Pharmacology of Antiplatelet and Anticoagulants Agents

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1 Pharmacology of Antiplatelet and Anticoagulants Agents 1

2 2

3 Antiplatelet Therapy: Common Oral Agents Acetylsalicylic acid (ASA) Clopidogrel bisulfate* Trade Name Aspirin Plavix Class Salicylate Thienopyridine Formulation Active Drug Pro-Drug Maintenance Dose mg daily 75 mg daily Major Bleeding Risk (%) 2-3% 1 1-4% alone 2,3 3-5% w/ ASA 4 1 Topol EJ et al. Circulation 2003;108: Diener HC et al. Lancet 2004;364; Plavix package insert. 4 Peters RJ et al. Circulation 2003;108: Hass WK. NEJM 1989;321: Urban P. Circulation 1998;98: Ticlid package insert. *Clopidogrel is generally given preference over Ticlopidine because of a superior safety profile 3

4 Antiplatelet Therapy: Targets clopidogrel bisulfate ticlopidine hydrochloride Gp 2b/3a Inhibitors ADP ADP dipyridamole phosphodiesterase Gp IIb/IIIa (Fibrinogen Receptor) COX Activation Collagen Thrombin TXA 2 aspirin TXA 2 ADP=Adenosine diphosphate, COX=Cyclooxygenase, TXA 2 =Thromboxane A 2 Schafer AI. Am J Med 1996;101:

5 Aspirin: Mechanism of Action Membrane Phospholipids Arachadonic Acid COX-1 Aspirin Prostaglandin H 2 Thromboxane A 2 Platelet Aggregation Vasoconstriction Prostacyclin Platelet Aggregation Vasodilation 5

6 Thienopyridine: Mechanism of Action Clopidogrel or Ticlopidine ADP / ATP P2Y 1 P2X1 P2Y 12 Gq coupled Cation influx Calcium mobilization Gi 2 coupled Ca 2+ Ca 2+ camp No effect on fibrinogen receptor Platelet shape change Transient aggregation Fibrinogen receptor activation Thromboxane A 2 generation Savi P et al. Biochem Biophys Res Commun 2001; 283: and Ferguson JJ. The Physiology of Normal Platelet Function. In: Ferguson JJ, Chronos N, Harrington RA (Eds). Antiplatelet Therapy in Clinical Practice. London: Martin Dunitz; 2000: pp Sustained Aggregation Response 6

7 Aspirin Evidence: Secondary Prevention Effect of antiplatelet treatment* on vascular events** Category Acute MI Acute CVA Prior MI Prior CVA/TIA Other high risk CVD (e.g. unstable angina, heart failure) PAD (e.g. intermittent claudication) High risk of embolism (e.g. Afib) Other (e.g. DM) All trials *Aspirin was the predominant antiplatelet agent studied **Include MI, stroke, or death % Odds Reduction Antiplatelet better Control better Antithrombotic Trialist Collaboration. BMJ 2002;324:

8 BDT, 1988 PHS, 1989 TPT, 1998 HOT, 1998 Aspirin Evidence: Primary Prevention RR of MI in Men RR of CVA in Men PPP, 2001 Combined RR = 0.68 ( ) P=0.001 RR = 1.13 ( ) P= HOT, 1998 RR of MI in Women RR of CVA in Women PPP, 2001 WHS, 2005 Combined RR = 0.99 ( ) P=0.95 RR = 0.81 ( ) P= Aspirin Better Placebo Better Aspirin Better Placebo Better CVA=Cerebrovascular accident, MI=Myocardial infarction, RR=Relative risk Ridker P et al. NEJM 2005;352:

9 Source biological Unfractionated(UFH) Low molecular weight(lmwh) Target:activated factors HEPARIN 9

10 Molecular weight distributions of LMWHs and heparin Hirsh, J. et al. Chest 2004;126:188S-203S 10

11 DRUG TARGETS Unfractionated heparin(ufh) 11

12 DRUG TARGETS LOW MOLECULAR WEIGHT HEPARIN(LMWH) Enoxaparin 12

13 HEPARIN CI: DVT/PE and prevention of VTE ADRs: Bleeding Thrombocytopenia-HIT Osteoporosis Monitor aptt & platelet count 13

14 Warfarin: Mechanism of Action Vitamin K Antagonism of Vitamin K VII IX X II Synthesis of Non- Functional Coagulation Factors Warfarin Ansell J et al. Council on Clinical Cardiology. 14

15 Warfarin Evidence: Secondary Prevention Warfarin and Antiplatelet Therapy in Heart Failure (WATCH) Trial 1,587 patients with HF and LVSD (EF <0.35) randomized to aspirin (162 mg), clopidogrel (75 mg), or warfarin (mean INR=2.6) for 23 months Outcome Aspirin (n=523) Warfarin (n=540) Clopidogrel (n=524) Death, MI, or stroke (%) HF hospitalizations (%) Major bleeding (number of episodes) * *p=0.012 vs warfarin There is no significant benefit to clopidogrel or warfarin over aspirin in LVSD for reduction of hard end points EF=Ejection fraction, HF=Heart failure, LVSD=Left ventricular systolic dysfunction, MI=Myocardial infarction Massie BM. American College of Cardiology 2004 Scientific Sessions; Mar 7-10, 2004; New Orleans, LA 15

16 Dabigatran Direct, specific, competitive thrombin inhibitor Half-life hours Uses P-gp transporter with bowel absorption Clearance : 80% renal excretion Not a substrate of CYP 450 enzymes Oral, twice daily dosing without need for coagulation monitoring TF/VIIa X IXa VIIIa Va Fibrinogen Xa II IIa IX Dabigatran Fibrin Adapted from Weitz et al, 2005;

17 Rivaroxaban TF/VIIa Direct, specific, competitive factor Xa inhibitor Half-life 5-13 hours Clearance : 1/3 direct renal excretion 2/3 metabolism via CYP 450 enzymes Oral, once daily dosing with largest meal without need for coagulation monitoring X VIIIa Va Xa II IIa IXa IX Rivaroxaban Fibrinogen Fibrin Adapted from Weitz et al, 2005;

18 Apixaban Direct, specific, competitive factor Xa inhibitor Half-life 12 hours Clearance : 27% direct renal excretion Biliary and direct intestinal excretion P-gp transport Oral, twice daily dosing without need for coagulation monitoring: 5mg bid. 2.5mg bid with at least 2 of: 80 or older, weight <60kg, creatinine >1.5 TF/VIIa X IXa VIIIa Va Fibrinogen Xa II IIa IX Apixaban Fibrin 18

19 Pradaxa Xarelto Eliquis 150mg bid Cr.Cl >30 75mg bid Cr.Cl Avoid Cr.Cl <15 20mg Cr.Cl >50 15mg Cr.Cl Avoid Cr.Cl <15 5mg bid 2.5mg bid if 2 or more: >80, <60kg, >creat 1.5 With or without food Largest meal With or without food Avoid with rifampin, quinidine If Cr.Cl 30-50, reduce dose to 75mg bid with Multaq and ketoconazole. If Cr.Cl <30, avoid Multaq and ketoconazole. Verapamil may increase levels Avoid rifampin, carbamazepine, phenytoin, St. John s wart. Avoid ketoconazole, traconazole, lopinavir/ritonavir, itonavir, indinavir/ritonavir, conivaptan. Avoid amiodarone,diltiazem, verapamil, Multaq, erythromycin, Ranexa, azithromycin, cimetidine if Cr.Cl Avoid rifampin, carbamazepine, phenytoin, St. John s wart. Reduce to 2.5mg bid with ketoconazole, itraconazole, Biaxan. If on 2.5mg bid, stop Eliquis. 19

20 PRADAXA XARELTO ELIQUIS Converting from warfarin: start when INR<2 Rapid onset No monitoring (PTT) Converting from warfarin: start when INR<3 Rapid onset No monitoring (INR, PTT, anti-factor Xa activity) Converting from warfarin: start when INR<2 Rapid onset No monitoring (INR, PTT, anti-factor Xa activity) 1-2 day hold if Cr.Cl > if Cr.Cl <50 Baseline Cr.Cl, at least 6 monthly Extreme caution with epidural catheters At least 24 hours Baseline Cr.Cl, at least 6 monthly Extreme caution with epidural catheters At least 24 hours low risk At least 48 hours high risk Baseline Cr.Cl, at least 6 monthly Extreme caution with epidural catheters Cannot crush Can crush (apple sauce) Cannot crush 20

21 PRADAXA XARELTO ELIQUIS DVT, PE, extended DVT, PE, extended Hip and knee prophylaxis DVT, PE, extended Hip and knee prophylaxis 21

22 Warfarin Evidence: Primary Prevention Thrombosis Prevention Trial (TPT) 5,499 men at high risk for CHD randomized to aspirin (75 mg), warfarin (mean INR=1.5), warfarin and aspirin, or placebo for 6.4 years WA* N=1277 W* N=1268 A* N=1268 P* N=1272 MI and coronary death (primary end point) 71 (0.87%) 83 (1.03%) 83 (1.02%) 107 (1.33%) Stroke 29 (0.36%) 22 (0.27%) 18 (0.22%) 26 (0.32%) All cause mortality 103 (1.24%) 95 (1.14%) 113 (1.36%) 110 (13.1%) RRR of primary end point compared to placebo 34% (p=0.006) 21% (p=0.02) 20% (p=0.04) N/A Warfarin has similar efficacy to aspirin *WA=Warfarin and aspirin, W=Warfarin, A=Aspirin, P=Placebo TPT Investigators. Lancet 1998;351:

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