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2 JOIN AAAS Get instant access to Science. Support all of the sciences. Since 1880 The American Association for the Advancement of Science (AAAS) is a non-proﬁt community that is open to everyone, from Nobel laureates to high school students. Ours is a global membership of over 120,000 people who believe in the power of science to make the world a better place. From the moment you join, you get immediate access to everything that AAAS s award-winning journal Science has to offer, including: ß 51 weeks of home delivery of Science; ß Instant online retrieval of every Science article ever published, from today, dating back to 1880; ß Anytime, anywhere access via the Science mobile site and apps for Android, ipad, and iphone devices; ß Members-only newsletters; and more. As a member, you are also making a critical contribution to AAAS s efforts to provide a public voice for all of science. With public skepticism about science increasing, and public funding for research more uncertain than ever, this work has never been more important. AAAS is hard at work promoting science in government ofﬁces, in schools, and in the public commons all around the world with programs like AAAS Senior Scientists and Engineers, which brings volunteer scientists into public school classrooms, or our sweeping petition drives calling for the preservation of federal R&D funding. Visit promo.aaas.org/joinaaas and join today. Together we can make a difference.
3 Produced by the Science/AAAS Custom Publishing Office LIFE SCIENCE TECHNOLOGIES NEW PRODUCTS Ambient Ionization Mass Spectrometer The new AccuTOF-DART4G comes with new performance capabilities including enhanced resolution, speed, versatile design. The AccuTOF-DART 4G couples the facile operation of the DART (Direct Analysis in Real Time) ion source with the high-resolution, accurate mass capability of the AccuTOF only can the user rapidly acquire data without sample carryover, but also the resulting spectra yield unambiguous assignments, isotopic ratios, and elemental compositions. Jeol For info: Lab Management System The NuGenesis Lab Management System is a unique and powerful alternative to a traditional Laboratory Information Management System with advances challenges, accelerated decisionmaking, better business results, and compliance with government regulations. The NuGenesis Lab Management New advances include NuGenesis SampleShare, an optional, secure webclient for sample submissions and results management; NuGenesis Stability, a complete stability protocol management and testing solution to facilitate a lab operations; NuGenesis Connectors, a bidirectional link between lab systems management capabilities to support the entire product lifecycle from discovery through manufacturing, the NuGenesis Lab Management Data Management System, Electronic Laboratory Notebook, and Waters Corporation For info: Semi-automatic Electronic Pipette The CyBi-SELMA is a semi-automatic electronic pipette, equipped with 96 or 384 parallel working tips with a volume range from 500 nl to 1 ml. Based on CyBioís well-proven tip sealing and reproducible results. Automatic tip tightening avoids laborious adjustments and preloaded CyBi-TipTrays guarantee design allows the processing of any 96- or 384-well microplates as well as the use of accessories like shakers. The pipette features intuitive operation via multilingual touchscreen and a comfortable selection saving of methods. Thanks to its intuitive touch screen user interface, CyBi-SELMA is amazingly easy to operate. All manualoperating tasks such as tip change or plate change are shown on the display. In addition, any kind of liquid handling parameters like volume and pipetting speed can be adjusted. Analytik Jena For info: +49-(0) Automated Chemistry Analyzer The new Flow Solution 3700 Automated Chemistry Analyzer is an advanced hardware that allows FIA, SFA, isfa, and SFIA methods to be run on the same unit. The FS 3700 incorporates the latest technology that enables higher accuracy and precision of measurement, and the modular design gives the FS 3700 re- integrated capabilities of the powerful and customizable FlowView software sample addition, and online data processing. A variety of robust detectors, preassembled chemistry cartridges, and plug-and-play valves for FIA/iSFA/ performance and versatility. Cartridges for validated USEPA, ASTM, and ISO standardized methods are available, as well as customized cartridges for spe- and modular, the Flow Solution 3700 provides the optimum platform for compliance monitoring, process control, QA/ QC, research, and proprietary methods. Xylem Analytics For info: Molecular Barcoding/Analysis Platform The GemCode Platform is a unique molecular barcoding and analysis platform that consists of instrumentation, reagents, and software, which delivers long range information, including haplotype phasing, structural variation, and de novo read sequencers the GemCode Platform generates a powerful new data type: linked reads. The GemCode Platform partitions arbitrarily long DNA molecules (including >100 kb) and prepares sequencing libraries in parallel, so that all fragments produced within a partition share a common barcode. A diverse barcode library to generate >100,000 barcode containing partitions, while only requiring ~1 ng of DNA input. The GemCode Platform will allow researchers to routinely access genomic information they canít see today. 10X GENOMICS For info: Electronically submit your new product description or product literature information! Go to for more information. Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availability of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier. SCIENCE sciencemag.org/products 14 AUGUST 2015 VOL 349 ISSUE
4 Next Generation Medicine 59th Annual Conference on Chemical Research Joseph L. Goldstein, University of Texas Southwestern Medical Center Te 2015 Welch Conference on Chemical Research, Next Generation Medicine, is organized to provide a broad perspective on recent genetic, biochemical, and pharmacological advances that will have a major impact on the future understanding and therapy of human diseases. David Botstein, Calico Life Sciences Michael Brown, University of Texas Southwestern Medical Center Zhijian (James) Chen, University of Texas Southwestern Medical Center Titia De Lange, Rockefeller University Karl Deisseroth, Stanford University Hal Dietz, Johns Hopkins University School of Medicine Jennifer Doudna, University of California, Berkeley Helen Hobbs, University of Texas Southwestern Medical Center An all-star cast of 17 Speakers will present their latest discoveries covering diverse areas of contemporary biomedical science that deal with genome sequencing, mapping the brain, new signaling pathways, molecular pathogenesis of common diseases, and modern approaches to drug therapy. Tasuku Honjo, Kyoto University Rudolf Jaenisch, Whitehead Institute for Biomedical Research and MIT William Kaelin, Dana-Farber Cancer Institute, Harvard Medical School Eric Lander, Broad Institute and MIT Richard Lifton, Yale University School of Medicine Steven McKnight, University of Texas Southwestern Medical Center In addition to the 17 Speakers, 4 prominent scientists will act as Session Leaders who will comment critically on the 17 talks Conference on Chemical Research: Next Generation Medicine Vamsi K. Mootha, Massachusetts General Hosptial, Harvard Medical School Eric Olson, University of Texas Southwestern Medical Center Stanley Prusiner, University of California, San Francisco Gerald Rubin, Janelia Farm Research Campus, HHMI October in Houston Charles Sawyers, Memorial Sloan Kettering Cancer Center Conference complimentary with registration. Program and registration: Kevan M. Shokat, University of California, San Francisco Huda Zoghbi, Baylor College of Medicine
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