10th Dresden Symposium on Autoantibodies

Transcription

1 10th Dresden Symposium on Autoantibodies September 22-25, 2011 FromPredictiontoPreventionofAutoimmuneDiseases Chairman: KarstenConrad(Dresden,Germany) Co Chairmen: EdwardK.L.Chan(Gainesville,USA) MarvinFritzler(Calgary,Canada) Rene LouisHumbel(Esch sur Alzette,Luxembourg) PierLuigiMeroni(Milano,Italy) YehudaShoenfeld(Tel Hashomer,Israel) NationalOrganizingCommittee RicoHiemann ThorstenKrieger RobertLange UlrichSack WernerSchößler (MembersoftheAdvisoryCommitteeoftheGFIDe.V) InternationalAdvisoryBoard LuisE.C.Andrade(SaoPaulo,Brazil) DimitriosP.Bogdanos(London,UK) ElenaCsernok(BadBramstedt,Germany) MartinHerrmann(Erlangen,Germany) FalkHiepe(Berlin,Germany) ArnoKromminga(Hamburg,Germany) MichaelMahler(SanDiego,USA) GünterSteiner(Vienna,Austria) AlanWiik(Copenhagen,Denmark) PeterZipfel(Jena,Germany)

2 DearColleagues From September 22 to September 25, 2011 the Institute of Immunology of the Dresden Technical University will realize in Dresden (Germany) in cooperation with the Accociation for the Advancement of Immune Diagnostics ( ev.de) and the Section Immunodiagnostics of the German Society for Clinical Chemistry and Laboratory Medicine ( the 10th Dresden SymposiumonAutoantibodies.Thecurrentsymposiumentitled FromPredictiontoPreventionof Autoimmune Diseases will focus on different aspects of the pathogenesis, the prediction, novel treatment regimes and prevention of systemic and organ specific autoimmune diseases as well as autoimmune graft rejections. For this, also rare autoimmunopathies such as autoimmune forms of thromboticmicroangiopathies,nephropathies,myopathiesandcardiomyopathieswillbediscussed. Furthermore it is a tradition of the Dresden meetings to speak about methodical aspects of autoantibodydeterminationsaswellasaboutdiagnosticstrategiesforautoimmunediseases. The purpose of prediction of autoimmune diseases is prevention of the clinical precipitation! In mostdiseaseswithanautoimmunepathology,alongprodromeisassociatedwiththeproductionof disease specific autoantibodies and may provide a window of opportunity to reverse the autoimmune process. However, large prospective studies are necessery to evaluate the risk of diseasedevelopmentinautoantibodypositivepersons.intype1diabetes,autoantibodyassaysmake it possible to accurately identify people at risk of future disease. A similar development can be promisedforrheumatoidarthritis.therefore,bothdiseasesmayserveasmodelsforpreventionand novel treatment strategies. A prerequisite for prevention and curative therapy is the very early or even predictive diagnosis by biomarker analyses. The improvement, optimization and standardizationofautoantibodydeterminationaswellasevaluationstudiesplayanimportantrolein thisprocess.weexpectthatthattheanniversarymeetingonautoantibodieswillstimulateallkindof activitiesregardingpredictionandpreventionofautoimmunediseases. Wehopethatyouwillbeabletojoinusforthisexcitingprogram. KarstenConrad OnbehalfoftheOrganizingCommittee

3 Thursday, :00 22:00 Registration 14:00 14:30 Welcome&Introduction 14:30 16:00 FromPredictiontoPreventionofAutoimmuneDiseases 16:00 16:30 Coffeebreak Frompredictiontopreventionofautoimmunediseases currentstateand perspectives KarstenConrad(Dresden,Germany) Thevalueofautoantibodiesforthepredictionofautoimmunediseases YehudaShoenfeld(TelHashomer,Israel) Antibodyproteasesaspreclinicaldiagnosticandpredictivetoolsinmonitoringclinical autoimmunityconditions SergeySuchkov(Moscow,Russia) 16:30 18:40 PathogenesisandPreventionofAutoimmuneDiseases PathogenesisofAPS:understandingtheantibodies PierLuigiMeroni(Milano,Italy) Ontheroleofnucleicacidsandtheirbindingproteinsinthepathogenesisof autoimmunearthritisinrats,miceandmen GünterSteiner(Vienna,Austria) TheroleofmiRNAsintheregulationofimmunologicalfunctionsandtheprevention ofautoimmunity EdwardK.L.Chan(Gainesville,USA) TheroleofVitaminDinimmunologichomeostasisandpreventionofautoimmunity NancyAgmon Levin(RamatGan,Israel) Anti dsdnaantibodyproductionisrestrictedbythegermlinecompositionofdh genes A.Silva Sanchez,CRLiu,P.Kapoor,TSchoeb,HWSchroeder(Birmingham,USA) Prognosticvalueofantibodiestooxydizedlow densitiylipoproteininacutecoronary syndromeandstablecoronaryarterydisease SándorSipka,R.Laczik,I.Scípö,P.Szodoray,S.SipkaJr,M.Sokol,P.Soltész(Debrecen, Hungary) LongpentraxinPTX3andautoantibodiesproductioninautoimmunediseases S.Valaperta,M.Monari,C.Alpini,E.Baldassarre,F.Gioia,A.Montanelli(Varese,Italy) Anti citrullinatedfibronectinantibodiesinrheumatoidarthritisareassociatedwith HLA DRB1sharedepitopealleles JoyceJ.B.C.vanBeers,AnnemiekWillemze,ReneE.M.Toes,GerJ.M.Pruijn(Nijmegen, TheNetherlands) 19:00 22:00 WelcomeReception

4 Friday, :00 09:40 PlenaryLecture Typ1diabetes:Amodelfordiseasepredictionandprevention MatthiasG.vonHerrath(LaJolla,USA) 09:40 10:30 AutoimmuneThromboticMicroangiopathies Thromboticmicroangiopathies:Towardsapathogeneticallybasedclassification PeterZipfel(Jena,Germany) Theanti factorhautoantibodyassociatedhemolyticuremicsyndrome Marie AgnésDragon Durey(Paris,France) Atypicalhemolyticuremicsyndrome associatedanti factorhautoantibodiesinhibit factorhbindingtopentraxin3 AnneBraunschweig,StefanieStrobel,MihályJózsi(Jena,Germany) 10:30 11:00 Coffeebreak 11:00 12:30 PerspectivesintheTreatmentofAutoimmuneDiseases Therapeuticconceptsoftargetingautoreactiveplasmacells FalkHiepe(Berlin,Germany) Adecadeofpeptidebasedimmunotherapyforautoimmunediseases MiriBlank(Tel Hashomer,Israel) Aptamerbasedimmunotherapy AnnekathrinHaberland(Berlin,Germany) Attenuationofautoimmunitybyanti human interleukin 17aptamerinmousemodels YoshikazuNakamura,HironoriAdachi,AkiraIshiguro(Tokyo,Japan) ClinicalimpactofneutralizingantibodiesagainstTNFainhibitors ArnoKromminga(Hamburg,Germany) 12:30 14:00 Lunchbreak IndustrialExhibitionandPosterViewing EASILunchMeeting(EASImembersonly) 14:00 15:20 ASIAsyndromeandautoimmunegraftrejection 15:20 15:50 Coffeebreak Autoimmunesyndromesinducedbyadjuvants(ASIA) YehudaShoenfeld(TelHashomer,Israel) Inductionandroleofautoantibodiesinearlygraftrejection GavinJ.Pettigrew(Cambridge,UK) Alloimmuneresponse inducedautoimmunity:roleinthepathogenesisofchronic allograftrejection ThalachallourMohanakumar(St.Louis,USA) AutoantibodiesagainstG proteincoupledreceptors(gpcrs) KaiSchulze Forster(Luckenwalde,Germany) 15:50 17:30 PresentationsoftheCandidatesfortheDresdenPrizeontheStudyof Autoantibodies DevelopmentandoptimizationofasensitivepeptideELISAforautoantibodytestingin earlyandseronegativera

5 LiesbethdeWinter,KlaartjeSomers,PietGeusens,DirkElewaut,PietStinissen,Veerle Somers(Diepenbeek,Belgium) Roleoffunctionalantibodiesagainstvascularreceptorsinsystemicsclerosis MikeBecker(Berlin,Germany) NovelautoantibodiestoEIF3inpolymyositis ZoeBetteridge(Bath,UK) Autoantibodiestocytoplasmicrod/ringstructuretargetingCTP/GTPsynthetic pathwayinhcvpatientstreatedwithinterferon/ribavirin W.C.Carcamo (Gainesville,USA) PatientderivedhumanmonoclonalisletautoantibodiesinType1Diabetes MaraCatani(Dresden,Germany) PeripheralandintrathecalimmortalizedBcellsfrommultiplesclerosispatientsshow clonalexpansionandproduceautoreactiveantibodies JudithFraussen(Limburg,Belgium) Anti Neurofascinautoantibodies:Assaydevelopmentandanalysisofinflammatory diseasesofthecnsandpns JudyKingManNg(Munich,Germany) AutoantibodysecretingcellsinthenephritickidneysoflupusproneNZB/WF1mice aresensitivetobortezomib CharlotteStarke(Erlangen,Germany) Discoveryofnovelantigenictargetsforclinicallyisolatedsyndrome MyrtheRouwette,KlaartjeSomers,G.Govarts,R.Hupperts,B.vanWijmeersch,B.de Jong,M.Verbeek,V.vanPesch,C.Sindlo,LVillar,PietStinissen,VeerleSomers (Diepenbeek,Belgium) 17:30 18:00 Coffeebreak&snacks 18:00 19:30 EASI Symposium:Rheumatoidarthritis ValueoftheACRGuidelinesforthediagnosis ManfredHerold(Innsbruck,Austria) RA33antibodies newdataofamarkerlinkedtoccpnegativerawithamild prognosis. GünterSteiner(Vienna,Austria) CarPantibodiesidentifyRApatientswithseverediseaseprogression LeendertTrouw(Leiden,TheNetherlands) Novelautoantibodymarkersforseronegativerheumatoidarthritis VeerleSomers(Hasselt,Belgium) PersonalizedmedicineapproachesinRA MarvinFritzler(Calgary,Canada)

6 Saturday, :00 09:30 PlenaryLecture Frompredictiontopreventionofrheumatoidarthritis KarinLundberg(Stockholm,Sweden) 09:30 10:30 AutoimmuneHeartDiseases 10:30 11:00 Coffeebreak Dilatedcardiomyopathyandmyocarditis:Classification,clinicalandautoimmune features AlidaL.P.Caforio(Padua,Italy) ChronicChagasHeartDisease Frompathogenesistonewtreatmentregimes IngolfSchimke(Berlin,Germany) Pathophysiologyofautoimmuneassociatedcongenitalheartblock:Frombenchto bedside MohamedBoutjdir(NewYork,USA) 11:00 12:45 NovelAutoantibodiesI 12:45 14:00 Lunchbreak Novelautoantibodies,clinicalphenotypesandpathogenesisofidiopathicmyopathies ZoeE.Betteridge(Bath,UK) Anti Mup44:thefirstinclusionbodymyositis specificautoantibody HelmaPluk,BazielG.vanEngelen,GerJ.M.Pruijn(Nijmegen,TheNetherlands) Novelautoantibodymarkersinautoimmunegastrointestinalandliverdiseases DimitriosP.Bogdanos(London,UK) Autoantibodiesagainstgalectinsasnovelbiomarkersfortheantiphospholipid syndrome? MartinHerrmann(Erlangen,Germany) IdentificationofATP bindingcassettetransporterproteinf1(abc F1)asanovel autoantigen MartinBlüthner,MartinVolkmann,HeribertAppelhans,I.Moosbrugger,C.Wiemann,C. Becker,Hans PeterSeelig(Karlsruhe,Germany) IndustrialExhibitionandPosterViewing GFIDLunchMeeting(GFIDmemberonly) 14:00 14:45 NovelAutoantibodiesII PLA2receptorantibodiesasserologicalmarkersofidiopathicmembranousnephritis areabsentinactivemembranouslupusnephritis IvaGunnarsson,WolfgangSchlumberger,JohanRönnelid (Lübeck,Germany) AutoantibodiesagainstchaperoninCCTinglomerularimmunedepositsandserain patientswithmembranousnephropathy:possibleroleindiseaseprogression FlorenceLefeu,FabienneFasani,ChantalJouanneau,PierreRonco,HannaDebiec(Paris, France) DresdenPrizeAwardCeremony andpresentationofthewinner

7 14:45 16:00 Coffeebreak TransfertotheKönigsteinFortress 16:00 23:00 GuidedVisitoftheKönigsteinFortress&GalaDinner The Königstein Fortress ( koenigstein.de), located in the beautiful Saxon Switzerlandabout40kmSouth EastfromDresdenontheriverElbe,isoneofEurope s architecturally and historically most unique mountain fortresses,. It is a unique monument to the art of European fortress construction. Its 750 years' history have made it an impressive configuration of late Gothic, Renaissance, Baroque and 19th centuryarchitecture.

8 Sunday, :00 10:30 AutoantibodyDeterminations HistoryandPerspectives 10:30 11:00 Coffeebreak Historyofautoimmuneserology ReneLouisHumbel(Luxembourg) Autoantibodytesting:Currentchallengesandfutureopportunities MarvinFritzler(Calgary,Canada) ANCATesting:Currentstageandperspectives ElenaCsernok(BadBramstedt,Germany) 11:00 12:30 ARenaissanceoftheHEp 2cellAssay? 12:30 14:00 Lunchbreak MulticentrecollaborationisneededtoreachunifiedclassificationofIIFANAand clinicaluseofstrictlydefinedfindings AlanWiik(Copenhagen,Denmark) Determinationofnon organspecificautoantibodiesbyindirectimmunofluorescence onhep 2cells:Advantages,challengesandperspectives RicoHiemann,NadjaRöber,KarstenConrad(Dresden,Germany) ComparisonofanANAautomatedreadingsystemwithconventionalfluorescence microscopy ThorstenKrieger(Hamburg,Germany) Distinctivefeaturesofautoantibodiesinandoutthecontextofovertautoimmunity LuisE.C.Andrade(SaoPaulo,Brasil) RedefiningANAtesting:DevelopmentofahighlyspecificANAHEp 2testbasedon immunoabsorptionofanti DFS70autoantibodies MichaelMahler,AndreaSeaman,ToddParker,AaronLlanes,CarolL.Peebles,JohnG. Hanly,MarvinJ.Fritzler (SanDiego,CA,USA) AutomaticreadingofANCA slides:evaluationoftheaklidessystem JanDamoiseaux,KathleenMallet,MiaVaessen.JosAusten,andJanWillemCohen Tervaert(Maastricht,TheNetherlands) IndustrialExhibitionandPosterViewing 14:00 15:30 MethodicalAspectsofAutoantibodyTesting Syntheticpeptidesasantigensinimmunoassays MichaelMahler(SanDiego,USA) Multiparametricserologicaltestinginautoimmuneencephalitisusingarecombinant immunofluorescenceassayandeurotidetechnology Klaus PeterWandinger,ChristineKlingbeil,PatrickWaters,JosepDalmau,Sandra Saschenbrecker,KathrinBorowski,AngelaVincent,ChristianProbst,WinfriedStöcker (Lübeck,Germany) Profilingofantiphospholipidantibodies Associationwithcerebrovasculareventsin antiphospholipidsyndrome(aps) KarlEgerer,DirkRoggenbuck,ThomasBüttner,BarbaraLehmann,AnnushkaKohn, PhilippvonLandenberg,EugenFeist,Gerd RüdigerBurmester,ThomasDörner(Berlin, Germany)

9 Congressvenue: HörsaalzentrumderTechnischenUniversitätDresden Bergstrasse64,D 01069Dresden ThemodernLectureHallCentreoftheTechnicalUniversityofDresdenis locatedontheuniversitycampusinthesouthofthecity,about15minutes walkawayfromthecentralrailwaystation.