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2 LifeCord Gainesville, FL John Wingard. M.D. LifeCord Medical Director Price Eminent Scholar and Professor of Medicine Deputy Director for Research, University of Florida Health Cancer Center Director, Bone Marrow Transplant Program Division of Hematology/Oncology University of Florida College of Medicine Office: Mowry Road, Suite 145 Gainesville, FL Yesi Sevilla Director of LifeCord Office: Cell: Megan Arthur Cord Blood Manager, Outreach and Collections Office: Cell:

3 Your hospital is key. You are essential. LifeCord s goal Because of our geographic location, HRSA and the NMDP are encouraging LifeCord to actively recruit African-American and black donors. Our goal is to increase the likelihood of African-American and black patients finding a match by increasing the number of umbilical cord blood units on the registry. Your hospital can help We want to partner with hospitals in the Southeast that have high minority birth rates. Your participation is the only way we can reach our goal. LifeCord Bank Hospital Transplant Staff Transplant Patient Mom and Baby Be The Match Registry Hospital partners Collection Staff LifeCord currently collects umbilical cord blood at ten hospitals in Florida, Georgia and Alabama. Baptist Medical Center East Montgomery, Alabama Baptist Medical Center South Montgomery, Alabama Brookwood Medical Center Brimingham, Alabama East Alabama Medical Center Opelika, Alabama Jackson Hospital Montgomery, Alabama North Florida Regional Medical Center Gainesville, Florida UF Health Shands Hospital Gainesville, Florida Jackson Memorial Hospital Miami, Florida Northeast Georgia Medical Center Gainesville, Georgia Piedmont Henry Hospital Stockbridge, Georgia [insert your hospital name here] We can t do it without you.

4 About LifeSouth Who we are Founded in 1974, LifeSouth is a 501(c)(3) non-profit community blood supplier for hospitals in Alabama, Florida and Georgia. LifeSouth employs nearly 800 people throughout our footprint. With more than 1,000 blood drives a month, 30 donor centers and 42 bloodmobiles, LifeSouth supplies over 350,000 blood components to more than 100 community hospitals annually. Our mission To provide a safe blood supply that meets or exceeds the needs in each community we serve, and to provide a variety of services in support of ongoing and emerging blood and transfusion-related activities. LifeSouth received FDA licensure for cord blood manufacturing in June 2013, becoming the fifth cord blood bank nationwide that is licensed by the FDA. LifeCord LifeCord is a program of LifeSouth Community Blood Centers. Established in 1998, it was the first public cord blood bank in the Southeast. LifeCord collects umbilical cord blood from newborns at hospitals in Florida, Georgia and Alabama. So far, the stem cells from LifeCord collections have been used for transplants in 29 states and 14 countries (see map). The LifeCord staff has demonstrated a passion for this, and they are tirelessly working to provide a needed service. Receiving the FDA license indicates that we are meeting the highest and most stringent standards for providing high quality products to the patients we serve. This is an example of how the cooperative effort of how our partner hospitals and LifeSouth can work together to promote health. - LifeCord Medical Director Dr. John Wingard

5 About Cord Blood Donation What is cord blood and how is it used? Cord blood is the blood remaining in the umbilical cord and placenta after a baby is born. It is rich with blood-forming cells. Life-threatening diseases, such as leukemia or sickle cell disease can be treated with a cord blood transplant. Cord blood replaces diseased blood-forming cells with healthy cells. There is no cost for donating cord blood to LifeCord. National Marrow Donor Program LifeCord partners with the National Marrow Donor Program (NMDP) to provide umbilical cord blood units for patients in need of a life-saving transplant. The NMDP operates the Be The Match Registry, the largest registry of potential bone marrow donors and umbilical cord blood units in the world. With nearly 185,000 cord blood units available, physicians around the world can search the registry if they have a patient that needs a transplant. LifeCord s partnership with the NMDP began in As of, LifeCord has listed more than 6,000 cord blood units on the Be The Match Registry. Ethnic Diversity Not all patients are able to find a match on the NMDP registry. Patients from racially or ethnically diverse backgrounds often have uncommon tissue types. A patient s likelihood of finding a match on the Be The Match Registry is estimated to range from 66% to 93%, depending on race or ethnicity. African American or black patients have an estimated 66% likelihood of finding a match on the registry. What this means is that African-Americans are least likely to find a match. By increasing the number of minority cord blood units on the registry, minority patients will be more likely to find a match.

6 Public vs. Private Cord Blood Banks Common Misconceptions about Private Banking One of the most common misconceptions about private cord blood banking is that a child s own cord blood can be transplanted if he develops a disease later in life. In many cases, diseases such as leukemia, are genetic, so the cord blood that is banked at birth already carries the same disease. Most people who need transplants use cord blood donated by a sibling or a public cord blood bank. Cord blood recipients have about a 25 percent chance of matching a sibling and a 75 percent chance of finding a match from a public bank. Only a small percentage of babies (estimated at between 1 in 1,000 to 1 in 200,000) ever use their own, privately banked cord blood. The American Academy of Pediatrics 2007 Policy Statement on Cord Blood Banking states that: Physicians should be aware of the unsubstantiated claims of private cord blood banks made to future parents that promise to insure infants or family members against serious illnesses in the future by use of the stem cells contained in cord blood. Size Plays a Role in Cord Blood After birth, the umbilical cord contains about 3 to 5 oz. of cord blood. While this amount is often sufficient for a cord blood transplant in a small child, it is generally not enough for a transplant in a child or adult who weighs more than 90 lbs. Researchers are investigating ways to multiply cord blood cells to make them useful for larger transplants or perform a multi-unit transplants. While public blood banks discard cord blood units that are too small for transplants or use them for research, many private cord blood banks store them anyway, at the family s expense, even though they may not be usable later. The Cost of Private Cord Blood Banks Private cord blood banks charge mothers up front, including registration fees, harvesting and processing fees, and storage fees. If the cord blood unit is requested for transplant, the parents will incur the cost of transportation, testing, HLA typing, infectious disease testing, CD34 testing, and any other necessary testing. Additionally, the costs associated with the transplant itself (hospital fees, doc fees, etc.) will be billed to the patient s insurance. Public or Private Cord Blood Bank: Making the Right Choice Parents who are interested in banking their baby s cord blood have the opportunity to store it in a private bank for their family s own use, or donate it to a public bank. Although public donation is free and makes the cord blood available to anyone in the world who needs it, it is not available in all areas. Private cord blood banking generally costs up to $2,000 in initial collection and storage fees, and about $150 a year in storage fees after that. Public cord blood banks charge an FDA-approved cost recovery fee upon shipment for transplant. Parents who are considering banking their baby s cord blood should consider how likely they are to need the cord blood, as well as the potential benefits of donating it to a public bank. On a case-by-case basis, the NMDP Be The Match Registry (which LifeCord uses) allows the individual public cord blood banks to work with the physicians if a cord blood unit is still available on the registry for use by a sibling. Each case is unique and policies and procedures for handling them are at the discretion of the medical director of the cord blood bank.

7 Diseases Treatable by Stem Cell Transplantation The following diseases may be treated by transplant using hematopoietic stem cells obtained from umbilical cord blood, peripheral blood or bone marrow under appropriately approved research protocols. Acute Lymphoblastic Leukemia (ALL) Acute Myelogenous Leukemia (AML) Chronic Myelogenous Leukemia (CML) Histiocytic Disorders Familial Erythrophagocytic Histiocyosis Histiocytosis-X Hemophagocytosis Other Histiocytic Disorders Hodgkin s Lymphoma Inherited Erythrocyte Abnormality Beta Thalassemia Major Fanconi Anemia Pure Red Cell Aplasia Sickle Cell Disease Inherited Immune System Disorders Ataxia-Telangiectasia Combined Immunodeficiency Kostmann Syndrome Leukocyte Adhesion Deficiency Chediak-Higashi Syndrome Ommenn s Syndrome Severe Combined Immunodeficiency (SCID) SCID with Adenosine Deaminase deficiency Absence of T & B Cells SCID Absence of T Cells, Normal B Cell SCID Other SCID Wiskott-Aldrich Syndrome X-Linked Lymphoproliferative Disorder Other Immune System Disorders Inherited Metabolism Disorders Adrenoleukodystrophy Sly Syndrome, Beta-Glucuronidase Deficiency Gaucher s Disease Hunter s Syndrome Hurler s Syndrome Krabbe Disease Maroteaux-Lamy Syndrome Metachromatic Leukodystrophy Neiman-Pick Disease Other Mucopolysaccharidosis Osteopetrosis Sanfilippo Syndrome Wolman Disease Other Inherited Metabolic Disorders Inherited Platelet Abnormalities Amegakaryocytosis/Congenital Thrombocytopenia Myelodysplastic Disorder Syndromes Acute Myelofibrosis Chronic Myelomonocytic Leukemia (CMML) Essential Thrombocythemia Idiopathic Sideroblastic Anemia Myelodysplastic Disorder Myelofibrosis /Myeloid Metaplasia Paroxysmal Nocturnal Hemoglobinuria Polycythemia Vera Refractory Anemia Refractory Anemia with Excess Blast Refractory Anemia with Excess Blast with Transformation Unknown Myelodysplastic Disorder Other Myelodysplastic Disorder Non-Hodgkin s Lymphoma Other Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Chronic Lymphocytic Leukemia Juvenile Chronic Myelogenous Leukemia Prolymphocytic Leukemia Other Leukemia Other Malignancy Breast Cancer Renal Cell Carcinoma Other Non- Malignant Diseases Plasma Cell Disorders Multiple Myeloma Plasma Cell Leukemia Unknown Plasma Cell Disorders Waldenstrom s Macroglobulinemia Other Plasma Cell Disorder Severe Aplastic Anemia

8 Devon Vickers received a cord blood transplant while undergoing treatment for leukemia. Today she s healthy thanks to a cord blood donor. When Braelyn Scott was born Jan. 30, 2013, she became her family s youngest blood donor. Just minutes after she was born, her doctor was able to collect the blood from her umbilical cord. I would love to have the opportunity to thank the mother and child who donated cord blood. To hear Devon s amazing story, visit youtube.com/lifesouthcbc It was very simple. I didn t have to do a thing, it was painless for me and the baby, and it was free, said Tiffany Scott, Braelyn s mom. Ask your doctor. Find out if it s an option at your hospital. Your tiny baby could be someone s lifesaver. Josh Ibarrientos received a cord blood transplant after battling leukemia for six years and is now cancer-free. Every time I know someone who is pregnant, I tell them your OB/GYN will give you some information on cord blood. Joshua is a living example that it really helps, don t let them waste it if you can donate it, said Gea Ibarrientos (Josh s mother). My friends, my relatives know how Josh was saved.

9 Archie 32 years old For 9 1/2 years, he waited for a lifesaving transplant and lost his battle with cancer on December 10, Devon Devon 24 years old She received a lifesaving transplant at the age of 15 and is fulfilling her dream of attending law school. The difference between them? One cord blood donation. (888)

10 LifeCord has provided cord blood units for transplants in 29 states and 14 countries. Together we can save lives all over the world. Washington Oregon California Colorado Canada Minnesota Utah Illinois Texas Missouri Kentucky Oklahoma Wisconsin Michigan Maryland Massachusetts New York New Jersey Indiana Pennsylvania Ohio Virginia S. Carolina N. Carolina Tennessee Georgia Kansas Alabama Louisiana Florida England Belgium France Scotland Denmark Germany Switzerland Austria Netherlands Israel Brazil Australia

11 1. Mom fills out preregistration information, including health history questionnaires, at LifeSouth donor center 8. Cord Blood unit is weighed and TNC evaluated. If cord meets all criteria, cord is processed and stored for future use by a patient in need. 2. Mom arrives at the hospital to deliver her baby. LifeCord stocks the hospital with all supplies needed for cord blood collection. 7. LifeCord staff picks up the kit from the hospital. 3. Collection staff obtains consent from mom to collect her cord blood 4. Mom is admitted and has blood samples drawn. Collection staff labels tubes with mom s hospital labels. 5. Cord blood is collected by a trained healthcare professional. 6. Collection staff labels the collection bag with mom s hospital label and a base label with unique DIN, packages it into a kit with the matching DIN for traceability and includes tubes and consent form. The kit is taken to the designated pickup area.

12 Newberry Road Gainesville, FL 32607

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