Table of Contents. Welcome to ISIC18 1. ISIC 18 Technical Programme 13. Conference Committee 2. Local Organizing Committee 2. ISIC 18 Secretariat 2

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1 Table of Contents Welcome to ISIC18 1 Conference Committee 2 Local Organizing Committee 2 ISIC 18 Secretariat 2 Keynote Lecturers 2 Scientific Committee 3 ISIC 18 Programme at a glance 4 Venue 5 Map of ETH Zurich Main Building (Hauptgebäude) 7 Conference information 8 Crystallization Conferences in ISIC 18 Technical Programme 13 TUESDAY, September 13, WEDNESDAY, September 14, THURSDAY, September 15, FRIDAY, September 16, Poster Session A (from nr. 1 to nr on Wednesday, September 14, 2011) 27 Poster Session B (from nr. 101 to nr on Thursday, September 15, 2011) 37 List of Authors 46 List of Participants 53

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3 Welcome to ISIC18 The ISIC (International Symposium on Industrial Crystallization) series is organized by the Working Party on Crystallization of the European Federation of Chemical Engineering (EFCE). Like all previous editions, ISIC18 aims at providing a unique opportunity for international exchange between scientists and engineers of all disciplines, academia and industry, and between novice and expert. The format and logistics of the conference are especially designed to favor the establishment of personal and professional relationships among participants.those who have an interest in crystallization, workingboth in academic institutions as well as in industry, will find ISIC18well worth attending. ISIC 18 presents a broad overview of the science and technology of crystallization, with an overall number of about 90 oral presentations and200 posters.for the first time at an ISIC event, ISIC 18 will be opened by three training tutorials about the fundamentals of industrial crystallization. We are very proud of the truly international character of ISIC 18, with contributions from all continents, with Germany, France, United Kingdom, United States, China, Japan, and Switzerland being the nations with the largest number of contributions. Oral presentations are scheduled during three days, and distributed in five plenary sessions and fifteen parallel sessions. During ISIC 18, five distinguished keynote speakers will provide their perspectives of five important areas of crystallization science and technology. Posters will be discussed in two ad-hoc sessions scheduled on Wednesday and Thursday. A number of exhibitors will be present at ISIC 18 with their state-of-the-art instrumentation and equipment.during the plenary session on Thursday afternoon the EFCE Excellence Award in Crystallization for young researchers will be presented. A goal of ISIC18 will also be to minimize its environmental impact.to this purpose, whenever possible, a sustainable approach in the use of material, means of transportation and food will be adopted and CO2 emissions generated by the congress will be offset by purchasing carbon offsets from the non-profit foundation myclimate (www.myclimate.org). We would like to thank the members of the EFCE Working Party on Crystallization and of the Local Organizing Committee for their help and support, as well as the colleagues in the Scientific Committee for contributing to prepare the scientific agenda. We are grateful to the companies and organizations (see back cover) that have provided financial support. Finally, we want to thank AIDIC, particularly RaffaellaDamerio, for the extraordinary efforts in organizing all aspects of ISIC 18. On behalf of the EFCE Working Party on Crystallization, of the Local Organizing Committee, and of the Scientific Committee, we wish you all a great time in Zurich and we look forward to a stimulating and productive ISIC 18 event. BéatriceBiscans and Marco Mazzotti ISIC 18co-chairs

4 Conference Committee Co-chairs BéatriceBiscans Marco Mazzotti CNRS, University of Toulouse, France ETH Zurich, Switzerland Local Organizing Committee Marco Mazzotti ETH Zurich, Switzerland PirminHidber F.Hoffmann-LaRoche, Switzerland Rolf Hilfiker Solvias, Switzerland Gerhard Muhrer Novartis Pharma, Switzerland Johannes Nagel SGVC & Ciba SC, Switzerland SauroPierucci Politecnico di Milano, Italy Robert Spruijtenburg DSM Nutritional Products, Switzerland Manfred Stepanski SulzerChemtech, Switzerland Thomas Vetter ETH Zurich, Switzerland JochenSchöll Mettler Toledo, Switzerland Elodie Verdurand DSM Nutritional Products, Switzerland DierkWieckhusen Novartis Pharma, Switzerland Uwe Zacher Lonza, Switzerland ISIC 18 Secretariat AIDIC The Italian Association of Chemical Engineering Raffaella Damerio Via Giuseppe Colombo, 81/A I Milano, Italy Phone: ; Fax: Keynote Lecturers Michael McBride DoraiswamiRamkrishna Jens Rieger Gabriele Sadowski Peter Vekilov Yale University, USA Purdue University, USA BASF, Germany TU Dortmund, Germany University of Houston, USA

5 Scientific Committee BéatriceBiscans CNRS, University of Toulouse, France Jerzy Bałdyga Warsaw University of Technology, Poland Wolfgang Beckmann Bayer Technology Services, Germany Richard D. Braatz MIT, Cambridge, USA HeikoBriesen TU Munich, Germany Philippe Carvin Rhodia, France Angelo Chianese Università La Sapienza, Roma, Italy Gerard Coquerel University of Rouen, France Roger Davey University of Manchester, United Kingdom Peter Daudey Albemarle, Netherlands Michael F. Doherty Universityof California Santa Barbara, USA Gilles Févotte École National Supérieure des Mines, Saint Etienne, France Jaime Gómez-Morales IACT-CSIC and University of Granada, Spain Brian Glennon University College Dublin, Ireland Marco Giulietti Sao Paulo State Instituteof Technology and Research, Brasil Mike Hounslow University of Sheffield, United Kingdom Peter Jansens DSM, Netherlands Matthew Jones Astra Zeneca, Sweden Kwang-Joo Kim Hanbat National University, Korea Matthias Kind University of Karlsruhe, Germany Terry Kougoulos Pfizer, United Kingdom Herman Kramer TU Delft, Netherlands Laurent Lafferrere Sanofi Aventis, France Béla G. Lakatos University of Pannonia, Hungary Alison Lewis University of Cape Town, South Africa Heike Lorenz Max Planck Institute, Magdeburg, Germany MarjattaLouhi-Kultanen University of Lappeenranta, Finland Allan S. Myerson MIT, Cambridge, USA Zoltan Nagy Loughborough University, United Kingdom Ka Ming Ng HKUST and NAMI, Hong Kong, China ÅkeRasmuson KTH, Stockholm, Sweden and Univesity of Limerick, Ireland Matthias Rauls BASF, Germany Kevin Roberts University of Leeds, United Kingdom Ronald W. Rousseau Georgia Institute of Technology, USA Andreas Seidel-Morgenstern Max Planck Institute and Univeristy of Magdeburg, Germany Reginald Tan National University of Singapore, Singapore Joachim Ulrich Martin-Luther-Universität Halle Wittenberg, Germany Elias Vlieg RadboudUniversiteit Nijmegen, Netherlands Pieter Vonk DSM, Netherlands Hongyuan(David) Wei Tianjin University, China

6 ISIC 18 Programme at a glance Tuesday, September 13 th, :15-17:00 F30 Tutorial: F3 Tutorial: Monitoring and Control FundamentalAspects 15:00-18:00 E Registration 18:00-19:30 E Welcome Reception Wednesday, September 14 th, :20-08:40 F30 Opening Session 08:40-10:20 F30 Plenary Session 1 - Nucleation 10:20-10:50 E Coffee break 10:50-12:30 F30 Kinetics of crystallization 12: Lunch F3 Fundamentals of nucleation 13:30-15:00 E Poster Session A (from nr. 1 to nr. 100) 15:00-16:20 F30 Plenary Session 2 - Noveldirections 16:20-16:50 E Coffee break 16:50-18:30 F30 Operation of crystallizers 19:15 Working Party Meeting Thursday, September 15 th, 2011 F3 Thermodynamics of crystallization 8:10-9:50 F30 Plenary Session 3 - Modeling and Monitoring 9:50-10:20 E Coffee break 10:20-12:00 F30 Crystal shape modeling and control 12:00-13:00 Lunch F3 Crystallization of inorganic compounds 13:00-14:30 E Poster Session B (from nr. 101 to nr. 198) 14:30-15:50 F30 Plenary Session 4 Chiral crystallization 15:50-16:20 F30 EFCE Award 16:20-16:50 E Coffee break 16:50-17:50 F30 Chiral crystallization processes 19:00 Conference Dinner Friday, September 16 th, 2011 F3 Fundamentals of crystallization 8:20-10:00 F30 Mixing and scale up F3 Novel characterization techniques 10:00-10:30 E Coffee break 10:00-12:30 F30 Plenary Session 5 - Industrial crystallization 12:50-13:00 F30 Closing 13:00-14:00 Lunch F5 Tutorial: Thermo-based Design and Synthesis F5 Novel directions1 F5 Polymorphs and cocrystals F5 Applications of crystallization F5 Monitoring and control F5 Novel directions2

7 Venue ETH Zurich Main Building (Hauptgebäude) Rämistrasse, 101 Zurich - Switzerland ISIC18 will be held in the main building of the ETH Zurich, the renowned Swiss Federal Institute of Technology. ETH Zurich has excellent conference facilities in a lively academic environment, and it is located downtown, 30 min from the airport and at walking distance from the main train station and tourist attractions. Founded in 1855, ETH Zurich today offers researchers an inspiring environment and students a comprehensive education as one of the leading international universities for technology and the natural sciences.eth Zurich has more than 16,000 students from approximately 80 countries, 3,500 of whom are doctoral candidates. More than 400 professors teach and conduct research in the areas of engineering, architecture, mathematics, natural sciences, system-oriented sciences, and management and social sciences.eth Zurich regularly appears at the top of international rankings as one of the best universities in the world. 21 Nobel Laureates have studied, taught or conducted research at ETH Zurich, underlining the excellent reputation of the institute. Zurich is Switzerland's largest city and an internationally reputed financial centre. Zurich hosts a wide variety of economic activities, cultural initiatives and high quality educational institutions. It is famous for its lakeside location and the green, densely wooded hills that crown it. Zurich consistently finds itself at the top of international rankings of cities in terms of quality of life.the weather in September is usually mild, with maximum and minimum average temperature of 20 C and 11 C, respectively. Switzerland is a multi-ethnic, multilingual and multi-confessional nation of almost 8 million inhabitants that has been a federal State since Switzerland has a long tradition of neutrality; it hosts many international organizations, although it joined the United Nations only in 2002.Switzerland s landscape is dominated by the Alps, which are a world-famous tourist attraction. It is a country that fosters high environmental standards, e.g. through a capillary and efficient system of public transportation. Directions By air: from Zurich International Airport, one can reach ETH Zurich either by taxi (15 min, 40.- to 50.- CHF), or by train (to Zurich Hauptbahnhof, see below, 6.- CHF), or by tram (30 min, with tram number 10 from the airport to ETH/Universitätspital, departures every 15 min, 6.- CHF). By train: from Zurich Hauptbahnhof (main station) either on foot (15 min uphill), or by tram (5 min, with trams number 6 or 10, from Hauptbahnhof to ETH/Universitätspital, 2.60 CHF Kurzstrecke). By car: to ETH ZurichZentrum (but parking is practically impossible in Zurich, unless your hotel provides you a parking place). Transportation All ISIC 18 participants will receive a 4-day pass valid on public transportation (tram, buses and boats) in the Zurich central area, the so called zone 10 (see

8 map at every tram- or bus-stop). This includes all the recommended hotels, and the restaurant where the conference dinner will be held, but it does not include the Zurich International Airport, for which a so called Anschlussbillett must be bought (4.10 CHF). The pass is valid only when exhibited together with the ISIC 18 badge. Lunch Lunches (from Wednesday to Friday) will be served at the ETH Zurich mensa Polyterrasse (see directions in the map below), where two different menus, plus one vegetarian menu or a choice from the salad buffet are available (use your lunch voucher that indicates exactly what is included). Those arriving early on Tuesday can use the same mensa, but in this case they have to pay the regular price. Internet At ETH Zurich wireless connection is available to everybody for free: use the network public ; no password is needed. Electrical 220 volts; 50 Hz Climate The weather in Zurich in September is usually mild, with maximum and minimum average temperature of 20 C and 11 C, respectively. Swimming in the lake and in the river is very popular in Zurich, and is often possible also in September; check public bathing facilities and water temperatures at: https://www.stadt-zuerich.ch/ssd/de/index/sport/schwimmen/sommerbaeder.secure.html. Collections at ETH Zurich and at the University of Zurich The scientific collections and archives of ETH Zurich represent a wealth of information, which is maintained, processed and made available to students, researchers and interested members of the public.among these we would like torecommend the GraphischeSammlung (Collection of Prints and Drawings), which is hosted in the main building of ETH, and focusterra, the Earth Science Research and Information Centre of ETH Zurich, which is located in Sonneggstrasse 5 (5 min on foot from the ISIC 18 venue). The University of Zurich hosts also several collections and museums, among which we would like to highlight the Zoological Museum and the Archeological Collection, which are both at a few minutes walking distance from the main building of ETH Zurich.

9 Map of ETH Zurich Main Building (Hauptgebäude)

10 Conference information Location All scientific activities of ISIC 18 take place in the main building (Hauptgebäude) of the ETH Zurich, in the downtown campus, wherethe conference desk, the conference rooms, the poster halls and the exhibitionare located (see the maps above for orientation). Registration The registration of the delegates will take place Tuesday, September 13 th from 12:00 to 18:00 and Wednesday, September14 th from 8:00. All the delegates are invited to register and collect the conference package at the conference desk situated in the entrance hall of the ETH Zurich. Tutorials For the first time at ISIC conferences three different 4-hour training tutorials to learn about various fundamental aspects of industrial crystallization will be offered in the afternoon of Tuesday September 13 th, Attendance is free. Oral Presentations Oral presentations will be allotted 20 minutes including discussion, except for the five keynote lectures (40 minutes with discussion). A PC will be available in the session rooms where authors are invited to upload their presentation well in advance, in order to avoid last minute problems. Posters Panels for posters have a width of 120 cm and a height of 170 cm. For the sake of readability, we recommend authors to prepare posters with A0 format. Poster panels will be identified by the same number assigned to the poster in the Technical Programme, as follows: P\5reads as: poster presentation\ panel number. Posters will be on display in two batches, i.e. from Wednesdaymorning to Wednesday evening and from Thursday morning to Thursday evening, according to the conference programme. Posters will be mounted on and removed from the supporting panels by the authors. Note that on each day posters have to be removed by the authors on the same evening before leaving the conference facility. Two specific Poster Presentation Sessions and discussions are scheduled on Wednesday, September 14 th, from 13:30 to 15:00, and on Thursday, September15 th, from 13:00 to 14:30 (see programme). During these, authors are requested to be in attendance at their poster board to facilitate interaction and exchange. Exhibition On the ground floor, close to the poster display venues and to the area where coffee breaks will be held, an area will be dedicated to the exhibition of state-of-the-art instrumentation and equipment of a few international commercial suppliers. Certificates All participants wishing to have a participation certificate should ask the Secretariat. The certificate will be available from Thursday,September 15 th (or after the conference).the invoice (as a receipt of your payment) will be ed only by the AIDIC Accountant after the fee payment (cash or credit card). Dress code In all conference venues casual attire is deemed adequate. Photographic equipment The use of camerasis not allowed during the programme sessions (oral and poster). Cameras are permitted on the exhibit floor; however permission from the exhibitors involved must be obtained before photographs may be taken.

11 Conference dinner The conference dinner will be served on Thursday, September15 th at 19:00 (with aperitives first) at the Lake Side Restaurant, BelleriveStrasse 170, Zurich (see map on the next page). The ticket to the dinner is included in the registration fee; it must be presented at the Restaurant entrance and exhibited at the table, so that the participants entitled to the vegetarian menu can be identified. Business casual attire is recommended, as well as a pullover. The restaurant can be reached on foot (4 km), by tram (20-30 min with tram 9 to Bellevue and then either tram 2 or 4 to Fröhlicherstrasse or bus 912 or 916 to Chinagarten), by boat with the Limmat River Boat (30 min of travel from Landesmuseum, but the boat leaves every 30 min and has limited seats; as alternative one can take tram 4 from the tram stop Central, which is 5 min from Landesmuseum). Meeting of the EFCE Working Party on Crystallization This meeting, including dinner, is only for invited members of the EFCE WP, and will be held on Wednesday, September 14 th at 19:15 at the Sorell HotelZürichberg, Orellistrasse 21, Zurich (see map below). The restaurant can be reached on foot (2 km, uphill) or by tram (15 min with tram 6 to Zoo, and then on foot 5 min). Social Programme for accompanying parties - Excursions can be suggested or organized for accompanying parties (minimum 10 people). For further information in case of interest please contact the ISIC 18 Secretariat. A B C

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13 Crystallization Conferences in 2012 Gordon Research Conference on Crystal Engineering The 2012 Gordon Research Conference on Crystal Engineering will be held on June 10-15, 2012 at the Waterville Valley Resort, Waterville Valley, New Hampshire. Website: Contact: Robin D. Rogers, The 10th International Workshop on Crystal Growth of Organic Materials (CGOM10) will take place at the University of Limerick, Ireland, onjune 11-14, Website: Contacts: Denise Croker, and The BACG and IOCG announce that the 4th European Conference on Crystal Growth (ECCG4) will take place June 17-20, 2012 in Glasgow, Scotland hosted at the University of Strathclyde. Website: Contact: Alastair BIWIC 2012 BIWIC 2012, the 19 th International Workshop on Industrial Crystallization will be held in September 2012 in Tianjin, China. Website: in preparation Contact: Joachim Ulrich, 18 th Larson Symposium The 18th Larson Workshop (2012 Meeting of the Association for Crystallization Technology) will be held October 7-10, 2012 at the Fess Parker Double Tree Hilton in Santa Barbara, CA. Website: in preparation Contact: Linda K. Edson,

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15 ISIC 18 Technical Programme TUESDAY, September 13, 2011 PARALLEL TUTORIAL SESSION Tu 13:15-17:00 Monitoring and Control Room: Audimax MONITORING, MODELING AND CONTROL OF CRYSTALLIZATION PROCESSES Févotte G., Kramer H., Nagy Z.K., Mesbah A. (Ecole Nationale Supérieure des Mines, France; Delft University of Technology, The Netherlands; Loughborough University, UK) Tu 13:15-17:00 Fundamental Aspects Room: F3 FUNDAMENTALS OF INDUSTRIAL CRYSTALLIZATION:PRODUCT QUALITY IN RELATION TO NUCLEATION AND CRYSTAL GROWTH ter Horst J.H., Meekes H. (Delft University of Technology, The Netherlands; Radboud University Nijmegen, The Netherlands) Tu 13:15-17:00 Thermodynamics-based Design and Synthesis Room: F5 THERMODYNAMICS-BASED DESIGN AND SYNTHESIS FROM SOLUBILITY TO OPTIMUM PROCESS Wibowo C. (ClearWaterBay Technology, Inc., USA) Tu 12:00-18:00 Registration Tu 18:00-19:30 Welcome Reception

16 WEDNESDAY, September 14, 2011 Wed 8:20-8:40 Opening Session Room: Audimax Chair: Mazzotti M., Biscans B. Wed 8:40-10:20 PLENARY SESSION 1 - Nucleation Room: Audimax Chair: Glennon B. NUCLEATION OF CRYSTALS IN SOLUTION Vekilov P.G. (University of Houston, USA) MICROFLUIDIC, A NEW SCALE TO STUDY NUCLEATION Ildefonso M., Candoni N., Veesler S. (CINaM-CNRS, France) MICROFLUIDIC TOOLBOX FOR THE CRYSTALLIZATION OF ORGANIC MOLECULES Teychene S., Biscans B. (CNRS, Univ. de Toulouse, France; CNRS- Laboratoire de Génie Chimique, France) A NEW VIEW ON CRYSTAL NUCLEATION IN INDUSTRIAL CRYSTALLIZATION Kadam S., Kulkarni S., ter Horst J.H., Kramer H. (Delft University of Technology, The Netherlands) Wed 10:20-10:50 Coffee break PARALLEL SESSIONS Wed 10:50-12:30 KINETICS OF CRYSTALLIZATION Room: Audimax Chair: Chianese A. CALCIUM CARBONATE: MODELING OF REACTION KINETICS IN TUBULAR REACTOR Hautaniemi M., Imppola O., Solismaa P., Kukkamaki E., Kallas J., Louhi-Kultanen M. (Lappeenranta University of Technology, Finland; Wetend Technologies Ltd, Finland; UPM Research Center, Finland; Tallinn University of Technology, Estonia) EFFECT OF NITRATE(V) IONS ON CSD OF STRUVITE PRODUCED IN A CONTINUOUS DT MSMPR CRYSTALLIZER NEURAL NETWORK MODEL OF REACTION CRYSTALLIZATION PROCESS Piotrowski K., Hutnik N., Matynia A. (Silesian University of Technology, Poland; Wroclaw University of Technology, Poland)

17 CONTROL OF SUPERSATURATION BY COMBINING SALTING OUT AND COOLING IN THE TECHNICAL PROTEIN CRYSTALLIZATION Alten S., Bohme P.P., Kind M. (Karlsruhe Institute of Technology, Germany) INVESTIGATION ON THE SPONTANEOUS NUCLEATION AND POLYMORPHIC TRANSFORMATION OF D-MANNITOL Su W., Glennon B., Hao H., Barrett M. (University College Dublin, Ireland) TURBIDITY AND ENDOSCOPY ASSISTED MONITORING OF PSEUDOPOLYMORPHIC TRANSFORMATION OF CITRIC ACID Simon L., Reinlein S., Hungerbuehler K. (ETH Zurich, Switzerland; Technical University of Munich, Germany) Wed 10:50-12:30 FUNDAMENTALS OF NUCLEATION Room: F3 Chair: Gómez-Morales J. METHOD TO STUDY THE PRIMARY NUCLEATION FOR SOLID SOLUTION: APPLICATION TO URANIUM NEODYMIUM OXALATE COPRECIPITATION Parmentier D., Bertrand M., Plasari E., Vigier N. (CEA Marcoule, France; ENSIC-CNRS, France; AREVA NC, France) SMALL VOLUME SYSTEM: A KEY TO CONTROL NUCLEATION Grossier R., Hammadi Z., Morin R., Magnaldo A., Veesler S. (MIT, USA; CNRS, France; CEA-Valrhô, France; CINaM-CNRS, France) PRECIPITATION AT VERY HIGH SUPERSATURATIONS A CHALLENGE FOR CLASSICAL THEORY AND INDUSTRIAL APPLICATIONS Lewis A.E., Mangere M., Mokone T., Van Hille R., Randall D.G., Hendricks U. (University of Cape Town, South Africa; University of Cape Town, South Africa) THE TIME-RESOLVED PH AND WAXS STUDIES OF CALCIUM CARBONATE BATCH PRECIPITATION Poh C., Hounslow M., Ryan A., Fairclough P., Ristic R. (University of Sheffield, UK) IDENTIFICATION OF BOUNDS ON NUCLEATION RATES IN DROPLET-BASED MICROFLUIDIC SYSTEMS Chen K., Goh L., He G., Bhamidi V., Kenis P.J.A., Zukoski C.F., Braatz R.D. (University of Illinois at Urbana-Champaign, USA; General Electric, Singapore; Institute of Chemical & Engineering Sciences, Singapore; Abbott Laboratories, USA; Massachusetts Institute of Technology, USA)

18 Wed 10:50-12:30 NOVEL DIRECTIONS 1 Room: F5 Chair: Wei D. NUCLEATION ON ENGINEERED SURFACES: CONCOMITANT POLYMORPHISM AND NANO-CRYSTAL FORMATION Chen J., Yang X., Myerson A. (Massachusetts Institute of Technology, USA) THEORETICAL AND EXPERIMENTAL STUDY OF THE PRECIPITATION MECHANISMS AND CRYSTAL GROWTH OF INSOLUBLE SALTS IN POROUS MEDIA Athanasakou G., Arvaniti E., Paraskeva C., Koutsoukos P. (University of Patras, Greece; FORTH/ICE-HT, Greece) ANTISOLVENT CRYSTALLIZATION IN SUPERCRITICAL FLUID: AN INTERESTING TECHNIQUE FOR POLYMORPH SCREENING Mangin D., Baltes D., Klein J.P., Monnier O. (Université Lyon 1, France; Sanofi Aventis, France; LAGEP, France) INTENSIFIED CRYSTALLIZATION IN COMPLEX MEDIA: HEURISTICS FOR CRYSTALLIZATION OF PLATFORM CHEMICALS Urbanus J., Roelands M., Verdoes D., ter Horst J.H. (TNO, The Netherlands; Delft University of Technology, The Netherlands) SUPERCRITICAL FLUIDS AS ALTERNATIVE MEDIA FOR THE FORMATION OF PHARMACEUTICAL COCRYSTALS Padrela L., Rodrigues M.A., Velaga S.P., Fernandes A.C., Matos H.A., Azevedo E.G. (Technical University of Lisbon, Portugal; Lulea University of Technology, Sweden) Wed 12: Lunch Wed 13:30-15:00 POSTER SESSION A (from nr. 1 to nr.100) Wed 15:00-16:20 PLENARY SESSION 2 - Novel Directions Room: Audimax Chair: Ulrich J. THERMODYNAMIC MODELING OF DRUG CRYSTALLIZATION PHENOMENA Sadowski G. (TU Dortmund, Germany) ELECTROSPRAYING ACTIVE PHARMACEUTICAL INGREDIENTS Revalor E., Wang M., Myerson A., Rutledge G., Trout B. (MIT, USA; Massachusetts Institute of Technology, USA)

19 HIGH SPEED IMAGING OF ULTRASOUND IN SEEDED CALCITE SONOCRYSTALLIZATION Wagterveld M., Boels L., Mayer M., Witkamp G.J. (Delft University of Technology, The Netherlands; Wetsus, The Netherlands) Wed 16:20-16:50 Coffee break Wed 16:50-18:30 OPERATION OF CRYSTALLIZERS Room: Audimax Chair: Wieckhusen D. ACHIEVING A TARGET CRYSTAL SIZE DISTRIBUTION BY CONTINUOUS SEEDING AND CONTROLLED GROWTH Jiang M., Fujiwara M., Wong M.H., Zhu Z., Zhang J., Zhou L., Wang K., Ford A.N., Si T., Hasenberg L.M., Braatz R.D. (Massachusetts Institute of Technology, USA; University of Illinois at Urbana-Champaign, USA; University of Illinois, USA) RAPID DETERMINATION OF A NEAR-OPTIMAL SEEDING PROCEDURE AT AN INDUSTRIAL SCALE BATCH CRYSTALLIZER Kadam S., Vissers J., Forgione M., Geertman R., Daudey P., Kramer H. (Delft University of Technology, The Netherlands; Eindhoven University of Technology, The Netherlands; MSD, The Netherlands; Albemarle Catalysts B.V., The Netherlands) WHEN BAD SEEDS BECOME GOOD Lee M.Y., Dominey A. (GlaxoSmithKline, UK) API CRYSTALLIZATION IN A CONTINUOUS-FLOW EQUIPMENT Eder R., Besenhard M., Schrank S., Roblegg E., Gruber-Woelfler H., Khinast J. (Graz University of Technology, Austria; Research Center Pharmaceutical Engineering GmbH, Austria; Karl-Franzens University Graz, Austria) GAS-LIQUID REACTIVE CRYSTALLIZATION OF LITHIUM CARBONATE BY A FALLING FILM TOWER Sun Y., Song X., Wang J., Yu J. (East China University of Science & Tech., P.R.China) Wed 16:50-18:30 THERMODYNAMICS OF CRYSTALLIZATION Room: F3 Chair: Roberts K. IMPROVING THE STABILITY OF CRYSTALLINE TUBES Wachsmuth A., Stelzer T., Ulrich J. (Martin-Luther Universitaet Halle- Wittenberg, Germany)

20 PROMOTING AND INHIBITING EFFECTS OF ADDITIVES ON THE GROWTH OF POLAR γ-glycine AND DL-ALANINE CRYSTALS Han G., Chow P.S., Tan R.B.H. (Institute of Chemical & Engineering Sciences, Singapore) DETERMINATION OF THE BROMLEY'S CONTRIBUTIONS TO ESTIMATE THE ACTIVITY COEFFICIENT OF NEODYMIUM COMPOUNDS Lalleman S., Bertrand M., Plasari E., Sorel C., Moisy P. (CEA Marcoule, France; ENSIC-CNRS, France) DECIPHERING COMPLICATED PHASE BAHAVIOR OF MULTI- POLYMORPH PHARMACEUTICAL COMPOUNDS - APPLICATION OF FREE ENERGY CALCULATION OF EUTECTIC MIXTURES Erdemir D., Gao Q., Hsieh D.S., Huang J., Leahy D., Ng A., Lai C. (Bristol-Myers Squibb co., USA) DEPENDENCE OF TRIGLYCERIDE CRYSTAL NUCLEATION RATES ON PRESSURE Yamamoto H., Katsube Y., Miyake S., Endou F., Takahashi Y., Okabayashi Y., Nakazaki C. (Fukuyama University, Japan) Wed 16:50-18:30 POLYMORPHS AND CO-CRYSTALS Room: F5 Chair: Verdurand E. TARGETING RIGHT POLYMORPHS AND HYDRATES IN MANUFACTURING OF ACTIVE PHARMACEUTICAL INGREDIENTS Karpinski P. (Novartis Pharma AG, USA) QBD BASED CRYSTALLIZATION PROCESS DEVELOPMENT FOR A POLYMORPHIC DRUG - TOLBUTAMIDE Thirunahari S., Chow P.S., Tan R.B.H. (Institute of Chemical & Engineering Sciences, Singapore) PHASE SCREENING AND SELECTION IN AN API SYSTEM WITH NUMEROUS CRYSTALLINE PHASES Petrova R., Lamberto D., Sirota E., Pyrz W., Kim B., Mcgachy N., Itoh T., Mckeown A., Tsou N., Ball R., Lohani S., Kendall R., Wenslow R. (Merck & Co., Inc, USA; Merck & Co., Inc., USA; Merck Sharp & Dohme Corp., UK) IS STOICHIOMETRIC DIVERSITY OF COCRYSTALS DETERMINED BY SOLUTION MICROSTRUCTURE?-- MOLECULAR DYNAMICS APPROACH AND A CASE STUDY Feng Y., Dang L., Wei Y., Wei H.Y. (Tianjin University of Science &Tech., P.R.China)

21 A THERMODYMANICALLY GUIDED APPROACH TO CO-CRYSTAL SCREENING: APPLICATION TO MALEIC ACID / CAFFEINE SYSTEM Leyssens T., Springuel G., Candoni N., Veesler S. (Université Catholique de Louvain, Belgium; CINaM-CNRS, France) Wed 19:15 WP Dinner THURSDAY, September 15, 2011 Thu 8:10-9:50 PLENARY SESSION 3 - Modeling and Monitoring Room: Audimax Chair: Hounslow M. TOWARDS CONTROL OF CRYSTAL SHAPE. CRYSTALLIZATION AND DISSOLUTION Singh M., Ramkrishna D. (Purdue University, USA) DESIGN AND OPTIMIZATION OF PLUG FLOW CRYSTALLIZERS Ferguson S., Morris G., Barrett M., Hao H., Glennon B. (University College Dublin, Ireland) PAT MONITORING AND PBE MODELING OF BATCH COOLING SOLUTION CRYSTALLIZATION IN THE PRESENCE OF IMPURITIES Gherras N., Févotte G. (Ecole Nationale Supérieure des Mines, France) A MODEL FOR CRYSTAL GROWTH FROM SOLUTIONS CONTAINING MULTIPLE CONFORMERS Derdour L., Pack S., Skliar D., Lai C., Vernille J., Kiang S. (Bristol-Myers Squibb co., USA) Thu 9:50-10:20 Coffee break PARALLEL SESSIONS Thu 10:20-12:00 CRYSTAL SHAPE MODELING AND CONTROL Room: Audimax Chair: Vetter T. CRYSTAL HABIT PREDICTION INCLUDING THE LIQUID AS WELL AS THE SOLID SIDE Schmidt C., Ulrich J. (Martin-Luther Universitaet Halle-Wittenberg, Germany) GENERIC FRAMEWORK FOR CRYSTAL MEASURE CALCULATION AND CRYSTAL MORPHOLOGY Reinhold A., Briesen H. (Technical University of Munich, Germany)

22 SOLVENT-INDUCED HABIT CHANGE OF SUCCINIC ACID Lemmer S., Ruether F., Sadowski G., Schembecker G. (TU Dortmund, Germany) CRYSTAL MORPHOLOGY CONTROL BY USING MODULATED OPERATION UNDER SUSPENSION CONDITIONS Takiyama H., Imanari M. (Tokyo Univ. of Agriculture and Tech., Japan) 2D POPULATION BALANCE MODEL FOR CRYSTALLIZATION OF NEEDLE-SHAPE CRYSTALS WITH FRAGMENTATION Borsos Á., Lakatos B. (University of Pannonia, Hungary) Thu 10:20-12:00 CRYSTALLIZATION OF INORGANIC COMPOUNDS Room: F3 Chair: Louhi-Kultanen M. CALCIUM CARBONATE CRYSTALLIZATION IN THE PRESENCE OF ADDITIVES Kirboga S., Oner M. (Yildiz Technical University, Turkey) ANTI-CAKING AGENTS FOR SODIUM CHLORIDE AS A CRYSTAL GROWTH INHIBITOR: INTERACTIONS STUDIED USING VARIOUS TECHNIQUES Bode A., Vonk V., Kok D., Steensma M., Jiang S., Meijer J., Van Enckevort W., Vlieg E. (Radboud University Nijmegen, The Netherlands; AkzoNobel Industrial Chemicals, The Netherlands) PRECIPITATION OF AMORPHOUS COLLOIDAL SILICA FROM AQUEOUS SOLUTIONS Baldyga J., Jasinska M., Jodko K., Petelski P. (Warsaw University of Technology, Poland) PROPERTIES OF AN AMORPHOUS MAGNESIUM SILICATE SYNTHESIZED BY PRECIPITATION. Dietemann M., Baillon F., Espitalier F., Calvet R., Accart P., Greenhill- Hooper M. (Ecole des Mines d'albi, France; Rio Tinto Minerals, France) KINETIC STUDY ON PEI-ASSISTED REACTIVE CRYSTALLIZATION OF MONODISPERSE STRONTIUM SULFATE MICROCRYSTALS Mikami T., Hirasawa I. (Tsuruoka National College of Technology, Japan; Waseda University, Japan) Thu 10:20-12:00 APPLICATIONS OF CRYSTALLIZATION Room: F5 Chair: Stepanski M. MELT CRYSTALLIZATION OF CAPROLACTAM IN A CONTINUOUS CRYSTALLIZER WITH FINES REMOVAL Misztal S. (Wroclaw University of Technology, Poland)

23 PRODUCTION AND EFFECT OF SPECIFIED SEED CRYSTALS ON CRYSTALLIZATION KINETICS AND STRUCTURE OF CONFECTIONARY FATS Ehlers D., Hanselmann W., Windhab E. (ETH Zurich, Switzerland) TWO CRYSTALLIZATION ROUTES TO SYNTHESIZE CARBONATE- APATITE NANOPARTICLES FOR BIOMEDICAL APPLICATIONS Delgado-Lopez J.M., Rodriguez I., Iafisco M., Hernandez-Hernandez A., Gòmez-Morales J. (IACT, CSIC-UGR, Spain; Università del Piemonte Orientale, Italy) MICROBIALLY INDUCED PHOSPHORUS PRECIPITATION INSIDE AEROBIC GRANULES FOR WASTEWATER TREATMENT Manas Llamas A., Biscans B., Sperandio M. (LISBP/LGC/INSA, France; CNRS-Laboratoire de Génie Chimique, France; LISBP/INSA, France) SEMI-BATCH CRYSTALLIZATION OF GYPSUM FROM CALCITE AND SULFURIC ACID Bard F., Garcia D., Févotte G. (Ecole Nationale Supérieure des Mines, France) Thu 12:00-13:00 Lunch Thu 13:00-14:30 POSTER SESSION B (from nr. 101 to nr. 198) Thu 14:30-15:50 PLENARY SESSION 4 - Chiral Crystallization Room: Audimax Chair: Davey R. GRINDING TO HOMOCHIRALITY THE MECHANISM OF VIEDMA RIPENING Mcbride M., Tully J., Ulas G. (Yale University, USA) NOVEL APPROACHES FOR ENANTIOSEPARATION BY CRYSTALLIZATION Lorenz H., Seidel-Morgenstern A. (Max Planck Institute Magdeburg, Germany) ODDITIES OF THE CHIRAL DISCRIMINATION BETWEEN ENANTIOMERS IN THE SOLID STATE Gonella S., Rougeot C., Mahieux J., Guillen F., Plaquevent J.C., Coquerel G. (Université de Rouen, France; Université Paul Sabatier, France) Thu 15:50-16:20 EFCE Award Thu 16:20-16:50 Coffee break

24 Thu 16:50-17:50 CHIRAL CRYSTALLIZATION PROCESSES Room: Audimax Chair: Lorenz H. DESIGN OF CRYSTALLIZATION PROCESSES FOR CHIRAL RESOLUTION APPLIED TO SYSTEMS EXHIBITING OILING OUT Codan L., Babler M.U., Mazzotti M. (ETH Zurich, Switzerland; KTH Royal Institute of Technology, Sweden) ENANTIOMERIC PURIFICATION OF A RACEMIC COMPOUND- FORMING SYSTEM BASED ON DIFFERENT HYDRATES Le Minh T., Lorenz H., Seidel-Morgenstern A. (Max Planck Institute Magdeburg, Germany) VIEDMA RIPENING: CHIRAL PURITY THROUGH ATTRITION- ENHANCED DERACEMIZATION Meekes H., Noorduin W., Van Enckevort W., Kaptein B., Kellogg R., Tully J., Mcbride M., Vlieg E. (Radboud University Nijmegen, The Netherlands; Harvard University, USA; DSM, The Netherlands; Syncom BV, The Netherlands; Yale University, USA) CHIRAL PURIFICATION OF GLUTAMIC ACID ENANTIOMERS USING A NON-SELECTIVE BARRIER MEMBRANE AND DUAL-CHAMBER CRYSTALLIZATION Svang-Ariyaskul S., Koros W., Rousseau R. (Georgia Institute of Technology, USA) Thu 16:50-17:50 FUNDAMENTALS OF CRYSTALLIZATION Room: F3 Chair: Lewis A.E. PRECIPITATION OF PIPERAZINE IN THE PIPERAZINE-H2O-CO2 SYSTEM Ma X., Kim I., Beck R., Knuutila H., Andreassen J.P. (Norwegian Univ. of Science & Techn., Norway; SINTEF, Norway) EXPLOITING POLYMORPHISM IN THE PURITY ENHANCEMENT OF LINCOMYCIN HYDROCHLORIDE Qian G., Wu Y., Zhou X. (East China University of Science &Tech., P.R.China) INFLUENCE OF RAPID INITIAL MIXING ON PARTICLE FORMATION KINETICS IN ANTISOLVENT CRYSTALLISATION OF VALINE Brown A., Schacht U., Florence A., Soos M., Sefcik J. (University of Strathclyde, UK; Swiss Federal Institute of Technology, Switzerland) AGEING MECHANISM OF SILVER NANORODS IN AQUEOUS SOLUTION Segets D., Damm C., Yang G., Vieweg B., Spiecker E., Peukert W. (University of Erlangen-Nuremberg, Germany; Center for Nanoanalysis and Electron Microscopy, Germany)

25 Thu 16:50-17:50 MONITORING AND CONTROL Room: F5 Chair: Tan R.B.H. ONLINE MULTIDIMENSIONAL PSD MONITORING AND PBE MODELING OF CRYSTAL GROWTH Schorsch S., Vetter T., Mazzotti M. (ETH Zurich, Switzerland) NOVEL CONTROL OF SUPERSATURATION ON AN INDUSTRIAL SCALE PHARMACEUTICAL BATCH COOLING CRYSTALLIZER Vissers J., Forgione M., Kadam S., Daudey P., Backx T., Huesman A., Kramer H., Van Den Hof P. (Eindhoven University of Technology, The Netherlands; Delft University of Technology, The Netherlands; Albemarle Catalysts B.V., The Netherlands) AUTOMATED PROCESS DEVELOPMENT VIA NOVEL ATR-FTIR FEEDBACK CONTROL STRATEGIES Barrett M., Hao H., Duffy D., Glennon B. (University College Dublin, Ireland) CRYSTALLIZATION-IN-EMULSION PROCESS IN STIRRED REACTOR: IN SITU MEASUREMEMNT OF DROPLET AND PARTICLE SIZE DISTRIBUTIONS Khalil A., Puel F., Chevalier Y., Galvan J.M., Rivoire A., Klein J.P. (Universite Claude Bernard Lyon 1, France; LAGEP, France) Thu 19:00 Conference Dinner FRIDAY, September 16, 2011 PARALLEL SESSIONS Fri 8:20-10:00 MIXING AND SCALE UP Room: Audimax Chair: Seidel-Morgenstern A. LARGE EDDY SIMULATION OF MIXING EFFECTS ON THE COURSE OF PRECIPITATION PROCESS Makowski L., Orciuch W., Baldyga J. (Warsaw University of Technology, Poland) MODELING OF THE TETRAVALENT URANIUM OXALATE PRECIPITATION BY COMBINING LARGE EDDY SIMULATION HYDRODYNAMIC MODEL AND KINETIC LAWS Bertrand M., Plasari E., Lamarque N., Lebaigue O., Ducros F. (CEA Marcoule, France; ENSIC-CNRS, France; European Centre for Research and Advanced Training in Scientific Computation, France)

26 CONTINUOUS PRECIPITATION OF L-ASPARAGINE IN A MICROMIXER: KINETIC CHARACTERIZATION AND PROCESS DESIGN Lindenberg C., Mazzotti M. (Novartis Pharma AG, Switzerland; ETH Zurich, Switzerland) SCALE-UP OF SUSPENSION CRYSTALLISERS USING A PREDICTIVE MODEL FRAMEWORK Westhoff G., Kramer H. (FrieslandCampina Domo, The Netherlands; Delft University of Technology, The Netherlands) CRYSTALLIZATION SCALE-UP IN THE CHEMICAL INDUSTRY ENSURING SUCCESS FROM LAB TO MANUFACTURING Schoell J., Redman T., Smith B., O Grady D., Barrett M. (Mettler Toledo, USA; University College Dublin, Ireland) Fri 8:20-10:00 NOVEL CHARACTERIZATION TECHNIQUES Room: F3 Chair: Kind M. POISEUILLE FLOW CRYSTALLIZER - A NOVEL DEVICE IN WHICH TO CHARACTERISE CRYSTAL AGGREGATION DURING PRECIPITATION FROM SOLUTION Hounslow M., Pitt K. (University of Sheffield, UK) IMPROVED CORRELATIONS OF SINGLE-FREQUENCY ULTRASOUND VELOCITY AND ATTENUATION TO MOST IMPORTANT SUSPENSION PROPERTIES VIA PHENOMENOLOGICAL MODELS Pertig D., Stelzer T., Ulrich J. (Martin-Luther Universitaet Halle- Wittenberg, Germany) A RAPID METHOD FOR SCREENING CRYSTALLIZATION CONDITIONS AND PHASES OF AN ACTIVE PHARMACEUTICAL INGREDIENT Detoisien T., Taulelle P., Colson D., Klein J.P., Veesler S. (CNRS, France; Oril industrie, France; LAGEP, France; CINaM-CNRS, France) ACOUSTIC ON-LINE MONITORING OF SOLUTION CRYSTALLIZATION PROCESS IN PURE AND IMPURE MEDIA Gherras N., Serris E., Févotte G. (Ecole Nationale Supérieure des Mines, France) ONLINE MONITORING OF CRYSTALLIZATION PROCESSES USING DIGITAL HOLOGRAPHY Khanam T., Rajendran A., Kariwala V., Asundi A.K. (Nanyang Technological University, Singapore)

27 Fri 8:20-10:00 NOVEL DIRECTIONS 2 Room: F5 Chair: Hirasawa I. EFFECT OF TAYLOR VORTEX ON THE POLYMORPHIC TRANSFORMATION OF SULFAMERAZINE Lee S., Kim W.S., Choi G.J., Myerson A. (Kyung Hee University, Korea; Inje University, Korea; Massachusetts Institute of Technology, USA) ELECTROSPRAY CRYSTALLIZATION: A SIMPLE TECHNIQUE TO CREATE HIGH QUALITY NANOCRYSTALS Radacsi N., Stankiewicz A.I., Aigner Z., Creyghton Y.L.M., Van Der Heijden A.E.D.M., ter Horst J.H. (Delft University of Technology, The Netherlands; University of Szeged, Hungary; TNO Defence, Security and Safety, The Netherlands) PREPARATION OF COMPOSITE PARTICLES BY LIQUID-LIQUID INTERFACIAL CRYSTALLIZATION Wake T., Shirakawa Y., Shimosaka A., Hidaka J. (Doshisha University, Japan) NANOPRECIPITATION IN CONFINED IMPINGING JET MIXERS: PRODUCTION AND CHARACTERIZATION OF PEGYLATED NANOPARTICLES FOR PHARMACEUTICAL USE Valente I., Celasco E., Marchisio D., Barresi A. (Politecnico di Torino, Italy) CHARACTERIZATION OF FLASH CRYSTALLIZATION PROCESS Wood B., Hao H., Barrett M., Glennon B. (University College Dublin, Ireland) Fri 10:00-10:30 Coffee break Fri 10:00-12:30 PLENARY SESSION 5 - INDUSTRIAL Room: Audimax Chair: Jansens P. PRECURSOR STRUCTURES IN CRYSTALLIZATION AND PRECIPITATION AND CONTROL OF PARTICLE FORMATION BY POLYMERS Rieger J. (BASF SE, Germany) MODIFYING API PHYSICAL PROPERTIES VIA PARTICLE ENGINEERING TECHNIQUES FROM THE SAME SOLVENT SYSTEM Boukerche M. (Pfizer, UK) CRYSTALLISATION PROCESS MODELS FOR THE PHARMACEUTICAL INDUSTRY: EFFICIENT WORKFLOWS FOR VALIDATION AGAINST EXPERIMENTS AND SCALE-UP Cocchini U., Bermingham S. (GSK R&D, UK; Process Systems Enterprise Ltd, UK)

28 INDUSTRIAL FEEDBACK ON THE USE OF PROCESS ANALYTICAL TECHNOLOGY (PAT) FOR CRYSTALLIZATION PROCESS DEVELOPMENT Gauer C., Bieri N.R., Meier U. (Novartis Pharma AG, Switzerland) SUPERSATURATION AND DIRECT NUCLEATION CONTROL OF AN INDUSTRIAL PHARMACEUTICAL CRYSTALLISATION PROCESS USING A CRYSTALLISATION PROCESS INFORMATICS SYSTEM Nagy Z.K., Baker M., Pedge N., Steele G. (Loughborough University, UK; AstraZeneca, UK) INDUSTRIAL CRYSTALLIZATION: CHALLENGES AND SCIENTIFIC ISSUES Biscans B. (CNRS-Laboratoire de Génie Chimique, France) Fri 12:50-13:00 Fri 13:00-14:00 Closing Lunch

29 Poster Session A (from nr. 1 to nr on Wednesday, September 14, 2011) Fundamentals of crystallization science 1) STUDY OF THE NUCLEATION AND GROWTH MECHANISM OF CEFODIZIME SODIUM Zhang X., Yin Q., Zhang M., Wang Y., Hou B. (Tianjin University of Science &Tech., P.R.China) 2) A NEW METHOD FOR PROTEIN PURIFICATION BY CRYSTALLIZATION Liu Y., Pietzsch M., Ulrich J. (Martin-Luther Universitaet Halle-Wittenberg, Germany) 3) INFLUENCE OF THE COMPOSITION OF WATER/ACETONE MIXTURES ON POLYMORPHIC TRANSFORMATION OF CANDESARTAN CILEXETIL Cui P., Yin Q., Gong J., Wang Y., Hou B., Wang J. (Tianjin University of Science &Tech., P.R.China) 4) MECHANISM OF SPECIFIC INFLUENCE OF L-GLUTAMIC ACID ON THE CRYSTAL SHAPE OF L-VALINE Yoshiura H., Nagano H., Hirasawa I. (Kyowa Hakko Bio Co., Ltd., Japan; Waseda University, Japan) 5) THE EFFECT OF IONIC LIQUIDS ON SOLUBILITY AND MORPHOLOGY OF LYSOZYME Wang Z., Dang L. (Tianjin University of Science &Tech., P.R.China) 6) GROWTH BEHAVIOUR AND SATURATION DEPENDENCE OF A MODEL CRYSTAL/SOLUTION INTERFACE Reilly A., Briesen H. (Technical University of Munich, Germany) 7) NUMERICAL SIMULATION OF METASTABLE ZONE WIDTH AND INDUCTION TIME FOR UNSEEDED POTASSIUM SULPHATE AQUEOUS SOLUTION Kobari M., Kubota N., Hirasawa I. (JGC corporation, Japan; Iwate University, Japan; Waseda University, Japan) 8) SOLUBILITY PREDICTION OF WEAK ELECTROLYTE MIXTURES Zhang X., Févotte G., Qian G., Zhou X., Yuan W. (East China University of Science & Tech., P.R.China; Ecole Nationale Supérieure des Mines, France; East China University of Science &Tech., P.R.China) 9) AGGLOMERATION OF 2-MERCAPTO-5-DIFLUOROMETHOXY-1H- BENZIMIDAZOLE DURING THE REACTIVE CRYSTALLIZATION PROCESS Wang Y., Lv X., Xie C. (Tianjin University of Science &Tech., P.R.China) 10) THE TRANSFORMATION OF Β TO Α FUMARIC ACID AS MONITORED IN SITU BY FBRM AND PVM Liu C., Dang L., Wei H.Y. (Tianjin University of Science &Tech., P.R.China)

30 11) TOWARDS UNDERSTANDING OF INDUCED NUCLEATION PHENOMENA Wohlgemuth K., Ruether F., Schembecker G. (TU Dortmund, Germany) 12) INFLUENCE OF SOLID PARTICLES ON GAS-LIQUID MASS TRANSFER IN STIRRED TANK Han B., Niemi H., Sha Z., Louhi-Kultanen M. (Lappeenranta University of Technology, Finland; Tianjin University of Science &Tech., P.R.China) 13) TRANSFORMATION AND CRYSTALLIZATION OF ANHYDRATE/HYDRATE OF CARBAMAZEPINE IN ALCOHOL-WATER SOLUTIONS Wang X., Yang X., Ching C.B. (Nanyang Technological University, Singapore) 14) CALCIUM SULPHATE DIHYDRATE NUCLEATION: THE RETARDANT EFFECT OF 2-PHOSPHONOBUTANE-1,2,4-TRICARBOXYLIC ACID Prisciandaro M., Olivieri E., Lancia A., Musmarra D. (Università dell'aquila, Italy; Università "Federico II" di Napoli, Italy; Seconda Università di Napoli, Italy) 15) CARBOXYLATE-MODIFIED INULINE BIOPOLYMERS: AN EFFECTIVE GREEN ALTERNATIVE FOR PHOSPHONATE-BASED ANTISCALANTS Boels L., Jarzembowska M., Witkamp G.J. (Delft University of Technology, The Netherlands; Wetsus, The Netherlands) 16) EVALUATION OF CITRIC ACID CRYSTALLIZATION IN VIBRATED BED CRYSTALLIZER Teixeira G., Finzer J.R., Malagoni R. (Federal University of Uberlândia, Brazil) 17) SPINODAL DECOMPOSITION IN PRECIPITATION PROCESSES Kiesow K., Ruether F., Sadowski G. (TU Dortmund, Germany) 18) RATES OF SODIUM CHLORIDE ATTRITION FRAGMENT GENERATION IN A MIXED-SUSPENSION CRYSTALLIZER Mueansichai T., Flood A. (Suranaree University of Technology, Thailand) 19) STABILITY AND CONVERSION OF THEOPHYLLINE SOLID FORMS Seton L., Khamar D., Bradshaw I., Hutcheon G. (Liverpool John Moores University, UK) 20) MODULATION OF CRYSTAL MORPHOLOGY ON ORGANIC MONOLAYERS Sarma B., Myerson A. (Massachusetts Institute of Technology, USA) 21) MODELING OF NUCLEATION, GROWTH AND RIPENING OF ZNO SEMICONDUCTOR NANOPARTICLES USING POPULATION BALANCE EQUATIONS Hartig M.A.J., Segets D., Gradl J., Peukert W. (University of Erlangen-Nuremberg, Germany; Robert Bosch GmbH, Germany)

31 22) INVESTIGATING THE INITIAL PRECIPITATION STAGES OF CUPRIC POLYMORPHS BY POPULATION BALANCE MODELING FOR THE PRODUCTION OF METHANOL SYNTHESIS CATALYSTS Hartig M.A.J., Kurr P., Peukert W. (University of Erlangen-Nuremberg, Germany; Süd- Chemie AG, Germany) 23) GROWTH AND MORPHOLOGY OF THE VATERITE POLYMORPH OF CALCIUM CARBONATE AT CONSTANT SUPERSATURATION Beck R., Mohamed R., Lewis A.E., Andreassen J.P. (Norwegian Univ. of Science & Techn., Norway; University of Cape Town, South Africa) 24) INFLUENCE OF SOLVENT ON THE NUCLEATION OF M-HYDROXYBENZOIC ACID POLYMORPHS Svard M., Rasmuson A. (Royal Institute of Technology (KTH), Sweden) 25) CRYSTALLISATION OF CONFORMATIONALLY FLEXIBLE PHARMACEUTICAL MOLECULES Back K., Slavin P., Mcghie S., Davey R. (University of Manchester, UK; GlaxoSmithKline, UK; The University of Manchester, UK) 26) COSMO-SAC MODEL FOR PREDICTING SOLUBILITY OF PHARMACEUTICAL PRODUCTS IN DIFFERENT SOLVENTS Bouillot B., Teychene S., Biscans B. (CNRS, Univ. de Toulouse, France; CNRS-Laboratoire de Génie Chimique, France) 27) INFLUENCE OF SURFACE CHARGE ON HETEROGENEOUS CRYSTALLIZATION Shirakawa Y., Akiyama K., Wake T., Shimosaka A., Hidaka J. (Doshisha University, Japan) 28) MORPHOLOGICAL CONTROL OF FINE PARTICLES IN MICROSPACE Wakamiya H., Shirakawa Y., Shimosaka A., Hidaka J. (Doshisha University, Japan) 29) COMPOSITE MATERIALS FABRICATION FOR HYDROGEN STORAGE BY REACTIVE CRYSTALLIZATION Naito T., Shirakawa Y., Shimosaka A., Hidaka J. (Doshisha University, Japan) 30) EVALUATION OF A KINETIC POPULATION BALANCE MODEL DESCRIBING NUCLEATION, GROWTH AND RIPENING Vetter T., Hanseler F., Ochsenbein D., Iggland M., Mazzotti M. (ETH Zurich, Switzerland) 31) SOLUBILITY OF FRUCTOSE DIPHOSPHATE SODIUM IN AQUEOUS ALCOHOL MIXTURES Wang Y., Zhu Y., Zhao X., Sha Z. (Tianjin University of Science &Tech., P.R.China) 32) THE THERMODYNAMIC WORKFLOW FOR THE RELATIVE STABILITY ASSESSMENT OF A COMPLEX POLYMORPHIC SYSTEM Hsieh D.S., Roberts D., Gao Q., Erdemir D., Lai C., Chang S.Y., Kiang S. (Bristol-Myers Squibb co., USA)

32 33) THE CHARACTOR OF MIXED POTASSIUM CHLORIDE AND AMMONIUM CHLORIDE CRYSTALS Chen J., Shi X., Yuan J., Ulrich J., Zhang H., Ji X. (Hebei University of Technology, P.R.China; Martin-Luther Universitaet Halle-Wittenberg, Germany) 34) KINETIC INVESTIGATIONS ON SUSPENSION CRYSTALLIZATION OF IONIC LIQUIDS Keil P., Koenig A. (University of Erlangen-Nuremberg, Germany) 35) TRANSFORMATION KINETICS OF MYO-INOSITOL CRYSTALS IN ORGANIC SOLVENT Kumashiro M., Kobayakawa A., Hirasawa I. (Waseda University, Japan) 36) IMPACT OF PRE-HEATING ON NUCLEATION KINETICS AND POLYMORPH Ramakrishnan S., Agrawal R., Devarakonda S., Kedia U., Rudraraju V. (Dr. Reddy s Laboratories Ltd., India; Aurigene Discovery Technologies Ltd., India) 37) PRECIPITATION OF MESOPOROUS NANOSIZED CALCIUM CARBONATE Kontrec J., Ukrainczyk M., Brecevic L., Kralj D. (Ruder Boskovic Institute, Croatia) 38) FLUORITE S PRECIPITATION IN KOH SOLUTIONS IN VIEW OF REMOVING FLUORIDES FROM WASTEWATERS Tavares A. R., Garcia D., Moutte J., Cameirao A., Févotte G., Amaraggi D., Morel B. (Ecole Nationale Supérieure des Mines, France; Areva-COMURHEX, France; AREVA- COMURHEX, France) 39) THE RATE OF SUPERSATURATION INCREASE/DECREASE AS AN IMPORTANT PARAMETER DURING CRYSTAL GROWTH Ferrreira C., Martins P., Damas A., Rocha F. (LEPAE, Faculdade de Engenharia Porto, Portugal; ICBAS Inst. de Ciencias Biomedicas Abel Salazar, Portugal; IBMC, Portugal; University of Porto, Portugal) 40) EFFECT OF INORGANIC IMPURITIES ON THE CRYSTAL GROWTH OF BORIC ACID FROM AQUEOUS SOLUTIONS Alavia W., Seidel-Morgenstern A., Lorenz H., Graber T. (Universidad de Antofagasta, Chile; Max Planck Institute Magdeburg, Germany) 41) AN EXAMINATION OF STRUCTURE OF NANO-SIZED MOLECULAR CLUSTER OF NAPHTHALENE AND BIPHENYL AS A FUNCTION OF CRYSTAL SIZE, IN RELATION TO THEIR CRYSTALLISABILITY Hammond R., Jiang H., More I., Roberts K.J. (Leeds University, UK; University of Leeds, UK; Infineum U K Ltd, UK) 42) USE OF IN-PROCESS ANALYTICAL TOOLS TO MEASURE NUCLEATION AND GROWTH RATES OF N-PHOSPHONOMETHYL GLYCINE (PMG) Izumi T., Blacker J., Banning S., George N., Hardie M., Marziano I., Roberts K.J., Quayle M., Wang X., Zhou Y. (The University of Leeds, UK; Avantium Technologies BV, The Netherlands; Pfizer, UK; University of Leeds, UK; AstraZeneca, UK)

33 43) EFFECTIVE CO-CRYSTAL SCREENING TROUGH STUCTURAL RESEMBLANCE Springuel G., Norberg B., Robeyns K., Wouters J., Leyssens T. (Université Catholique de Louvain, Belgium; Facultés Universitaires Notre-Dame de la paix, Namur, Belgium) 44) RDX POLYMORPHISM REVISITED Goldberg I., Swift J. (Georgetown University, USA) 45) DETERMINATION OF TERNARY PHASE DIAGRAMS IN THE TOLUENE SULPHONALIDE:TRIPHENYLPHOSPINE OXIDE CO-CRYSTAL SYSTEM Croker D., Foreman M.E., Elcoate C.J., Maguire A.R., Lawrence S.E., Rasmuson A.C. (University of Limerick, Ireland; University College Cork, Ireland) 46) THE EFFECT OF IMPURITIES ON CRYSTAL GROWTH Hutchinson A., Davey R., George N. (University of Manchester, UK; The University of Manchester, UK; Syngenta Ltd, UK) 47) INVESTIGATION ON THE CRYSTAL STRUCTURE OF ZEOLITE NAA AND MODELING THE SORBTION KINETICS OF CU(II) IONS FROM AQUEOUS SOLUTIONS Georgiev D., Bogdanov B., Markovska I., Hristov Y., Stanev D. (Assen Zlatarov University, Bulgaria) 48) CRYSTALLIZATION AND PROPERTIES OF MARBLE-LIKE GLASS-CERAMIC MATERIALS USING OF ASH FROM THERMAL POWER PLANTS Bogdanov B., Hristov Y., Markovska I., Georgiev D. (Assen Zlatarov University, Bulgaria) 49) NUCLEATION AND CRYSTAL GROWTH: A CLASSICAL MOLECULAR DYNAMICS APPROACH Giberti F., Tribello G.A., Parrinello M. (ETH Zurich, Switzerland; USI, Switzerland) Characterization and monitoring techniques 50) QUANTITATIVE ANALYSIS OF L-GLUTAMIC ACID POLYMORPHS: POWDER X- RAY DIFFRACTION, FT-IR AND RAMAN SPECTROMETRIC STUDY Mo Y., Dang L., Wei H.Y. (Tianjin University of Science &Tech., P.R.China) 51) INSTANTANEOUS MONITORING OF CRYSTAL ATTRITION OF TWO POLYMORPHIC FORMS OF L-GLUTAMIC ACID BY ON LINE AND IN-SITU FBRM AND PIV Rajoub N., White G., Wilkinson D. (Heriot-Watt University, UK) 52) INFLUENCE OF THE SOLVENT COMPOSITION ON CRYSTALLIZATION OF CITRIC ACID MEASURED BY AN ULTRASONIC DEVICE Helmdach L., Ulrich J. (Martin-Luther Universitaet Halle-Wittenberg, Germany) 53) IN SITU DETERMINATION OF METASTABLE ZONE WIIDTH USING DIELECTRIC OCNSTANT MEASUREMENT He G., Hermanto M., Tjahjono M., Chow P.S., Tan R.B.H., Garland M. (Institute of Chemical & Engineering Sciences, Singapore)