Department of Psychiatry VU University Medical Center and Department of Research GGZ ingeest

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1 Department of Psychiatry VU University Medical Center and Department of Research GGZ ingeest Annual Report 2014

2 Table of Contents Preface 3 Scientific Research 4 Staff 7 Highlights of An example of a project 12 - A paper of importance 14 - An example of societal impact 15 Scientific Output Indicators of esteem and societal impact - Clinical guidelines 20 - Memberships of editorial boards of journals 21 - Memberships of advisory boards/scientific organisations 22 - Personal grants 29 - Examples of media attention in Invited lectures 40 Publications in International scientific publications 49 - Publications in Dutch 61 - Reports 62 - Books and book chapters 62 Dissertations in 2014 (PhD theses) 63 Dissertations expected in Contact information 73 2

3 Preface An annual report is a resume of achievements of the past year. Earlier ambitions that have materialized. It summarizes the results of creative and very hard work by our colleagues at the department of Psychiatry VUmc and at GGZ ingeest was a very good year for our department. The annual report bears testimony to this success. We have the ambition to help creating better lives for our patients through a combination of research, teaching and clinical work. In order to be able to do that, we realize we need the best people to do the job. Therefore the most important challenge for an academic department is to attract the best people and to keep them working as best they can. Our field is as multidisciplinary as medical fields can be. This is reflected in our staff and in the partners we work with. It is often at the edges, where different fields of research and disciplines meet, that new ideas and hypotheses that may be tested are born. Most of our work is embedded within the large research institutes at VUmc, providing exactly the kind of environment that one would wish for. Given our clinical ambition, infusion of our research by clinical experience and the needs of our patients may be even more important than the interdisciplinary collaboration with our peers Prof. Aartjan Beekman Prof. Jan Smit in science. The merging of our academic medical department of psychiatry with the research department of GGZ ingeest and our embedding within the academische werkplaatsen (academic working places) of GGZ ingeest is the third ingredient of successful work. Dear reader, please feel free to decide for yourself whether you agree that, indeed, 2014 was an excellent year for our department and whether you agree that a great staff, working in a stimulating environment may be the reason for this success! Prof. Aartjan Beekman, MD, PhD, Head Department of Psychiatry VUmc and Board member GGZ ingeest Prof. Jan Smit, PhD, Director Research Department GGZ ingeest 3

4 Scientific Research The research groups of GGZ ingeest and the Department of Psychiatry of the VU University Medical Center are collaborating intensively in their conduct of scientific research of psychiatric disorders. Our key research questions are: what are the underlying causes and course of psychiatric disorders, and the best prevention and treatment options? The main disease focus of our research line is on the most common diseases: (unipolar and bipolar) depressive disorders and anxiety disorders. Additional, overarching themes are old-age psychiatry and the interaction between somatic and psychiatric disorders (soma & psyche). To address our central research questions, we conduct research that ranges e.g. from examining the impact of DNA or brain dysregulations on diesease, through clinical intervention studies that examine the effects of (innovative) therapies in patients and studies examining the societal impact of common mental disorders. Prof. Brenda Penninx Embedding and collaboration A historical strong asset to our research group is the existence of large research infrastructures that have been developed in collaboration with other national academic centers and with surrounding networks of general practices and mental health institutions. This has led to a series of long lasting and large-scale observational studies such as NESDA, LASA, NOCDA and NESDO. These research infrastructures are being updated with innovative data collections and serve as a useful basis to address many different research questions. Staff data collection and data management 4

5 Scientific Research Our scientific clinical research is embedded within seven academic working places at GGZ ingeest: anxiety disorders, depressive disorders, bipolar disorders, old-age psychiatry, soma and psyche, recovery and rehabilitation and Prezens (basic mental health care). At these academic working places, clinicians and researchers are intensively collaborating and conducting various innovative research projects. Examples of such projects are e-health interventions in which standard clinical practice is enriched with intervention strategies provided through internet, and projects testing innovative therapies such as running therapy, light therapy and brain stimulation. Partly due to the ongoing research in clinical setting, in 2014 the national TOPGGz quality label was obtained by the academic working places anxiety disorders, depressive disorders and old-age psychiatry and their corresponding departments of GGZ ingeest. Both the intervention an observational projects are supported through a strong datamanagement and fieldwork team composed of over 10 fte. At the VU University Medical Center, our epidemiological and clinical research is embedded in the EMGO+ Institute for Health and Care Research. Our neurobiological and genetic research is embedded in the Neuroscience Campus Amsterdam (NCA) in which several groups collaborate on fundamental and translational neuroscience research. Both research institutes have been evaluated as excellent by recent external review committees, and provide interdisciplinary collaboration with various other research groups at the campus. Through this embedding and the close collaboration, the psychiatric research group of VUmc and GGZ ingeest has grown consistently over the last years, both in terms of quality as well as quantity of research output. Results 2014 The year 2014 has once again been an extremely successful year for our research group. First, this becomes visible through the high number of 251 international, scientific papers produced by the research group. This is an all-time record! Many of these have been published in the highest psychiatric or medical journals such as: Nature Genetics (2x), Molecular Psychiatry (5x), American Journal of Psychiatry (2x), Biological Psychiatry (2x), Psychological Medicine (6x), and Journal of Clinical Psychiatry (4x). For a more detailed overview of our scientific publications see the scientific output 2014 on page 16. Second, in 2014 a total of 8 PhD-candidates successfully defended their thesis under (co)supervision of one of our senior staff members. Currently about 80 PhD-trajectories are ongoing, which illustrates the vitality of our research group. Third, we have been very successful in ob- 5

6 Scientific Research taining new research funding. Lianne Schmaal has obtained a prestigious career grant from the Hersenstichting, and both Lianne Schmaal and Odile van den Heuvel obtained funding from the US NIH to lead large collaborative imaging consortia (ENIGMA) around depressive and obsessive compulsive disorder, respectively. In addition, we obtained EU Horizon 2020 funding for the Mastermind project and for national projects to examine victimization in depressed persons (PI Aartjan Beekman) and collect depression phenotype data in large-scale genetic cohorts (BIONIC project, PIs Brenda Penninx and Mariska Bot in collaboration with colleagues from the biological psychology department). Together, these research projects provide almost 5 million Euros of future research funding for our group. Staff management support 6

7 Staff Department of Psychiatry VUmc / GGZ ingeest Senior research staff (PhD thesis 3 years ago) Prof. A.J.L.M. (Ton) van Balkom, MD, PhD N.M. (Neeltje) Batelaan, MD, PhD Prof. A.T.F (Aartjan) Beekman, MD, PhD (Head Department of Psychiatry) M.A. (Marijke) Bremmer, MD, PhD H.C. (Hannie) Comijs, PhD Prof. D.J.H. (Dorly) Deeg, PhD Prof. J. (Joost) Dekker, PhD A. (Annemieke) Dols, MD, PhD P.J. (Nel) Draijer, PhD 7

8 Staff S. (Stasja) Draisma, PhD Prof. R.M. (Rose-Marie) Dröes, PhD Prof. P. (Piet) Eikelenboom, MD, PhD (professor emeritus) E. (Eric) van Exel, MD, PhD L. (Lotte) Gerritsen, PhD O.A. (Odile) van den Heuvel, MD, PhD Prof. A. (Adriaan) Honig, MD, PhD A. (Adriaan) Hoogendoorn, PhD Prof. R.W. (Ralph) Kupka, MD, PhD F. (Femke) Lamers, PhD P. (Patricia) van Oppen, PhD Prof. B.W.J.H. (Brenda) Penninx, PhD 8

9 Staff Prof. H. (Heleen) Riper, PhD D.J.F. (Anneke) van Schaik, MD, PhD J. (Josien) Schuurmans, PhD Prof. J.H. (Jan) Smit, PhD (Director Research Department) Prof. M. (Max) Stek, MD, PhD J. (Jaap) van der Stel, PhD J. (Jan) Theunissen, PhD R. (Rob) Veerhuis, PhD Prof. D.J. (Dick) Veltman, MD, PhD N. (Nicole) Vogelzangs, PhD 9

10 Staff Post-doc researchers (PhD thesis < 3 years ago) Some of our post-doc researchers W. (Wouter) van Ballegooijen, PhD A. (Anna) Muntingh, PhD M. (Mariska) Bot, PhD A.(Arianne) van Reedt-Dortland, PhD M. (Marijn) Distel, PhD D. (Didi) Rhebergen, MD, PhD E. (Els) Dozeman, PhD L. (Lianne) Schmaal, PhD K.L. (Klaas) Huijbregts, PhD S. (Sigfried) Schouws, PhD R. (Rick) Jansen, PhD A. (Adrie) Seldenrijk, PhD U.M.H. (Ursula) Klumpers, MD, PhD B. (Barbara) Stringer, PhD Y. (Yuri) Milaneschi, PhD K. (Kathleen) Thomaes, PhD P.D. (Paul David) Meesters, MD, PhD J.E. (Jenneke) Wiersma, PhD 10

11 Staff PhD students VUmc Department of Psychiatry in 2014: 1. Ilse van Beljouw 42. Bart Loosman 2. Pierre Bet 43. J. Meeuwissen 3. Catherine Black 44. Sanne Mensing 4. Petra Boersma 45. Margo Metz 5. Rosa Boeschoten 46. Marieke Michielsen 6. Wicher Bokma 47. Bianca Mooi 7. Annemarie Braamse 48. Jan Mokkenstorm 8. Annet Bron 49. Annemarie Noord 9. Annelies Brouwer 50. Mardien Oudega 10. Maarten van Dijk (thesis in 2014) 51. Lucas van Oudheusden 11. Marijke van Dijk 52. Nadine Paans 12. Merijn Eikelenboom 53. Thomas Pattyn 13. Sarah Fan 54. Wouter Peyrot 14. Roxanne Gaspersz 55. Janwillem Renes 15. Ellen Generaal 56. Dóra Révész 16. Deborah Gibson-Smith 57. Georg Riemann 17. Flora Gossink 58. Andrea Ruissen 18. Gerard van Grootheest 59. Sonja Rutten 19. Bart Hattink 60. Joost Sanders 20. Gerlinde Haverkamp 61. Roxanne Schaakxs 21. Hansje Heller 62. Willemijn Scholten 22. Iris Hendriks 63. Claudia Schuurhuizen 23. Sanne Hendriks 64. Evert Semeijn 24. Tjalling Jan Holwerda 65. Henny Sinnema 25. Wim Houtjes 66. Harm Pieter Spaans 26. Mandy Hu 67. Anja Stevens 27. Hans Jeuring 68. Sascha Struijs 28. Lise Kemmeren 69. Sanne Swart 29. Yvonne Kerkhof 70. Laura van Velzen 30. Noera Kieviet 71. Judith Verduijn 31. Ruth Klaming 72. Josine Verhoeven 32. Mieke Klein-Hofmeijer-Sevink 73. Henny Visser 33. Lisette Koorevaar 74. Suzan Vogel 34. Nicole Korten (thesis in 2014) 75. Nienke van der Voort 35. Clara Kurniawan 76. Chris Vriend 36. Ho Ming Lau 77. Froukje de Vries 37. Arnold van der Lee 78. Ilse Wielaard 38. Jacqueline van der Lee 79. Marleen Wildschut 39. Bianca Lever- van Milligen 80. Stella de Wit 40. Juliette van der Linden 81. Dora Wynchanck 41. Annelies van Loon And more than 60 PhD students from other Departments or Universities with involvement of one of our senior staff members as (co-)supervisor. 11

12 Highlights An example of a project LiDDia: Light therapy for Depression in Diabetes The LiDDia-study investigates whether light therapy improves depressive symptoms and insulin sensitivity in patients with a major depressive episode and type 2 diabetes, and whether these effects are mediated by restoration of the biological rhythm. Major depression and type 2 diabetes frequently co-occur, which is an issue of medical concern. Depression is more persistent and highly recurrent in patients with type 2 diabetes and additionally complicates the management of diabetes. Consequently, the comorbidity is associated with poor prognosis, such as an increased risk for diabetes complications and mortality. Antidepressants have only a moderate efficacy in patients with depression and diabetes and have been related to poor metabolic control via weight gain and glucose dysregulation. Accordingly, there is a need for efficacious treatment strategies, and treatments that improve psychiatric symptoms in concert with metabolic control. Light therapy is a patient friendly, non-pharmacological antidepressant that stimulates the suprachiasmatic nucleus of the brain, the biological clock, which regulates melatonin release, cortisol production, and sleep-wake patterns. Sleep disturbances, which often co-occur with major depression, have been related to glucose dysregulation and previous research showed that one single night of sleep restriction is sufficient to induce a significant decrease in insulin sensitivity. Insulin sensitivity describes how sensitive the body is to the effects of insulin, a hormone which promotes uptake of glucose from the blood, and is normally compromised in patients with type 2 diabetes. Whether the reverse, increased insulin sensitivity, can be reached after restoration of sleep in patients with sleep disturbances, e.g. by light therapy, has not been tested. Hence, we put forward that light therapy, which stimulates the biological rhythm, may be effective in treating depression in type 2 diabetes patients, but may also decrease insulin resistance in type 2 diabetes. The LiDDia-study is a clinical trial in 140 subjects with a major depressive episode and type 2 diabetes. Subjects follow light therapy half an hour every morning for four weeks at their homes. At three time points several psychometrical, psychophysiological, and 12

13 Highlights endocrine measures are performed: just before the start of light therapy, after completion of four weeks of light therapy, and after four weeks follow-up. Photography: Mark van den Brink The study is supported by department of psychiatry, department of medical psychology, and the Diabetes Center. The first participant was enrolled in the study in June, So far, 15 participants have been included in the study. Meanwhile, we have formed an enthusiastic team with psychiatrists, medical psychologists, endocrinologists, research-assistants and data managers to make the LiDDia-study a success. If light therapy is an effective treatment for a major depressive episode in type 2 diabetes patients and improves insulin sensitivity, light therapy may be a valuable patient-friendly addition to currently available treatment strategies, assuming that a decrease in insulin resistance may lead to improvements in glucose regulation. Additionally, if our data support the role of restoration of the biological rhythm in these effects, such a finding may guide further development of chronobiological treatment strategies in this patient population. 13

14 Highlights A paper of importance Milaneschi Y, Hoogendijk W, Lips P, Heijboer AC, Schoevers R, van Hemert AM, Beekman AT, Smit JH, Penninx BW. The association between low vitamin D and depressive disorders. Molecular Psychiatry Apr;19(4): Background Vitamin D is an hormone with multifaceted functions, the most prominent of which is the regulation of bone health. Recently vitamin D has been increasingly related also to mental health and it has been hypothesized that low levels of vitamin D may contribute to depression. However, to date epidemiological evidence concerning the link between vitamin D and depression is limited and non-conclusive. The majority of large studies were more commonly performed in older persons and measured depression generally through symptoms questionnaires instead of assessing psychiatric diagnoses by means of clinical interviews. In this study, we examined the association between vitamin D and depression in a large and relatively young cohort well-characterized in terms of psychiatric diagnoses. Methods Data from the Netherlands Study of Depression and Anxiety (NESDA) were used. Blood concentrations of 25-hydroxyvitamin-D [25(OH)D] - the best indicator of vitamin D body reserve - were compared across 1102 currently depressed patients, 790 persons with remitted depression and 496 healthy controls. Results Overall, 33.6% of participants had 25(OH)D levels that are considered insufficient. Lower 25(OH)D levels were found in patients with current depression, particularly in those with the most severe symptoms. In currently depressed persons, lower 25(OH)D was associated with greater symptoms severity and higher risk of having a depressive disorder after 2 years. Conclusion The results of this study suggest that low levels of vitamin D may represent a biological vulnerability for depression. Although no firm causal conclusions can be drawn from such observational study, the results provided for the first time a solid base for further longitudinal and experimental studies. Demonstrating an involvement of vitamin D in the pathway to depression may have important implications. While low levels of vitamin D are highly prevalent, potentially modifiable determinants of vitamin D status, such as dietary habits, use of dietary supplements, and behavior related to sun exposure could provide new selective cost-effective strategies aimed at preventing depression and its disease burden. 14

15 Highlights An example of societal impact Mamakits online, an intervention to improve treatment rates for pregnant women with stress, depressive and anxiety symptoms Women in pregnancy and postpartum have an increased vulnerability to develop an affective disorder. The prevalence of depressive disorder, respectively anxiety disorder, during pregnancy is 12 and 11%. Prevalence rates of mild affective symptoms is 17%. Affective dysregulation in pregnancy is often not diagnosed because the overlapping symptomatology with pregnancy itself. Moreover, shame, stigma, and the fear of being labelled mentally ill are also preventing women seeking help. Both depression and anxiety disorders affective disorders are associated with adverse perinatal outcomes such as an increased risk of prematurity, dysmaturity, impaired development, and decreased breastfeeding initiation. Moreover, antenatal depressive and/or anxiety symptoms are a risk factor for the development of post partum depressive disorder. Finally, untreated affective disorders and their complications may also result in considerable costs. Recent meta-analyses show interventions for affective disorders offered antepartum are less effective than than postpartum interventions. This is probably because of high attrition due to the barriers pregnant women experience with attending sessions outside their homes as a result of which they don t accomplish a sufficient intervention dose. An internet-based self-help intervention may overcome pregnancy-specific barriers related to face-to-face interventions. By contrast, internet interventions are easy accessible, home-based and can be followed in one s own time without letting other people know that someone is receiving therapy. The costs of an internet-based selfhelp intervention are less than visiting a therapist and sometimes even free of charge. reducing anxiety and depressive symptoms in the general adult population ( Alles onder controle ). Women are recruited over the whole country and Belgium. They can apply themselves on the website if they are older than 18 years, have access to internet and are less than 30 weeks pregnant. After informed consent is provided, they are randomised to the intervention group or the waiting-list group. The waiting-list group is allowed to participate in the intervention 6 weeks after giving birth. Through offering an internet-based coached self-help intervention we hope to reach pregnant women with affective symptoms who otherwise don t seek help and hence, to prevent adverse perinatal outcomes, postpartum depressive and anxiety disorders, and impaired development of the children. The (cost) effectiveness of an online intervention for pregnant women with affective symptoms: protocol of a randomised controlled trial. BMC Pregnancy and Childbirth 2014, 14:273 Hanna M Heller, psychiatrist, Annemieke van Straten, professor in clinical psychology, Christianne JM de Groot, gynaecologist, Adriaan Honig, professor in psychiatry. Hanna Heller is performing a study to investigate the (cost) effectiveness of an internet-based selfhelp intervention for pregnant women with affective symptoms ( Mamakits online ). The intervention is based on a on an internet version of Problem Solving Treatment. This intervention is proven effective for 15

16 Scientific Output The Department of Psychiatry has been able to extend the success of the past years! Again, we are proud of the scientific output we have achieved, seen from a qualitative as well as a quantitative perspective. In 2014, 251 international papers have been published, an increase of almost 10% as compared to Almost half of these papers have been published in top quartile journals. In 2014, 2 PhDcandidates from our department have successfully defended their thesis, and we have been involved in the dissertation of 6 PhD-candidates from other departments or universities. The total number of PhD-students has increased from 66 in 2013 to 79 in And finally, in collaboration with (international) partners, almost 5 million euros of research funding have been obtained. The combination of research funding, our staff and PhD students, and our well organized research infrastructure will enable to prolong the success of the Department of Psychiatry in oncoming years. The scientific output of the Department of Psychiatry is presented below in several tables and figures. In Table 1, the numbers of publications of 2014 are presented. For the full references of all published papers, see page 49. Table 2 provides an overview of publications that have been published in top-journals with an impact factor of 5 and above. In Table 3, PhD trajectories and the internal and external dissertations of 2014 are displayed. Figure 1 shows the H-index of our senior staff members (PhD thesis 3 years ago). In Table 4 research funding obtained in 2014 is displayed. Finally, Table 5 shows an overview of the dissertations and publications over the past few years. Table 1 Number of publications in 2014 International papers refereed 251 Proportion of publications in journal with a top 25% impact factor for the relevant research field 47% Publications in Dutch 26 Reports 7 Books and book chapters 4 16

17 Scientific Output Table 2 Overview of publications in 2014 in scientific top-papers (impact factor 5) Paper Impact factor Number of papers Nature Genetics 30 2 Molecular Psychiatry 15 5 American Journal of Psychiatry 14 2 World Psychiatry 13 3 Biological Psychiatry 9 2 Psychotherapy and Psychosomatics 9 3 Plos Genetics 8 1 British Journal of Psychiatry 7 1 Psychoneuroendocrinology 6 6 Pain 6 3 Psychological Medicine 5 6 Journal of Clinical Psychiatry 5 4 Bipolar Disorders 5 4 Table 3 Number of dissertations in 2014 PhD trajectories 79 Dissertations department of psychiatry 2 Dissertations at VUmc or other department of VU University, involvement of staff member department of psychiatry 4 External dissertations, involvement of staff member Psychiatry 2 17

18 Scientific Output Figure 1 H-index of our senior researchers (n=31) Number of senior researchers H-index score Table 4 Acquisition in 2014 Funding Amount in EU programs ZonMw/NWO BBMRI-NL NIH/NIMH (USA) VUmc / GGZ ingeest (Soma & Psyche, EMGO+) VUmc/LUMC/UMCG (NESDA continuation) Industry (Janssen pharmaceuticals (J&J)) Photopharmics Hersenstichting Fonds Psychische Gezondheid Zorgverzekeraar Achmea Stichting tot Steun van VCVGZ Several foundations Total

19 Scientific Output Table 5 Overview dissertations and publications Internal dissertations* External dissertations** Books and book chapters Publications in Dutch International publications (refereed) *Dissertations at Department of Psychiatry, staff member is first supervisor **Dissertations at other Department of VU or other university, staff member involved as (co-)supervisor 19

20 Indicators of esteem and societal impact Involvement in clinical guidelines Researcher Name committee Title guideline Balkom AJLM van Multidisciplinary CBO-guidelineline committee Update multidisciplinary guideline (chair) for Anxiety disorders and Depression for anxiety and depression Beekman ATF Dutch Society for Psychiatry (NVvP) Guideline committee Psychiatric Guideline for the first psychiatric assessment Assessment (Psychiatrisch Onderzoek) Dröes RM Council for Public Health and Health Care Arbeidsmarkt en zorgvraag (2006) (Arbeidsmarkt en zorgvraag RVZ, Den Haag) Droës RM Expert group dementia care Zorgstandaard Dementie (2012) + Regiegroep Zorgstandaard dementie Kupka RW (chair) Dutch Society for Psychiatry (NVvP) Multidisciplinary guideline for bipolar Dols A Guideline committee Bipolar Disorders disorders Stringer B V&VN / Trimbos guideline committee Update multidisciplinary guideline personality disorders personality disorders 20

21 Indicators of esteem and societal impact Membership editorial board of scientific journals Researcher Title journal Ballegooijen W van - BMC Psychiatry Beekman ATF - American Journal of Geriatric Psychiatry - Journal of Aging and Mental Health Deeg DJH - European Journal of Ageing: Social, Behavioural and Health Perspectives (founding editor-in-chief) - Journal of Ageing and Health Dekker J - International Journal of Behavioral Medicine - Arthritis Care & Research - Osteoarthritis and Cartilage - Chinese Journal of Behavioral Medicine and Brain Sciences - Applied Psychology: Health and Well-Being - BioPsychoSocial Medicine Dröes RM - Aging & Mental Health - Nonpharmacological therapies in dementia - Dementia; the international journal of social research and practice Eikelenboom P - Journal of Neuroinflammation - American journal of Alzheimer s disease & other dementias Honig A - Current Medical Literature Psychiatry Kupka RW - Nascholingstijdschrift Psyfar Oppen P van - Frontiers in Impulsivity, Compulsivity and Behavioral Dyscontrol (associate editor) - Journal of obsessive-compulsive and related disorders Penninx BWJH - Journal of Gerontology: Medical Sciences - Lancet Psychiatry Rhebergen D -Tijdschrift voor Psychiatrie Riper H - Anxiety, stress & coping (associate editor) Smit JH - Frontiers in Psychiatry (associate editor) - Journal of Longitudinal and Life Course Studies (associate editor) Veltman DJ - Frontiers in Psychopathology (review editor) 21

22 Indicators of esteem and societal impact Membership of advisory boards/scientific organizations/funding agencies Researcher Organisation Balkom AJLM van - Academic working place Anxiety Disorders GGZ ingeest (chair) - Dutch Society for Psychiatry (NVvP), Consilium Psychiatrium (chair) - Dutch Knowledge center Anxiety and Depression (NedKAD)(board) - BKOP foundation (for stimulating clinical psychiatric research) (Corsendonkcursus) (chair) - Fonds Psychische Gezondheid (Dutch Mental Health Foundation) (scientific board) - Obsessive-compulsive and related disorders research network (OCRN) in ENCP - International College of Obsessive Compulsive Spectrum disorders Ballegooijen W van - Triple E (EMGO+ E-Health Excellence) EMGO+ Institute VUmc Batelaan N - Committee scientific research GGZ ingeest (chair) - Academic working place Anxiety Disorders GGZ ingeest (vice-chair) - Expert commitee Anxiety Disorders GGZ ingeest (chair) - Dutch Knowledge center Anxiety and Depression (NedKAD) Beekman ATF - VUmc Department of Psychiatry (chair) - GGZ ingeest (board) - Dutch Society for Psychiatry (NVvP) (president) - EURODEP research network on late-life depression - EU-Roamer Public Mental Health Group - Global depression prevention initiative - The Irish Longitudinal Study on Ageing (TILDA) (scientific advisory board) - Technology Research for Independently Living University College Dublin (scientific advisory board) - Mirro foundation (board) - Raad voor Civiel Militaire Zorg en Onderzoek (RZO) (board) - Nemesis II (advisory board) - Continuum Psychiatry (advisory board) - Dutch Public Health Federation (advisory board) - Volksgezondheid Toekomst Verkenningen (RIVM) (advisory board) - TOP committee Netherlands Organisation for Scientific Research (NOW/ZonMw) (reviewer grant proposals) Bot M - European MoodFOOD consortium - BBMRI-NL, BIONIC project (project manager) 22

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