P-38 Temporary dysfunction of outer hair cells after intratympanic application of Pseudomonas aeruginosa exotoxin A

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1 Poster Session II P-38 Temporary dysfunction of outer hair cells after intratympanic application of Pseudomonas aeruginosa exotoxin A Adnan Lidian, Birgitta Linder, Barbara Canlon and Matti Anniko P-39 Ototoxic effects of Mefloquine in cochlear organotypic cultures Haiyan Jiang, Dalian Ding and Richard Salvi P-40 Otoacoustic emissions and cochlear functionality in workers exposed to styrene R. Sisto, L. Cerini, M.P. Gatto, M. Gherardi, A. Gordiani, E. Paci, F. Sanjust, T. Botti, G. Tranfo and A. Moleti P-41 Afferent pathology and repair associate with vestibular dysfunction and recovery during chronic ototoxicity in the rat Lara Sedó-Cabezón and Jordi Llorens P-42 Oncostatin M - induced protection against cisplatin ototoxicity is mediated via STAT3 Elisabeth Gerschner, Olga Hegend, Heidi Olze, Birgit Mazurek and Agnieszka Szczepek P-43 Protective role of edaravone against neomycin-induced ototoxicity in zebrafish Jiwon Chang, Kang Woo Kim, Gi Jung Im, Hak Hyun Jung and June Choi P-44 Systemic treatment with resveratrol and N-acetylcysteine prevents from local ototoxicity with kanamycin and furosemide in rats F. García-Alcántara, S. Murillo-Cuesta, R. Martínez-Vega, J. Contreras, L. Sanz, I. Varela-Nieto and T. Rivera P-45 Ear in a dish: development of an in vitro assay for ototoxic and otoprotective drugs screening Aurélie Dos Santos, Andreas Eckhard, Ngoc-Nhi Luu, Marcus Müller and Hubert Löwenheim 1.-

2 P-46 Deiters cells regulate the remodelling of aminoglycoside-injured organ of Corti, through the release of HMGB1 Sabine Ladrech, Marc Mathieu, Hassan Boukhaddaoui, Jean-Luc Puel and Marc Lenoir P-47 Preliminary results with the NMDA antagonist memantine in salicylate-induced tinnitus M. Ralli, R. Salvi, F. Paciello, S.L.M. Eramo, D. Troiani, A.R. Fetoni and G. Paludetti P-48 Effects of the calyx on the apparent properties of vestibular type I hair cells K + currents Elisa Tavazzani, Giancarlo Russo, Jacopo Magistretti, Paolo Spaiardi, Teresa Soda, Ivo Prigioni and Sergio Masetto P-49 Proteomic analysis of vestibular schwannoma Jae-Hyun Seo, Kyoung-Ho Park and Seong-Cheon Bae P-50 Suddens sensorineural hearing loss, inflammatory disease & TNF-alpha Elias Q. Scherer, Andreas Knopf and Elmar Oestreicher P-51 Polymorphisms in genes involved in the free-radical process in patients with Ménière s disease and sudden sensorineural hearing loss Masaaki Teranishi, Yasue Uchida, Naoki Nishio, Ken Kato, Hironao Otake, Tadao Yoshida, Michihiko Sone, Saiko Sugiura, Fujiko Ando, Hiroshi Shimokata and Tsutomu Nakashima P-52 Reducing noise-induced hearing loss by peptides targeting transforming growth factor β1 Silvia Murillo-Cuesta, Lourdes Rodríguez-de la Rosa, Lorena Sanz, Carlos Avendaño, Teresa Rivera and Isabel Varela-Nieto P-53 IGF-I deficit predisposes to noise-induced hearing loss in mice Adelaida Celaya, Silvia Murillo-Cuesta, Lourdes Rodríguez-de la Rosa, Rafael Cediel, Carlos Avendaño, Julio Contreras and Isabel Varela-Nieto 2.-

3 P-54 Functional and anatomical correlation in noise-induced hearing loss mouse model L. Sanz, C. Avendaño, S. Murillo-Cuesta, R. Cediel, F. García-Alcántara, P. Cobo, I. Varela-Nieto and T. Rivera P-55 Protective effect of rosmarinic acid in noise induced hearing loss: a functional and morphological study F. Paciello, S.L.M. Eramo, R. Rolesi, A.R. Fetoni, D. Troiani and G. Paludetti P-56 Role of p66shc in noise induced hearing loss: a functional and morphological study in mice and rats S.L.M. Eramo, A.R. Fetoni, F. Paciello, D. Troiani, G. Paludetti and G. Pani P-57 Analysis of vulnerability of hearing loss over age subsequent to the deletion of BDNF or Cav1.2 in the cochlea S.C. Lee, D. Campanelli, K. Varakina, D. Bing, A. Zuccotti, W. Singer, L. Rüttiger, T. Schimmang and M. Knipper P-58 Analysis of acute stress on long-term vulnerability after an acoustic injury in a mature rat model K. Kasini, I. Köpschall, K. Rohbock, L. Rüttiger, M. Knipper and M. Jaumann P-59 Lack of BDNF in the cochlea but not in the brain influences sound processing Dario Campanelli, Sze Chim Lee, Annalisa Zuccotti, Wibke Singer, Katja Gutsche, Lukas Rüttiger, Thomas Schimmang and Marlies Knipper P-60 Hearing and comorbidities in patients with professional hearing loss Natalia N. Petrova and Viya S. Panshina P-61 Synergistic effect of Styrene exposure and acoustic trauma: a functional and morphological study in a model of noise induced hearing loss (NIHL) R. Rolesi, F. Paciello, S.M.L. Eramo, D. Troiani, A.R. Fetoni and G. Paludetti P-62 Review of TNF blockers and other biological therapy agents in autoimmune inner ear disease David Lobo, José Ramón García-Berrocal, José María Verdaguer and Rafael Ramírez-Camacho 3.-

4 P-63 Efficacy of etanercept in an animal model of autoimmune labyrinthitis David Lobo, José Ramón García-Berrocal, Almudena Trinidad and Rafael Ramírez- Camacho P-64 Guidance of spiral ganglion cell neurites using a nanomatrix in vitro Claudia Frick, Marcus Müller, Ute Wank, Karl-Heinz Wiesmüller and Hubert Löwenheim P-65 Methylprednisolone injection to the inner ear: an alternative to the systemic therapy Jeanette Sáenz-Piñones, José Ramón García-Berrocal, Ithzel Villarreal, Emilia T. Martin-Mata, Almudena Trinidad and Rafael Ramírez-Camacho P-66 Fibrin-collagen coating of cochlea implant electrodes for transplantation of adipose-derived stem cells Philipp Schendzielorz, Agmal Scherzed, Kristen Rak, Johannes Völker, Thomas Gehrke, Christian Ginzkey, Rudolf Hagen and Andreas Radeloff P-67 A novel method for transplantation of terminally differentiated neurons derived from pluripotent stem cells into the cochlea Hiroe Ohnishi, Takayuki Nakagawa, Masaaki Ishikawa, Yousuke Tona, Nakarin Asaka and Juichi Ito P-68 Survival of human ips cell-derived neurons after transplantation into guinea pig cochleae Masaaki Ishikawa, Takayuki Nakagawa, Hiroe Onishi, Yosuke Tona, Nakarin Asaka, Yoshitaka Kawai and Juichi Ito P-69 Molecular optical imaging enables visualization of exogenous stem cells in the intact guinea pig cochlea John C.M.J. de Groot, Laura Mezzanotte, TimoSchomann, Clemens W.G.M. Löwik, Johan H.M. Frijns and Margriet A. Huisman 4.-

5 P-70 Mondini dysplasia: conceptual new and new electrode designed for cochlear implantation Mª José Lavilla Marti de Valmaseda, Silvia V. Domínguez Ovejas, Daniella Laguado Bulgheroni, Javier Cervera Escario, José Marcos Calle and M. Aparicio P-71 Application of new generation technologies (NGS and acgh) to the integral diagnosis and investigation of inherited hearing loss Matías Morín, Lucia Borreguero, Maria Palomares, Ángeles Mencía, Luciana S. Serrao de Castro, Fernando Mayo, Julián Nevado, Pablo Lapunzina, Ignacio del Castillo, Javier Santoyo, Felipe Moreno and Miguel Ángel Moreno-Pelayo P-72 Highly efficient diagnostic testing in patients with hereditary hearing loss using Panel-based Next Generation Sequencing Sarah Fehr, Moritz Menzel, Saskia Biskup, Konstanze Hörtnagel, Tim Scheurenbrand, Andrea Sprecher, Anke Tropitzsch and Hubert Löwenheim P-73 SVT-AP-99: Inhibition of Apaf-1 as a potential therapeutic strategy to prevent cisplatin-induced hearing loss Sandra Marchán, Celia Casares, Estefanía Traver, Almudena Trinidad, José Ramón García Berrocal, Natividad García Villar, Javier Sanagustín, Carmen Herrero, Carmen Lagunas and Rafael Ramírez-Camacho P-74 Plucked human scalp hair follicles may serve inner ear cell- based therapy Coen Gho, Suzy Varderesyan, Johan H.M Frijns, Marcelo N. Rivolta and Margriet A. Huisman P-75 Analysis of the effect of stimulated cgmp cascade on the vulnerability for hearing loss after noise exposure during aging Ksenya Varakina, Mahdieh Alinaghikhani, Dan Bing, Sze Chim Lee, Iris Köpschall, Marlies Knipper and Lukas Rüttiger P-76 Preventive effect of polyphenols on hearing loss comparing evoked potentials hearing of brain stem responses and stable state hearing in experimental animals age-related R. Sanz-Fernández, Carolina Sánchez-Rodríguez, J. Esteban-Sánchez, E. Martín- Sanz, L. Rodrigáñez, L. De Toro Gil and E. Durio-Calero 5.-

6 P-77 Autoantibodies and sudden hearing loss Johanna Rebholz, Kerstin Ratzlaff, Reinhild Klein and Mark Praetorius P-78 Methods for hearing threshold measurements with ABR in guinea pigs Johannes Fischer, Jochen Steinhoff and Thomas Stark P-79 Influence of cochleostomy and implant insertion on drug gradients following intratympanic application in guinea pigs E.B. King, J.J. Hartsock, S.J. O Leary and A.N. Salt P-80 Change in endocochlear potential during experimental insertion of a simulated cochlear implant electrode in the guinea pig Hidetoshi Oshima, Ryoukichi Ikeda, Kazuhiro Nomura, Muneharu Yamazaki, Hiroshi Hidaka, Takeshi Oshima, Tetsuaki Kawase and Toshimitsu Kobayashi P-81 Functional and histological outcomes following cochlear implantation in the mouse Nina Mistry, Lisa S. Nolan, Andrew Forge, Shakeel R. Saeed and Ruth R. Taylor P-82 Laser assisted cochleostomy in guinea pigs Digna M.A. Kamalski, Jeroen P.M. Peters, Tjeerd de Boorder, Rudolf M. Verdaasdonk, Sjaak F.L. Klis and Wilko Grolman P-83 A comparison of two vasoactive/vasodilative agents in combination with corticosteroid for treatment of sudden sensorineural hearing loss Špela Kordiš, Miha Žargi and Saba Battelino P-84 High speed imaging in laser-assisted stapedotomy Digna M.A. Kamalski, Tjeerd de Boorder, H.P.M. (Jeroen) Peters, Huib Versnel, Rudolf M. Verdaasdonk and Wilko Grolman P-85 Characterization of neural stem cells in the rat cochlear nucleus J. Voelker, K. Rak, R. Hagen and R. Mlynski 6.-

7 P-86 Study of the role of mirnas in the development of the auditory portion of the inner ear P. Van Den Ackerveken, A. Huyghe, R. Sacheli, F. Rogister, P.P. Lefebvre, L. Nguyen and B. Malgrange P-87 First steps towards a gapless interface between auditory neurons and multielectrode arrays in vitro Stefan Hahnewald, Marta Roccio, Pascal Senn, Anne Tscherter, Jürg Streit, Julien Brossard, Herbert Keppner and Hans Rudolf Widmer P-88 Autophagy is required for apoptotic cell clearance and neural differentiation in early otic development Rocío de Iriarte, Marta Magariños, María Rodríguez Aburto, Hortensia Sanchez- Calderón, Juan M. Hurlé and Isabel Varela-Nieto P-89 TIS21 is involved in the development of spiral ganglion cells Takao Yamada, Ryosei Minoda, Momoko Ise and Eiji Yumoto P-90 Inhibition of matrix metalloproteinase-2 but not metalloproteinase-9 influences spiral ganglion neurons in vitro Cristian Setz, Eric Wei, Michael Sung, Soledad Levano, Daniel Bodmer and Yves Brand P-91 The regulation of Hes/Hey factors during sensory development of the chicken inner ear Jelena Petrovic, Gina Abelló, Héctor Gálvez, Joana Neves and Fernando Giraldez P-92 Netrin-4 promotes and modulates inner ear spiral ganglion neurite outgrowth in vitro Yves Brand, Michael Sung, Eduardo Chavez, Kwang Pak, Eric Wei, Soledad Levano, Vesna Radojevic, Daniel Bodmer and Allen F. Ryan P-93 Spiral ganglion-derived fibroblast cell culture Annett Anacker, Karl-Heinz Esser, Thomas Lenarz and Gerrit Paasche 7.-

8 P-94 Rolipram improves survival of spiral ganglion cells in vitro Katharina Kranz, Athanasia Warnecke, Kirsten Wissel, Thomas Lenarz and Verena Scheper P-95 Extracellular matrix from human mesenchymal stem cells for cell-based drug delivery into the inner ear Kirsten Wissel, Athanasia Warnecke, Thomas Lenarz, Marina Prewitz and Carsten Werner P-96 Differentiation of Boettcher's cells during postnatal development of rat cochlea Marie Cloes, Thomas Renson, Nicolas Johnen, Nicolas Thelen and Marc Thiry 8.-