3 rd Annual Johns Hopkins Critical Care Rehabilitation Conference

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1 3 rd Annual Johns Hopkins Critical Care Rehabilitation Conference Literature List 1) Adler J, Malone D. Early mobilization in the intensive care unit: a systematic review. Cardiopulm Phys Ther J Mar;23(1):5-13. PubMed PMID: ; PubMed Central PMCID: PMC ) Affleck AT, Lieberman S, Polon J, Rohrkemper K. Providing occupational therapy in an intensive care unit. Am J Occup Ther May;40(5): PubMed PMID: ) Aitken LM, Rattray J, Hull A, Kenardy JA, Le Brocque R, Ullman AJ. The use of diaries in psychological recovery from intensive care. Crit Care Dec 18;17(6):253. PubMed PMID: ; PubMed Central PMCID: PMC ) APTA. The Role of Physical Therapy in Safe Patient Handling. 2012; DOI: 5) Arnold M, Radawiec S, Campo M, Wright LR. Changes in functional independence measure ratings associated with a safe patient handling and movement program. Rehabil Nurs Jul-Aug;36(4): PubMed PMID: ) Bailey P, Thomsen GE, Spuhler VJ, Blair R, Jewkes J, Bezdjian L, Veale K, Rodriquez L, Hopkins RO. Early activity is feasible and safe in respiratory failure patients. Crit Care Med Jan;35(1): PubMed PMID: ) Bailey PP, Miller RR 3rd, Clemmer TP. Culture of early mobility in mechanically ventilated patients. Crit Care Med Oct;37(10 Suppl):S PubMed PMID: ) Balas MC, Rice M, Chaperon C, Smith H, Disbot M, Fuchs B. Management of delirium in critically ill older adults. Crit Care Nurse Aug;32(4): PubMed PMID: ) Balas MC, Vasilevskis EE, Olsen KM, Schmid KK, Shostrom V, Cohen MZ, Peitz G, Gannon DE, Sisson J, Sullivan J, Stothert JC, Lazure J, Nuss SL, Jawa RS, Freihaut F, Ely EW, Burke WJ. Effectiveness and safety of the awakening and breathing coordination, delirium monitoring/management, and early exercise/mobility bundle. Crit Care Med May;42(5): PubMed PMID: ; PubMed Central PMCID: PMC ) Barr J, Fraser GL, Puntillo K, Ely EW, Gélinas C, Dasta JF, Davidson JE, Devlin JW, Kress JP, Joffe AM, Coursin DB, Herr DL, Tung A, Robinson BR, Fontaine DK, Ramsay MA, Riker RR, Sessler CN, Pun B, Skrobik Y, Jaeschke R, American College of Critical Care Medicine. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med Jan;41(1): PubMed PMID: ) Bassett RD, Vollman KM, Brandwene L, Murray T. Integrating a multidisciplinary mobility programme into intensive care practice (IMMPTP): a multicentre collaborative. Intensive Crit Care Nurs Apr;28(2): PubMed PMID: ) Batt J, dos Santos CC, Cameron JI, Herridge MS. Intensive care unit-acquired weakness: clinical phenotypes and molecular mechanisms. Am J Respir Crit Care Med Feb 1;187(3): PubMed PMID: ) Berenholtz SM, Lubomski LH, Weeks K, Goeschel CA, Marsteller JA, Pham JC, Sawyer MD, Thompson DA, Winters BD, Cosgrove SE, Yang T, Louis TA, Meyer Lucas B, George CT, Watson SR, Albert-Lesher MI, St Andre JR, Combes JR, Bohr D, Hines SC, Battles JB, Pronovost PJ, On the CUSP: Stop BSI program. Eliminating central line-associated bloodstream infections: a national patient safety imperative. Infect Control Hosp Epidemiol Jan;35(1): PubMed PMID:

2 14) Berenholtz SM, Pham JC, Thompson DA, Needham DM, Lubomski LH, Hyzy RC, Welsh R, Cosgrove SE, Sexton JB, Colantuoni E, Watson SR, Goeschel CA, Pronovost PJ. Collaborative cohort study of an intervention to reduce ventilator-associated pneumonia in the intensive care unit. Infect Control Hosp Epidemiol Apr;32(4): PubMed PMID: ) Blair SN, Kohl HW 3rd, Paffenbarger RS Jr, Clark DG, Cooper KH, Gibbons LW. Physical fitness and all-cause mortality A prospective study of healthy men and women. JAMA Nov 3;262(17): PubMed PMID: ) BLS. Nonfatal Occupational Injuries and Illnesses Requiring Days Away From Work. 2012; DOI: 17) Bolton CF, Young GB. Managing the nervous system effects of sepsis. Chest May;131(5): PubMed PMID: ) Books and Chapters 19) Brown CJ, Redden DT, Flood KL, Allman RM. The underrecognized epidemic of low mobility during hospitalization of older adults. J Am Geriatr Soc Sep;57(9): PubMed PMID: ) Brusco NK, Watts JJ, Shields N, Taylor NF. Are weekend inpatient rehabilitation services value for money? An economic evaluation alongside a randomized controlled trial with a 30 day follow up. BMC Med May 29;12:89. PubMed PMID: ; PubMed Central PMCID: PMC ) Burtin C, Clerckx B, Robbeets C, Ferdinande P, Langer D, Troosters T, Hermans G, Decramer M, Gosselink R. Early exercise in critically ill patients enhances short-term functional recovery. Crit Care Med Sep;37(9): PubMed PMID: ) Campo M, Shiyko MP, Margulis H, Darragh AR. Effect of a safe patient handling program on rehabilitation outcomes. Arch Phys Med Rehabil Jan;94(1): PubMed PMID: ) Campo M, Weiser S, Koenig KL, Nordin M. Work-related musculoskeletal disorders in physical therapists: a prospective cohort study with 1-year follow-up. Phys Ther May;88(5): PubMed PMID: ; PubMed Central PMCID: PMC ) Carling PC, Parry MF, Bruno-Murtha LA, Dick B. Improving environmental hygiene in 27 intensive care units to decrease multidrug-resistant bacterial transmission. Crit Care Med Apr;38(4): PubMed PMID: ) Cheung AM, Tansey CM, Tomlinson G, Diaz-Granados N, Matté A, Barr A, Mehta S, Mazer CD, Guest CB, Stewart TE, Al-Saidi F, Cooper AB, Cook D, Slutsky AS, Herridge MS. Two-year outcomes, health care use, and costs of survivors of acute respiratory distress syndrome. Am J Respir Crit Care Med Sep 1;174(5): PubMed PMID: ) Clini EM, Crisafulli E, Antoni FD, Beneventi C, Trianni L, Costi S, Fabbri LM, Nava S. Functional recovery following physical training in tracheotomized and chronically ventilated patients. Respir Care Mar;56(3): PubMed PMID: ) Damluji A, Zanni JM, Mantheiy E, Colantuoni E, Kho ME, Needham DM. Safety and feasibility of femoral catheters during physical rehabilitation in the intensive care unit. J Crit Care Aug;28(4):535.e9-15. PubMed PMID: ) Darragh AR, Huddleston W, King P. Work-related musculoskeletal injuries and disorders among occupational and physical therapists. Am J Occup Ther May-Jun;63(3): PubMed PMID:

3 29) Davydow DS, Gifford JM, Desai SV, Needham DM, Bienvenu OJ. Posttraumatic stress disorder in general intensive care unit survivors: a systematic review. Gen Hosp Psychiatry Sep-Oct;30(5): PubMed PMID: ; PubMed Central PMCID: PMC ) Davydow DS, Hough CL, Langa KM, Iwashyna TJ. Symptoms of depression in survivors of severe sepsis: a prospective cohort study of older Americans. Am J Geriatr Psychiatry Sep;21(9): PubMed PMID: ; PubMed Central PMCID: PMC ) Davydow DS, Hough CL, Russo JE, Von Korff M, Ludman E, Lin EH, Ciechanowski P, Young B, Oliver M, Katon WJ. The association between intensive care unit admission and subsequent depression in patients with diabetes. Int J Geriatr Psychiatry Jan;27(1): PubMed PMID: ; PubMed Central PMCID: PMC ) Davydow DS, Russo JE, Ludman E, Ciechanowski P, Lin EH, Von Korff M, Oliver M, Katon WJ. The association of comorbid depression with intensive care unit admission in patients with diabetes: a prospective cohort study. Psychosomatics Mar-Apr;52(2): PubMed PMID: ; PubMed Central PMCID: PMC ) De Jonghe B, Sharshar T, Lefaucheur JP, Authier FJ, Durand-Zaleski I, Boussarsar M, Cerf C, Renaud E, Mesrati F, Carlet J, Raphaël JC, Outin H, Bastuji-Garin S, Groupe de Réflexion et d'etude des Neuromyopathies en Réanimation. Paresis acquired in the intensive care unit: a prospective multicenter study. JAMA Dec 11;288(22): PubMed PMID: ) de Letter MA, Schmitz PI, Visser LH, Verheul FA, Schellens RL, Op de Coul DA, van der Meché FG. Risk factors for the development of polyneuropathy and myopathy in critically ill patients. Crit Care Med Dec;29(12): PubMed PMID: ) Dinglas VD, Colantuoni E, Ciesla N, Mendez-Tellez PA, Shanholtz C, Needham DM. Occupational therapy for patients with acute lung injury: factors associated with time to first intervention in the intensive care unit. Am J Occup Ther May-Jun;67(3): PubMed PMID: ; PubMed Central PMCID: PMC ) Dinglas VD, Parker AM, Reddy DR, Colantuoni E, Zanni JM, Turnbull AE, Nelliot A, Ciesla N, Needham DM. A quality improvement project sustainably decreased time to onset of active physical therapy intervention in patients with acute lung injury. Ann Am Thorac Soc Oct;11(8): PubMed PMID: ) Dowdy DW, Eid MP, Dennison CR, Mendez-Tellez PA, Herridge MS, Guallar E, Pronovost PJ, Needham DM. Quality of life after acute respiratory distress syndrome: a meta-analysis. Intensive Care Med Aug;32(8): PubMed PMID: ) Egbers PH, Bultsma R, Middelkamp H, Boerma EC. Enabling speech in ICU patients during mechanical ventilation. Intensive Care Med Jul;40(7): PubMed PMID: ; PubMed Central PMCID: PMC ) Elliott D, Davidson JE, Harvey MA, Bemis-Dougherty A, Hopkins RO, Iwashyna TJ, Wagner J, Weinert C, Wunsch H, Bienvenu OJ, Black G, Brady S, Brodsky MB, Deutschman C, Doepp D, Flatley C, Fosnight S, Gittler M, Gomez BT, Hyzy R, Louis D, Mandel R, Maxwell C, Muldoon SR, Perme CS, Reilly C, Robinson MR, Rubin E, Schmidt DM, Schuller J, Scruth E, Siegal E, Spill GR, Sprenger S, Straumanis JP, Sutton P, Swoboda SM, Twaddle ML, Needham DM. Exploring the scope of post-intensive care syndrome therapy and care: engagement of non-critical care providers and survivors in a second stakeholders meeting. Crit Care Med Dec;42(12): PubMed PMID: ) Elliott R, McKinley S. The development of a clinical practice guideline to improve sleep in intensive care patients: a solution focused approach. Intensive Crit Care Nurs Oct;30(5): PubMed PMID: ) Ely EW, Inouye SK, Bernard GR, Gordon S, Francis J, May L, Truman B, Speroff T, Gautam S, Margolin R, Hart RP, Dittus R. Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA Dec 5;286(21): PubMed PMID:

4 42) Ely EW, Margolin R, Francis J, May L, Truman B, Dittus R, Speroff T, Gautam S, Bernard GR, Inouye SK. Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit Care Med Jul;29(7): PubMed PMID: ) Ely EW, Shintani A, Truman B, Speroff T, Gordon SM, Harrell FE Jr, Inouye SK, Bernard GR, Dittus RS. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA Apr 14;291(14): PubMed PMID: ) Engel HJ, Needham DM, Morris PE, Gropper MA. ICU early mobilization: from recommendation to implementation at three medical centers. Crit Care Med Sep;41(9 Suppl 1):S PubMed PMID: ) Fahlgren N, Bollmann SR, Kasschau KD, Cuperus JT, Press CM, Sullivan CM, Chapman EJ, Hoyer JS, Gilbert KB, Grünwald NJ, Carrington JC. Phytophthora have distinct endogenous small RNA populations that include short interfering and micrornas. PLoS One. 2013;8(10):e PubMed PMID: ; PubMed Central PMCID: PMC ) Fan E, Dowdy DW, Colantuoni E, Mendez-Tellez PA, Sevransky JE, Shanholtz C, Himmelfarb CR, Desai SV, Ciesla N, Herridge MS, Pronovost PJ, Needham DM. Physical complications in acute lung injury survivors: a two-year longitudinal prospective study. Crit Care Med Apr;42(4): PubMed PMID: ; PubMed Central PMCID: PMC ) Fan E, Needham DM, Brunton J, Kern RZ, Stewart TE. West Nile virus infection in the intensive care unit: a case series and literature review. Can Respir J Jul-Aug;11(5): PubMed PMID: ) Fan E, Needham DM. The science of quality improvement. JAMA Jul 23;300(4):390-1; author reply PubMed PMID: ) Fan E, Shahid S, Kondreddi VP, Bienvenu OJ, Mendez-Tellez PA, Pronovost PJ, Needham DM. Informed consent in the critically ill: a two-step approach incorporating delirium screening. Crit Care Med Jan;36(1):94-9. PubMed PMID: ) Fan E, Zanni JM, Dennison CR, Lepre SJ, Needham DM. Critical illness neuromyopathy and muscle weakness in patients in the intensive care unit. AACN Adv Crit Care Jul-Sep;20(3): PubMed PMID: ) Ferrando AA, Lane HW, Stuart CA, Davis-Street J, Wolfe RR. Prolonged bed rest decreases skeletal muscle and whole body protein synthesis. Am J Physiol Apr;270(4 Pt 1):E PubMed PMID: ) Fink H, Helming M, Unterbuchner C, Lenz A, Neff F, Martyn JA, Blobner M. Systemic inflammatory response syndrome increases immobility-induced neuromuscular weakness. Crit Care Med Mar;36(3): PubMed PMID: ) Flanders SA, Harrington L, Fowler RJ. Falls and patient mobility in critical care: keeping patients and staff safe. AACN Adv Crit Care Jul-Sep;20(3): PubMed PMID: ) Fletcher SN, Kennedy DD, Ghosh IR, Misra VP, Kiff K, Coakley JH, Hinds CJ. Persistent neuromuscular and neurophysiologic abnormalities in long-term survivors of prolonged critical illness. Crit Care Med Apr;31(4): PubMed PMID: ) Girard TD, Jackson JC, Pandharipande PP, Pun BT, Thompson JL, Shintani AK, Gordon SM, Canonico AE, Dittus RS, Bernard GR, Ely EW. Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med Jul;38(7): PubMed PMID: ; PubMed Central PMCID: PMC ) Hager DN, Dinglas VD, Subhas S, Rowden AM, Neufeld KJ, Bienvenu OJ, Touradji P, Colantuoni E, Reddy DR, Brower RG, Needham DM. Reducing deep sedation and delirium in acute lung injury patients: a quality improvement project. Crit Care Med Jun;41(6): PubMed PMID:

5 57) Hamburg NM, McMackin CJ, Huang AL, Shenouda SM, Widlansky ME, Schulz E, Gokce N, Ruderman NB, Keaney JF Jr, Vita JA. Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. Arterioscler Thromb Vasc Biol Dec;27(12): PubMed PMID: ; PubMed Central PMCID: PMC ) Hermans G, Van Mechelen H, Clerckx B, Vanhullebusch T, Mesotten D, Wilmer A, Casaer MP, Meersseman P, Debaveye Y, Van Cromphaut S, Wouters PJ, Gosselink R, Van den Berghe G. Acute outcomes and 1-year mortality of intensive care unit-acquired weakness A cohort study and propensity-matched analysis. Am J Respir Crit Care Med Aug 15;190(4): PubMed PMID: ) Hermans G, Wilmer A, Meersseman W, Milants I, Wouters PJ, Bobbaers H, Bruyninckx F, Van den Berghe G. Impact of intensive insulin therapy on neuromuscular complications and ventilator dependency in the medical intensive care unit. Am J Respir Crit Care Med Mar 1;175(5): PubMed PMID: ) Herridge MS, Cheung AM, Tansey CM, Matte-Martyn A, Diaz-Granados N, Al-Saidi F, Cooper AB, Guest CB, Mazer CD, Mehta S, Stewart TE, Barr A, Cook D, Slutsky AS, Canadian Critical Care Trials Group. One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med Feb 20;348(8): PubMed PMID: ) Herridge MS, Tansey CM, Matté A, Tomlinson G, Diaz-Granados N, Cooper A, Guest CB, Mazer CD, Mehta S, Stewart TE, Kudlow P, Cook D, Slutsky AS, Cheung AM, Canadian Critical Care Trials Group. Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med Apr 7;364(14): PubMed PMID: ) Hinton MV. Establishing a Safe Patient Handling/Minimal Lift Program. Orthop Nurs Sep-Oct;29(5):325-30; quiz PubMed PMID: ) Hodgson C, Needham D, Haines K, Bailey M, Ward A, Harrold M, Young P, Zanni J, Buhr H, Higgins A, Presneill J, Berney S. Feasibility and inter-rater reliability of the ICU Mobility Scale. Heart Lung Jan-Feb;43(1): PubMed PMID: ) Hodgson CL, Stiller K, Needham DM, Tipping CJ, Harrold M, Baldwin CE, Bradley S, Berney S, Caruana LR, Elliott D, Green M, Haines K, Higgins AM, Kaukonen KM, Leditschke I, Nickels MR, Paratz J, Patman S, Skinner EH, Young PJ, Zanni JM, Denehy L, Webb SA. Expert consensus and recommendations on safety criteria for active mobilization of mechanically ventilated critically ill adults. Crit Care Dec 4;18(6):658. [Epub ahead of print] PubMed PMID: ) Holder NL, Clark HA, DiBlasio JM, Hughes CL, Scherpf JW, Harding L, Shepard KF. Cause, prevalence, and response to occupational musculoskeletal injuries reported by physical therapists and physical therapist assistants. Phys Ther Jul;79(7): PubMed PMID: ) Hopkins RO, Spuhler VJ, Thomsen GE. Transforming ICU culture to facilitate early mobility. Crit Care Clin Jan;23(1): PubMed PMID: ) Hopkins RO, Spuhler VJ. Strategies for promoting early activity in critically ill mechanically ventilated patients. AACN Adv Crit Care Jul-Sep;20(3): PubMed PMID: ) Hough CL, Needham DM. The role of future longitudinal studies in ICU survivors: understanding determinants and pathophysiology of weakness and neuromuscular dysfunction. Curr Opin Crit Care Oct;13(5): PubMed PMID: ) Hough CL. Neuromuscular sequelae in survivors of acute lung injury. Clin Chest Med Dec;27(4): ; abstract x. PubMed PMID:

6 70) Hoyer EH, Needham DM, Miller J, Deutschendorf A, Friedman M, Brotman DJ. Functional status impairment is associated with unplanned readmissions. Arch Phys Med Rehabil Oct;94(10): PubMed PMID: ) Hudson LD, Hough CL. Therapy for late-phase acute respiratory distress syndrome. Clin Chest Med Dec;27(4):671-7; abstract ix-x. PubMed PMID: ) Kamdar BB, King LM, Collop NA, Sakamuri S, Colantuoni E, Neufeld KJ, Bienvenu OJ, Rowden AM, Touradji P, Brower RG, Needham DM. The effect of a quality improvement intervention on perceived sleep quality and cognition in a medical ICU. Crit Care Med Mar;41(3): PubMed PMID: ; PubMed Central PMCID: PMC ) Kamdar BB, Needham DM, Collop NA. Sleep deprivation in critical illness: its role in physical and psychological recovery. J Intensive Care Med Mar-Apr;27(2): PubMed PMID: ; PubMed Central PMCID: PMC ) Kamdar BB, Niessen T, Colantuoni E, King LM, Neufeld KJ, Bienvenu OJ, Rowden AM, Collop NA, Needham DM. Delirium Transitions in the Medical ICU: Exploring the Role of Sleep Quality and Other Factors. Crit Care Med Sep 16;PubMed PMID: ) Kamdar BB, Yang J, King LM, Neufeld KJ, Bienvenu OJ, Rowden AM, Brower RG, Collop NA, Needham DM. Developing, implementing, and evaluating a multifaceted quality improvement intervention to promote sleep in an ICU. Am J Med Qual Nov;29(6): PubMed PMID: ; PubMed Central PMCID: PMC ) Kayambu G, Boots R, Paratz J. Physical therapy for the critically ill in the ICU: a systematic review and metaanalysis. Crit Care Med Jun;41(6): PubMed PMID: ) Kho ME, Truong AD, Brower RG, Palmer JB, Fan E, Zanni JM, Ciesla ND, Feldman DR, Korupolu R, Needham DM. Neuromuscular electrical stimulation for intensive care unit-acquired weakness: protocol and methodological implications for a randomized, sham-controlled, phase II trial. Phys Ther Dec;92(12): PubMed PMID: ; PubMed Central PMCID: PMC ) Kho ME, Truong AD, Zanni JM, Ciesla ND, Brower RG, Palmer JB, Needham DM. Neuromuscular electrical stimulation in mechanically ventilated patients: A randomized, sham-controlled pilot trial with blinded outcome assessment. J Crit Care Sep 22;PubMed PMID: ) Korupolu R, Zanni JM, Fan E, Butler M, Needham DM. Early mobilisation of intensive care unit patient: the challenges of morbid obesity and multiorgan failure. BMJ Case Rep. 2010;2010PubMed PMID: ; PubMed Central PMCID: PMC ) Lacomis D. Neuromuscular disorders in critically ill patients: review and update. J Clin Neuromuscul Dis Jun;12(4): PubMed PMID: ) Leijten FS, Harinck-de Weerd JE, Poortvliet DC, de Weerd AW. The role of polyneuropathy in motor convalescence after prolonged mechanical ventilation. JAMA Oct 18;274(15): PubMed PMID: ) Li Z, Peng X, Zhu B, Zhang Y, Xi X. Active mobilization for mechanically ventilated patients: a systematic review. Arch Phys Med Rehabil Mar;94(3): PubMed PMID: ) Lin SM, Liu CY, Wang CH, Lin HC, Huang CD, Huang PY, Fang YF, Shieh MH, Kuo HP. The impact of delirium on the survival of mechanically ventilated patients. Crit Care Med Nov;32(11): PubMed PMID: ) Lipitz-Snyderman A, Steinwachs D, Needham DM, Colantuoni E, Morlock LL, Pronovost PJ. Impact of a statewide intensive care unit quality improvement initiative on hospital mortality and length of stay: retrospective

7 comparative analysis. BMJ Jan 28;342:d219. PubMed PMID: ; PubMed Central PMCID: PMC ) Lord RK, Mayhew CR, Korupolu R, Mantheiy EC, Friedman MA, Palmer JB, Needham DM. ICU early physical rehabilitation programs: financial modeling of cost savings. Crit Care Med Mar;41(3): PubMed PMID: ) Maffiuletti NA, Roig M, Karatzanos E, Nanas S. Neuromuscular electrical stimulation for preventing skeletalmuscle weakness and wasting in critically ill patients: a systematic review. BMC Med May 23;11:137. PubMed PMID: ; PubMed Central PMCID: PMC ) Maramattom BV, Wijdicks EF. Acute neuromuscular weakness in the intensive care unit. Crit Care Med Nov;34(11): PubMed PMID: ) McNicoll L, Pisani MA, Zhang Y, Ely EW, Siegel MD, Inouye SK. Delirium in the intensive care unit: occurrence and clinical course in older patients. J Am Geriatr Soc May;51(5): PubMed PMID: ) Mehlhorn J, Freytag A, Schmidt K, Brunkhorst FM, Graf J, Troitzsch U, Schlattmann P, Wensing M, Gensichen J. Rehabilitation interventions for postintensive care syndrome: a systematic review. Crit Care Med May;42(5): PubMed PMID: ) Morello RT, Lowthian JA, Barker AL, McGinnes R, Dunt D, Brand C. Strategies for improving patient safety culture in hospitals: a systematic review. BMJ Qual Saf Jan;22(1):11-8. PubMed PMID: ) Morris PE, Goad A, Thompson C, Taylor K, Harry B, Passmore L, Ross A, Anderson L, Baker S, Sanchez M, Penley L, Howard A, Dixon L, Leach S, Small R, Hite RD, Haponik E. Early intensive care unit mobility therapy in the treatment of acute respiratory failure. Crit Care Med Aug;36(8): PubMed PMID: ) Morris PE, Griffin L, Berry M, Thompson C, Hite RD, Winkelman C, Hopkins RO, Ross A, Dixon L, Leach S, Haponik E. Receiving early mobility during an intensive care unit admission is a predictor of improved outcomes in acute respiratory failure. Am J Med Sci May;341(5): PubMed PMID: ; PubMed Central PMCID: PMC ) Needham DM, Davidson J, Cohen H, Hopkins RO, Weinert C, Wunsch H, Zawistowski C, Bemis-Dougherty A, Berney SC, Bienvenu OJ, Brady SL, Brodsky MB, Denehy L, Elliott D, Flatley C, Harabin AL, Jones C, Louis D, Meltzer W, Muldoon SR, Palmer JB, Perme C, Robinson M, Schmidt DM, Scruth E, Spill GR, Storey CP, Render M, Votto J, Harvey MA. Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference. Crit Care Med Feb;40(2): PubMed PMID: ) Needham DM, Dennison CR, Dowdy DW, Mendez-Tellez PA, Ciesla N, Desai SV, Sevransky J, Shanholtz C, Scharfstein D, Herridge MS, Pronovost PJ. Study protocol: The Improving Care of Acute Lung Injury Patients (ICAP) study. Crit Care Feb;10(1):R9. PubMed PMID: ; PubMed Central PMCID: PMC ) Needham DM, Korupolu R, Zanni JM, Pradhan P, Colantuoni E, Palmer JB, Brower RG, Fan E. Early physical medicine and rehabilitation for patients with acute respiratory failure: a quality improvement project. Arch Phys Med Rehabil Apr;91(4): PubMed PMID: ) Needham DM, Korupolu R. Rehabilitation quality improvement in an intensive care unit setting: implementation of a quality improvement model. Top Stroke Rehabil Jul-Aug;17(4): PubMed PMID: ) Needham DM, Wozniak AW, Hough CL, Morris PE, Dinglas VD, Jackson JC, Mendez-Tellez PA, Shanholtz C, Ely EW, Colantuoni E, Hopkins RO, National Institutes of Health NHLBI ARDS Network. Risk factors for physical impairment after acute lung injury in a national, multicenter study. Am J Respir Crit Care Med May 15;189(10): PubMed PMID: ; PubMed Central PMCID: PMC

8 98) Needham DM. Mobilizing patients in the intensive care unit: improving neuromuscular weakness and physical function. JAMA Oct 8;300(14): PubMed PMID: ) Ohtake PJ, Strasser DC, Needham DM. Rehabilitation for people with critical illness: taking the next steps. Phys Ther Dec;92(12): PubMed PMID: ) Orford NR, Saunders K, Merriman E, Henry M, Pasco J, Stow P, Kotowicz M. Skeletal morbidity among survivors of critical illness. Crit Care Med Jun;39(6): PubMed PMID: ) Page VJ, Ely EW, Gates S, Zhao XB, Alce T, Shintani A, Jackson J, Perkins GD, McAuley DF. Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, doubleblind, placebo-controlled trial. Lancet Respir Med Sep;1(7): PubMed PMID: ) Pandharipande P, Shintani A, Peterson J, Pun BT, Wilkinson GR, Dittus RS, Bernard GR, Ely EW. Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology Jan;104(1):21-6. PubMed PMID: ) Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, Brummel NE, Hughes CG, Vasilevskis EE, Shintani AK, Moons KG, Geevarghese SK, Canonico A, Hopkins RO, Bernard GR, Dittus RS, Ely EW, BRAIN-ICU Study Investigators. Long-term cognitive impairment after critical illness. N Engl J Med Oct 3;369(14): PubMed PMID: ; PubMed Central PMCID: PMC ) Pandharipande PP, Pun BT, Herr DL, Maze M, Girard TD, Miller RR, Shintani AK, Thompson JL, Jackson JC, Deppen SA, Stiles RA, Dittus RS, Bernard GR, Ely EW. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA Dec 12;298(22): PubMed PMID: ) Pandian V, Smith CP, Cole TK, Bhatti NI, Mirski MA, Yarmus LB, Feller-Kopman DJ. Optimizing Communication in Mechanically Ventilated Patients. J Med Speech Lang Pathol. 2014;21(4): PubMed PMID: ; PubMed Central PMCID: PMC ) Parry SM, Berney S, Granger CL, Koopman R, El-Ansary D, Denehy L. Electrical muscle stimulation in the intensive care setting: a systematic review. Crit Care Med Oct;41(10): PubMed PMID: ) Parry SM, Berney S, Koopman R, Bryant A, El-Ansary D, Puthucheary Z, Hart N, Warrillow S, Denehy L. Early rehabilitation in critical care (ericc): functional electrical stimulation with cycling protocol for a randomised controlled trial. BMJ Open. 2012;2(5)PubMed PMID: ; PubMed Central PMCID: PMC ) Patel J, Baldwin J, Bunting P, Laha S. The effect of a multicomponent multidisciplinary bundle of interventions on sleep and delirium in medical and surgical intensive care patients. Anaesthesia Jun;69(6): PubMed PMID: ) Peiris CL, Shields N, Brusco NK, Watts JJ, Taylor NF. Additional Saturday rehabilitation improves functional independence and quality of life and reduces length of stay: a randomized controlled trial. BMC Med Sep 10;11:198. PubMed PMID: ; PubMed Central PMCID: PMC ) Perme C, Chandrashekar R. Early mobility and walking program for patients in intensive care units: creating a standard of care. Am J Crit Care May;18(3): PubMed PMID: ) Peterson JF, Pun BT, Dittus RS, Thomason JW, Jackson JC, Shintani AK, Ely EW. Delirium and its motoric subtypes: a study of 614 critically ill patients. J Am Geriatr Soc Mar;54(3): PubMed PMID: ) Porter ME, Teisberg EO. Redefining Health Care: Creating Value-Based Competition on Results,. USA: Harvard Business School Press; 2006.

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