dr. J. Hendriksen Walmari Pilz Swallowing in patients with dystrophia myotonica and reliability analysis of swallowing variables. Prof. Dr. B. Kremer Dr. L. Baijens / Dr. Valeria Lima Passos Babette Reijs Biomarkers for early diagnosis and prognosis of Alzheimer s disease. Prof. Dr. F.R.J. Verhey Dr. P.J. Visser / Dr. S. Vos Linda Rolf Immune and disease modulating effects of vitamin D in Multiple Scleroris. Prof. Dr. R.M.M. Hupperts Dr. J. Damoiseaux Syenna Schievink Cognition and Affect after Stroke. Prof. Dr. F.R.J. Verhey Dr. S. Köhler / Prof. Dr. R.J. van Oostenbrugge Francesca Schouwenaars The effect of seizures on behavioural disorders. Prof. Dr. A.P. Aldenkamp Sanne Smeets Awareness after brain injury. Prof. Dr. C.M. van Heugten / Prof. Dr. R.W.H.M. Ponds / Prof. Dr. F.R.J. Verhey Diane Smit Experimental viral labyrinthitis: a neonatal sheep model. Prof. Dr. B. Kremer Prof. Dr. R.J. Stokroos / Prof. Dr. B.W.W. Kramer Peggy Spauwen Diabetes and cognition. Prof. Dr. F.R.J. Verhey 51 MH&NS Annual Report 2013

4 Michele Speth Effects of vagal nerve stimulation in children. Prof. Dr. J.S.H. Vles Prof. Dr. R.J.E.M. Smeets Sylvia Stappenberg-Klinkenberg Effects of vagal nerve stimulation in children. Prof. Dr. J.S.H. Vles / Prof. Dr. A.P. Aldenkamp Dr. H.J.M. Majoie Nienke Tielemans Stimulating self-management strategies in stroke patients and their spouses. Prof. Dr. C.M. van Heugten / Prof. Dr. D. Wade Dr. J. Visser-Meily / Dr. V. Schepers Renske Uiterwijk Prediction of cognitive function in patients with cerebral small vessel disease. Prof. Dr. R.J. van Oostenbrugge Dr. J.E.A. Staals Jordie van van Tuijl Post-stroke epilepsy; prevention and treatment. Prof. Dr. A.P. Aldenkamp / Prof. Dr. J. Lodder Dr. E.P.M. van Raak Els Vanhoutte Peripheral Neuropathy Outcome Measures Standardisation Study. Dr. C.G. Faber / Dr. P.A. van Doorn Dr. I.S.J. Merkies Tamar Veenendaal Neurotransmitter Metabolism of Cognitive Adverse Events of Anti-Epileptic Drugs. Prof. Dr. A.P. Aldenkamp Dr. J.F.A. Jansen Stephanie Vos The role of biomarkers in preclinical and prodromal Alzheimer s desease. Prof. Dr. F.R.J. Verhey Dr. P.J. Visser Sanne Wagemakers Vestibular Schwannoma: optimizing diagnostics and treatment. Prof. Dr. R.J. Stokroos Jerome Waterval Hyperostosis cranialis interna. Prof. Dr. R.J. Stokroos Lonneke Willemstein The influence of the care context on neuropsychiatric symptoms in the demented elderly in nursing homes. Prof. Dr. F.R.J. Verhey Prof. Dr. J.M.G.A. Schols / Dr. M.E. de Vugt Sau May Wong Microvascular Brain Magnetic Resonance Imaging. Prof. Dr. J.E. Wildberger Dr. W.H. Backes Eleana Zhang Blood-brain barrier in cerebral small vessel disease, a dynamic contrast-enhanced MRI study. Prof. Dr. R.J. van Oostenbrugge Dr. J.E.A. Staals Anne Zumach Language perception and production in impaired children. Dr. L.J.C. Anteunis Dr. E. Gerrits 52 MH&NS Annual Report 2013

5 Divison Mental Health Name Title Thesis Supervisor(s) Co-Supervisor(s) Geor Bakker Clinical and neurobiological characterization of muscarinic receptor-deficit schizophrenia (MRDS). Prof. Dr. Th. van Amelsvoort Prof. J Booij / Dr. M Caan Jindra Bakker Reward processing and its association with some relevant biological processes and experimental measures. Prof. Dr. I. Myin-Germeys Dr. M.C. Wichers / Dr. R. Lieverse Tim Batink Third Wave Behaviour Therapies; Measures & Interventions. Prof. Dr. J.J. van Os Dr. M.C. Wichers / Dr. F. Peeters Ibrahim Tolga Binbay Dissecting the ecogenetic interactions in the urban social environment for psychosis? Prof. Dr. J.J. van Os Dr. M. Drukker Lonneke Bodar Depression and memory: a search for a link with Event-related potentials. Prof.dr. J.J. van Os Dr. R. Lousberg Wilma Boevink What psychiatric patients effectively do to help themselves. Prof. Dr. J.J. van Os Prof. Dr. W. van Tilburg / Dr. B. Kroon / Dr. Ph. Delespaul Frank van Dael Obsessive compulsive disorder and psychosis. Prof. Dr. I. Myin-Germeys Prof. Dr. J. van Os Jeroen Decoster Gene-environment interactions in psychosis. Prof. Dr. I. Myin-Germeys Dr. R. van Winkel Patrick Domen Dysconnectivity in Psychosis: a neuroimaging study. Prof. Dr. J.J. van Os Dr. M.C. Marcelis Bernice Doove Preventive child health care in dialogue with data on developmental outcome. Understanding pathways of adaptation: Prof. Dr. J.J. van Os / Prof. Dr. F. Ferron Dr. M. Drukker MOMknowsbest. Rens Evers Cognitive function, psychosis and 22q11DS. Prof. Dr. Th. van Amelsvoort/Prof L. Curfs Aleida Frissen Psychosis and urbanicity. Prof. Dr. J.J. van Os Dr. R. Lieverse / Dr. M. Drukker Martin Gevonden Social exclusion and psychosis: linking minority stress, brain metabolism & mental health. Prof. Dr. I. Myin-Germeys Prof. Dr. J.P.C.J. Selten / Prof. Dr. J. Booij Sinan Gülöksüz Gene-environment interactions in the curriculum. Prof. Dr. J.J. van Os / Dr. B. Rutten Dr. M. Drukker Caroline Hammels A novel anti-inflammatory IgG immunotherapy in Alzheimer s disease. Prof. Dr. J.J. van Os Dr. B.P.F. Rutten Jessica Hartmann A good laugh and a long sleep - Insights from prospective and ambulatory assessments about the importance of Prof. Dr. J.J. van Os Dr. M.C. Wichers positive affect and sleep in mental health. Laila Hasmi Cultural epidemiology in psychosis. Prof. Dr. J.J. van Os Dr. M. Drukker Manuela Heins Stress-reactivity in daily life: prediction of outcome. Prof. Dr. I. Myin-Germeys Dennis Hernaus Psychotic reactivity to daily life stress: an experimental approach. Prof. Dr. I. Myin-Germeys Dr. D. Collip Petra Höhn e/v Vercauteren Use of momentary assessment technology in clinical interventions. Prof. Dr. I. Myin-Germeys Dr. M.C. Wichers Nathalie Janssen Childhood Adversity and Salience Dysregulation. Prof. Dr. I. Myin-Germeys Dr. J. Schieveld Mayke Janssens Predictors of functional outcome in psychosis. Prof. Dr. I. Myin-Germeys Dr. H.W.G. Lataster Janique Jessurun Cost-effectiveness of CYP 2D6 and 2C19 provision Antilleans in Curacao Netherlands. Prof. Dr. P.N. van Harten / Prof..dr. A.C.G. Egberts Dr. D.E. Tenback Marasha de Jong Mindfulness Based Cognitive Therapy for Chronic Pain and Comorbid Depression. Prof. Dr. J.J. van Os Dr. F.P.M.L. Peeters Zuzana Kasanova Reciprocal interactions in Psychosis. Prof. Dr. I. Myin-Germeys Dr. D. Collip Annelie Klippel The underlying mechanisms of psychosis: a dynamic network approach of psychological phenomena. Prof. Dr. I. Myin-Germeys Dr. M.C. Wichers Inge Knuts Factors of Nicotine Dependance in Panic Disorder. Prof. Dr. E. Griez Dr. K. Schruers / Prof. Dr. I Myin-Germeys Gerdy Konings Bariatric surgery, facts and feelings, patients perspective. Prof. Dr J van Os; Prof Dr Rudolf Ponds Dr. Ruud Severeijns / Dr. M Drukker Anne Koopmans Kosteneffectiviteit van CYP 2D6 en 2C19 bepaling bij Antillianen in Curaçao en Nederland. Prof. Dr. P.N. van Harten / Prof.dr. H.W. Hoek Dr. D.J. Vinkers Ingrid Kramer Daily life emotional dynamics: new source for understanding and treating mental health symptoms. Prof. Dr. J.J. van Os Dr. M.C. Wichers Iris Lange Novel self-management techniques for early expressior of psychopathology: an experimental study linking neural and Prof. Dr. Th. van Amelsvoort Dr. K.R.J. Schruers mental state. Christine van der Leeuw The search for endophenotypes and their structural cerebral correlates in psychotic disorder. Prof. Dr. J.J. van Os Dr. M.C. Marcelis Nicole Leibold The role of Serotonergic function in a translational panic model involving carbon dioxide exposure. Prof. Dr. I. Myin-Germeys Dr. K. Schruers / Dr. D.L.A. van den Hove Carsten Leue Studies at the interface of psychosomatic medicine costs and trends, from clinic to primary care. Prof. Dr. J.J. van Os Claudia Lothmann e/v Menne Reward experience in daily life: from fundamentals to clinical practice. Prof. Dr. J.J. van Os Dr. M.C. Wichers Rosanne Luijcks Psychophysiological effects of stress. Prof. Dr. J.J. van Os Dr. R. Lousberg Charlotte Mentzel The electronic measurement of bradykinesia, a pilot study. The electronic measurement of movement disorders. Prof. Dr. P.N. van Harten / Prof.Dr. M.A.J. de koning Dr. R. Bakker Thierry Mentzel Electronic assessment of movement disorders. Movement disorders in patients on short-term treatment with antipsychotics, and their sibs: a prospective study. The Group Study. Prof. Dr. P.N. van Harten / Prof. Dr. H. Daanen Dr. R. Lieverse 53 MH&NS Annual Report 2013

6 Stijn Michielse Brain plasticity in adolescents of the general population with prodromal psychotic symptoms; effects of Acceptance Prof. Dr. J.J. van Os Dr. M.C. Marcelis and Commitment Therapy (ACT) on the reward system. Tais Moriyama Correlation of dopamine transporter density and repetitive behaviours (compulsive and impulsive) in Parkinson s Prof. Dr. J.J. van Os Disease. Bert ter Mors Single Case Experimental Design (SCED) in Patients with Acquired Brain Injury. Prof. Dr. P.N. van Harten / Prof. Dr. C.M. van Heugten Martine van Nierop Social stress and psychose. Prof. Dr. J.J. van Os Prof. Dr. I. Myin-Germeys / Dr. R. van Winkel Maarten Otter Psychopathology and cognitive function in Triple X syndrome. Prof. Dr. Th. van Amelsvoort Wieske Overbeek Overweight and metabolic abnormalities in children with autismspectrumdisorders with and without antipsychotic Prof. Dr. P.N. van Harten/ Prof dr Th van Amelsvoort Dr. Yvette Roke medication. Sanne Peeters Brain plasticity in psychosis: a prospective neuroimaging study. Prof. Dr. J.J. van Os Dr. M.C. Marcelis Ehsan Pishva Biological mechanisms underliging the impact of environmental risk factors in psychotic disorder. Prof. Dr. J.J. van Os Dr. B.P.F. Rutten / Dr. G. Kenis Suzanne Roggeveen The influence of mobile phone radiation on EEG and ECG. Prof. Dr. J.J. van Os Dr. R. Lousberg Mushde Shakir The effect of reducing from two to one antipsychotic in patients with Severe Mental Illness. Subjective aspects of Prof. Dr. P.N. van Harten Dr. D.E. Tenback drug-induced movement disorders. Feikje Smeets ithink: Psychotic disorder: positive, negative and cognitive symptoms in daily life. Prof. Dr. J.J. van Os Dr. H.W.G. Lataster René van der Snoek Rating scale with use of digital device for Movement disorders. Prof. Dr. P.N. van Harten Yori van der Steen Daily life cognitive risk factors in early psychosis. Prof. Dr. I. Myin-Germeys Dr. R. van Winkel / Dr. H.W.G. Lataster Henrietta Steinhart Predictors of therapeutic effects. Prof. Dr. I. Myin-Germeys Dr. H.W.G. Lataster Thomas Vaessen INTERACT: a novel intervention for psychosis. Prof. Dr. I. Myin-Germeys Dr. D. Collip Claudia Vingerhoets Clinical and neurobiological characterization of muscarinic receptor deficit schizophrenia (MRDS). Prof. Dr. Th. van Amelsvoort Prof..J Booij / Dr. O. Bloemen Carine Vossen Habituation of pain. Prof. Dr. J.J. van Os Dr. R. Lousberg Jonas Weijers Mentalization-Based Treatment for Psychosis: A randomized controlled trial for outpatients with a nonaffective Prof. Dr. J.P.C.J. Selten Prof. Dr. I. Myin-Germeys psychotic disorder. Anna Willems Borderline Personality disorders and Movement disorders. Prof. Dr. P.N. van Harten Dr. D.E. Tenback Mark van Winkel Active mobilisation of psychological resources and work engagement during burn out treatment. Prof. Dr. I. Myin-Germeys Dr. M.C. Wichers / Dr. F.P.M.L. Peeters Mirjam Wouda Childhood Adversity and Salience Dysregulation. Prof. Dr. J.J. van Os Dr. J. Schieveld Catherine van Zelst Destigmatizing mental illness. Prof. Dr. J.J. van Os Dr. Ph. Delespaul 54 MH&NS Annual Report 2013

7 Divison Neuroscience Name Title Thesis Supervisor(s) Co-Supervisor(s) Raul Abella Biomarkers of pediatric cardiac and brain injury in open heart surgery. Prof. Dr. L. Zimmermann / Prof. Dr. J.S.H. Vles MD, PhD D. Gazzolo / Dr. A.W.D. Gavilanes Sven Akkerman Temporal dynamics of the second messengers camp and cgmp in memory processes. Prof. Dr. H.W.M. Steinbusch Dr. J. Prickaerts Leandro Antero Da Silva Dorsal hippocampus M3 and M1 muscarinic receptors modulate the autonomic and behavioral responses of contextual fear conditioning in rats. Prof. Dr. H.W.M. Steinbusch Mayienne Bakkers Small fibre neuropathy in sarcoidosis. Diagnosis, athogenesis and implications for treatment. Dr. C.G. Faber / Prof. Dr. M.H.V. de Baets Dr. I.S.J. Merkies Andrea Balthasar The use of the photonic needle during pain procedures. Prof. Dr. M. van Kleef Dr. M. Sommer Maarten van Beek SCS in polyneuropathies painful diabetic polyneuropathy. Prof. Dr. W.F. Buhre / Prof. Dr. E.A. Joosten Bart Biallosterski Afferent recording and non voiding activity in the motor sensory system of the bladder. Prof. Dr. Ph. van Kerrebroeck Dr. G.A. van Koeveringe / Dr. S. de Wachter Gerard Bode Crossing the blood-brain barrier and finding novel players in neurodegenerative protein aggregation. Prof. Dr. M.H.V. de Baets Prof. Dr. H.W.M. Steinbusch / Dr. P. Martinez-Martinez Eva Bollen Glutamatergic signal transduction in hippocampal memory processes. Prof. Dr. H.W.M. Steinbusch Dr. J. Prickaerts Esther Bouman Quality Standards in Aneasthesiological Medical Systems. Prof. Dr. W.F. Buhre Prof. Dr. M. Marcus / Dr. H.F. Gramke Koen van Boxem Effects of pulsed radiofrequency of the dorsal root ganglia in sciatica. Prof. Dr. M. van Kleef / Prof. Dr. A.E. Joosten Dr. J. van Zundert Davi Campos la Gatta Involvement of the medial prefrontal cortex TRPV1 receptors in the modulation of the baroreflex activity. Prof. Dr. H.W.M. Steinbusch João Carreira RNA modulating therapy in Huntington s disease. Prof. Dr. J.J. van Overbeeke / Prof. Dr. Y. Temel Dr. A. Jahanshahianvar Yanny Cheng Keratoplasty. Dr. R.M.M.A. Nuijts / Prof. Dr. C.A.B. Webers Joris Coonen Fetal Nociception and Pain. Prof. Dr. A.E. Marcus Prof. Dr. A.E. Joosten Kimberly Cox Fetal and perinatal asphyxia Preconditioning - genomic response. Prof. Dr. J.S.H. Vles Boris Cox Multimodal Concept after Liver Surgery. Prof. Dr. A.E. Marcus / Prof. Dr. W.F. Buhre Prof. Dr. C. de Jong Supriya Dabir Anti-vascular endothelial growth factor, inflammatory and neurotrophic factors in aqueous, vitreous and serum of Prof. Dr. C.A.B. Webers Dr. J.S.A.G. Schouten patients with diabetic retinopathy. Julie Dela Cruz Dopamine mechanisms in learning and memory: Evidence from rodent studies. Prof. Dr. H.W.M. Steinbusch / Prof. Dr. R.J. Bodnar Dr. B.P.F. Rutten Mor Dickman Orthostatic Blood Pressure Changes in Familial Dysautonomia Patients and their Correlation to IKBKAP WT and Dr. R.M.M.A. Nuijts Dr. T.T.J.M. Berendschot Mutant mrna Levels. Wouter Donders Modeling cerebral blood flow; estimation of microvascular properties from macrovascular blood flow patterns. Prof. Dr. T. Delhaas Dr. ir. W. Huberts Muriël Doors The Value of Optical Coherence Tomography in Anterior Segment Surgery. Prof. Dr. R.M.M.A. Nuijts / Prof. Dr. C.A.B. Webers Dr. T.T.J.M. Berendschot Antonio Drago A step towards a genome-wide molecular pathway analysis of response to pharmacological treatment of psychiatric Prof. Dr. H.W.M. Steinbusch disorders. Jamie Drossaerts Sacral neuromodulation; evolving and elucidating treatment. Prof. Dr. Ph.E.V.A. van Kerrebroeck Marie Elshout Outcome studies and monitoring of patients in ophthalmology. Prof. Dr. C.A.B. Webers Dr. J.S.A.G. Schouten Markus Gantert Fetal inflammatory injury as origin of long term disease: Lessons from animal models. Prof. Dr. B.W.W. Kramer / Prof. Dr. L.J.I. Zimmermann Dr. A.W.D. Gavilanes Romina Gentier Studying the anatomy of Aß and a-synuclein aggregation in Alzheimer s disease and Parkinson s disease in an Prof. Dr. H.W.M. Steinbusch environment of proteasomal stress. Nick van Goethem Cholinergic mechanisms underlying memory processes. Prof. Dr. H.W.M. Steinbusch Dr. J. Prickaerts Bart van Gorp Translational research on spinal cord injury and cell-based therapies; a focus on pain and sensorimotor disturbances. Prof. Dr. E.A. Joosten / Prof. Dr. M. van Kleef Dr. J. Patijn / Dr. R. Deumens Roel Haeren Blood-brain barrier functioning in patients with drug-resistant temporal lobe epilepsy. Prof. Dr. J.J. van Overbeeke Dr. G. Hoogland Pim Heckman Targeting PDE4 for improving early cognition processes: a translational approach. Prof. Dr. J. Ramaekers Dr. J. Prickaerts / Dr. A. Blokland Sarah Hescham Deep brain stimulation in experimental Alzheimer s disease. Prof. Dr. Y. Temel Prof. Dr. K. van Overbeeke Ramona Hohnen The role of intermvral messenger substances in normal and pathological control of urinary bladder activity. Prof. Dr. Ph. van Kerrebroeck Dr. G.A. van Koeveringe Daisy Hoofwijk Chronification of acute postoperative pain after outpatient surgery. Prof. Dr. A.E. Marcus Dr. H. Gramke / Drs A. Fiddeler Mark van den Hurk Neuropsychiatric disease modeling using induced pluripotent stem cells (ipscs): a stem cell-based approach to studying Prof. Dr. H.W.M. Steinbusch Dr. B.P.F. Rutten / Dr. G.R.L. Kenis epigenetic and neurogenic changes, and investigating the impact of environmental exposures. Matthias Hütten Quantitative Signal- und Artefaktuntersuchungen zur Kategorisierung von Gefäßendoprothesen in vitro Möglichkeiten der kontrastverstärkten 3D-Magnetresonanz-Angiographie im Vergleich zur Computertomographie. Prof. Dr. B.W.W. Kramer Dr. Tim Wolfs 55 MH&NS Annual Report 2013

8 Mark Janssen SelectStim: towards a selective stimulation of the motor part of the subthalamic nucleus. Prof. Dr. Y. Temel Prof. Dr. V. Visser-Vandewalle Reint Jellema Preterm babies with neurological damage as patients for stem cell therapy. Prof. Dr. B.W.W. Kramer Dr. A.W.D. Gavilanes Pamela Kleikers NADPH oxidases in ischemia-reperfusion injury: frend or foe? Prof. Dr. H.W.M. Steinbusch / Dr. H. Schmidt Pieter Kubben Ultra low-field strenght intraoperative MRI for Glioblastoma Surgery. Prof. Dr. J.J. van Overbeeke Dr. H. van Santbrink Steffen Kunzmann Exposure to antenatal inflammation mechanisms of fetal adaptation. Prof. Dr. B.W.W. Kramer Dr. A.W.D. Gavilanes Elke Kuypers Fetal development after antenatal exposures: Chorioamnionitis and maternal glucocorticoids. Prof. Dr. B.W.W. Kramer / Prof. Dr. H.W.M. Steinbusch / Prof. Dr. S.G. Kallapur Sarah Lenz Neural Correlates of Conflict Processing in an Auditory Stroop Task measured with intracranial EEG. Prof. Dr. J. Schulz / Prof. Dr. H.W.M. Steinbusch Anouk Linssen Cost effectiveness of screening for hearing lost in adults. Prof. Dr. B. Kremer Dr. L.J.C. Anteunis Filipa Lopes de Campos Contribution of GDNF to the Estrogen-mediated Neuroprotection in Nigrostriatal System. Prof. Dr. H.W.M. Steinbusch / Prof. Dr. Y. Temel Anneke Maas Sleep problems in individuals with genetic disorders associated with intellectual disability. Prof. Dr. l. Curfs / Prof. Dr. R. Didden Franciscus van der Meer Methods for development of optimal sampling strategies for therapeutic drug monitoring and population Prof. Dr. L. Zimmermann Prof. Dr. M. Marcus pharmacokinetics using Maximum A Posteriori Bayesian estimation. Maartje Melse The subthalamic nucleus and midbrain serotonergic neurons: the origin of mood changes in Parkinson s disease? Prof. Dr. Y. Temel/ Prof. Dr. T. Sharp Hans de Munter ATMP product development (Xcell-Center/CellPass/Amarna Stem Cells SL). Prof. Dr. E. Wolters / Prof. Dr. H.W.M. Steinbusch Jose Luis Nava Investigation of a human stem cell based intervention strategy in an experimental model of amyotrophic lateral Prof. Dr. H.W.M. Steinbusch Prof. Dr. J. Weis sclerosis. Maria Nikiforou Effects of stem cell therapy after hypoxic ischemia on the gastrointestinal innervation. Prof. Dr. B.W.W. Kramer Dr. Tim Wolfs Dennis Oerlemans Further progress in Sacral Nerve Stimulation for neuromodulation of the lower urinary tract. Prof. Dr. Ph.E.V.A. van Kerrebroeck / Prof. Dr. R.A. de Bie Dr. E.H.J. Weil Daan Ophelders Effects of stem cell therapy and exosome treatment after hypoxic ischemia on the brain. Prof. Dr. B.W.W. Kramer Dr. Tim Wolfs Evelyn Peelen Neurological and immunological aspects of vitamin D in MS patients. Prof. Dr. R.M.M. Hupperts Prof. Dr. J. Cohentervaert Birgit Plantinga Improved deep brain stimulation to relieve Parkinson patients. Prof. Dr. Y. Temel / Ter Haar Romeny Prof. Dr. Y. Temel Wouter Pluijms The Mechanism of Spinal Cord Stimulation Treatment in Diabetic Polyneuropathy. Prof. Dr. M. van Kleef / Prof. Dr. E.A. Joosten Dr. C.G. Faber Yara Pujol López Effect of prenatal immune challenge with polynosinic: polycytidylic acid (Poly I:C) on behaviour and biochemical Prof. Dr. H.W.M. Steinbusch Dr. Aye Mu Myint changes in the adult offspring. Kevin Rademakers Determination and quantification of detrusor activity. Prof. Dr. Ph.E.V.A. van Kerrebroeck Dr. G.A. van Koeveringe Marjolein Raijmakers Hippocampal plasticity of excitability after experimental febrile seizures. Prof. Dr. J.-M. Rigo / Prof. Dr. H.W.M. Steinbusch Margriet van der Reis Outcome and quality of life of patients with exudative macular degeneration. Prof. Dr. C.A.B. Webers Dr. J.S.A.G. Schouten Francesco Risso Biomarkers of perinatal asphyxia. Prof. Dr. J.S.H. Vles MD, PhD D. Gazzolo / Dr. A.W.D. Gavilanes Hellen Römkens Angle closure glaucoma. Prof. Dr. C.A.B. Webers Dr. H.J.M. Beckers Andrea Sannia High risk newborns and brain biochemical monitoring. Prof. Dr. J.S.H. Vles Dr. D. Gazzolo / Dr. A.W.D. Gavilanes Remco Santegoeds Improvement of Deep brain simulation (DBS) therapies for Parkinson s, OCD, Anorexia and depression using advanced Prof. Dr. Y. Temel / Prof.Dr. J.J. van Overbeeke multi-channel neuro-simulation and neural response recording. Simone Schaëfer Auditory pathway damage in the neonate. Prof. Dr. R.J. Stokroos / Prof. Dr. B. Kremer / Prof. Dr. B.W.W. Kramer Olaf Schijns Visualisation of the Gaba-transporter in temporal lobe epilepsie. Prof. Dr. J.J. van Overbeeke Dr. G. Hoogland Sandra Schipper Receptor trafficking as a novel anti-epileptic target. Prof. Dr. J.J. van Overbeeke / Prof. Dr. J.S.H. Vles Dr. G. Hoogland Lisa Schönfeld Motor cortex stimulation combined with immune modulation to achieve brain repair in vivo Prof. Dr. Y. Temel / Prof. Hendrix (UHasselt) Anna Schüth Structural and physiological mapping of the control system of the bladder and the urethra. Dr. G.A. van Koeveringe Matthias Seehase Chorioamnionitis as a multi-organ disease of the fetus. Prof. Dr. L.J. Zimmermann / Prof. Dr. B.W.W. Kramer Rohit Shetty Keratoconous. Prof. Dr. R.M.M.A. Nuijts / Prof. Dr. C.A.B. Webers Rachel Slangen Effect of spinalcord stimulation in painful diabetic neuropathy. Prof. Dr. M. van Kleef Dr. C.G. Faber Jasper Smit Finding a suitable treatment for severe tinnitus with Deep Brain Stimulation. Prof. Dr. R.J. Stokroos / Prof. Dr. Y. Temel Martijn Smits Sacral neuromodulation: new developments. Prof. Dr. Ph. van Kerrebroeck Prof. Dr. S.G.G. de Wachter 56 MH&NS Annual Report 2013

9 Michelle Sparnaaij The placental impact on perinatal asphyxia and fetal asphyctic preconditioning. Prof. Dr. J.S.H. Vles Dr. A.W.D. Gavilanes / Dr. E. Strackx Björn Stessel Pharmacological and non-pharmacological interventions to reduce acute postoperative pain after day-case surgery. Prof. Dr. A.E. Marcus Prof. Dr. H. ten Cate / Dr. H.F. Gramke Jo Stevens Immunotherapie voor Alzheimer. Prof. Dr. H.W.M. Steinbusch Prof. Dr. M.H.V. de Baets / Dr. M. Losen Sonny Tan The subthalamic nucleus and midbrain serotonergic neurones: a novel motor limbic interface. Prof. Dr. Y. Temel Prof. Dr. V. Visser-Vandewalle Annelien Tan The quality of glaucoma surgery. Prof. Dr. C.A.B. Webers Dr. H.J.M. Beckers Maurice Theunissen Prevalence and predictors of chronic postsurgical pain after hysterectomy. Prof. Dr. M.L. Peters / Prof. Dr. A.E. Marcus Dr. H.F. Gramke Yuan Tian Uveitis and age related macular degeneration(amd). Prof. Dr. C.A.B. Webers Dr. T. Berendschot Sizzle Vanterpool Periodontal disease and preterm birth. Prof. Dr. L.J. Zimmermann / Prof. Dr. B.W.W. Kramer Dr. Jasper Been Alessandro Varrica Clinical and biochemical markers of brain injury in open heart surgery. Prof. Dr. L. Zimmermann / Prof. Dr. J.S.H. Vles MD, PhD D. Gazzolo / Dr. A.W.D. Gavilanes Anand Vinekar A comprehensive evaluation of the prevalence of retinopathy of prematurity, application of tele-medicine as a service Prof. Dr. C.A.B. Webers Dr. N.J. Bauer delivery tool and to estimate the disease burden, also using digital imaging techniques as a clinical severity predictive tool and identification of the causative genes. Nienke Visser Toric intracoular lenses in correcting astigmatism. Prof. Dr. R.M.M.A. Nuijts / Prof. Dr. C.A.B. Webers Rinske Vlamings Deep brain stimulation in Huntington s disease. Prof. Dr. Y. Temel Prof. Dr. V. Visser-Vandewalle Carine Vossen Event-related potentials and pain: a new method to unravel the pain-erp. Prof. Dr. M. van Kleef / Prof. Dr. J.J. van Os Dr. R. Lousberg Desiree Vrijens Bladder function and affective symptoms Prof. Dr. Ph.E.V.A. van Kerrebroeck Dr. G.A. van Koeveringe Magdalena Weidner Developmental epigenetic programming of aggressive and emotional behavior. Prof. Dr. H.W.M. Steinbusch Prof. Dr. K.P.J. Lesch Maria Wertli Prognose of Chronic Clinical Pain Conditions: the example of complex regional pain syndrome 1 and low back pain. Prof. Dr. M. van Kleef Dr. F. Brunner / Dr. R. Perez Laura Wielders The PREMED study. Prof. Dr. R.M.M.A. Nuijts Dr. J.S.A.G. Schouten Youssef Yakkioui Prognostic factors in skull base chordomas. Prof. Dr. Y. Temel/ Prof. Dr. J.J. Van Overbeeke Dagmar Zeef Diepe hersenstimulatie bij neurodegeneratieve ziektenbeelden. Prof. Dr. Y. Temel Shuo Zhang Molecular identification in the living eye: a mobile Raman spectrometer for non invasive determination of the Prof. Dr. C.A.B. Webers Dr. T. Berendschot molecular composition of the eye. Tom van Zundert Tracheal intubation and airway devices. Prof. Dr. A.E. Marcus Alex Zwanenburg Foetale Bewaking. Prof. Dr. H.W.M. Steinbusch / Prof. Dr. B.W.W. Kramer 57 MH&NS Annual Report 2013