Connecting solutions of excellence

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1 MODULAR PRE-ANALYTICS EVO analyzer Connecting solutions of excellence COBAS, COBAS C, COBAS E, COBAS P, LIFE NEEDS ANSWERS, MODULAR ANALYTICS EVO, MODULAR PRE-ANALYTICS EVO, MODULAR, ELECSYS and COBAS INTEGRA are trademarks of Roche. STA-R EVOLUTION is a trademark of Stago S.A. 00 Roche Roche Diagnostics Ltd. CH-6 Rotkreuz Switzerland WW

2 Take the right steps - consolidation, organization, integration Consolidation and integration to drive efficiency and quality Integration Workflow solutions Proven performance meets new connectivities and more functionalities MODULAR PRE-ANALYTICS EVO with Roche Work Area Manager (WAM), MODULAR ANALYTICS EVO, cobas 8000 modular analyer series, and STA-R Evolution Key for process efficiency Sample Sorting Serum/Urine Plasma EDTA Centrifugation Decapping Decapping MODULAR PRE-ANALYTICS EVO Centrifuge Aliquotting Consolidation of analytics Reduction of complexity Fewer analyzers Less process steps Process organization Streamlining of processes IT networking of all components Data and workflow management Sorting cobas 8000 modular analyzer series / STA-R Evolution Clinical Chemistry Proteins Drugs Thyroid Tumor Markers Hormones Others/ Immunology Coagulation Hematology Consolidation Integration by automation solutions Standardized processes Shorter, predictable TAT Reduction of labor intensive processes Less contact with biohazard materials Archive / Waste

3 MODULAR PRE-ANALYTICS EVO Optimizes your workflow efficiency Dedicated solution for satellite, commercial and large STAT labs. The new MODULAR PRE-ANALYTICS EVO combines the proven features and benefits of modular pre-analytics (MPA) with new connectivities, more functionalities and consultancy expertise utilizing novel workflow analysis tools. New connectivity and more functionality can be applied to all MPA systems in operation. MODULAR PRE-ANALYTICS EVO Model C with cobas 6000 analyzer series Up to 50 peak sample throughput/hr Centrifugation, decapping and online to cobas 6000 analyzer series Supports primary tube workflow MODULAR PRE-ANALYTICS EVO Model C cobas c 50 module / cobas e 60 module Solution with all pre-analytical steps including bar-coded aliquots for offline analyzers. MODULAR PRE-ANALYTICS EVO Model B with and STA-R Evolution Up to 50 peak sample throughput/hr Centrifugation, decapping, on- and offline aliquotting, barcode labeling, sorting/archiving and online to Optionally online to STA-R Evolution MODULAR PRE-ANALYTICS EVO Model B cobas c 50 module / cobas e 60 module cobas c 50 module / cobas e 60 module STA-R Evolution

4 MPA configurations models to suit a wide range of demands Solution with all pre- and postanalytical steps including bar-coded aliquots for offline analyzer. MODULAR PRE-ANALYTICS EVO Model B with cobas 8000 modular analyzer series and cobas p 50 post-analytical unit / cobas p 70 postanalytical unit Up to 00 peak sample throughput/hr Centrifugation, decapping, on- and offline aliquotting, barcode labeling, sorting, archiving on cobas p 50 post-analytical unit, cobas p 70 post-analytical unit and online to cobas 8000 modular analyzer series Optionally online to STA-R Evolution MODULAR PRE-ANALYTICS EVO Model B cobas 8000 modular analyzer series cobas 8000 modular analyzer series cobas p 50 post-analytical unit MODULAR PRE-ANALYTICS EVO Model A Centrifugation, decapping, online aliquotting, sorting/ archiving, online connection to MODULAR ANA- LYTICS EVO,, cobas 8000 modular analyzer series, cobas p 50 postanalytical unit / cobas p 70 post-analytical unit and STA-R Evolution MODULAR PRE-ANALYTICS EVO Model B Centrifugation, decapping, online aliquotting, offline aliquotting, barcode labeling, recapping, sorting/ archiving, online connection to MODULAR ANA- LYTICS EVO, cobas 6000 analyzer series, cobas 8000 modular analyzer series, cobas p 50 postanalytical unit / cobas p 70 post-analytical unit and STA R Evolution MODULAR PRE-ANALYTICS EVO Model C Centrifugation, decapping, online connection to cobas 6000 analyzer series, cobas 8000 modular analyzer series, cobas p 50 post-analytical unit / cobas p 70 post-analytical unit and STA R Evolution Primary tube workflow MODULAR PRE-ANALYTICS Options & Upgrades Primary Sample Sorter (PSS), nd centrifuge (ACU) and Additional Flexible Sample Sorter (FSS)

5 MODULAR PRE-ANALYTICS EVO A wide variety of pre-analytical modules to meet individual needs 9 IPB Input Buffer Capacity: up to 00 samples (in trays) Tube rotation for barcode reading Dedicated STAT port Default buffer for unknown samples DSP 5 5 Destopper module Throughput: up to 00 s/hr Supported tube types: Hemogard, Vacuette, Venosafe, Monovette, Kabe, Kima 6 BCL 7 7 Barcode Labeler module Throughput: up to 50 s/hr Print code: NW7/Code9/ Code8/ITF* Printing: including userdefinable, human readable data 8 FSS Flexible Sample Sorter module Sorting of barcoded aliquots and primary tubes Throughput: up to 500 s/hr Targets: up to 5 New archive trays for up to 00 samples per module Up to modules *with check digit ACU Automatic Centrifuge module Throughput: up to 50 s/hr (at 5 minutes spin time) Up to 00 s/hr with nd centrifuge Speed:,000 rpm Batch size: 0 samples Auto-balancing Up to modules AQN Online Aliquoter module Aliquots for connected analyzers Secondary tubes for other targets Throughput: up to 00 s/hr with on-line aliquote Aliquots: up to 0 aliquots/sample Clotting/short sample detection 6 RSF Restopper module Throughput: up to 500 s/hr Stopper type: Flex stopper for mm and 6 mm tubes 8 OPB Output Buffer Capacity: up to 50 samples 9 PSS Primary Sample Sorter Option: Sorting out of Hematology, Coagulation or other special tubes (RD 5 pos. rack, Sysmex 0 pos. rack) Design your tailor-made MODULAR PREANALYTICS EVO solution together with our experienced consulting team

6 MODULAR PRE-ANALYTICS EVO Proven features and benefits Primary tube input MODULAR PRE-ANALYTICS EVO Shorter, predictable TAT Carry-over, free operation Early access of primary tubes Reduced biohazard exposure Aliquot cups/ primary tubes Clinical Chemistry STAT samples are loaded into a dedicated STAT port Aliquot cups/ primary tubes STAT samples by-pass modules on the transport line Special Chemistry MODULAR PRE-ANALYTICS EVO Model B Primary as reference tube for archiving Proteins Bar-coded aliquots tubes to consolidate offline workstations STAT samples have priority for cen- TDM/DMT trifugation and get unloaded first Aliquot cups/ primary tubes Immunology Coagulation primary tubes Coagulation Layout flexibility More than 90 released layouts with 8 different connection element lengths (TUL: 00 to,00 mm) allow compact configurations and fit in almost every lab. Coagulation tubes stay on STA-R Evolution STAT samples by-pass routine samples in the Sample Buffer Unit (SBU) for direct transfer to online connected systems cobas 8000 modular analyzer series Process quality and optimized sample workflow by online aliquots (cups) to connected Clin. Chem. and Het. IA analyzer, bar-coded aliquots for other workplaces and archiving of primar tubes as reference tubes to support Real STAT capability STAT racks are by-passing routine racks to allow total STAT turn around times of in average 5 to 5 minutes to offer the option to integrate your STAT testing in the routine operation.

7 Upgrading with a nd ACU (Automatic Centrifuge module) Upgrading with additional FSS (Flexible Sample Sorter module) Excellent IT networking All instruments connected online to MPA as well as offline analyzers are connected to the Roche Work Area Manager (WAM) for workflow and data management to provide optimized processes and one interface to LIS. Extendability and adaptability on site More than 00 MPA s have been extended on site with additional modules to deal with current and future needs. Lab Information System Pre-Analytic & Work Area Manager LIS Roche WAM One LIS interface Data and Workflow Management Online systems Integration and online consolidation MODULAR PRE-ANALYTICS EVO MODULAR ANALYTICS EVO STA-R Evolution cobas 8000 modular analyzer series cobas p 50 post-analytical unit / cobas p 70 post-analyitical unit others Elecsys 00 analyzer cobas 000 analyzer series cobas 000 analyzer series COBAS INTEGRA 00 plus analyzer COBAS INTEGRA 800 analyzer Offline analyzer

8 MODULAR PRE-ANALYTICS EVO New archiving concept with cobas p 50 postanalytical unit / cobas p 70 post-analytical unit Expert consultancy and comprehensive simulation tools Roche has successfully implemented more than 900 lab automation solutions worldwide. Various simulation tools are available to analyze the current situation and generate performance data for proposed solutions including future growths. cobas 8000 modular analyzer series MODULAR PRE-ANALYTICS EVO Virtual Automation solutions Task Targeted Automation solutions Total Lab Automation solutions Efficiency The storage of primary and secondary tubes is a time consuming daily activity in all laboratories. In addition the efforts and time for the staff increases due to retrieval of samples for additional analysis (add-on testing). Safety The manual handling of the archiving process increases the operator biohazard exposure. Quality Manual archiving provides limited sample quality monitoring and traceability. The Roche solution The cobas p post-analytical units for automated sample archiving provides the laboratory with: Reduction/elimination of manual handling for storage and retrieval Reduction/elimination of biohazard exposure Continuous sample quality monitoring of the storage area and complete traceability of all the processes (storage, retrieval, wasting) Intended use The cobas p post-analytical units are the Roche automated solution for sample archiving. Barcoded primary and aliquote tubes are stored in a refrigerated area and are available for retrieval for add-on testing.

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