Promotion and the Rational Use of Medicines in a Global Market. Health Projects for Latvia November 2012
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1 Promotion and the Rational Use of Medicines in a Global Market Health Projects for Latvia November 2012 Tim Reed Health Action International Amsterdam
2 Acknowledgements: Renée Vasbinder, HAI Global Bobbi Klettke, HAI Global Barbara Mintzes, HAI Member Financial disclosure: No pharmaceutical or advertising industry funding Funding for my position: DFID, UK; DG Sanco, EU
3 Talk Outline Heath Action International (HAI) Interests in the Medicines Market Promotions Imperative Impact of Promotion Promotion and Rational Use
4 HAI Constitution: Article 2.1 a. to promote rational and economic medicines policy, therapy and use in high, middle and low income countries b. to work towards global justice in health by increasing access to essential medicines and improving the rational use of medicines
5 HAI Mission statement: Health Action International (HAI) is an independent, global network working to increase access to essential medicines and improve the rational use of medicines through research excellence and evidencebased advocacy.
6 The HAI Global Network Health Action International (HAI) is an independent global network, working to increase access to essential medicines and improve the rational use of medicines through research excellence and evidence-based advocacy
7 Interests and the Political Landscape Promotion and its Regulation intervention in an imperfect market that affect public health interests All interests are affected Pharmaceutical Industry Healthcare Professionals Government Patients Consumer Civil Society
8 Indentifying Conflict of Interest an inherent conflict of interest between the legitimate business goals of manufacturers and the social, medical and economic needs of providers and the public to select and use drugs in the most rational way. World Health Organization, Regional Office for Europe, 1993
9 The Promotion Imperative Accountability to Share Holders = to make money Poor Innovation = not much therapeutic advantage Me-Too Medicines = more of the same Disease Mongering = new non-diseases Incentivised R&D Modelling = markets not needs
10 The Promotion Imperative: Innovation Ratings of 961 new drugs and indications in France, 1999 to 2008 La Revue Prescrire
11 The Promotion Imperative: Registration & Me-Too medicines No therapeutic innovation Placebo Trials: Requirement to demonstrate efficacy against placebo (only) Me-Too medicines
12 The Promotion Imperative: R&D Modelling Innovation rewarded with a patent Market Monopoly Encourages promotion (removes market forces) Cost of medicines linked to the cost of R&D No R&D into diseases that disproportionately affect the poor
13 Does pharmaceutical promotion affect prescribing: Question One. How much influence do sales representatives have on your prescribing? A lot 1% A little 38% None 61% n=102 internal medicine residents Am J Med 2001; 110:551
14 Does pharmaceutical promotion affect prescribing: Question Two. How much influence do sales representatives have on other physicians' prescribing? None 16% A lot 51% A little 33% n=102 internal medicine residents n=102 internal medicine residents Am J Med 2001; 110:551 Am J Med 2001; 110:551
15 Gagnon and Lexchin. Cost of pushing pills. PLoS Med 2008 e1 Gagnon and Lexchin. Cost of pushing pills. PLoS Med 2008 e1
16 EFFECTS OF CME ON VOLUME OF PRESCRIBING Prescribing at major medical institutions Orlowski et al. Chest 1992
17 Tying it together: Rational Use Essential Medicines Essential medicines are those that satisfy the priority health care needs of the population selected with due regard to disease prevalence, evidence on efficacy and safety, and comparative cost-effectiveness Rational Use of Medicines Patients receive medications appropriate to their clinical needs, in doses that meet their own individual requirements, for an adequate period of time, and at the lowest cost to them and their community." (WHO, 1985). Irrational Use of Medicines Patients receive the wrong medications inappropriate to their clinical needs, in doses that do not meet their own individual requirements, for an inadequate period of time, and at an often unaffordable cost to n=102 internal medicine residents Am J Med 2001; 110:551 them and their community."
18 Further Information links to other sites in the network, promotions manual, methodology for measuring promotion enforcement, MeTA, Price and Availability methodology Unique encyclopaedia of the politics of medicine, accessible essays that will grow and change with time n=102 internal medicine residents Am J Med 2001; 110:551
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