Cover Page. The handle holds various files of this Leiden University dissertation

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1 Cover Page The handle holds various files of this Leiden University dissertation Author: Yiu, Kai-Hang Title: Advanced clinical applications of cardiac computed tomography and novel echocardiographic modalities Issue Date:

2 Advanced clinical applications of cardiac computed tomography and novel echocardiographic modalities Kai-Hang Yiu

3 Advanced clinical applications of cardiac computed tomography and novel echocardiographic modalities The studies described in this thesis were performed at the Department of Cardiology of Leiden University Medical Center (LUMC), Leiden, The Netherlands Cover: Kai-Hang Yiu Layout and Printing: Optima Grafische Communicatie, Rotterdam, the Netherlands ISBN: Copyright 2016 Kai-Hang Yiu, Leiden, The Netherlands. All rights reserved. No part of this book may be reproduced or transmitted, in any form or by any means, without permission of the author.

4 Advanced clinical applications of cardiac computed tomography and novel echocardiographic modalities Proefschrift Ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker, volgens besluit van het College voor Promoties te verdedigen op dinsdag 28 april 2016 klokke uur door Kai-Hang Yiu Geboren te Hong Kong, in 1977

5 Promotor Prof. Dr. JJ Bax Co-promotor Dr. N Ajmone Marsan Leden promotiecommissie: Prof. Dr. MJ Schalij Prof. Dr. RJ Klautz Prof. Dr. JW Jukema Prof. Dr. DE Atsma Prof. Dr. TWJ Huizinga Dr. V Delgado Prof. Dr. HF Tse (University of Hong Kong, Hong Kong) Prof. Dr. P Feijter (Erasmus MC, Rotterdam, The Netherlands)

6 TABLE OF CONTENTS General introduction and outline of thesis 9 PART I Advanced clinical application of cardiac computed tomography Chapter 1 Age- and gender-specific differences in the prognostic value of CT coronary angiography. Yiu KH, de Graaf FR, Schuijf JD, van Werkhoven JM, Marsan NA, Veltman CE, de Roos A, Pazhenkottil A, Kroft LJ, Boersma E, Herzog B, Leung M, Maffei E, Leung DY, Kaufmann PA, Cademartiri F, Bax JJ, Jukema JW. Heart. 2012;98(3): Chapter 2 Different value of coronary calcium score to predict obstructive coronary artery disease in patients with and without moderate chronic kidney disease. Yiu KH, de Graaf FR, van Velzen JE, Marsan NA, Roos CJ, de Bie MK, Tse HF, van der Wall E, Schalij MJ, Bax JJ, Schuijf JD, Jukema JW. Neth Heart J. 2013;21(7-8): Chapter 3 Prognostic value of renal dysfunction for the prediction of outcome versus results of computed tomographic coronary angiography Yiu KH, de Graaf FR, Schuijf JD, van Werkhoven JM, van Velzen JE, Boogers MJ, Roos CJ, de Bie MK, Pazhenkottil A, Kroft LJ, Boersma E, Herzog B, de Roos A, Kaufmann PA, Bax JJ, Jukema JW. Am J Cardiol. 2011;108(7): Chapter 4 Influence of left ventricular geometry and function on aortic annular dimensions as assessed with multi-detector row computed tomography: implications for transcatheter aortic valve implantation. Ng AC, Yiu KH, Ewe SH, van der Kley F, Bertini M, de Weger A, de Roos A, Leung DY, Schuijf JD, Schalij MJ, Bax JJ, Delgado V. Eur Heart J. 2011;32(22): PART II Advanced clinical application of novel echocardiographic modalities

7 Chapter 5 Myocardial structural alteration and systolic dysfunction in preclinical hypertrophic cardiomyopathy mutation carriers. Yiu KH, Atsma DE, Delgado V, Ng AC, Witkowski TG, Ewe SH, Auger D, Holman ER, van Mil AM, Breuning MH, Tse HF, Bax JJ, Schalij MJ, Marsan NA. PLoS One. 2012;7(5):e Chapter 6 Increased myocardial fibrosis and left ventricular dysfunction in Cushing's syndrome. Yiu KH, Marsan NA, Delgado V, Biermasz NR, Holman ER, Smit JW, Feelders RA, Bax JJ, Pereira AM. Eur J Endocrinol. 2012;166(1): Chapter 7 Left ventricular dysfunction assessed by speckle-tracking strain analysis in patients with systemic sclerosis: relationship to functional capacity and ventricular arrhythmias. Yiu KH, Schouffoer AA, Marsan NA, Ninaber MK, Stolk J, Vlieland TV, Scherptong RW, Delgado V, Holman ER, Tse HF, Huizinga TW, Bax JJ, Schuerwegh AJ. Arthritis Rheum. 2011;63(12): Chapter 8 Relationship between right ventricular function, pulmonary fibrosis and pulmonary pressures in patients with systemic sclerosis. Yiu KH, Ninaber MK, Kroft L, Schouffoer AA, Stolk J, Vlieland TV, Delgado V, Tse HF, Bax JJ, Holman ER, Huizinga TW, Schuerwegh AJ, Marsan NA. Rheumatology (Oxford) 2016 ;55(3): Summary and Conclusions 115 Samenvatting en Conclusies 119 List of publications 125 Acknowledgements 135 Curriculum Vitae 137

8 To my father, Dr. Sing-Nam Yiu

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