References. Anonymous, International drug monitoring-the role of the hospital, WHO. Drug Intelligence clin pharm 4:101, 1970.

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1 References Anonymous, Adverse drug-related events: need for increased efficiency in international transfer of information. WHO Drug Information 1994:8:1-2. Anonymous, Federal register. 1993;58: Anonymous, International drug monitoring-the role of the hospital, WHO. Drug Intelligence clin pharm 4:101, Anonymous. Impotentie, PW 1996;131:672. Anonymous. Living with risk. The British Medical Association Guide. John Wiley & Sons Arora, A., Gambardella, A., The changing technology of technological change: general and abstract knowledge and the division of innovative labour. Research policy 1994;23: Bastide, F., Courtial, J.P., Callon, M., The use of review articles in the analysis of a research area. Scientometrics 1989;15: Belkin, N.J., Croft, W.B., Retrieval techniques. In: Annual review of information science and technology (ARIST), Williams, M.E. (editor) Volume 22, Elsevier science publishers. Blumenthal, S.J., Discovery of new drug therapies based on the study of adverse reactions, Drug information joural, 1989;23: Breton, E.J., Indexing for invention. Journal of the american society for information science 1991;42: Burrows, J.F., Computation into criticism. a study of Jane Austen s novels and an experiment in meethod. Clarendon press, oxfrod, Butler, c.s., (editor) Computers and written text. Basil Blackwell, Oxford, Buurma, H., Jong-van den Berg, L.T.W. de, Leufkens, H.G.M., Het geneesmiddel, Wetenschappelijke uitgeverij Bunge, Utrecht Callon, M, Law, J., Rip, A., Mapping the dynamics of science and technology. The Macmillan Press, 1986 Callon, M., Courtial, J.P., Laville, F., Co-word analysis as a tool for describing the network of interactions between basic and technological research: the case of polymer chemistry. Scientometrics 1991;22: Callon, M., Courtial, J.P., Turner, W.A., Bauin, S., From translations to problematic networks: An introduction to co-word analysis. Social studies of science 1983;22: Callon, M., Law, J., On interests and their transformation: enrolement and counter-enrolment. Social studies of science 1982;12: Callon, M., Some elements of a sociology of translation: domestication of the scallops and the fisherman of ST Brieuc Bay. In: Power, action and belief, sociological review monograph No. 32, Ed. J. Law. London: routledge & Kegan paul, 1985 Chang B.B., DiGiacomo R., Kremer J., Kay C., Shah D.M. Effects of fish oil fatty acid ingestion in patients with Raynaud s syndrome. Surgical forum 1988;39: CIOMS working group, International reporting of adverse drug reactions. CIOMS Courtial, J.P., Callon, M., Indicators for the identification of strategic themes within a research programme. Scientometrics 1991;21: Courtial, J.P., Qualitative models, quantitative tools and network analysis. Scientometrics 1989;15: Davies, D.M. (editor), Textbook on Adverse Drug Reactions, 4th edition, Oxford medical publications, Evans, D.A., Lefferts, R.G., Grefenstette, G., Handerson, S.K., Hersh, W.R., Archbold, A.A., "CLARIT TREC Design, Experiments and results". In D. Harman (editor), The first text retrieval conference (TREC-1). NIST Special Publication Washington, DC: U.S. Government printing office, 1993, ; Forsythe, D.E., Buchanan, B.G., Osheroff, J.A., Miller, R. A., Expanding the concept of medical information: An observational study of physicians information needs. Computers and biomedical research 1992;25: Forsythe, D.E., Engineering knowledge: the construction of knowledge in artificial intelligence. Social studies of science 1993;23:

2 Fujimura, J.H., Crafting science: Standardized packages, boundary objects, and "translation". J.H. Fujimura. In: Science as practice and culture. Ed. A. Pickering, University of Chicago press, Gotzsche, P., Lange, B., Comparison of search strategies for recalling double-blind trials from medline. Danisch medical bulletin 1991;38: Hagendijk, R.P., Cramer, J.M., Smeenk, J.W., Handeling en structuur in wetenschapsbeoefening. De ontwikkeling van het ecologisch onderzoek van zoete wateren in Nederland. P In: Wetenschap en technologie: constructie en dynamiek: de ontwikkeling van het wetenschapsonderzoek in Nederland. Peshar, J.J., Rossum, van W., editors. Deventer: van Loghum Slaterus, Hansen, E.H., Launso, L., Is the controlled clinical trial sufficient as a drug technology assessment? J Soc Admin Pharm 1989;6: Huydecoper, J.L.R.A., Verleging van de beschermingsduur voor farmaceutische octrooien. In: Een gulden pil, opstellen over farmaceutisch recht aangeboden aan Jhr. Mr J.A. Stoop, Kluwer, Deventer, Jolles, G., Wooldridge, K.R.H., Drug design: Fact or Fantasy? Academic press, inc. London Jong, H. de, Rip, A., Ontdekkingspraktijk in plaats van logica: Wetenschappelijk ontdekken in computer-ondersteunde ontdekkingsomgevingen. Paper enschede. Karch, F.E., Lasagna, L., Adverse drug reactions. A critical review. JAMA 1975;234: King, J., A review of bibliometric and other science indicators and their role in research evaluation. Journal of information science 1987;13: Kleijnen, J., Knipschild, P. The comprehensiveness of Medline and Embase computer searcher. Searches for controlled trials of homoeopathy, ascorbic acid for common cold and ginkgo biloba for cerebral insufficiency and intermittent claudication. Pharm Weekbl [sci] 1992;14(5): Koning, G.H.P. de, Egberts, A. C. G., Stichting Landelijke Registratie en Evaluatie Bijwerkingen: Meldingen van vermoede bijwerkingen. Pharmaceutisch Weekblad 1996;131: Koning, G.H.P. de, Egberts, A.C.G., Leufkens, H.G.M., Bakker, A., Postmarketing surveillance in de farmacie: plaats bepaald? PW special edition, june 1996 p Larson, E.B., Adverse Drug Effects: The harder we look, the more we find, Journal of general internal medicine, 1993;8: Latour, B., Wetenschap in actie (Science in action), Uitgeverij Bert Bakker, Amsterdam, Law, J., Whittaker, J., Mapping acidification research: a test of the co-word method. Scientometrics 1992;23: Leufkens, H., Haaijer-Ruskamp, F., Bakker, A., Dukes, G., Scenario analysis of the future of medicines. BMJ 1994;309: Leufkens, H.G., Herings, R.M.C., Vergelijking van veiligheidsprofielen van geneesmiddelen. PW 1995;130: Leufkens, H.G., Urquhart, J., Automated record linkage and other approaches to pharmacoepidemiology in the Netherlands. In: Pharmacoepidemiology. Editor Strom, B.L Leufkens, H.G., Urquhart, J., Variability in patterns of drug usage. J Pharm Pharmacol 1994;46(Suppl 1): Leydesdorff, L., Relations among science indicators or more generally among anything one might wish to count about texts. II.The dynamics of science. Scientometrics 1990;19: Leydesdorff, L., Relations among science indicators or more generally among anything one might wish to count about texts. I.The static model. Scientometrics 1990;18: Leydesdorff, L., Various methods for the mapping of science. Scientometrics 1987;11: Leydesdorff, L., Words and co-words as indicators of intellectual organization. Research policy 1989;18: Lilja, J., Theoretical Social Pharmacy. The drug sector from a social science perspective. Kuopio, Uiversity of Kuopio, (An historical perspective of drug research and diffusion). Loonen, A.J.M., Klinisch veiligheidsonderzoek van geneesmiddelen: methoden en instrumenten. PW 1989;124: Maxwell RA, Eckhardt SB. Drug discovery. A case book and analysis. Humana press, clifton, New Jersey 1990, P McKibbon, K.A., Haynes, R.B., Walker Dilks, C.J., Ramsden, M.F., Ryan, N.C., Baker, L., Flemming, T., Fitzgerald, D. How good are clinical Medline searches? A comparative study of clinical end-user and librarian searches. Computers and biomedical research 1990;23:

3 Meyboom, R.H.B., Stricker, B.H.Ch., Het landelijke meldingssysteem voor bijwerkingen van geneesmiddelen. Principes, procedures en resultaten. Bijblijven 1991;7: Modell, W., On whose side are side effects? JAMA 1961;176: Moed, H.F., The use of bibliometric indicators for the assessment of research performance in the natural and life sciences: aspects of data collctio, reliability, validity and applicability. Leiden: DSWO Press, Nieuwenhoeven Helbach, E.A. van, De tweede indicatie, uit Een gulden pil, opstellen over farmaceutisch recht aangeboden aan Jhr. Mr J.A. Stoop, Kluwer, Deventer, 1992 Omar, R., Artificial intelligence through logic? AICOM 1994;7: Ondetti, M.A., Cushman, D.W., Rubin, B., Captopril. In: Chronicles of drug discovery, Bincha, Lednicer, New York, 1983 Peny, J.M., ACE-inhibitors - an analysis of marketing strategy, Scrip Magazine, 1994;oct:18-21 Peters, H.P.F., Raan, A.F.J. van, Co-word-based science maps of chemical engineering. Part I: Representations by direct multidimensional scaling. Research policy 1993;22: Peters, H.P.F., Raan, A.F.J. van, Co-word-based science maps of chemical engineering. Part II: Representations by combined clustering and multidimensional scaling. Research policy 1993;22: Petri, H, Touw, D.J., De bijwerking betrapt. De medicatiegeschiedenis als indicator voor een mogelijke bijwerking. PW 1989;124: Petri, H., Urquhart, J., Channeling bias in the interpretation of drug effects., Statistics in medicine, 1991;10: Petri, H., Urquhart, J., Herings, R., Bakker, A., Characteristics of patients prescribed three different inhalation beta-2 agonists: An example of the channeling phenomenon. Postmarketing Surveillance 1991;5:57-66 Raan, A.F.J. van, The role of bibliometric data in university research policy. Boerhaavw committee for postgraduate medical education Raan, A.F.J., van, Tijssen, R.J.W., The neural net of neural network research. An exercise in bibliometric mapping. Scientometrics 1993;26: Rada, R., Barlow, J., Potharst, J., Zanstra, P., Bijstra, D. Document ranking using an enriched thesaurus. Journal of documentation 1991;47: Rawlins, Thompson, Pathogenesis of adverse drug reactions. In: textbook of adverse drug reactions. Ed. D.M.Davies. Oxford university press Riezebos, J., Asten, P. van, Brink, G. van den., Signalering en verificatie van type-b-bijwerkingen PW 1989;124: Rip, A., Courtial, J.P., Co-word maps of biotechnology: an example of cognitive scientometrics. Scientometrics 1984;6: Rip, A. Mapping of science: possibilities and limitations. In: Handbook of Quantitative Studies of Science and Technology. Editor: A.J.F. van Raan. Elsevier Science Publishers B.V Rip, A., Onderzoek van de ontwikkeling van wetenschapsgebieden. Kennis en methode 1977;4: Roberts, R.M., Serendipity: accidental discoveries in science John Wiley & Sons. Rossum, W. van, De ontwikkeling van een wetenschappelijk begrip?; een co-woord-analyse van het MBD-syndroom. In: Wetenschap en technologie: constructie en dynamiek: de ontwikkeling van het wetenschapsonderzoek in Nederland. Peshar, J.J., Rossum, van W., editors. Deventer: van Loghum Slaterus, Sandler, M., Smith, H.J., Design of enzyme inhibitors as drugs. Oxford university press, p Schoolman, H.M., The future: Libraries, librarians and users. Library trends 1974;july: Scott, J.T., Is it worth writing about? J Royal Soc Med 1993;86:5-6. Shaw, J.G., Article-by-article citation analysis of medical journals. Scientometrics 1987;12: Small, H., Sweeney, E., Greenlee, E., Clustering the science citation index using co-citations. II. mapping science. Scientometrics 1985;8: Sneader, W, Drug Development: from laboratory to clinic, John Wiley & Sons Ltd., 1986

4 Spilker, B., Guide to clinical trials, Raven press Ltd, New York, Spilker, B. Multinational drug companies. Issues in drug discovery and development, Raven press Ltd, New York, 1989 Star, S.L., Griesemar, J.R., Institutional Ecology, translations and boundary objects: Amateurs and professionals in Berkeley s museum of vertebrate zoology, Social studies of science 1989;19: Stolley, P.D., Lashy, T., Medicines that backfire. From: Investigating disease patterns. The science of epidemiology Scientific American Library, New York. Stolley, P.D., The use of vital and morbidity statistics for the detection of adverse drug reactions and for monitoring of drug safety. J Clin Pharmacol. 1982;22: Strom, B.L., Other approaches to pharmacoepidemiology studies. In: Pharmacoepidemiology. Editor Strom, B.L Strom, B.L., The future of pharmacoepidemiology. In: Pharmacoepidemiology. Editor Strom, B.L Strom, B.L., What is pharmacoepidemiology? In: Pharmacoepidemiology. Editor Strom, B.L Strom, B.L., When should one perform pharmacoepidemiology studies? In: Pharmacoepidemiology. Editor Strom, B.L Swanson D.R. Complementary Structures in Disjoint Literatures, Proceedings of the 14th Annual International ACM SIGIR Conference; Oct 1991, Chicago. NY: ACM Press. Swanson D.R. Fish oil, Raynaud s syndrome, and undiscovered public knowledge, Perspectives in Biology and Medicine 1986;30: Swanson D.R. Intervening in the Life Cycles of scientific Knowledge. Library trends 1993;41: Swanson D.R. Medical literature as a potential source of new knowledge, Bull Med Libr Assoc 1990;78: Swanson D.R. Migraine and magnesium: Eleven neglected connections, Perspectives in biology and medicine 1988;31: Swanson D.R. Somatomedin C and Arginine: Implicit connections between mutually isolated literatures, Perspectives in biology and medicine, 1990;33: Swanson D.R. Two medical literatures that are logically but not bibliographically connected, Journal of the american society for information science 1987;38: Thagard, P. Conceptual revolutions. Princeton university press Tijssen, R.J. W., Raan, A.F.J. van, Mapping co-word structures: a comparison of multidimensional scaling and leximappe. Scientometrics 1989;15: Tijssen, R.J.W., Carthography of science: scientometric mapping with Multidimensional scaling methods. Leiden: DSWO press, Trigt, A.M. van, Making news about medicine. Thesis, Groningen U.S. Congress, Office of Technology Assessment, Pharmaceutical R&D: Costs, Risks and Rewards, OTA-H-522 (Washington, DC: U.S. Government Printing Office, February 1993). Urquhart, J., Role of pharmacoepidemiology in drug development. International journal of clinical pharmacology, therapy and toxicology?? Venulet, J., Establishing requirements for the use of terms for reporting adverse drug reactions (ADR), Materia Medica Polona, 1993;85: Vos, R. Drugs looking for diseases. A descriptive model for the process of innovative drug research with special references to the development of the beta blockers and the calcium antagonists. Dordrecht: Kluwer Academic Publishers, Vos, R., Hoek, J., Guided co-author and co-word analysis of competing scientific groups in pharmaceutical research - the developemtn of the beta blockers. Proceedings of the 5th Biennal Conference of the International Society for Scientometrics and Informatrics. Eds Koenig, M.E.D., Bookstein, A. Medford, N.J.: Learned Information, Inc., 1995: Vos, R., Innovatie en de ontwikkeling van geneesmiddelen. In: Buurma, H., Jong-van den Berg, L.T.W. de, Leufkens, H.G.M. (editors), Het geneesmiddel, Wetenschappelijke uitgeverij Bunge, Utrecht Wallander, M.A., The way towards adverse event monitoring in clinical trials, Drug safety 1993;8: Waller, P.C., Measuring the frequency of adverse drug reactions. Br J Clin Pharmac 1992;33:249-52

5 Whitmarsch, V.B., Monitoring of adverse drug reactions in the pharmaceutical industry - the scene in the United Kingdom. Ann Acad Med 1993;22:65-8 Whittaker, J., Creativity and conformity in science: Titles, keywords and co-word analysis. Social Studies of Sciences, 1989:19: Wright, L.C., Sutherland, H.J., Jackson, J.I., Till, J.E., Comparison of search strategies on CD plus/medline. Can Med Assoc J 1991;145: Wyatt, J., Computer-based knowledge systems. Lancet 1991;338: Wyatt, J., Use and sources of medical knowledge. Lancet 1991;338:

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