Name, Last name Reyhan NERGIZ-UNAL Nationality / Gender Date/ Place of Birth Address Phone Number (work) (mobile) Address ; Career Summary

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1 1 Name, Last name : Reyhan NERGIZ-UNAL Nationality / Gender : Turkey & Belgium / Female Date/ Place of Birth : /Ankara Address : Hacettepe University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Sıhhiye, Ankara, Turkey Phone Number (work) : ext: 122 (mobile) : Address : rnergiz@hacettepe.edu.tr ; rnergizunal@gmail.com Career Summary She obtained her bachelor s degree in Nutrition and Dietetics in 2003 at the School of Health Sciences, Hacettepe University, Ankara (Turkey). There, she obtained a student success award as well as a İhsan Doğramacı superior success award realized by Hacettepe University. While studying as a MSc student, she worked as nutritionist in the Acıbadem Hospital in Istanbul, and later worked as a research assistant at Department of Nutrition and Dietetics, Hacettepe University. In 2006 she received her master s degree and continued to work as research assistant in the same department. In August 2007 she received a fellowship as talented PhD student from the Council of Higher Education of Turkey (YÖK). With this fellowship, she worked as PhD student in the Department of Biochemistry at the Cardiovascular Research Institute Maastricht (CARIM) of Maastricht University. The research performed was supervised by Prof. Dr. J.W.M. Heemskerk. She obtained the status of Article 9 expert according to the Netherlands Law on Animal Experiments. Recenty, she visited congresses in Birmingham (United Kingdom), Wittenberg (Germany), Boston (USA) and Nürnberg (Germany), Kyoto (Japan), Vancouver (Canada), Maastricht (Netherlands), St Petersburg (Russia) and obtained several prices. As a Post-doc and lecturer she has scientific projects and undergraduate/postgraduate students. The field of interest is nutritional sciences, nutritional biochemistry and metabolism. From August 2012, she is employed as Assistant Professor by Hacettepe University, Turkey.

2 2 Work Experiences Nutritionist and Dietitican Acıbadem Hospital İstanbul, Turkey Research Assistant - Hecettepe University Ankara,Turkey PhD fellow/student - Maastricht University Maastricht,The Netherlands Postdoc fellow - Hacettepe University Ankara,Turkey Assistant Proffessor - Hacettepe University Ankara,Turkey until now Education BSc Degree, Faculty of Health Sciences, Department of Nutrition and Dietetics, Hacettepe University, Ankara, Turkey, GPA: 3,42 (over 4) MSc Degree, Institute of Health Sciences, Division of Nutritional Sciences, Hacettepe University, Ankara, GPA: 3,64 (over 4) PhD Degree, Faculty of Health Medicine and Life Sciences, Department of Biochemistry CARIM, University of Maastricht, The Netherlands, Language profiency Turkish: native language English: excellent, TOEFL Certifaced Dutch : elementary/intermediate Fultext Articles (SCI indexed international papers) 1. Reyhan Nergiz-Unal, Pelin Bilgiç, Nurcan Yabancı. High tendency to the substantial concern on body shape and eating disorders risk of the students majoring Nutrition or Sport Sciences. Nutrition Research and Practice Dec;8(6): doi: /nrp Epub 2014 Nov 5.

3 3 2. Yeliz Angin, Robert W. Schwenk, Reyhan Nergiz-Unal, Nicole Hoebers, Johan W. M. Heemskerk, Kuijpers MJ, Coumans W.A., Marc A. M. J. van Zandvoort, Arend Bonen, Dietbert Neumann, Jan F.C. Glatz and Joost J.F.P. Luiken. Calcium signaling recruits substrate transporters GLUT4 and CD36 to the sarcolemma without increasing cardiac substrate uptake. The American Journal of Physiology - Endocrinology and Metabolism Jul 15;307(2):E doi: /ajpendo Epub 2014 Jun Marijke J.E. Kuijpers, Susanne de Witt, Reyhan Nergiz-Unal, Roger van Kruchten, Suzanne J.A. Korporaal, Peter Verhamme, Maria Febbraio, Marc Tjwa, Peter J. Voshol, Marc F. Hoylaerts, Judith M.E.M. Cosemans and Johan W.M. Heemskerk. Supporting Roles of Platelet Thrombospondin-1 and CD36 in Thrombus Formation on Collagen. Arteriosclerosis, Thrombosis, and Vascular Biology Jun;34(6): doi: /ATVBAHA Epub 2014 Mar Atilla Güleç, Reyhan Nergiz-Unal, Aslı Akyol, Jale Acar. Phenolic content and ascorbic acid are major contributors to antioxidant capacity of fruits and vegetables commonly consumed in Turkey. Journal of Food Agriculture and Environment 10/2013; 11(3&4): Reyhan Nergiz-Unal, Marijke J.E. Kuijpers, Susanne de Witt, Sylvia Heeneman, Marion A.H. Feijge, Sonia C. Garcia Caraballo, Erik A.L Biessen, Guido R.M.M. Haenen, Judith M.E.M. Cosemans, Johan W.M Heemskerk. Atheroprotective effect of dietary walnut intake in ApoEdeficient mice: involvement of lipids and coagulation factors. Thrombosis Research, 2013 May 131 (5): Paola E. van der Meijden, Marion A Feijge, Frauke Swieringa, Karen Gilio, Reyhan Nergiz- Unal, Karly Hamulyák, Johan W. Heemskerk. Key role of integrin α(iib)β (3) signaling to Syk kinase in tissue factor-induced thrombin generation. Cellular and Molecular Life Sciences (CML) Oct;69(20): doi: /s Epub 2012 Jun Reyhan Nergiz-Unal, Moniek M.E. Lamers, Roger van Kruchten, Joost J. F.P. Luiken, Judith M.E.M. Cosemans, Jan F.C. Glatz, Marijke J.E. Kuijpers, Johan W.M. Heemskerk. Signaling role of CD36 in platelet activation and thrombus formation on immobilized thrombospondin or oxidized low-density lipoprotein. Journal of Thrombosis and Haemostasis Sep;9(9): doi: /j x. 8. Reyhan Nergiz-Unal, Timo Rademakers, Judith M.E.M. Cosemans, Johan W.M. Heemskerk. CD36 as a multiple-ligand signaling receptor in atherothrombosis. Cardiovascular & Hematological Agents in Medicinal Chemistry Jan;9(1): Review. 9. Reyhan Nergiz-Unal, Judith M.E.M. Cosemans, Marion A.H. Feijge, Paola E.J. van der Meijden, Robert F. Storey, J.J.J. (Hans) van Giezen, Mirjam G.A. oude Egbrink, Johan W.M.

4 4 Heemskerk, Marijke J.E. Kuijpers. Stabilizing role of platelet P2Y 12 receptors in sheardependent thrombus formation following plaque rupture. Plos One Apr 12;5(4):e doi: /journal.pone Marijke J.E. Kuijpers, Karen Gilio, Sietse Reitsma, Reyhan Nergiz-Unal, Lenneke Prinzen, Sylvia Heeneman, Esther Lutgens, Marc A.M.J. van Zandvoort, Bernhard Nieswandt, Mirjam G.A. oude Egbrink, Johan W.M Heemskerk. Complementary roles of platelets and coagulation in thrombus formation on plaques acutely ruptured by targeted ultrasound treatment: a novel intravital model. Journal of Thrombosis and Haemostasis Jan;7(1): doi: /j x. Epub 2008 Oct Reyhan Nergiz-Unal, Emine Akal Yıldız, Gülhan Samur, H. Tanju Besler, Neslişah Rakıcıoğlu. Trends of fluid consumption and beverage choices among adults point ayran and black tea in the middle side of Turkey. Under revision, Nutritition and Dietetetics Fultext Articles (national): 1. Armağan Aytuğ Yuruk, Reyhan Nergiz-Unal. The Effect of Maternal Fructose Intake in Terms of Triglyceride and Free Fatty Acid Levels in Mother Rats and Pups. Turkish Journal of Nutrition and Dietetics, accepted, Epub Ahead of Print. April, Reyhan Nergiz Ünal. Food Safety - II. Nitrate-Nitrite: Risk-Benefit and Metabolic Effects. KATKI Journal of Pediatrics, 2014; 36 (2): Reyhan Nergiz Ünal, F. Gülhan Samur. Effect of Pica behaviour on health. Turkish Journal of Nutrition and Dietetics, 2012; 40 (2): Neslişah Rakıcıoğlu, Reyhan Nergiz, Şerife Özkan. Evaluation of nutritional status and dietary hadits of patients under hemodialysis. Turkish Journal of Nutrition and Dietetics, 2005; 32(1): Book and Book Chapters (international/national) 1. Reyhan Nergiz Ünal, H. Tanju Besler. Importance of milk in human nutrition. Turkish Ministry of Health. (ISBN: ) Ankara, Turkey, 2006.

5 5 2. Reyhan Nergiz Ünal. Platelets in atherothrombosis: Roles of CD36 and P2Y 12 receptors. (ISBN: ), Palme Publications, Maastricht, Thhe Netherlands, Abstracts (SCI indexed international) 1. Susanne M. de Witt, Reyhan Nergiz-Unal, Marion A.H. Feijge, Wiese A., Jupe, S., Prins M.H., Judith M.E.M. Cosemans, Johan W.M. Heemskerk. Genes in arterial thrombus formation: a comparison of in vivo and in vitro studies. Journal of Thrombosis and Haemostasis. Volume 11 Supplement 2, pages: , Special Issue: SI, July Yeliz Angin, Robert Schwenk, Reyhan Nergiz-Unal, Nicole Hoebers, Johan Heemskerk, Benoit-Gilles Kerfant, Willl Coumans, Marc Zandvoort, Dietbert Neumann, Jan Glatz, Joost Luiken. Calcium signaling recruits substrate transporters GLUT4 and CD36 to the sarcolemma without increasing substrate uptake. FEBS Journal Supplement. Volume 280, Issue Supplement s1, pages 1-661, July Susanne M. de Witt, Moniek M.E. Lamers, Reyhan Nergiz, Frauke Swieringa, Erik Westein E, Judith M.E.M. Cosemans, Johan W.M. Heemskerk. Platelet receptors in thrombus formation on spotted microarray surfaces. Journal of Thrombosis and Haemostasis. Volume 9, Issue Supplement s2, pages , July Reyhan Nergiz-Unal, Moniek M.E. Lamers, Roger van Kruchten, Judith M.E.M. Cosemans, Joost J. F.P. Luiken, Jan F.C. Glatz, Marijke J.E. Kuijpers, Johan W.M. Heemskerk. Signaling role of CD36 in platelet adhesion and spreading. Journal of Thrombosis and Haemostasis. Volume 9, Issue Suppl 2, pages 1 250, July Reyhan Nergiz-Unal, Moniek M.E. Lamers, Jan F.C. Glatz, Marijke J.E. Kuijpers, Johan W.M. Heemskerk. Role of CD36 in platelet activation and thrombus formation on immobilized thrombospondin and oxidized LDL. Hämostaseologie. 2010; 1/ Reyhan Nergiz-Unal, Judith M.E.M. Cosemans, Paola E.J. van der Meijden, Marion A.H. Feijge, Mirjam G.A. oude Egbrink, Johan W.M. Heemskerk, Marijke J.E. Kuijpers. Thrombus stabilization by P2Y 12 contributes to atherothrombosis and is restricted to high shear flow conditions. Journal of Thrombosis and Haemostasis. 2009; Volume 7, Issue Suppl 2: Abstract Number AS-TU Reyhan Nergiz-Unal, Marijke J.E. Kuijpers, Imke C.A. Munnix, Jan F.C. Glatz, Johan W.M Heemskerk. Outside-in signaling induced by thrombospondin-1 enhances thrombus formation:

6 6 involvement of CD36. Journal of Thrombosis and Haemostasis. 2009; Volume 7, Issue Suppl 2: Abstarct Number PP-TH-012. Proceedings at International Congress 1. Armağan Yürük, Reyhan Nergiz-Unal. High fructose intake with maternal diet associated with obesity-preliminary look to fetal programming. 15 th International Nutrition & Diagnostics Conference. Prague, Czech Republic. September (Oral presentation) 2. Armağan Yürük, Reyhan Nergiz Ünal. High fructose intake with maternal diet resulted in elevated plasma and liver triglycerides in mother rats and pups. IX. International Nutrition and Dietetics Congress. Ankara, Turkey, April 2014 (Oral presentation) 3. Nurcan Yabancı, Alev Keser, Esma Asil, Reyhan Nergiz Ünal, Pelin Bilgiç. Eating Disorders Risk of Students at the Department of Nursing: A Pilot Study. IX. International Nutrition and Dietetics Congress. Ankara, Turkey, April 2014 (Poster presentation) 4. Aylin Ayaz, Hazal Küçükkaraca, Enes Bahadır Kılıç, Gökçen Kınay, Aysun Göktürk, Arife acit, Ezgi Bellikçi Koyu, Aslı Akyol, Reyhan Nergiz, Zehra Büyüktuncer Demirel, H. Tanju Besler. Evaluation of Meal Habbits in Adolescents. IX. International Nutrition and Dietetics Congress. Ankara, Turkey, April 2014 (Poster presentation) 5. Aslı Akyol, Reyhan Nergiz-Ünal, Firdevs İnce, Emine İyiol,, Hacer Kabukbelen, Selin Karaer, Merve Betül Karakuş, Özge Mengi, Merve Nur Mertaslan, Elmas Önde, Yıldız Çisem Özarslan, Aysu Çalılşır Özden. Does body perception affect snack consumption in adolescencents? IX. International Nutrition and Dietetics Congress. Ankara, Turkey, April 2014 (Poster presentation) 6. Reyhan Nergiz-Unal, Eray Albayrak, Melis Agma, Tuğba Alkan, Seray Akalın, Kübra Işgın Burcu Aksoy, Aslı Akyol, Aylin Ayaz, Zehra Büyüktuncer Demirel ve H. Tanju Besler. Relationship between abdominal fatness, energy and macro nutrient intake in adolescents: A pilot study. IX. International Nutrition and Dietetics Congress. Ankara, Turkey, April 2014 (Poster presentation) 7. Yeliz Angin, Robert Schwenk, Reyhan Nergiz-Unal, Nicole Hoebers, Johan Heemskerk, Benoit-Gilles Kerfant, Willl Coumans, Marc Zandvoort, Dietbert Neumann, Jan Glatz, Joost Luiken. Calcium signaling recruits substrate transporters GLUT4 and CD36 to the sarcolemma without increasing substrate uptake. 38th Federation of European Biochemical Societies (FEBS) Congress. St. Petersburg, Russia, July, 2013 (Poster presentation)

7 7 8. Susanne de Witt, Reyhan Nergiz-Unal, Marion Feijge, Anna Wiese, Steve Jupe, Martin Prins, Judith M.E.M. Cosemans, Johan W.M. Heemskerk. Genes in arterial thrombus formation: A comparison of in vivo and in vitro studies. International Society on Thrombosis and Haemostasis (ISTH), XXIV th ISTH Congress, Amsterdam, The Netherlands, July, 2013 (Poster presentation) 9. Marijke J.E. Kuijpers, Reyhan Nergiz-Unal, Susanne de Witt, Roger van Kruchten, Suzanne J.A. Korporaal, Maria Febbraio, Marc F. Hoylaerts, Marc Tjwa, Peter J. Voshol, Judith M.E.M. Cosemans, Johan W.M. Heemskerk. Subtle role of platelet thrombospondin- 1 interaction with CD36 in murine thrombus formation on collagen. 1st EUPLAN Platelet Conference Maastricht, The Netherlands, September, 2012 (Poster presentation) 10. Yeliz Angin, Reyhan Nergiz-Unal, N.T.H Hoebers. J.W.M Heemskerk. Jan F.C Glatz., Joost F.P. Luiken. Interactions between membrane fatty acid transporter CD36 and Ca 2+ signaling in cardiomyocytes.10 th Congress of the International Society for the Study of Fatty Acids and Lipids (ISSFAL). Vancouver, Canada, May 2012 (Poster presentation) 11. Reyhan Nergiz-Unal, Berat Nursal-Tosun, Atila Güleç, H.Tanju Besler. Effect of Different durations of traditional heat treatment on amino acid and nitrogen content of raw milk. VIII th International Nutrition and Dietetics Congress. Antalya, Turkey, April, 2012 (Poster presentation) 12. Reyhan Nergiz-Unal, Nur Gülsüm Coşkun, Yağmur Küçükaşçı, Ayşe Özbilir, Özge Yılmaz, Nesrin Çelik, Dilek Kaçaranoğu, Şeyda Uzun, Beyza Yılmaz, Hande Yılmaz, Aslı Akyol. Inappropriate complementary feeding practices are contributing to the high sodium intakes of infants at 6-12 months. VIII th International Nutrition and Dietetics Congress. Antalya, Turkey, April, 2012 (Oral presentation) 13. Reyhan Nergiz-Unal, Pelin Bilgiç, Nurcan Yabancı, Hülya Akko, Şeyma Nur Ece, Meryem Saban, İbrahim Salman, Gönül Tolan, Gamze Turhal. Assessment of Tendency to Eating Disorders and Substantial Body Shape Perception in Students at the Departments of Sport Sciences and Nutrition and Dietetics. VIII th International Nutrition and Dietetics Congress. Antalya, Turkey, April, 2012 (Oral presentation) 14. Aslı Akyol, Nesrin Çelik, Nur Gülsüm Coşkun, Dilek Kaçaranoğu, Yağmur Küçükaşçı, Ayşe Özbilir, Şeyda Uzun, Beyza Yılmaz, Hande Yılmaz, Özge Yılmaz, Reyhan Nergiz- Unal. Contribution of complementary feeding to the sugar intake of 6-12 month old infants. VIII th International Nutrition and Dietetics Congress. Antalya, Turkey, April, 2012 (Oral presentation)

8 8 15. Pelin Bilgiç, Reyhan Nergiz-Unal, Nurcan Yabancı, Hülya Akko, Şeyma Nur Ece, Meryem Saban, İbrahim Salman, Gönül Tolan, Gamze Turhal. Sociocultural approach to physical appearence in students at nutrition and dietetics and sports science departments. VIII th International Nutrition and Dietetics Congress. Antalya, Turkey, April, 2012 (Poster presentation) 16. Reyhan Nergiz-Unal, Marijke J.E. Kuijpers, Sylvia Heeneman, Marion A.H. Feijge, Sonia C. Garcia Caraballo, Erik A.L Biessen, Guido R.M.M. Haenen, Judith M.E.M. Cosemans, Johan W.M Heemskerk. Effect of dietary whole walnut or walnut oil on atherothrombosis in ApoE-deficient mice. 1st American Society of Nutrition Middle East Congress (Nutrition in Health & Disease) Istanbul, Turkey, February, 2012 (Poster presentation) 17. Reyhan Nergiz-Unal, Marijke J.E. Kuijpers, Sylvia Heeneman, Marion A.H. Feijge, Sonia C. Garcia Caraballo, Erik A.L Biessen, Guido R.M.M. Haenen, Judith M.E.M. Cosemans, Johan W.M Heemskerk. Effect of dietary grape seed extract on plaque development and coagulant state ensuing atherosclerosis in ApoE-deficient mice. 1st American Society of Nutrition Middle East Congress (Nutrition in Health & Disease), Istanbul, Turkey, February, 2012 (Oral presentation) 18. Susanne M. de Witt, Moniek M.E. Lamers, Reyhan Nergiz, Frauke Swieringa, Erik Westein,Judith M.E.M. Cosemans, Johan W.M. Heemskerk. Platelet receptors in thrombus formation on spotted microarray surfaces. International Society on Thrombosis and Haemostasis (ISTH), XXIII rd ISTH Congress, Kyoto, Japan, 2011 (Poster presentation) 19. Reyhan Nergiz-Unal, Moniek M.E. Lamers, Roger van Kruchten, Judith M.E.M. Cosemans, Joost J. F.P. Luiken, Jan F.C. Glatz, Marijke J.E. Kuijpers, Johan W.M. Heemskerk. Signaling role of CD36 in platelet adhesion and spreading Signaling role of CD36 in platelet adhesion and spreading. International Society on Thrombosis and Haemostasis (ISTH), XXIII rd ISTH Congress, Kyoto, Japan, 2011 (Poster presentation) 20. Reyhan Nergiz-Unal, Moniek M.E. Lamers, Jan F.C. Glatz, Marijke J.E. Kuijpers, Johan W.M. Heemskerk. Role of CD36 in platelet activation and thrombus formation on immobilized thrombospondin and oxidized LDL. First Gesellschaft für Thrombose- und Hämostaseforschung (GTH) and Nederlandse Vereniging voor Trombose en Hemostase (NVTH) Congress, Nürnberg, Germany, 2010 (Poster presentation) 21. Reyhan Nergiz-Unal, Judith M.E.M. Cosemans, Paola E.J. van der Meijden, Marion A.H. Feijge, Mirjam G.A. oude Egbrink, Johan W.M. Heemskerk, Marijke J.E. Kuijpers. Thrombus stabilization by P2Y 12 contributes to atherothrombosis and is restricted to high

9 9 shear flow conditions. International Society on Thrombosis and Haemostasis (ISTH), XXII nd ISTH Congress, Boston, USA, 2009 (Poster presentation) 22. Reyhan Nergiz-Unal, Marijke J.E. Kuijpers, Imke C.A. Munnix, Jan F.C. Glatz, Johan W.M Heemskerk. Outside-in signaling induced by thrombospondin-1 enhances thrombus formation: involvement of CD36. International Society on Thrombosis and Haemostasis (ISTH), XXII nd ISTH Congress, Boston, USA, 2009 (Oral presentation) Invited Speaker 1. Nergiz-Unal R. Dietary Supplements in Weight Control. V. Hacettepe Post Graduate Training Course. Ankara, Turkey, June Nergiz-Unal R. Macronutrients in Fetal Programming.V. Hacettepe Post Graduate Training Course. Ankara, Turkey, June Nergiz-Unal R. Mechanisms in Vascular Degeneration.V. Metabolic and Biochemical Changes in Nutrition Related Diseases Course. Ankara, Turkey, June Nergiz-Unal R. Is dairy consumption harmful for health? IX. International Nutrition and Dietetics Congress. Ankara, Turkey, April Nergiz-Unal R. Mechanisms of inflamation and Immun System. IV. Hacettepe Post Graduate Training Course. Ankara, Turkey, June Nergiz-Unal R. Lipid and fatty acid biology. International Nutrition and Dietetics Congress. Ankara, Turkey, April Nergiz-Unal R. Effect of heat treatment on the nutritional value of milk. VIII. International Nutrition and Dietetics Congress. Ankara, Turkey, April Projects 1. Project owner/manager: Reyhan Nergiz-Unal Project name: The effects of dietary carbohydrate and fat on the liver inflammation and lipogenesis of mice Start - finish date: (ongoing) Supporting organization: The Scientific and Technological Research Council of Turkey (TUBİTAK) Support of Scientific and Technological Research Projects Program 1001 (Project Number: 114S726)

10 10 2. Project owner/manager: Reyhan Nergiz-Unal Project name: Effect of maternal high fructose corn syrup or sucrose intake on insulin and lipogenesis. Start - finish date: (ongoing) Supporting organization: Support of Hacettepe University Scientific Research Projects Coordination Unit (Project Number: THD ) 3. Project owner/manager: Reyhan Nergiz-Unal Project name: Determination the effect of maternal fructose intake in terms of lipogenesis and some lipid parameters in rats. Start - finish date: (finished) Supporting organization: Support of Hacettepe University Scientific Research Projects Coordination Unit (Project Number: 013D ) Lectures ( : graduate and postgraduate level) Introduction to Foods Introduction to Dietetics Nutritional Biochemistry Nutrition and Immun System Nutrient and Drug Interactions Awards 1. The best oral presentation award. IX. International Nutrition and Dietetics Congress. Ankara, Turkey, April 2014 (project owner) 2. Asian-Pacific Scholarship, Japanese Society on Thrombosis and Hemostasis (JSTH) at XXIIIrd Congress of ISTH, Kyoto, Japan, 2011.

11 11 3. Poster award, First combined meeting of Gesellschaft für Thrombose- und Hämostaseforschung (GTH) & Nederlandse Vereniging voor Trombose en Hemostase (NVTH), Nürnberg, Germany, 2010 (research assistant) 4. Young investigator award, International Society on Thrombosis and Haemostasis (ISTH) at XXIIth Congress of ISTH, Boston, USA, Fellowship for talented PhD student, Council of Higher Education (YÖK), Hacettepe University, Ankara, Turkey, İhsan Doğramacı superior success award, Hacettepe University, Ankara, Turkey, Student success award, Hacettepe University, Ankara, Turkey, 2003.