Publicaties Dissertaties 2011

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1 Publicaties 2011 Dissertaties 2011 Ruifrok WPT Erythropoietin in heart failure. Effects beyond erythropoiesis ISBN: ISBN: elektronische versie Promotiedatum: 12 januari 2011 Promotores: Prof.dr. W.H. van Gilst Prof.dr. D.J. van Veldhuisen Copromotor: Dr. R.A. de Boer Vlaar PJJ Strategies to improve myocardial reperfusion after primary PCI. The value of pharmacological interventions and thrombus aspiration ISBN: Promotiedatum: 20 april 2011 Promotor: Prof.dr. F. Zijlstra Copromotor: Dr. B.J.G.L. de Smet Willemsen S Advanced glycation end-products in chronic heart failure ISBN: ISBN: / electronische versie Promotiedatum: 16 mei 2011 Promotores: Prof.dr. A.A. Voors Prof.dr. D.J. van Veldhuisen Smit MD Clinical and therapeutic implications of remodeling in atrial fibrillation ISBN: Promotiedatum: 8 juni 2011 Promotores: Prof.dr. I.C. van Gelder Prof.dr. D.J. van Veldhuisen Copromotor: Dr. A.H. Maass Huzen J Telomere biology in cardiovascular disease ISBN Promotiedatum: 13 juli 2011 Promotores: Prof.dr. W.H. van Gilst Prof.dr. D.J. van Veldhuisen Copromotores: Dr. P. van der Harst Dr. R.A. de Boer

2 Linssen GCM BNP and NT-proBNP in cardiovascular disease ISBN Promotiedatum: 28 november 2011 Promotores: Prof.dr. D.J. van Veldhuisen Prof.dr. J.L. Hillege Prof.dr. A.A. Voors Prof.dr. T. Jaarsma Boeken Pundziute G, Willem TP Plaque detection and characterization. Chapter 9 in The Complete Guide to Cardiac CT, Abramson S, McGraw Hill Medical, ISBN , pp

3 Internationale tijdschriften Camm AJ, Capucci A, Hohnloser SH, Torp-Pedersen C, Van Gelder IC, Mangal B, Beatch G; AVRO Investigators A randomized active-controlled study comparing the efficacy and safety of vernakalant to amiodarone in recent-onset atrial fibrillation. J Am Coll Cardiol 2011;57: Pons D, Trompet S, De Craen AJ, Thijssen PE, Quax PH, De Vries MR, Wierda RJ, Van den Elsen P, Monraats PS, Ewing MM, Heijmans BT, Slagboom PE, Zwinderman AH, Doevendans PA, Tio RA, De Winter RJ, De Maat MP, Iakoubova OA, Sattar N, Shepherd J, Westendorp RG, Jukema JW; PROSPER study group; WOSCOPS study group; GENDER study group Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies. Heart 2011;97: Willemsen S, Hartog JW, Hummel YM, Van Ruijven MH, Van der Horst IC, Van Veldhuisen DJ, Voors AA Tissue advanced glycation end products are associated with diastolic function and aerobic exercise capacity in diabetic heart failure patients. Eur J Heart Fail 2011;13:76-82 Willemsen HM, Van den Berg MP A few more pieces in the puzzle of non-compaction cardiomyopathy. Eur J Heart Fail 2011;13: De Vetten L, Bergman KA, Elzenga NJ, Van Melle JP, Timmer A, Bartelds B Neonatal myocardial infarction or myocarditis? Pediatr Cardiol 2011;32:492-7 Zhu H, Wang X, Gutin B, Davis CL, Keeton D, Thomas J, Stallman-Jorgensen I, Mooken G, Bundy V, Snieder H, Van der Harst P, Dong Y Leukocyte telomere length in healthy Caucasian and African-American adolescents: relationships with race, sex, adiposity, and physical activity. J Pediatr 2011;158: Bouma W, Lexis CP, Willems TP, Suurmeijer AJ, Van der Horst IC, Ebels T, Mariani MA Successful surgical excision of primary right atrial angiosarcoma. J Cardiothorac Surg 2011;6:47 Vlaar PJ, De Smet BJ, Van den Heuvel AF, Anthonio RL, Jessurun GA, Tan ES, Hillege HL, Zijlstra F Operator depence of outcome after primary percutaneous coronary intervention. EuroIntervention 2011;6:760-7 Kirchhof CJ, Crijns HJ, Van Gelder IC Propafenone contraindicated in the elderly? Heart 2011;97:262, author reply 262 De Boer RA, Lok DJ, Jaarsma T, Van der Meer P, Voors AA, Hillege HL, Van Veldhuisen DJ Predictive value of plasma galectin-3 levels in heart failure with reduced and preserved ejection fraction. Ann Med 2011;43:60-8

4 Böger CA, Chen MH, Tin A,, Van der Harst P, et al CUBN is a gene locus for albuminuria. J Am Soc Nephrol 2011;22: Pieper PG, Silversides CK Assessment of severity of pulmonary regurgitation. Eur J Echocardiogr 2011;12:88; author reply 88-9 Vlaar PJ, Mahmoud KD, Holmes DR Jr, Van Valkenhoef G, Hillege HL, Van der Horst IC, Zijlstra F, De Smet BJ Culprit vessel only versus multivessel and staged percutaneous coronary intervention for multivessel disease in patients presenting with ST-segment elevation myocardial infarction: a pairwise and network meta-analysis J Am Coll Cardiol 2011;58: Voors AA, Davison BA, Felker GM, Ponikowski P, Unemori E, Cotter G, Teerlink JR, Greenberg BH, Filippatos G, Teichman SL, Metra M; on behalf of the Pre-RELAX-AHF study group Early drop in systolic blood pressure and worsening renal function in acute heart failure: renal results of Pre-RELAX-AHF. Eur J Heart Fail 2011;13:961-7 Balci A, Drenthen W, Mulder BJ, Roos-Hesselink JW, Voors AA, Vliegen HW, Moons P, Sollie KM, Van Dijk AP, Van Veldhuisen DJ, Pieper PG Pregnancy in women with corrected tetralogy of Fallot: occurrence and predictors of adverse events. Am Heart J 2011;161: Balci A, Sollie KM, Mulder BJ, De Laat MW, Roos-Hesselink JW, Van Dijk AP, Wajon EM, Vliegen HW, Drenthen W, Hillege HL, Aarnoudse JG, Van Veldhuisen DJ, Pieper PG Associations between cardiovascular parameters and uteroplacental Doppler (blood) flow patterns during pregnancy in women with congenital heart disease: Rationale and design of the Zwangerschap bij Aangeboren Hartafwijking (ZAHARA) II study. Am Heart J 2011;161: Gu YJ, Van Oeveren W, Mungroop HE, Epema AH, Den Hamer IJ, Keizer JJ, Leuvenink RP, Mariani MA, Rakhorst G Clinical effectiveness of centrifugal pump to produce pulsatile flow during cardiopulmonary bypass in patients undergoing cardiac surgery. Artif Organs 2011;35:E18-26 Zannad F, McMurray JJ, Krum H, Van Veldhuisen DJ, Swedberg K, Shi H, Vincent J, Poccock SJ, Pitt B; EMPHASIS-HF Study Group. Eplerenone in patients with systolic heart failure and mild symptoms. N Eng J Med 2011;364:11-21 Yin M, Van der Horst IC, Van Melle JP, Qian C, Van Gilst WH, Silljé HH, De Boer RA Metformin improves cardiac function in a nondiabetic rat model of post-mi heart failure. Am J Physiol Heart Circ Physiol 2011;301:H Barbareschi G, Sanderman R, Leegte IL, Van Veldhuisen DJ, Jaarsma T Educational level and the quality of life of heart failure patients: a longitudinal study. J Card Fail 2011;17:47-53

5 Broekema FI, Van Oeveren W, Zuidema J, Visscher SH, Bos RR In vitro analysis of polyurethane foam as a topical hemostatic agent. J Mater Sci Mater Med 2011;22: Onuta G, Groenewegen HC, Klatter FA, Walther Boer M, Goris M, Van Goor H, Roks AJ, Rozing J, De Smet BJ, Hillebrands JL Long-term type 1 diabetes enhances in-stent restenosis after aortic stenting in diabetes-prone BB rats. J Biomed Biotechnol 2011;2011: Scholtens AM, Tio RA, Willemsen A, Dierckx RA, Boersma HH, Zeebregts CJ, Glaudemans AW, Slart RH Myocardial perfusion reserve compared with peripheral perfusion reserve: a [13N] ammonia PET study. J Nucl Cardiol 2011;18: Maas AH, Van Veldhuisen DJ Heart rates in cardiac resynchronization: the art of optimal device programming. Europace 2011;13:157-8 Voors AA, Dittrich HC, Massie BM, DeLucca P, Mansoor GA, Metra M, Cotter G, Weatherley BD, Ponikowski P, Teerlink JR, Cleland JG, O Connor CM, Givertz MM Effects of the adenosine A1 receptor antagonist rolofylline on renal function in patients with acute heart failure and renal dysfunction: results from PROTECT (Placebo-Controlled Randomized Study of the Selective Adenosine A1 Receptor Antagonist Rolofylline for Patients Hospitalized with Acute Decompensated Heart Failure and Volume Overload to Assess Treatment Effect on Congestion and Renal Function). J Am Coll Cardiol 2011;57: Mariani MA, Arrigoni SC, Grandjean JG Endoscopic vein harvesting : just a promised land? Innovations (Phila) 2011;6:207-8 Huzen J, Peeters W, De Boer RA, Moll FL, Wong LS, Codd V, De Kleijn DP, De Smet BJ, Van Veldhuisen DJ, Samani NJ, Van Gilst WH, Pasterkamp G, Van der Harst P Circulating leukocyte and carotid atherosclerotic plaque telomere length: interrelation, association with plaque characteristics, and restenosis after endarterectomy. Arterioscler Thromb Vasc Biol 2011;31: De Boer RA, van Veldhuisen DJ, Gansevoort RT, Muller Kobold AC, van Gilst WH, Hillege HL, Bakker SJ, van der Harst P The fibrosis marker galectin-3 and outcome in the general population. J Intern Med 2011; Ambrosio G, Flather MD, Böhm M, Cohen-Solal A, Murrone A, Mascagni F, Spinucci G, Conti MG, Van Veldhuisen DJ, Tavazzi L, Coats AJ ß-blockade with nebivolol for prevention of acute ischaemic events in elderly patients with heart failure. Heart 2011;97: Tomaszewski M, Charchar FJ, Nelson CP, Barnes T, Denniff M, Kaiser M, Debiec R, Christofidou P, Rafelt S, Van der Harst P, Wang WY Maric C, Zukowska-Szczechowska E Pathway analysis shows association between FGFBP1 and hypertension. J Am Soc Nephrol 2011;22:947-55

6 Gu YL, Voors AA, Zijlstra F, Hillege HL, Struck J, Masson S, Vago T, Anker SD, Van den Heuvel AF, Van Veldhuisen DJ, De Smet BJ Comparison of the temporal release pattern of copeptin with conventional biomarkers in acute myocardial infarction Clin Res Cardiol 2011;100: Johansson P, Nieuwenhuis M, Lesman-Leegte I, Van Veldhuisen DJ, Jaarsma T Depression and the delay between symptom onset and hospitalization in heart failure patients. Eur J Heart Fail 2011;13: Stoker T, Klinkenberg TJ, Maass AH, Mariani MA Video-assisted implantation of a left ventricular lead and intrathoracic tunneling to a right-sided CRT-D device. Innovations (Phila) 2011;6:341-3 Verbeek DE, Van Riezen J, De Boer RA, Van Melle JP, De Jonge P A review on the putative association between beta-blockers and depression. Heart Fail Clin 2011;7:89-99 Manzano L, Babalis D, Roughton M, Shibata M, Anker SD, Ghio S, Van Veldhuisen DJ, Cohen-Solai A, Coats AJ, Poole-Wilson PP, Flather MD; SENIORS Investigators Predictor of clinical outcome in elderly patients with heart failure. Eur J Heart Fail 2011;13: Mariani MA, Stoker T, Scholten MF, Addis A, Corradi D, Alfieri O, Benussi S Concomitant off-pump modified maze and coronary surgery. Ann Thorac Surg 2011;91:e96-8 Wong LS, Huzen J, de Boer RA, van Gilst WH, van Veldhuisen DJ, van der Harst P Telomere length of circulating leukocyte subpopulations and buccal cells in patients with ischemic heart failure and their offspring. PLoS One 2011;6:e23118 Nauta FL, Bakker SJ, Van Oeveren W, Navis G, Van der Heide JJ, Van Goor H, De Jong PE, Gansevoort RT Albuminuria, proteinuria, and novel urine biomarkers as predictors of long-term allograft outcomes in kidney transplant recipients. Am J Kidney Dis 2011;57: Damman K, Voors AA, Navis G, Van Veldhuisen DJ, Hillege HL The cardiorenal syndrome in heart failure. Prog Cardiovasc Dis 2011;54: Meems LS, Van der Harst P, Van Gilst WH, De Boer RA Vitamin D biology in heart failure: molecular mechanisms and systematic review. Curr Drug Targets 2011;12:29-41 Fox ER, Young JH, Li Y,., Van der Harst P, et al Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet 2011;20: Kerstjens-Frederikse WS, Du Marchie Sarvaas GJ, Ruiter JS, Van Den Akker PC, Temmerman AM, Van Melle JP, Hofstra RM, Berger RM

7 Left ventricular outflow tract obstruction: should cardiac screening be offered to First-degree relatives? Heart 2011;97: De Borst MH, De Boer RA, Stolk RP, Slaets JP, Wolffenbuttel BH, Navis G Vitamin D deficiency: universal risk factor for multifactorial diseases? Curr Drug Targets 2011;12: Douglas YL, Jongbloed MRM, De Ruiter MC, Gittenberger-de Groot AC Normal and abnormal development of pulmonary veins: State of the art and correlation with clinical entities. Int J Cardiol 2011;147:13-24 Zhu H, Belcher M, van der Harst P Healthy aging and disease: role for telomere biology? Clin Sci (Lond). 2011;120: Hirsch A, Nijveldt R, Van der Vleuten PA, Tijssen JG, Van der Giessen WJ, Tio RA, Waltenberger J, Ten Berg JM, Doevendans PA, Aengevaren WR, Zwaginga JJ, Biemond BJ, Van Rossum AC, Piek JJ, Zijlstra F; HEBE Investigators Intracoronary infusion of mononuclear cells from bone marrow or peripheral blood compared with standard therapy in patients after acute myocardial infarction treated by primary percutaneous coronary intervention: results of the randomized controlled HEBE trial. Eur Heart J 2011;32: Verheugt CL, Uiterwaal CS, Van der Velde ET, Meijboom FJ, Pieper PG, Veen G, Stappers JL, Grobbee DE, Mulder BJ Turning 18 with congenital heart disease: prediction of infective endocarditis based on a large population. Eur Heart J 2011;32: Van Gelder IC, Haegeli LM, Brandes A, Heidbuchel H, Aliot E, Kautzner J, Szumowski L, Mont L, Morgan J, Willems S, Themistoclakis S, Gulizia M, Elvan A, Smit MD, Kirchhof P Rationale and current perspective for early rhythm control therapy in atrial fibrillation. Europace 2011;13: Bouma W, Klinkenberg TJ, Mariani MA Bilateral single-port thoracoscopic sympathectomy with the VasoView device in the treatment of palmar and axillary hyperhidrosis. Interact Cardiovasc Thorac Surg 2011;12:106-9 Kirchhof P, Lip GYH, Van Gelder IC, Bax J, Hylek E, Kääb S, Schotten U, Wegscheider K, Boriani G, Ezekowitz M, Diener H, Heidbuchel H, Lane D, Mont L, Willems S, Dorlan P, Vardas P, Breithardt G, Camm AJ Comprehensive risk reduction in patients with atrial fibrillation: Emerging diagnostic and therapeutic options. Thromb Haemost 2011;106; Schuuring MJ, Vis JC, Bouma BJ, Van Dijk AP, Van Melle JP, Pieper PG, Vliegen HW, Sieswerda GT, Mulder BJ Rationale and design of a trial on the role of bosentan in Fontan patients: improvement of exercise capacity? Contemp Clin Trials 2011;32:586-91

8 Ruifrok WP, Qian C, Silljé HH, Van Goor H, Van Veldhuisen DJ, Van Gilst WH, De Boer RA Heart failure-associated anemia: bone marrow dysfunction and response to erythropoietin. J Mol Med 2011;89: Van der Horst IC, Tack CJ Treating diabetes by improving cardiac output. Eur J Heart Fail 2011;13:133-4 Brouwer CA, Postma A, Vonk JM, Zwart N, Van den Berg MP, Bink-Boelkens MT, Dolsma WV, Smit AJ, De Vries EG, Tissing WJ, Gietema JA Systolic and diastolic dysfunction in long-term adult survivors of childhood cancer. Eur J Cancer 2011;47: Vlaar PJ, De Smet BJ Impact of heart failure on outcome after percutaneous coronary intervention: is it the patient or the intervention? Eur J Heart Fail 2011;13:364-5 Lexis CP, Van der Horst IC, Rahel BM, Lexis MA, Kampinga MA, Gu YL, De Smet BJ, Zijlstra F Impact of chronic total occlusions on markers of reperfusion, infarct size, and long-term mortality: A substudy from the TAPAS-trial. Catheter Cardiovasc Interv 2011;77: Ehret GB, Munroe PB, Rice KM,., van der Harst P, et al Common polymorphisms impacting blood pressure and cardiovascular disease in diverse populations highlight novel biological pathways. Nature 2011;478: Gieger C, Radhakrishnan, Cvejic A,., van der Harst P, et al High biological connectivity between genetic determinants of platelet biology. Nature 2011;480:201-8 Schumann G, Coin LJ, Lourdusamy A,., van der Harst P, et al Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proc Natl Acad Sci U S A. 2011;108: Yin M, Silljé HH, Meissner M, Van Gilst WH, De Boer RA Early and late effects of the DPP-4 inhibitor vildagliptin in a rat model of post-myocardial infarction heart failure. Cardiovasc Diabetol 2011;10:85 Liu LC, Voors AA, Van Veldhuisen DJ, Van der Veer E, Belonje AM, Szymanski MK, Silljé HH, Van Gilst WH, Jaarsma T, De Boer RA Vitamin D status and outcomes in heart failure patients. Eur J Heart Fail 2011;13: Funck-Brentano C, Van Veldhuisen DL, Van de Ven LL, Follath F, Goulder M, Willenheimer R; on behalf of the CIBIS-III investigators Influence of order and type of drug (bisoprolol vs. enalapril) on outcome and adverse events in patients with chronic heart failure: a post hoc analysis of the CIBIS-III trial. Eur J Heart Fail 2011;13:

9 De Jong AM, Maass AH, Oberdorf-Maass SU, Van Veldhuisen DJ, Van Gilst WH, Van Gelder IC Mechanisms of atrial structural changes caused by stretch occurring before and during early atrial fibrillation. Cardiovasc Res 2011;89: Damman K, Masson S, Hillege HL, Maggioni AP, Voors AA, Opasich C, Van Veldhuisen DJ, Montagna L, Cosmi F, Tognoni G, Tavazzi L, Latini R Clinical outcome of renal tubular damage in chronic heart failure. Eur Heart J 2011;32: Van der Zwaag PA, Van Tintelen JP, Gerbens F, Jongbloed JDH, Boven LG, Van der Smagt JJ, Van der Roest WP, Van Langen IM, Bikker H, Hauer RNW, Van den Berg MP, Hofstra RMW, Te Meerman GJ Haplotype sharing test maps genes for familial cardiomyopathies. Clin Genet 2011;79: Surakka I, Isaacs A, Karssen LC,., Van der Harst P, et al A genome-wide screen for interactions reveals a new locus on 4p 15 modifying the effect of waist-to-hip ratio on total cholesterol. PLoS Genet 2011;7:e Voors AA, Van der Horst IC Diabetes: a driver for heart failure. Heart 2011;97: Van der Meer P, Van Veldhuisen DJ To bind or not to bind: potassium-lowering drugs in heart failure. Eur Heart J 2011;32:791-2 Van den Heuvel AFM, Alfieri O, Mariani MA MitraClip in end-stage heart failure: a realistic alternative to surgery? Eur J Heart Fail 2011;13:472-4 Krul SPJ, Van der Smagt JJ, Van den Berg MP, Sollie KM, Pieper PG, Van Spaendonck-Zwarts Y Systematic review of pregnancy in women with inherited cardiomyopathies. Eur J Heart Fail 2011; Luijckx GJ, Van den Berg MP Heart failure and the brain, a wake-up call. Eur J Heart Fail 2011;13:597-8 Christiaans I, Birnie E, Bonsel GJ, Mannens MM, Michels M, Majoor-Krakauer D, Dooijes D, Van Tintelen JP, Van den Berg MP, Volders PG, Arens YH, Van den Wijngaard A, Atsma DE, Helderman-van den Enden AT, Houweling AC, De Boer K, Van der Smagt JJ, Hauer RN, Marcelis CL, Timmermans J, Van Langen IM, Wilde AA Manifest disease, risk factors for sudden cardiac death, and cardiac events in a large nationwide cohort of predictively tested hypertrophic cardiomyopathy mutation carriers: determining the best cardiological screening strategy. Eur Heart J 2011;32:

10 Brouwers FP, Asselbergs FW, Hillege HL, De Boer RA, Gansevoort RT, Van Veldhuisen DJ, Van Gilst WH Long-term effects of fosinopril and pravastatin on cardiovascular events in subjects with microalbuminuria. Ten years of follow-up of Preventation of Renal and Vascular End-stage Disease Intervention Trial (PREVEND IT). Am Heart J 2011;161: Johansson P, Lesman-Leegte I, Svensson E, Voors A, Van Veldhuisen DJ, Jaarsma T Depressive symptoms and inflammation in patients hospitalized for heart failure. Am Heart J 2011;161: Damman K, Ng Kam Chuen MJ, Macfadyen RJ, Lip GY, Gaze D, Collinson PO, Hillege HL, Van Oeveren W, Voors AA, Van Veldhuisen DJ Volume status and diuretic therapy in systolic heart failure and the detection of early abnormalities in renal and tubular function. J Am Coll Cardiol 2011;57: Von Haehling S, Van Veldhuisen DJ, Roughton M, Babalis D, De Boer RA, Coats AJ, Manzano L, Flather M, Anker SD Anaemia among patients with heart failure and preserve or reduced ejection fraction: results from the SENIORS study. Eur J Heart Fail 2011;13: Wain LV, Verwoert GC, O Reilly PF,, Van der Harst P, et al Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet 2011;43: Bogale N, Priori S, Gitt A, Alings M, Linde C, Dickstein K; on behalf of the Scientific Committee, National coordinators, and the investigators The European cardiac resynchronization therapy survey: patient selection and implantation practice vary according to centre volume. Europace 2011;13: Slart RH, Zeebregts CJ, Hillege HL, De Sutter J, Dierckx RA, Van Veldhuisen DJ, Zijlstra F, Tio RA Myocardial perfusion reserve after a PET-driven revascularization procedure: a strong prognostic factor. J Nucl Med 2011;52:873-9 Metra M, O Connor CM, Davison BA, Cleland JG, Ponikowski P, Teerlink JR, Voors AA, Givertz MM, Mansoor GA, Bloomfield DM, Jia G, Delucca P, Massie B, Dittrich H, Cotter G Early dyspnoea relief in acute heart failure: prevalence, association with mortality, and effect of rolofylline in the PROTECT Study. Eur Heart J 2011;32: Van den Berg MP, Bezzina CR KCND3 mutations in Brugada syndrome: the plot thickens. Heart Rhythm 2011;8: Zomer AC, Uiterwaal CS, Van der Velde ET, Tijssen JG, Mariman EC, Verheugt CL, Vaartjes I, Pieper PG, Meijboom FJ, Grobbee DE, Mulder BJ Mortality in adult congenital heart disease: are national registries reliable for cause of death? Int J Cardiol 2011;152:212-7

11 Mahmoud KD, De Smet BJ, Zijlstra F, Rihal CS, Holmes DR Jr Sudden cardiac death: epidemiology, circadian variation, and triggers. Curr Probl Cardiol 2011;36:56-80 O Connor CM, Starling RC, Hernandez AF,, Voors AA, et al Effect of nesiritide in patients with acute decompensated heart failure. N Engl J Med 2011;365:32-43 Hummel YM, Voors AA Grading diastolic left ventricular function. Eur J Heart Fail 2011;13:698-9 Hartog JW, Willemsen S, Van Veldhuisen DJ, Posma JL, Van Wijk LM, Hummel YM, Hillege HL, Voors AA; for the BENEFICIAL investigators Effects of alagebrium, an advanced glycation endproduct breaker, on exercise tolerance and cardiac function in patients with chronic heart failure. Eur J Heart Fail 2011;13: Fokkema ML, Wieringa WG, Van der Horst IC, Boersma E, Zijlstra F, De Smet BJ Quantitative analysis of the impact of total ischemic time on myocardial perfusion and clinical outcome in patients with ST-elevation myocardial infarction. Am J Cardiol 2011;108: Ke L, Meijering RA, Hoogstra-Berends F, Mackovicova K, Vos MJ, Van Gelder IC, Henning RH, Kampinga HH, Brundel BJ HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes. PLoS One 2011;6:e20395 Nieuwenhuis MM, Jaarsma T, Van Veldhuisen DJ, Van der Wal MH Factors associated with patient delay in seeking care after worsening symptoms in heart failure patients. J Card Fail 2011;17: Maisel AS, Mueller C, Fitzgerald R, Brikhan R, Hiestand BC, Iqbal N, Clopton P, Van Veldhuisen DJ Prognostic utility of plasma neutrophil gelatinase-associated lipocalin in patients with acute heart failure: The NGAL EvaLuation Along with B-type NaTriuretic Peptide in acutely decompensated heart failure (GALLANT) trial. Eur J Heart Fail 2011;13: Groenveld HF, Crijns HJGM, Van den Berg MP, Van Sonderen E, Alings M, Tijssen JGP, Hillege HL, Tuininga YS, Van Veldhuisen DJ, Ranchor AV, van Gelder IC, for the RACE II Investigators The effect of rate control on quality of life in patients with permanent atrial fibrillation. J Am Coll Cardiol 2011;58: ACTIVE I Investigators, Yusuf S, Healey JS, Pogue J, Chrolavicius S, Flather M, Hart RG, Hohnloser SH, Joyner CD, Pfeffer MA, Connolly SJ Irbesartan in patients with atrial fibrillation. N Engl J Med 2011;364: Meijer A, Conradi HJ, Bos EH, Thombs BD, Van Melle JP, De Jonge P Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis of 25 years of research.

12 Gen Hosp Psychiatry 2011;33: Ahmed S, Van Gelder IC, Wiesfeld AC, Van Veldhuisen DJ, Links TP Determinants and outcome of amiodarone-associated thyroid dysfunction. Clin Endocrinol (Oxf) 2011;75: Wolowacz SE, Samuel M, Brennan VK, Jasso-Mosqueda JG, Van Gelder IC The cost of illness of atrial fibrillation: a systematic view of the recent literature. Europace 2011;13: Smit MD, Crijns HJ, Tijssen JG, Hillege HL, Alings M, Tuininga YS, Groenveld HF, Van den Berg MP, Van Veldhuisen DJ, Van Gelder IC; RACE II Investigators Effect of lenient versus strict rate control on cardiac remodeling in patients with atrial fibrillation data of the RACE II (Rate Control Efficacy in permanent atrial fibrillation II) study. J Am Coll Cardiol 2011;58:942-9 Van Spaendonck-Zwarts KY, Van Hessem L, Jongbloed JDH, De Walle HEK, Capetanaki Y, Van der Kooi AJ, Van Langen IM, Van den Berg MP, Van Tintelen JP Desmin-related myopathy. Clin Genet 2011;80: Van Veldhuisen DJ, Swedberg K Treatment of chronic heart failure with aldosterone-blocking agents. Eur Heart J 2011;13:B43-B45 Chambers JC, Zhang W, Sehmi J,., Van der Harst P, et al Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet 2011;43: Damman K, Maass AH, Van der Meer P Heart failure highlights in Eur J Heart Fail 2011;13: Szymanski MK, Damman K, Van Veldhuisen DJ, Van Gilst WH, Hillege JL, De Boer RA Prognostic value of renin and prorenin in heart failure patients with decreased kidney function. Am Heart J 2011;162: Lexis CP, Van der Horst IC, Rahe BM, Lexis MA, Kampinga MA, Gu YL, De Smet BJ, Zijlstra F Impact of chronic total occlusions on markers of reperfusion. Infarct size, and long-term mortality: A substudy from the TAPAS-trial Catheter Cardiovasc Interv 2011;77: Schoormans D, Sprangers MA, Pieper PG, Van Melle JP, Van Dijk AP, Sieswerda GT, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, Mulder BJ The perspective of patients with congenital heart disease: does health care meet their needs? Congenit Heart Dis 2011;6: Smit MD, Van Gelder IC New treatment options for atrial fibrillation: towards patient tailored therapy. Heart 2011;97:

13 Lipsic E, Van der Meer P, Van Veldhuisen DJ Erythropoiesis-stimulating agents and heart failure. Cardiovasc Ther 2011;29:e52-9 Ahmed S, Van Gelder IC, Wiesfeld ACP, Van Veldhuisen DJ, Links TP Determinants and outcome of amiodarone-associated thyroid dysfunction. Clin Endocrinol 2011;75: Altena R, Hummel YM, Nuver J, Smit AJ, Lefrandt JD, De Boer RA, Voors AA, Van den Berg MP, De Vries EGE, Boezen HM, Gietema JA Longitudinal changes in cardiac function after cisplatin-based chemotherapy for testicular cancer. Ann Oncol 2011;22: Radonic T, De Witte P, Groenink M, De Bruin-Bon RACM, Timmermans J, Scholte AJH, Van den Berg MP, Baars MJH, Van Tintelen JP, Kempers M, Zwinderman AH, Mulder BJM Critical appraisal of the revised Ghent criteria for diagnosis of Marfan syndrome. Clin Genet 2011;80: Van der Linde D, Yap SC, Van Dijk AP, Budts W, Pieper PG, Van der Burgh PH, Mulder BJ, Witsenburg M, Cuypers JA, Lindemans J, Takkenberg JJ, Roos-Hesselink JW Effects of rosuvastatin on progression of stenosis in adult patients with congenital aortic stenosis (PROCAS Trial). Am J Cardiol 200;108: Van De Wauwer C, Verschuuren EA, Van der Bij W, Nossent GD, Erasmus ME The use of non-heart-beating lung donors category III can increase the donor pool. Eur J Cardiothorac Surg 2011;39:e175-80; discussion e180 Linssen GC, Rienstra M, Jaarsma T, Voors AA, Van Gelder IC, Hillege HL, Van Veldhuisen DJ Clinical and prognostic effects of atrial fibrillation in heart failure patients with reduced and preserved left ventricular ejection fraction. Eur J Heart Fail 2011;13: Trompet S, Pons D, Kanse SM, De Craen AJ, Ikram MA, Verschuren JJ, Zwinderman AH, Doevendans PA, Tio RA, De Winter RJ, Slagboom PE, Westendorp RG, Jukema JW Factor VII activating protease polymorphism (G534E) is associated with increased risk for stroke and mortality. Stroke Res Treat 2011;2011: Zomer AC, Verheugt CL, Vaartjes I, Uiterwaal CS, Langemeijer MM, Koolbergen DR, Hazekamp MG, Van Melle JP, Konings TC, Bellersen L, Grobbee DE, Mulder BJ Surgery in adults with congenital heart disease. Circulation 2011;124: Hermus L, Schuitemaker JH, Tio RA, Breek JC, Slart RH, De Boef E, Zeebregts CJ Novel serum biomarkers in carotid artery stenosis: useful to identify the vulnerable plaque? Clin Biochem 2011;44: De Witte P, Aalbers JJJ, Radonic T, Timmermans J, Scholte AJ, Zwinderman AH, Mulder BJM, Groenink M, Van den Berg P Intrinsic biventricular dysfunction in Marfan syndrome. Heart 2011;97:2063-8

14 Sampietro ML, Trompet S, Verschuren JJ, Talens RP, Deelen J, Heijmans BT, De Winter RJ, Tio RA, Doevendans PA, Ganesh SK, Nabel EG, Westra HJ, Franke L, Van den Akker EB, Westendorp RG, Zwinderman AH, Kastrati A, Koch W, Slagboom PE, De Knijff P, Jukema JW A genome-wide association study indentifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention. Hum Mol Genet 2011;20: Wieringa WG, Pundziute G, Willems TP, De Smet BJGL Clinical advances in imaging: how useful is computed tomography for guiding and evaluating cardiac interventions, Interv Cardiol 2011;3: Masteling MG, Zeebregts CJ, Tio RA, Breek JC, Tietge UJ, De Boer JF, Glaudemans AW, Dierckx RA, Boersma HH, Slart RH High-resolution imaging of human atherosclerotic carotid plaques with micro(18)f-fdg PET scanning exploring plaque vulnerability. J Nucl Cardiol 2011; Mahmoud KD, Vlaar PJ, Van den Heuvel AFM, Hillege HL, Zijlstra F, De Smet BJGL Usefullness of thrombus aspiration for the treatment of coronary stent thrombosis. Am J Cardiol 2011;108: Shah S, Nelson CP, Gaunt TR,, Van der Harst P, Van Veldhuisen DJ, De Boer RA,, et al Four genetic loci influencing electrocardiographic indices of left ventricular hypertrophy. Circ Cardiovasc Genet 2011;4: Van Veldhuisen DJ, Anker SD, Ponikowski P, Macdougall IC Anemia and iron deficiency in heart failure: mechanisms and therapeutic approaches. Nat Rev Cardiol 2011;31: Arrigoni SC, Kuijpers M, Mecozzi G, Mariani MA PulseCath as a right ventricular assist device. Interact Cardiovasc Thorac Surg 2011;12:891-4 Constantinides A, Van Pelt LJ, Van Leeuwen JJ, De Vries R, Tio RA, Van der Horst IC, Sluiter WJ, Dullaart RP Carotid intima media thickness is associated with plasma lipoprotein-associated phospholipase A(2) mass in nondiabetic subjects but not in patients with type 2 diabetes. Eur J Clin Invest 2011:41:820-7 Smit MD, Maass AH, Hillege HL, Wiesfeld AC, Van Veldhuisen DJ, Van Gelder IC Prognostic importance of natriuretic peptides and atrial fibrillation in patients receiving cardiac resynchronization therapy. Eur J Heart Fail 2011;13: Hoekstra T, Lesman-Leegte I, Van Veldhuisen DJ, Sanderman R, Jaarsma T Quality of life is impaired similarly in heart failure patients with preserved and reduced ejection fraction. Eur J Heart Fail 2011;13: Van der Meer P, Van Veldhuisen DJ Acute coronary syndromes: The unfulfilled promise of erythropoietin in patients with MI. Nat Rev Cardiol 2011;8:425-6 Van Gelder IC, Phan HM, Wilkoff BL, Brown ML, Rogers T, Peterson BJ, Birgersdottergreen UM

15 Prognostic significance of atrial arrhythmias in a primary prevention ICD population. Pacing Clin Electrophysiol 2011; De Jonge GJ, Van der Vleuten PA, Overbosch J, Lubbers DD, Jansen-van der Weide MC, Zijlstra F, Van Ooijen PM, Oudkerk M Semi-automatic measurement of left ventricular function on dual source computed tomography using five different software tools in comparison with magnetic resonance imaging. Eur J Radiol 2011;80: Damman K, Masson S, Hillege HL, Maggioni AP, Voors AA, Opasich C, Van Veldhuisen DJ, Montagna L, Cosmi F, Tognoni G, Tavazzi L, Latini R Clinical outcome of renal tubular damage in chronic heart failure. Eur Heart J 2011;32: Kirchhof P, Lip GYH, Van Gelder IC, Bax J, Hylek E, Kääb S, Schotten U, Wegscheider K, Boriani G, Ezekowitz M, Diener H, Heidbuchel H, Lane D, Mont L, Willems S, Dorian P, Vardas P, Breithardt G, Camm AF Comprehensive risk reduction in patients with atrial fibrillation: emerging diagnostic and therapeutic options. Executive summary of the report for the 3 rd AFNET/EHRA consensus conference. Thromb Haemost 2011;106: Bosma OH, Vermeulen KM, Verschuuren EA, Erasmus ME, Van der Bij W Adherence to immunosuppression in adult lung transplant recipients; prevalence and risk factors. J Heart Lung Transplant 2011;30: Endorsed by the European Society of Gynecology (ESG), the Association for European Paediatric Cardiology (AEPC) and the German Society for Gender Medicine (DGesGM); Authors/Task Force Members, Regitz-Zagrosek V, Blomstrom Lundqvist C, Borghi C,, Pieper PG, et al ESC Guidelines on the management of cardiovascular diseases during pregnancy: The Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC). Eur Heart J 2011;32: Hellemons ME, Agarwal PK, Van der Bij W, Verschuuren EA, Postmus D, Erasmus ME, Navis GJ, Bakker SJ Former smoking is a risk factor for chronic kidney disease after lung transplantation. Am J Transpl 2011;11: Davison BA, Cotter G, Sun H, Chen L, TeerlinkJR, Metra M, Felker GM, Voors AA, Ponikowski P, Filippatos G, Greenberg B, Techman SL, Unemori E, Koch GG Permutation criteria to evaluate multiple clinical endpoints in a proof-of-concept study: lessons from Pre- RELAX-AHF. Clin Res Cardiol 2011;100: Böhm M, Voors AA, Ketelslegers JM, Schirmer SH, Turgonyi E, Bramlage P, Zannad F Biomarkers: optimizing treatment guidance in heart failure. Clin Res Cardiol 2011;100: Klip IT, Voors AA, Anker SD, Hillege HL, Struck J, Squire I, Van Veldhuisen DJ, Dickstein K; OPTIMAAL Investigators Prognostic value of mid-regional pro-adrenomedullin in patients with heart failure after an acute myocardial infarction. Heart 2011;97:892-8

16 Smid MD, Van Gelder IC New treatment options for atrial fibrillation: towards tailored therapy. Heart 2011;97: Nijenhuis T, Sloan AJ, Hoenderop JG, Flesche J, Van Goor H, Kistler AD, Bakker M, Bindels RJ, De Boer RA, Möller CC, Hamming I, Navis G, Wetzels JF, Berden JH, Reiser J, Faul C, Van der Vlag J Antiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway. Am J Pathol 2011;179: Douwes JM, Van Loon RL, Hoendermis ES, Vonk-Noordegraaf A, Roofthooft MT, Talsma MD, Hillege HL, Berger RM Acute pulmonary vasodilator response in paediatrics and adult pulmonary arterial hypertension: occurrence and prognostic value when comparing three response criteria. Eur Heart J 2011;32: Jongbloed MR, Vicente-Steijn R, Douglas YL, Wisse LJ, Mori K, Yokota Y, Bartelings MM, Schalij MJ, Mahtab EA, Poelmann RE, Gittenberger-De Groot AC Expression of ld2 in the second heart field and cardiac defects in ld2 knock-out mice. Dev Dyn 2011;240: Johnson T, Gaunt TR, Newhouse SJ., Van der Harst P, et al Blood pressure loci identified with a gene-centric array. Am J Hum Genet 2011;89: Westenbrink BD, leijn L, De Boer RA, Tijssen JG, Warnica WJ, Baillot R, Rouleau JL, Van Gilst WH; IMAGINE Investigators Sustained postoperative anaemia is associated with an impaired outcome after coronary artery bypass graft surgery: insights from the IMAGINE trial. Heart 2011;97: Postmus D, Pari AA, Jaarsma T, Lukkik ML, Van Veldhuisen DJ, Hillege HL, Buskens E A trial-based economic evaluation of 2 nurse-led disease management programs in heart failure. Am Heart J 2011;162: O Connor CM, Fiuzat M, Lombardi C, Fujita K, Jia G, Davison BA, Cleland J, Bloomfield D, Dittrich HC, Delucca P, Givertz MM, Mansoor G, Ponikowski P, Teerlink JR, Voors AA, Massie BM, Cotter G, Metra M Impact of serial troponin release on outcomes in patients with acute heart failure: analysis from the PROTECT pilot study. Circ Heart Fail 2011;4: Ehret GB, Munroe PB, Rice KM,, Van der Harst P, et al Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 2011;478:103-9 Gieger C, Radhakrishnan A, Cvejic A,, De Boer RA, et al New gene functions in megakaryopoiesis and platelet formation. Nature 2011;480:201-8

17 Cleland JG, Coletta AP, Cullington D, Castiello T, De Boer RA, Clark AL Clinical trials update from the European Society of Cardiology Meeting 2011: ARISTOTLE, SMART-AV: QLV substudy, SHIFT: echocardiography and quality of life substudies. European CRTY Survey, and Basic Science Update. Eur J Heart Fail 2011;13: El Messaoudi S, Rongen GA, De Boer RA, Riksen NP The cardioprotective effects of metformin. Curr Opin Lipidol 2011;22:445-53

18 Nationale tijdschriften Voors AA, Walma EP, Twickler TB, Rutten FH, Hoes AW Multidisciplinaire richtlijn Hartfalen Ned Tijdschr Geneeskd 2011;155:A2957 Hemels ME, Hoendermis ES, Van Melle JP, Pieper PG Therapy refractory hypertension in adults: aortic coarction has to be ruled out. Neth Heart J 2011;19: Smit MD, Van Gelder IC Risk-benefit ratio assessment for stroke prevention in intermediate risk atrial fibrillation patients: will TEEbases aspirin treatment fill the gap? Neth Heart J 2011;19:212-3 Van den Wijngaard A, Volders P, Van Tintelen JP, Jongbloed JD, Van den Berg MP, Lekanne Deprez RH, Mannens MM, Hofmann N, Slegtenhorst M, Dooijes D, Michels M, Arens Y, Jongbloed R, Smeets BJ Recurrent and founder mutations in the Netherlands: cardiac Troponin (TNN134) gene mutations as a cause of severe forms of hypertrophic and restrictive cardiomyopathy. Neth Heart J 2011;19: Pieper PG Pre-pregnancy risk assessment and counseling of the cardiac patient. Neth Heart J 2011;19; Pieper PG, Hoendermis ES Pregnancy in women with pulmonary hypertension. Neth Heart J 2011;19:504-8 Hoendermis ES Pulmonary arterial hypertension: an update Neth Heart J 2011;19:514-22