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1 Established set of general parameters General parameters for lung cancer detection it is characteristics of patient and the diagnosis methods with results. Patient Characteristics Initial patient characteristic, which can be got after first visit. Characteristics values based on visual inspection. Patient characteristics: of characteristic C_G C_S C_R Values of patient characteristics: of characteristic value C_G_1 C_G_2 C_S_1 C_S_2 C_S_3 C_S_4 C_S_5 C_S_6 C_S_7 C_S_8 C_S_9 C_S_10 C_S_11 C_S_12 C_R_1 C_R_2 C_R_3 C_R_4 C_R_5 of characteristic Gender Symptom Risk factor of characteristic value Female Male Bone pain Breathing changes Change in a cough Chest pain Chest sign Cough Dyspnoea Haemoptysis Hoarseness Shoulder pain Weight loss Enlarged neck lymph nodes Chronic lung disease Family history of lung cancer Other cancer history Previous radiation therapy Professional exposure to radon, asbestos, silica

2 of characteristic value C_R_6 C_R_7 C_R_8 C_R_9 C_R_10 C_R_11 C_R_12 C_R_13 of characteristic value or chromium Age > 74 years Age years Age years Smoking < 20 pack-year history Smoking pack-year history Smoking > 30 pack-year history Quit smoking less than 15 years ago Second-hand smoking

3 Diagnostic Results Values of diagnostic results: of result value R_P R_1 R_2 R_3 R_4 R_5 R_6 R_7 R_8 R_9 R_10 R_11 R_12 R_13 R_14 R_BR_1 R_BR_2 R_LSND_1 R_LSND_2 R_LSND_3 R_LSND_4 R_LSND_5 R_LSND_6 R_LSND_7 R_LSND_8 R_LSND_9 R_LSND_10 R_LSND_11 R_LSND_12 of result value Positive Neck nodes Atelectasis Broncheal stenosis Hilar enlargement Mediastinal lymp nodes enlargement Mediastinal widening Peribronchial infiltration Pleural fluid Infiltration of lung parenchyma Lung nodules Lung mass Pleural mass Bone lesions Pleural nodule Brain metastasis Meningeal metastasis Ground glass nodule <5 mm Ground glass nodule 5-9 mm Ground glass nodule >9 mm Solid nodule <4 mm Solid nodule 4-6 mm Solid nodule 6-8 mm Solid nodule >8 mm Several nodules <5 mm Several nodules >=5 mm Several solid with ground glass nodule nodule, when solid part <5 mm nodule, when solid

4 of result value R_LSND_13 R_LSND_14 R_LSND_15 R_LSND_16 R_LSND_17 of result value part 5-7 mm nodule, when solid part >7 mm Fat containing Calcified Growing nodule No growing nodule

5 Diagnostic Methods Diagnostic methods: Diagnostic method code M_BPS M_BSG M_BRC M_CTG M_LCT M_EBU M_EUS M_MRI M_NUS M_PTG M_TBA M_ULS M_XRY M_TTB M_VMS M_CMS M_VTS Relations of methods and results: Diagnostic method M_BPS Biopsy or surgical resection Diagnostic method name Biopsy or surgical resection Bone scintigraphy Bronchoscopy Computed tomography Low dose computed tomography Endobronchial ultrasound Endoscopic ultrasound Magnetic resonance imaging Neck ultrasound Positron emission tomography (PET/CT) Transbronchial needle biopsy Ultrasound X-ray Transthoracic percutaneous needle biopsy under CT or other method guidance Videoassisted mediastinoscopy Cervical mediastinoscopy Videoassisted thoracoscopy Diagnostic result M_BSG Bone scintigraphy D_MT_4 M1b M_BRC Bronchoscopy D_TN_2 T1

6 Diagnostic method D_TN_3 D_TN_4 D_TN_5 D_TN_6 Diagnostic result T2 T3 T4 Tis M_CTG Computed tomography R_LSND_1 R_LSND_2 R_LSND_3 R_LSND_4 R_LSND_5 R_LSND_6 R_LSND_7 R_LSND_8 R_LSND_9 R_LSND_10 R_LSND_11 R_LSND_12 R_LSND_13 R_LSND_14 R_LSND_15 R_LSND_16 R_LSND_17 R_11 R_5 R_8 R_9 R_2 R_12 Ground glass nodule <5 mm Ground glass nodule 5-9 mm Ground glass nodule >9 mm Solid nodule <4 mm Solid nodule 4-6 mm Solid nodule 6-8 mm Solid nodule >8 mm Several nodules <5 mm Several nodules >=5 mm Several solid with ground glass nodule nodule, when solid part <5 mm nodule, when solid part 5-7 mm nodule, when solid part >7 mm Fat containing Calcified Growing nodule No growing nodule Lung mass Mediastinal lymp nodes enlargement Pleural fluid Infiltration of lung parenchyma Atelectasis Pleural mass

7 Diagnostic method R_13 Diagnostic result Bone lesions M_LCT Low dose computed tomography R_LSND_1 R_LSND_2 R_LSND_3 R_LSND_4 R_LSND_5 R_LSND_6 R_LSND_7 R_LSND_8 R_LSND_9 R_LSND_10 R_LSND_11 R_LSND_12 R_LSND_13 R_LSND_14 R_LSND_15 R_LSND_16 R_LSND_17 R_11 R_5 R_8 R_9 R_2 R_12 R_13 Ground glass nodule <5 mm Ground glass nodule 5-9 mm Ground glass nodule >9 mm Solid nodule <4 mm Solid nodule 4-6 mm Solid nodule 6-8 mm Solid nodule >8 mm Several nodules <5 mm Several nodules >=5 mm Several solid with ground glass nodule nodule, when solid part <5 mm nodule, when solid part 5-7 mm nodule, when solid part >7 mm Fat containing Calcified Growing nodule No growing nodule Lung mass Mediastinal lymp nodes enlargement Pleural fluid Infiltration of lung parenchyma Atelectasis Pleural mass Bone lesions M_EBU

8 Diagnostic result Diagnostic method Endobronchial ultrasound D_LN_1 N0 D_LN_2 N1 D_LN_3 N2 D_LN_4 N3 D_TN_2 T1 D_TN_3 T2 D_TN_4 T3 D_TN_5 T4 M_EUS Endoscopic ultrasound D_LN_1 D_LN_2 D_LN_3 D_LN_4 N0 N1 N2 N3 M_MRI Magnetic resonance imaging R_BR_1 R_BR_2 R_BR_3 Brain metastasis Meningeal metastasis Edema M_NUS Neck ultrasound R_P Positive M_PTG Positron emission tomography (PET/CT) M_TBA Transbronchial needle aspiration R_P D_LN_1 D_LN_2 D_LN_3 D_LN_4 Positive N0 N1 N2 N3 M_ULS

9 Diagnostic result Diagnostic method Ultrasound R_P Positive D_MT_4 M1b M_XRY X-ray R_10 R_11 R_5 R_6 R_8 R_9 R_2 R_12 R_13 Lung nodules Lung mass Mediastinal lymp nodes enlargement Mediastinal widening Pleural fluid Infiltration of lung parenchyma Atelectasis Pleural mass Bone lesions M_TTB Transthoracic percutaneous fine biopsy under CT guidance D_TN_1 D_TN_2 D_TN_3 D_TN_4 D_TN_5 T0 T1 T2 T3 T4 M_VMS Videoassisted mediastinoscopy D_LN_1 D_LN_2 D_LN_3 D_LN_4 D_MT_3 N0 N1 N2 N3 M1a M_VTS Videoassisted thoracoscopy D MT 3 R_8 M1a Pleural fluid

10 Diagnostic method R_14 R_12 Diagnostic result Pleural nodule Pleural mass M_CMS Cervical mediastinoscopy D_LN_1 D_LN_2 D_LN_3 D_LN_4 N0 N1 N2 N3

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