EMERGING THERAPIES IN GYNECOLOGICAL CANCER

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1 MD ANDERSON INTERNATIONAL MEETING IN GYNECOLOGIC ONCOLOGY: EMERGING THERAPIES IN GYNECOLOGICAL CANCER Directors: Dr. Luis Chiva. Head of Department of Gynecologic Oncology. Dr. Antonio González-Martín. Head of Department of Medical Oncology. Dr. Pedro Ramírez. Director of Minimally Invasive Surgical Research & Education. Department of Gynecologic Oncology. The University of Texas MD Anderson Cancer Center, Houston. USA February2014 MADRID Auditorio Mutua Madrileña. Paseo de la Castellana 33. Madrid. Spain.

2 LIST OF SPEAKERS AND MODERATORS: Nadeem Abu-Rustum José María del Campo Natalia Carballo Dennis Chi Luis Chiva David Cibula Robert Coleman Christina Fotopoulou Michael Frumovitz David Gershenson Antonio Gil-Moreno Antonio González-Martín Sudeep Gupta Anuja Jhingran Stan Kaye Fernando Lapuente Jonathan Ledermann Karen Lu Andrea Mariani Xavier Matias-Guiu Mansoor Mirza Ana Oaknin Jordi Ponce Andrés Poveda Eric Pujade Pedro Ramirez Francesco Raspagliesi Alexandros Rodolakis Kathleen Schmeler Jalid Sehouli Anil Sood MSKCC. New York, USA. Hospital Universitario Vall d Hebron. Barcelona, Spain. MSKCC. New York, USA. General Teaching Hospital in Prague. Charles University Prague. Prague, The Czech Republic. Imperial College London, United Kingdom. Hospital Vall d Hebrón. Barcelona, Spain. Tata Memorial Centre Mumbai, India. The Royal Marsden Hospital. Sutton, United Kingdom. UCL Cancer Institute, University College London, United Kingdom. Mayo Clinic. Minnesota, USA. Hospital Universitari Arnau de Vilanova. Lérida, Spain. Rigshospitalet. Copenhagen, Denmark. Hospital Universitario Vall d Hebron. Barcelona, Spain. Hospital Universitario Bellvitge. Barcelona, Spain. Instituto Valenciano de Oncología. Valencia, Spain. Centre Hospitalier Universitaire Hotel-Dieu. Paris, France. Istituto Nazionale dei Tumori. Milan, Italy. Alexandra Hospital. Athens University. Athens, Greece. Charite University Hospital. Berlin, Germany.

3 IV MD ANDERSON INTERNAT Wednesday-February 19, SURGICAL SYMPOSIUM- INNOVATIVE & COMPLEX PROCEDURES IN GYNECOLOGIC ONCOLOGY Introduction: Dr. Fernando Lapuente. Dr. Pedro Ramirez. Dr. Francesco Raspagliesi. Istituto Nazionale dei Tumori. Milan, Italy. Dr. Alexandros Rodolakis. Alexandra Hospital. Athens University. Athens, Greece. Cervical cancer: Nerve-sparing radical hysterectomy. Dr. David Cibula. General Teaching Hospital in Prague. Charles University Prague. Prague, The Czech Republic. 12:45-13:00 Oncologic results of extended pelvic resection. Dr. Dennis Chi. MSKCC. New York, USA. Uterine cancer: FireFly fluorescent sentinel node mapping. Dr. Pedro Ramirez. The University of Texas MD Anderson Cancer Center. Houston, USA. 13:15-13:30 Ultra-staging in endometrial cancer and nanometastases. Dr. Nadeem Abu-Rustum. MSKCC. New York, USA. 13:30-13:45 Single-port hysterectomy for endometrial cancer. Dr. Michael Frumovitz. Ovarian cancer: Radical upper abdominal lymphadenectomy. Dr. Fernando Lapuente. MD Anderson Cancer Center Madrid, Spain. 14:00-14:15 Colorectal resection in advanced disease. Dr. Dennis Chi. MSKCC. New York, USA. Dr. Luis Chiva. MD Anderson Cancer Center Madrid. Spain. Reconstructive surgery: Urinary diversion. Dr. Fernando Lapuente. Dr. Luis Chiva. MD Anderson Cancer Center Madrid. Spain Cocktail WELCOME. Dr. Pedro Ramirez. Dr. Antonio González-Martín. OPENING KEY LECTURE Gynecologic cancer genetics: The practical implications. Dr. Karen Lu. Chair and Professor, Gynecologic Oncology and Reproductive Medicine. J. Taylor Wharton Distinguished Chair. MOLECULAR DISCOVERIES IN GYNECOLOGICAL CANCERS AND THERAPEUTIC IMPLICATIONS Dr. Stan Kaye. The Royal Marsden Hospital. Sutton, United Kingdom. Dr. Gema Moreno The cancer genome atlas (TCGA). Innovations in ovarian and uterine cancer. Dr. Anil Sood The ovarian cancer Moonshot. A translational research perspective. Dr. Robert Coleman.

4 IONAL MEETING IN GYNECOLOGIC DISCUSSION Coffee Dr. Stan Kaye. The Royal Marsden Hospital. Sutton, United Kingdom. Dr. José María del Campo. Hospital Universitario Vall d Hebron. Barcelona, Spain Updates on the role of PARP inhibitors. The molecular perspective. Dr. Jonathan Ledermann. UCL Cancer Institute, University College London, United Kingdom RNAi strategies in future therapeutics of ovarian cancer. Dr. Anil Sood. The University of Texas MD Anderson Cancer Center. Houston, USA Novel target discovery and therapeutic implications in gynecological cancers. Dr. Jalid Sehouli. Charite University Hospital. Berlin, Germany DISCUSSION Thursday-February 20, 2014 UPFRONT THERAPY IN OVARIAN CANCER Dr. Pedro Ramirez. Dr. Antonio González-Martín Laparoscopic assessment prior to debulking: Should this be the new standard of care in advanced ovarian cancer? Dr. Nadeem Abu-Rustum. MSKCC. New York, USA Role of HIPEC therapy: A new frontier or therapy with no future? Dr. Dennis Chi. MSKCC. New York, USA DISCUSSION Novel therapeutic options for specific ovarian subtypes: Low grade, clear cell and mucinous. Dr. David Gershenson DISCUSSION Coffee INTEGRATION OF ANTI-ANGIOGENIC THERAPY INTO FRONT-LINE OVARIAN CANCER TREATMENT Dr. Eric Pujade. Centre Hospitalier Universitaire Hotel-Dieu. Paris, France. Dr. Andrés Poveda. Instituto Valenciano de Oncología. Valencia, Spain Anti-angiogenic agents in front-line therapy for ovarian cancer. Dr. Antonio González-Martín Future clinical trial designs and biomarkers for anti-angiogenic therapy. Dr. Robert Coleman DISCUSSION

5 ONCOLOGY: EMERGING THERAPIE RECURRENT OVARIAN CANCER UPDATES ON MEDICAL AND SURGICAL OPTIONS Dr. Robert Coleman. Dr. Antonio González-Martín Standard treatment and promising non-antiangiogenesis options in the medical management of recurrent disease. Dr. José María del Campo. Hospital Universitario Vall d Hebron. Barcelona, Spain Use of anti-vegf and other anti-angiogenic agents for relapsed ovarian cancer. Dr. Eric Pujade. Centre Hospitalier Universitaire Hotel-Dieu. Paris, France Indications for surgical resection of recurrent disease. Have criteria changed? Dr. Christina Fotopoulou. Imperial College London, United Kingdom DISCUSSION Lunch UPDATES AND INNOVATIONS IN THE MANAGEMENT OF CERVICAL CANCER Dr. Natalia Carballo. Dr. Andrés Poveda. Instituto Valenciano de Oncología. Valencia, Spain. Dr. Antonio Gil-Moreno. Hospital Vall d Hebrón. Barcelona, Spain Role of sentinel node in early-stage disease & surgical options in locally-advanced cervical cancer. Dr. Michael Frumovitz Evolution of cervical cancer surgery. Tailoring radicality to risk factors. Dr. Kathleen Schmeler DISCUSSION Current indications and latest technologies in radiation oncology. Dr. Anuja Jhingran Standard and novel therapeutics in advanced or recurrent cervical cancer. Dr. Ana Oaknin. Hospital Universitario Vall d Hebron. Barcelona, Spain DISCUSSION Coffee DISCUSSING CONTROVERSIAL TOPICS IN ENDOMETRIAL CANCER Moderator: Dr. Michael Frumovitz. Dr. Jordi Ponce. Hospital Universitario Bellvitge. Barcelona, Spain. Lymphadenectomy and role of lymphatic mapping in endometrial cancer. A multi-institutional perspective Mayo Clinic Experience. Dr. Andrea Mariani. Mayo Clinic. Minnesota, USA Memorial Experience. Dr. Nadeem Abu-Rustum. MSKCC. New York, USA.

6 S IN GYNECOLOGICAL CANCER MD Anderson Experience. Dr. Pedro Ramirez. The University of Texas MD Anderson Cancer Center. Houston, USA European Experience. Dr. Francesco Raspagliesi. Istituto Nazionale dei Tumori. Milan, Italy Adjuvant therapy for intermediate and high risk endometrial cancer. Dr. Mansoor Mirza. Rigshospitalet. Copenhagen, Denmark DISCUSSION Friday-February 21, TUMOR BOARD Presenters: Dr. Pedro Ramirez. Dr. Antonio González-Martín. Panel: Dr. Dennis Chi Dr. Nadeem Abu-Rustum Dr. Andrea Mariani Dr. David Gershenson Dr. Karen Lu Dr. Eric Pujade Dr. Robert Coleman Dr. Xavier Matias-Guiu Dr. Anuja Jhingran MD ANDERSON FOUNDATION SPAIN AWARDS 2014 A life devoted to a great endeavor: Gynecologic oncology. The gynecologic oncology perspective: Dr. David Gershenson. The gynecologic medical oncology perspective: Dr. Stan Kaye. The Royal Marsden Hospital. Sutton, United Kingdom Coffee PREVENTION AND THERAPY OF GYNECOLOGICAL CANCER IN DEVELOPING COUNTRIES: WHEN LIMITATIONS LEAD TO INNOVATION Changing the world of cervical cancer. Technology for everyone. The Central American experience. Dr. Kathleen Schmeler. The University of Texas MD Anderson Cancer Center. Houston, USA. The Indian experience. Dr. Sudeep Gupta. Tata Memorial Centre. Mumbai, India. International round table: Brazil: Dr. Ricardo dos Reis. Hospital de Câncer de Barretos. Brazil. Mexico: Dr. David Cantu. Istituto Nacional de Cancerología de México. México, D. F. Colombia: Dr. Rene Pareja & Dr. Gabriel Rendon. Instituto de Cancerología. Clínica las Américas. Medellin. Colombia. Thailand: Dr. Wichai Termrungruanglert. Chulalongkorn University. Bangkok, Thailand FILM FESTIVAL Dr. David Cibula. General Teaching Hospital in Prague. Charles University Prague. Prague, The Czech Republic. Dr. Pedro Ramirez. Dr. Alexandros Rodolakis. Alexandra Hospital. Athens University. Athens, Greece CLOSING REMARKS Dr. Pedro Ramirez. Dr. Antonio González-Martín.

7 LOCAL COMMITTEE: Sonsoles Alonso Marisa Argente Raquel Bratos Natalia Carballo Teresa Castellanos Luis Chiva Virginia Corraliza Ana Cortijo Irene Fernández Juan Fernando García Javier García Prado Antonio González-Martín Luis Granados Fernando Lapuente Mª José López de Paredes Raúl Márquez Mar Mendivil Gema Moreno Mª Jesús Pablos Virginia Peyró Alejandro Rojo Gemma Toledo

8 Sponsorship: SILVER GOLDEN PLATINUM Collaborators: Under the auspice of: Esta actividad docente (con nº de expediente 13/11010), está acreditada por la Comisión de Formación Continuada de las Profesiones Sanitarias de la Comunidad de Madrid-Sistema Nacional de Salud, con 2,6 créditos de formación continuada para las profesiones: Licenciados en Medicina y Diplomados en Enfermería. Organizing industry: Technical Secretariat: Laura Flores. laura.flores@totalteam.es

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