Curriculum Vitae. Education: Italian Degree of Doctor in Biology, 1972, University of L Aquila (Italy)

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1 Curriculum Vitae Name: Pasquale Battista Date and place of birth: 17 st October 1949, Pescara, ITALY Nationality: ITALIAN Married, 1 daughter Official address, phone and fax numbers: G. d Annunzio University of Chieti-Pescara School of Human Movement Sciences Department of Human Movement Sciences Chieti Campus Via dei Vestini CHIETI ITALY Telephone: Telefax: battista@unich.it Education: Italian Degree of Doctor in Biology, 1972, University of L Aquila (Italy) Career/Employment: Specialization: Pathology Teacher of practical laboratory exercises (School of Medicine, Chieti University Italy Assistant Professor in Pathology (School of Medicine, Chieti University - Italy) Associate Professor of Pathology (School of Medicine, Chieti University - Italy) 2001-present Full Professor of Pathology (School of Human Movement Sciences, Chieti University Italy) Stages John Fogarty Visiting Fellow, Laboratory of Immunobiology, National Cancer Institute, NIH, Bethesda, MD, USA 1986 Guest Worker, Laboratory of Immunobiology, National Cancer Institute, NIH, Bethesda, MD, USA 1

2 Main teaching activity "Istitution of General Pathology" (School of Medicine, University of Chieti-Pescara Italy) "Patholgy and General Physiopathology (School of Medicine, Chieti University Italy) "General Pathology" (School of Pharmacy, University of Chieti-Pescara Italy) 2001-presente " Pathology and General Physiopathology (School of Human Movement Sciences, Chieti University Italy) Supervisor Responsable of the PhD course in Scienze del Sistema Motorio (School of Human Movement Sciences, University of Chieti-Pescara Italy) Specialization: current research interests: (i) genetic alterations of genes predisposing to familial and/or hereditary forms of breast and colorectal cancers. Genetic instability in intronic or exonic mono-ditri-quadrinucleotide repeats of target genes associated with cancer progression. Genetic alterations of the Insulin Receptor Substrates 1 and 2 involved in type 2 diabetes. Scientific Affiliations Italian Society of Pathology Italian Society of Oncology American Association for Cancer Research Italian Association study Familial and Ereditary Gastrointestinal cancers (A.I.F.E.G.) Member of the Scientific and Organizing Committee of: 2 nd National Congress of AIFEG Chieti, 2003 Vice-President of the A.I.F.E.G. Scientific Publications: HUMAN GENE MUTATIONS: Breast/Ovarian Cancer. Aceto G, Di Fulvio P, Stuppia L, Veschi S, Contegiacomo A, Pensabene M, Cama A, Curia MC, Palka G, Mariani-Costantini R, Battista P. Hum Genet, 110: ,

3 THE ITALIAN MULTI-CENTRE PROJECT ON EVALUATION OF MRI AND OTHER IMAGING MODALITIES IN EARLY DETECTION OF BREAST CANCER INSUBJECTS AT HIGH RISK. Podo F, Sardanelli F, Canese R, Battista P et al. J Exp Clin Cancer Res, 21: , 2002 MEDICINA MOLECOLARE E STORIA DELLA MEDICINA:DALLA PALEOPATOLOGIA ALLA GENETICA DELLE POPOLAZIONI. Verginelli F, Ottini L, Esposito DL, Cama A, Battista P, Tiranni R, Zagaglia K, Mariani-Costantini R, Fornaciari G. Medicina nei Secoli: Arte e Scienza, 14: , 2002 A NOVEL T608R MISSENSE MUTATION IN INSULIN RECEPTOR SUBSTRATE-1 IDENTIFIED IN A SUBJECT WITH TYPE 2 DIABETES IMPAIRS METABOLIC INSULIN SIGNALING. Esposito DL, Li Y, Vanni C, Mammarella S, Veschi S, Della Loggia F, Mariani-Costantini R, Battista P, Quon MJ, Cama A. J Clin Endocr & Metab, 88: , 2003 VARIATION OF THE HYPERVARIABLE REGION-1 OF MITOCHONDRIAL DNA IN CENTRAL -EASTERN ITALY. Verginelli F, Donati F, Coia V, Boschi I, Palmirotta R, Battista P, Mariani-Costantini R,Destro- Bisiol G. J Forensic Sci, 48: 1-3, 2003 BRAC-1 AND BRCA-2 MUTATIONS IN BREAST/OVARIAN CANCER PATIENTS FROM CENTRAL ITALY. Stuppia L, Di Fulvio P, Aceto G, Pintor S, Veschi S, Gatta V, Colosimo A, Cianchetti E, Cama A, Mariani-Costantini R, Battista P, Palka G. Hum Mutat, 635: 1-8, 2003 MOLECULAR ANALYSIS OF BRCA1/BRCA2 MUTATIONS IN 68 FAMILIES WITH BREAST OR OVARIAN CANCER FROM CENTRAL ITALY. Stuppia L, Di Fulvio P, Pintor S, Aceto G, Veschi S, Gatta V, Colosimo A, Cianchetti E, Cama A, Battista P, Mariani-Costantini R, Palka G. Recent Advances Research Updates, 4: , 2003 CORRELATION BETWEEN PHENOTYPE AND MICROSATELLITE INSTABILITY IN HNPCC: IMPLICATIONS FOR GENETIC TESTING. Palmirotta R, Matera S, Curia MC, Aceto G, El Zhobi B, Verginelli F, Guadagni F, Casale V, Stigliano V, Messerini L, Mariani-Costantini R, Battista P, Cama A. Familial Cancer, 3: , 2004 IDENTIFICATION ON A NOVEL MUTATION AFFECTING DOMAIN V OF THE 23S rrna IN HELICOBACTER PYLORI. 3

4 Toracchio S, Aceto GM, Mariani-Costantini R, Battista P, Marzio L. Helicobacter, , 2004 GENETIC EVIDENCE THAT JUVENILE NASOPHARYNGEAL ANGIOFIBROMA IS AN INTEGRAL FAP-TUMOR. Valanzano R, Curia MC, Aceto G, Veschi S, De Lellis L, Catalano T, La Rocca G, Battista P, Cama A, Tonelli, Mariani-Costantini R. Gut, , 2005 MUTATIONS IN THE P53 AND KI-RAS GENES, MICROSATELLITE INSTABILITY AND SITE OF TUMOR ORIGIN IN COLORECTAL CANCER. Catalano T, Curia MC, Aceto G, Verginelli F, Cascinu S, Cama A, Mariani-Costantini, Teti D, Battista P. Oncology Reports, 14: , 2005 MUTATIONS OF APC AND MYH IN UNRELATED ITALIAN PATIENTS WITH ADENOMATOUS POLYPISIS COLI. Aceto G, Curia MC, Veschi S, De Lellis L, Mammarella S, Catalano T, Stuppia L, Palka G, Valanzano R, Tonelli F, Casale V, Stigliano V, Cetta F, Battista P, Mariani-Costantini R, Cama A. Hum Mutat, #841:1-8, 2005 (On line) COMBINED USE OF MLPA AND NON-FLUORESCENT MULTIPLEX PCR ANALYSIS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (NFMP-HPLC) FOR THE DETECTION OF GENOMIC REARRANGEMENTS. De Lellis L, Curia MC, Catalano T, De Toffol S, Bassi C, Mareni C, Bertario L, Battista P, Mariani-Costantini R, Radice P, Cama A. Hum Mutat, 27: , 2006 BRCA1 AND BRCA2 STATUS IN A CENTRL SUDANESE SERIES OF BREAST CANCER PATIENTS: INTERACTIONS WITH GENETIC, ETHNIC AND REPRODUCTIVE FACTORS. Awadelkarim KD, Aceto G, Veschi S, Elhag A, Morgano A, Mohamadani AA, Eltayeb EA, Abuidris D, Di Gioacchino M, Battista, P, Verginelli F, Cama A, Elwali NE, Mariani-Costantini R. Breast Cancer Res Treat, 102: , 2007 BALANCE BETWEEN ENDOSCOPIC AND GENETIC INFORMATION IN THE CHOICE OF ILEORECTAL ANASTOMOSIS FOR FAMILIAL ADENOMATOUS POLYPOSIS. Valanzano R, Ficari F, Curia MC, Aceto G, Veschi S, Cama A, Battista P, Tonelli F. Journal of Surgical Oncology 95:28-33, 2007 OBESITY MODIFIES THE EFFECTS OF THE ASP905TYR VARIANT OF PPP1R3A ON RISK OF TYPE 2 DIABETES AND INSULIN SENSITIVITY. Mammarella S, Creati B, Staniscia T, Manzoli L, Di Valerio A, Aceto G, Romano R, Giovanni Cama, Capani F, Consoli A, Vitacolonna E, Esposito-Del Puente A, Battista P, Della Loggia F, Mariani-Costantini R, Quon MJ, Cama A. Diabetes Obes Metab, 5: ,

5 HIGH PREVALENCE OF BRCA1 DELETIONS IN BRCAPro-POSITIVE PATIENTS WITH HIGH CARRIER PROBABILITY. Veschi S, Aceto G, Scioletti AP, Gatta V, Palka G, Cama A, Mariani-Costantini R, Battista P, Calò V, Barbera F, Bazan V, Russo A, Stuppia L. Annals of Oncology, 18(suppl.6): 86-92,