GYMR A4 Study Long Form Film

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "GYMR A4 Study Long Form Film"

Transcription

1 VIDEO INTRO GRAPHICS GRAPHIC DR. SPERLING AUDIO 0:00 [Music & Graphics Only] 0:05 The A4 Study is a landmark clinical trial to prevent the memory loss associated with Alzheimer s disease. 0:10 Thank you for your interest in learning more about the A4 Study. We think this is an incredible opportunity to try to prevent the memory decline associated with Alzheimer's disease. And we're very excited to tell you more about this groundbreaking study. 0:26 Unfortunately everybody over the age of 65 is at increased risk of developing Alzheimer's disease. 0:34 The longer you live, the more likely you are to develop Alzheimer's disease. Research has also shown that having a family history of Alzheimer's disease increases the lifetime risk of developing Alzheimer's disease dementia, particularly a first degree relative. 0:48 There are several factors that may put you at higher risk for Alzheimer s disease, including advanced age and family history. People at higher risk include women and African Americans, Hispanics and Latinos, as well as older individuals of all backgrounds with evidence of elevated amyloid plaque buildup in their brains. Alzheimer s Disease Risk Factors: Age Family history/genes People with Higher Risk to Develop Alzheimer s: Women African Americans Hispanics/Latinos People with an elevated amount of the amyloid protein or elevated amyloid plaque in their brain. DR. SPERLING 1:11 The A4 study is the first study that really tries to identify older individuals who are at risk for Alzheimer's disease on the basis of showing evidence of amyloid plaque buildup in their DB Productions A division of DeSantis Breindel GMYR A4 Study FINAL v2 May 11,

2 brains, by trying to treat them before they have symptoms. We re looking for people who really are still normal, who are living at home and functioning normally. They don t have to have a perfect memory however all of our memories change as we get older, and we re certainly looking for people who are a little bit worried about their memory. 1:43 Scientists believe that the accumulation of amyloid in the brain may play a key role in the memory loss associated with Alzheimer s Disease. The investigational drug being tested in the A4 Study targets the amyloid in the brain with the aim of slowing memory loss. Scientists believe that amyloid accumulation my play a key role in the memory loss associated with Alzheimer s. and Neuron Animation The investigational drug tested in the A4 Study targets amyloid in the brain with the aim of slowing that memory loss. 2:02 Amyloid protein is a protein that accumulates outside, between the brain cells, if you will, and is associated with neuron death. We're now able to visualize amyloid protein in a living person using what's called a PET scan. 2:19 And so we've set up a step by step process so that an interested potential participant can learn about what is amyloid, how do we measure it, how do we interpret the amyloid imaging scans and what we know and what we don't know. 2:39 There are a number of steps involved in the A4 study, including 5 screening visits. At the first visit, we will explain the study and perform a series of basic tests. GRAPHIC: Visit I A4 Study explained and basic screening Medical history Cognitive tests Physical exam ECG DB Productions A division of DeSantis Breindel GMYR A4 Study FINAL v2 May 11,

3 Blood work 2:51 The first step is a very rigorous screening. There are five screening visits during which time we want to make sure that individuals are medically and emotionally fit for participation in the trial and meet all of our criteria. 3:14 We are looking for women and men like you, between the ages of 65 and 85, who have generally normal thinking and memory abilities. You might be a little bit worried about your own memory, which is OK for this study, and you need to have a study partner who can answer questions about how you are doing. We really need older individuals like you who are willing and able to participate in the A4 Study for approximately 3 ½ years. Eligible A4 Participants: Are between the ages of 65 to 85 Have normal thinking and memory abilities Have a study partner (someone with weekly contact, available to answer questions once a year) Are willing and able to participate in the study for approximately 3 ½ years 3:42 The first thing that we will do when you come in for your screening is to make sure that your memory and other cognitive functions are at a level that's normal for your age, your level of education. 3:54 GRAPHIC: Visit 2 PET scan to determine whether there is elevated amyloid, a known AD risk factor 3:54 Then we will have you undergo a PET imaging scan. This is a picture, not of your brain, but actually of the amyloid in your brain. You will lie in a PET scanning machine, where the machine actually tells us how much amyloid is in the brain. DB Productions A division of DeSantis Breindel GMYR A4 Study FINAL v2 May 11,

4 4:18 The PET scan has two possible results. One can either have a result that shows what we call an elevated amyloid level, or a not elevated amyloid level. PET Amyloid Imaging Graphics An elevated amyloid level means that based on the criteria for reading the scan, the person has an accumulation of amyloid that makes them eligible to receive the investigational drug. GRAPHIC with VO 4:38 It doesn't mean you have Alzheimer's disease dementia. It does put you in a group of people who more likely over time to develop cognitive changes that could lead to Alzheimer's disease dementia. In fact one of the goals of the study is to better understand that risk. 4:57 On your third visit, we will review your PET scan results together, and talk about your amyloid status. Visit 3 Review PET scan results for disclosure of amyloid status 5:05 During the 4 th visit, we will perform an MRI, which helps us look at your brain by using a large magnet. Visit 4 MRI Scan 5:12 On visit five, we will talk about the option of participating in a sub-study. Visit 5 Optional Sub-study 5:17 And on your 6 th visit, we will begin treatment, either with the investigational drug or with a placebo. Visit 6 Randomized treatment phase begins Participants receive either the investigational drug or placebo once every 4 weeks via IV DB Productions A division of DeSantis Breindel GMYR A4 Study FINAL v2 May 11,

5 5:26 You will then be scheduled to make monthly visits to the center in order to get infusions. And these infusions require putting a line into your arm; it's an IV. And you'll be sitting comfortably in a chair and the drug or placebo is infused over a period of a half hour. 5:51 In the course of the A4 study an individual can receive the active substance that we are testing, or they may receive a placebo. 6:00 We need to compare whether the investigational drug is working or whether an individual might get better because they've taken the tests many times or because they feel they're doing something and their mood is improved. 6:16 The study is planned to last about three and a half years. And you should plan to make monthly visits for the infusions after the initial screening, which will take about five visits. OUTRO GRAPHICS 6:28 [Music & Graphics Only] Total Running Time 6:54 DB Productions A division of DeSantis Breindel GMYR A4 Study FINAL v2 May 11,

Local Clinical Trials

Local Clinical Trials Local Clinical Trials The Alzheimer s Association, Connecticut Chapter does not officially endorse any specific research study. The following information regarding clinical trials is provided as a service

More information

Participating in Alzheimer s Disease Clinical Trials and Studies

Participating in Alzheimer s Disease Clinical Trials and Studies Participating in Alzheimer s Disease Clinical Trials and Studies FACT SHEET When Margaret was diagnosed with earlystage Alzheimer s disease at age 68, she wanted to do everything possible to combat the

More information

What is dementia with Lewy bodies?

What is dementia with Lewy bodies? What is dementia with Lewy bodies? Contents Introduction 03 What is DLB? 04 Symptoms 06 Diagnosis 08 Support 11 Causes 12 Risk factors 12 Research 15 Treatments 10 02 visit: www.alzheimersresearchuk.org

More information

Changes in the Brain

Changes in the Brain Alzheimer s Disease Alzheimer s disease is an irreversible, progressive brain disorder that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks. In most

More information

Memory: What is normal, and what is Alzheimer s?

Memory: What is normal, and what is Alzheimer s? Memory: What is normal, and what is Alzheimer s? Andrew Frank M.D. B.Sc.H. F.R.C.P.(C) Cognitive Neurologist, and Medical Director, Bruyère Memory Program Élisabeth Bruyère Hospital Ottawa, Ontario Memory:

More information

Alzheimer s and. memory loss

Alzheimer s and. memory loss Alzheimer s and memory loss This leaflet aims to help you understand about memory loss, Alzheimer s disease and other forms of dementia. You can also find out how to get more information. It s for anyone

More information

1 About dementia. In this section

1 About dementia. In this section 5 In this section Key points: 6 What is dementia? 7 What are the symptoms? 7 What are the causes? 8 Why do some people get dementia? 8 Types of dementia 9 Mild cognitive impairment 3 6 Key points: Dementia

More information

Wellington Parc Always There When Caring Makes A Difference

Wellington Parc Always There When Caring Makes A Difference Wellington Parc Always There When Caring Makes A Difference FAQ - Frequently Asked Questions re: Alzheimer s Disease What is Alzheimer s disease? First described by Dr. Alois Alzheimer in 1906, Alzheimer

More information

Alzheimer s disease. What is Alzheimer s disease?

Alzheimer s disease. What is Alzheimer s disease? Alzheimer s disease What is Alzheimer s disease? What we know about dementia and Alzheimer s disease Alzheimer s disease is the most common of a large group of disorders known as dementias. It is an irreversible

More information

What is Alzheimer s disease

What is Alzheimer s disease PBO 930022142 NPO 049-191 What is Alzheimer s disease Alzheimer s disease is the most common form of dementia. This information sheet outlines the symptoms and cause of Alzheimer s disease and describes

More information

58A SOCIAL AND LEISURE ACTIVITIES IN YOUR ASSISTED LIVING FACILITY

58A SOCIAL AND LEISURE ACTIVITIES IN YOUR ASSISTED LIVING FACILITY 58A-5.0182 SOCIAL AND LEISURE ACTIVITIES IN YOUR ASSISTED LIVING FACILITY Residents shall be encouraged to participate in social, recreational, educational and other activities within the facility and

More information

Steps to getting a diagnosis: Finding out if it s Alzheimer s Disease.

Steps to getting a diagnosis: Finding out if it s Alzheimer s Disease. Steps to getting a diagnosis: Finding out if it s Alzheimer s Disease. Memory loss and changes in mood and behavior are some signs that you or a family member may have Alzheimer s disease. If you have

More information

Understanding Alzheimer s Disease: It s Not Just Forgetfulness

Understanding Alzheimer s Disease: It s Not Just Forgetfulness : It s Not Just Forgetfulness Alzheimer s Disease Research 2 Alzheimer s disease affects people s memories, but it involves far more than simple forgetfulness. It is a progressive, degenerative, and incurable

More information

Cognitive Impairment. Patient Information Sheet

Cognitive Impairment. Patient Information Sheet Cognitive Impairment Patient Information Sheet What is dementia? Dementia is a term used to describe the loss of mental function. Memory loss is its most common symptom. Patients can have problems with

More information

Understanding. Alzheimer s Disease. Lora, diagnosed in 2004, with her daughter, Jill.

Understanding. Alzheimer s Disease. Lora, diagnosed in 2004, with her daughter, Jill. Understanding Alzheimer s Disease Lora, diagnosed in 2004, with her daughter, Jill. What Is Alzheimer s Disease? Alzheimer s disease is a neurologic disorder that affects the brain. It causes dementia.

More information

Alzheimer s and memory loss

Alzheimer s and memory loss Alzheimer s and memory loss Introduction This introductory leaflet aims to help you understand about memory loss, Alzheimer s disease and other forms of dementia. You can also find out how to get more

More information

What is vascular dementia?

What is vascular dementia? What is vascular dementia? Contents Introduction 03 What is vascular dementia? 04 Symptoms 06 Diagnosis 08 Support 12 Causes 13 Risk factors 14 Research 15 Treatments 10 02 visit: www.alzheimersresearchuk.org

More information

DISCUSSION GUIDE. Momentum in Science A 4-PART DOCUMENTARY SERIES CHANGING THE WAY AMERICA THINKS ABOUT ALZHEIMER S DISEASE

DISCUSSION GUIDE. Momentum in Science A 4-PART DOCUMENTARY SERIES CHANGING THE WAY AMERICA THINKS ABOUT ALZHEIMER S DISEASE DISCUSSION GUIDE Momentum in Science A 4-PART DOCUMENTARY SERIES CHANGING THE WAY AMERICA THINKS ABOUT ALZHEIMER S DISEASE Momentum in Science Introduction Momentum in Science is the story of many scientists

More information

Diagnosis of Alzheimer s Disease

Diagnosis of Alzheimer s Disease Diagnosis of Alzheimer s Disease At the age of 58, Matthew Blair began to have difficulty reading, speaking, and performing daily tasks at work. His wife, Isabel, was convinced that he had Alzheimer s.

More information

Early-onset Alzheimer s disease. affecting people under 65

Early-onset Alzheimer s disease. affecting people under 65 Early-onset Alzheimer s disease affecting people under 65 Introduction What is dementia? Dementia is used to describe a group of symptoms including memory loss, confusion, mood changes and difficulty with

More information

What is dementia? Types of dementia. Alzheimer s disease. Vascular dementia

What is dementia? Types of dementia. Alzheimer s disease. Vascular dementia What is dementia? Dementia is the name for several conditions that lead to the progressive loss of the powers of the brain and changes in a person s behaviour. The most common change is in a person s memory,

More information

Alzheimer s disease and diabetes

Alzheimer s disease and diabetes 1007029 CM1053CS Alzheimer s disease and diabetes Nearly 21 million Americans in the United States have diabetes, a disease that makes the body less able to convert sugar to energy. More than 6 million

More information

What is Alzheimer s disease?

What is Alzheimer s disease? alzheimers.org.uk What is Alzheimer s disease? Alzheimer s disease is the most common cause of dementia, affecting around 496,000 people in the UK. The term dementia describes a set of symptoms which can

More information

PARTNERING WITH YOUR DOCTOR:

PARTNERING WITH YOUR DOCTOR: PARTNERING WITH YOUR DOCTOR: A Guide for Persons with Memory Problems and Their Care Partners Alzheimer s Association Table of Contents PARTNERING WITH YOUR DOCTOR: When is Memory Loss a Problem? 2 What

More information

Histones and all that

Histones and all that Huntington s disease research news. In plain language. Written by scientists. For the global HD community. HDAC inhibitor drug protects memory in HD mice CBP, a gene-switching protein, protects memory

More information

What is Alzheimer s disease?

What is Alzheimer s disease? What is Alzheimer s disease? Contents Introduction 03 What is Alzheimer s? 04 Symptoms 06 Diagnosis 08 Support 14 Causes 15 Risk factors 16 Research 19 Treatments 10 02 visit: www.alzheimersresearchuk.org

More information

What is. Alzheimer s disease?

What is. Alzheimer s disease? What is Alzheimer s disease? Contents 03 What is Alzheimer s? What is dementia? 04 Symptoms 06 Diagnosis 08 Treatments This introductory booklet aims to provide an overview of Alzheimer s disease. It is

More information

Depression in Older Persons

Depression in Older Persons Depression in Older Persons How common is depression in later life? Depression affects more than 6.5 million of the 35 million Americans aged 65 or older. Most people in this stage of life with depression

More information

Surgery in Individuals Age 65+ Possible Risks. Possible Benefits. Potential Causes of POCD 11/24/2014. What is POCD?

Surgery in Individuals Age 65+ Possible Risks. Possible Benefits. Potential Causes of POCD 11/24/2014. What is POCD? Surgery in Individuals Age 65+ Postoperative Cognitive Dysfunction in Older Adults Ryan W. Schroeder, Psy.D., LP, ABPP-CN Neuropsychologist & Assistant Professor University of Kansas School of Medicine

More information

Working with Your Doctor When You Suspect Memory Problems Hope & Help for those with memory loss:

Working with Your Doctor When You Suspect Memory Problems Hope & Help for those with memory loss: Working with Your Doctor When You Suspect Memory Problems Hope & Help for those with memory loss: Creating a partnership with your doctor. Hope & help for those with memory loss 1 Table of Contents Working

More information

Biomarkers for Alzheimer's Disease in Down Syndrome

Biomarkers for Alzheimer's Disease in Down Syndrome Biomarkers for Alzheimer's Disease in Down Syndrome Brad Christian, Ph.D. Waisman Laboratory for Brain Imaging Outline Rationale for Studying AD in Down Syndrome Background of Alzheimer s Disease Biomarkers

More information

Early-onset Alzheimer s disease

Early-onset Alzheimer s disease Early-onset Alzheimer s disease Introduction This leaflet aims to give an introduction to early-onset Alzheimer s disease. It s for anyone who might be worried about themselves or somebody else. It was

More information

Chronic Kidney Disease

Chronic Kidney Disease Chronic Kidney Disease Introduction Chronic kidney disease, also known as CKD, is the gradual loss of kidney function. When CKD reaches an advanced stage, dangerous levels of fluid, electrolytes and wastes

More information

LET S CLEAR UP THE CONFUSION RECOGNIZING WHEN IT IS NOT PARKINSON S OR ALZHEIMER S DISEASE

LET S CLEAR UP THE CONFUSION RECOGNIZING WHEN IT IS NOT PARKINSON S OR ALZHEIMER S DISEASE LET S CLEAR UP THE CONFUSION RECOGNIZING WHEN IT IS NOT PARKINSON S OR ALZHEIMER S DISEASE GET THE FACTS ABOUT LEWY Introduce those you care about to the facts about Lewy body dementia. FACT: Lewy body

More information

Lewy body dementia, the second most common type of progressive dementia after Alzheimer's disease, causes a progressive decline in mental abilities.

Lewy body dementia, the second most common type of progressive dementia after Alzheimer's disease, causes a progressive decline in mental abilities. Diseases and Conditions Lewy body dementia By Mayo Clinic Staff Lewy body dementia, the second most common type of progressive dementia after Alzheimer's disease, causes a progressive decline in mental

More information

Your Visit to the Magnet Machine!

Your Visit to the Magnet Machine! Your Visit to the Magnet Machine! Hi and welcome! Are you ready for an exciting activity? You re going to be visiting the Magnet Machine! The official name for this Magnet Machine is the MRI machine. M

More information

Social Security Disability Insurance and young onset dementia: A guide for employers and employees

Social Security Disability Insurance and young onset dementia: A guide for employers and employees Social Security Disability Insurance and young onset dementia: A guide for employers and employees What is Social Security Disability Insurance? Social Security Disability Insurance (SSDI) is a payroll

More information

Bury Dementia Guide. A brief guide for people with dementia and memory problems, and their carers

Bury Dementia Guide. A brief guide for people with dementia and memory problems, and their carers Bury Dementia Guide A brief guide for people with dementia and memory problems, and their carers Contents Introduction - about this booklet 2 Memory problems 3 What is dementia? 4 Diagnosis and support

More information

Parkinson s Disease. What is Parkinson s Disease? Who Gets Parkinson s Disease? Symptoms

Parkinson s Disease. What is Parkinson s Disease? Who Gets Parkinson s Disease? Symptoms Parkinson s Disease What is Parkinson s Disease? Parkinson s Disease (PD) is a progressive, neurological disease that mainly affects movement. Parkinson s disease results from the destruction of nerve

More information

Background on Alzheimer s Disease

Background on Alzheimer s Disease DEMENTIA 12 Background on Alzheimer s Disease About Dementia Dementia is a general term for a group of brain disorders, of which Alzheimer s disease is the most common. Alzheimer s disease accounts for

More information

MS Learn Online Feature Presentation Understanding MS Research Robert Lisak, MD. Tom>> And I'm Tom Kimball. Welcome to MS Learn Online.

MS Learn Online Feature Presentation Understanding MS Research Robert Lisak, MD. Tom>> And I'm Tom Kimball. Welcome to MS Learn Online. Tracey>> Hi I'm Tracey Kimball MS Learn Online Feature Presentation Understanding MS Research Robert Lisak, MD Tom>> And I'm Tom Kimball. Welcome to MS Learn Online. Tracey>> There's so much to learn when

More information

Understanding Alzheimer s Disease

Understanding Alzheimer s Disease Understanding Alzheimer s Disease Table of Contents About this booklet...................... 1 What is Alzheimer s disease?............. 4 What happens when you have Alzheimer s disease?................

More information

Understanding Dementia

Understanding Dementia Dementia Handbook for Carers Essex Understanding Dementia What is dementia? 1 Summary of dementia symptoms 4 Medication and treatment 5 1 2 Dementia is the name for several conditions that lead to the

More information

Neurological Disorders

Neurological Disorders Neurological Disorders Grades 9-12 Driving Question: In what ways do neurological impairments affect brain function? Objectives: Students will be able to Describe how migraines, Alzheimer s disease, and

More information

Introduction Breast cancer is cancer that starts in the cells of the breast. Breast cancer happens mainly in women. But men can get it too.

Introduction Breast cancer is cancer that starts in the cells of the breast. Breast cancer happens mainly in women. But men can get it too. Male Breast Cancer Introduction Breast cancer is cancer that starts in the cells of the breast. Breast cancer happens mainly in women. But men can get it too. Many people do not know that men can get breast

More information

Alzheimer s and dementia: your questions answered

Alzheimer s and dementia: your questions answered Alzheimer s and dementia: your questions answered This booklet gives answers to some commonly-asked questions about Alzheimer s disease and dementia. Information in this booklet is for anyone who wants

More information

What is vascular dementia?

What is vascular dementia? alzheimers.org.uk What is vascular dementia? Vascular dementia is the second most common form of dementia after Alzheimer s disease. It is caused by problems in the supply of blood to the brain. This factsheet

More information

Parallel Issues, Behavioral Issues and Care Provider Struggles

Parallel Issues, Behavioral Issues and Care Provider Struggles Parallel Issues, Behavioral Issues and Care Provider Struggles C L A I R E B R A N N A N M O B I L E C L A S S E S A N D C O N S U L T I N G A P R I L 1 0 T H, 2 0 1 5 An Aging Population The number of

More information

Lewy's Body Dementia. user SaudiPEU

Lewy's Body Dementia. user SaudiPEU 2013 Lewy's Body Dementia user SaudiPEU 91 / 20 / 43 Lwey's Body Dementia What is a Lewy's body dementia? Lewy body dementia, the second most common type of progressive dementia after Alzheimer's disease,

More information

Understanding FTD Clinical Trials Continuing Education Training FTD Support Group Facilitators May 13, 2013

Understanding FTD Clinical Trials Continuing Education Training FTD Support Group Facilitators May 13, 2013 Understanding FTD Clinical Trials Continuing Education Training FTD Support Group Facilitators May 13, 2013 Our Shared Vision We envision a world where frontotemporal degeneration is understood, effectively

More information

TABLE OF CONTENTS. Introduction... 1. Preventing a Complex Disease Like AD is a Challenge... 3. AD Risk Factors We Can t Control...

TABLE OF CONTENTS. Introduction... 1. Preventing a Complex Disease Like AD is a Challenge... 3. AD Risk Factors We Can t Control... TABLE OF CONTENTS Introduction........................................... 1 Preventing a Complex Disease Like AD is a Challenge......... 3 AD Risk Factors We Can t Control......................... 3 The

More information

Pain and symptom management. For persons. Alzheimer s Disease and Hospice Care. What is Hospice Care? Hospice Can Help. Hospice

Pain and symptom management. For persons. Alzheimer s Disease and Hospice Care. What is Hospice Care? Hospice Can Help. Hospice Caregivers Guidance Pain management Hospice Can Help Assistance Compassion Support Hospice What is Hospice Care? Alzheimer s Disease and Hospice Care Presented by Hospice Foundation of America, in Partnership

More information

What Cancer Patients Need To Know

What Cancer Patients Need To Know Taking Part in Clinical Trials What Cancer Patients Need To Know NATIONAL INSTITUTES OF HEALTH National Cancer Institute Generous support for this publication was provided by Novartis Oncology. Taking

More information

BRCA Genes and Inherited Breast and Ovarian Cancer. Patient information leaflet

BRCA Genes and Inherited Breast and Ovarian Cancer. Patient information leaflet BRCA Genes and Inherited Breast and Ovarian Cancer Patient information leaflet This booklet has been written for people who have a personal or family history of breast and/or ovarian cancer that could

More information

Scientists don t yet fully

Scientists don t yet fully Alzheimer s Disease Genetics FACT SHEET Scientists don t yet fully understand what causes Alzheimer s disease. However, the more they learn about this devastating disease, the more they realize that genes*

More information

BBC LEARNING ENGLISH 6 Minute English Brain training

BBC LEARNING ENGLISH 6 Minute English Brain training BBC LEARNING ENGLISH 6 Minute English Brain training NB: This is not a word-for-word transcript Hello and welcome to 6 Minute English. I'm Watashi-wa Ni-ru. What did you say? Watashi-wa Ni-ru. 'I'm.' It's

More information

<ECE1778H> Submitted by: Jinyoung Kim (997864173) Rowa Karkokli (992424159)

<ECE1778H> Submitted by: Jinyoung Kim (997864173) Rowa Karkokli (992424159) Submitted by: Jinyoung Kim (997864173) Rowa Karkokli (992424159) Date: April 12, 2011 EXECITIVE SUMMARY: Dementia is a cognitive disorder resulting in loss of memory, changes in personality,

More information

Today in Canada, over 450,000 people over the age of 65, and 1/3 of those over 85, have Alzheimer s disease or a related disease.

Today in Canada, over 450,000 people over the age of 65, and 1/3 of those over 85, have Alzheimer s disease or a related disease. What is Alzheimer s disease? Alzheimer s disease is a type of dementia an illness of the brain that affects a person s ability to carry out daily activities. Memory, emotions, mood, behaviour and language

More information

Hearth Management, LLC

Hearth Management, LLC INSIGHT INTO Alzheimer s PROVIDED AS A PUBLIC SERVICE BY Hearth Management, LLC Premier Senior Living Communities FORWARD Because of the increasing problem of Alzheimer s disease within a rapidly expanding

More information

Pathophysiology of Alzheimer Disease

Pathophysiology of Alzheimer Disease Amyvid PET/CT Scan Pathophysiology of Alzheimer Disease β-amyloid neuritic plaques (black arrows) Neurofibrillary tangles (abnormally phosphorylated tau protein) (red arrow) Temporal cortex in AD, modified

More information

Alzheimer Disease (AD)

Alzheimer Disease (AD) 1 Alzheimer Disease (AD) 2 Alzheimer's disease is a progressive degenerative disease that attacks the brain and results in impaired memory, thinking and behavior. It was first described by Dr. Alois Alzheimer

More information

BBBT Podcast Transcript

BBBT Podcast Transcript BBBT Podcast Transcript About the BBBT Vendor: The Boulder Brain Trust, or BBBT, was founded in 2006 by Claudia Imhoff. Its mission is to leverage business intelligence for industry vendors, for its members,

More information

Questions/Answers on Dementia due to Alzheimer s Disease Presentation at Governor s Conference on Aging Friday, December 15, 2012 Raj C.

Questions/Answers on Dementia due to Alzheimer s Disease Presentation at Governor s Conference on Aging Friday, December 15, 2012 Raj C. Questions/Answers on Dementia due to Alzheimer s Disease Presentation at Governor s Conference on Aging Friday, December 15, 2012 Raj C. Shah, MD How many people are there in the United States? A little

More information

Thymus Cancer. This reference summary will help you better understand what thymus cancer is and what treatment options are available.

Thymus Cancer. This reference summary will help you better understand what thymus cancer is and what treatment options are available. Thymus Cancer Introduction Thymus cancer is a rare cancer. It starts in the small organ that lies in the upper chest under the breastbone. The thymus makes white blood cells that protect the body against

More information

Living well with dementia

Living well with dementia Living well with dementia alzheimers.org.uk Pauline Meakins, Information Worker Alzheimer s Society Dementia prevalence and cost to the economy 850,000 people with dementia in the UK by 2015 Soaring to

More information

NCRAD. Changing Concepts of Alzheimer's Disease. Inside this Issue Articles Changing Concepts of AD FAQs about New Diagnosis Guidelines The ADNI Study

NCRAD. Changing Concepts of Alzheimer's Disease. Inside this Issue Articles Changing Concepts of AD FAQs about New Diagnosis Guidelines The ADNI Study The National Cell Repository for Alzheimer s Disease (NCRAD) is a data and specimen collection source for families with Alzheimer disease (AD) or serious memory loss. Families having two or more living

More information

LOW HANGING FRUITS: PROJECTS THAT ARE CANDIDATES FOR BEING PURSUED IMMEDIATELY

LOW HANGING FRUITS: PROJECTS THAT ARE CANDIDATES FOR BEING PURSUED IMMEDIATELY S. No 1. (Semantic, Indian, Mining) Database crawler for Amyloid related info Peritoneal dialysis: risk factor analysis Project Objective Impact Confidence Remarks by Others 3 3 Develop a common mining

More information

10 warning signs of alzheimer s disease

10 warning signs of alzheimer s disease 10 warning signs of alzheimer s disease the compassion to care, the leadership to conquer Your memory often changes as you grow older. But memory loss that disrupts daily life is not a typical part of

More information

Regardless of the type of dementia, individuals can obtain information and support from the Alzheimer Society.

Regardless of the type of dementia, individuals can obtain information and support from the Alzheimer Society. Mental Health Dementia and Alzheimer s Disease Is Alzheimer s disease the same as dementia? Dementia is a syndrome consisting of a number of symptoms that include loss of memory, judgment and reasoning

More information

2 Treatments. In this section. Key points: Treatments 15 Drugs to treat dementia 16 Non-drug treatments 18 Treating depression and anxiety 21

2 Treatments. In this section. Key points: Treatments 15 Drugs to treat dementia 16 Non-drug treatments 18 Treating depression and anxiety 21 14 The dementia guide In this section Key points: 15 Drugs to treat dementia 16 Non-drug treatments 18 Treating depression and anxiety 1 Call the National Dementia Helpline on 0300 11 15 Key points: There

More information

Mesothelioma. 1995-2013, The Patient Education Institute, Inc. www.x-plain.com ocft0101 Last reviewed: 03/21/2013 1

Mesothelioma. 1995-2013, The Patient Education Institute, Inc. www.x-plain.com ocft0101 Last reviewed: 03/21/2013 1 Mesothelioma Introduction Mesothelioma is a type of cancer. It starts in the tissue that lines your lungs, stomach, heart, and other organs. This tissue is called mesothelium. Most people who get this

More information

alz.org/10signs Know the 10 signs

alz.org/10signs Know the 10 signs Know the 10 signs Your memory often changes as you grow older. But memory loss that disrupts daily life is not a typical part of aging. It may be a symptom of dementia. Dementia is a slow decline in memory,

More information

2012 Medical School for Actuaries Nov. 6-7, 2012 Session #1: Alzheimer s Disease

2012 Medical School for Actuaries Nov. 6-7, 2012 Session #1: Alzheimer s Disease 2012 Medical School for Actuaries Nov. 6-7, 2012 Session #1: Alzheimer s Disease Dylan Wint, M.D. ALZHEIMER DISEASE Dylan Wint, M.D. Lou Ruvo Center for Brain Health DEFINITIONS Cognitive related to thinking,

More information

Environmental enrichment mitigates cognitive deficits in a mouse model for Alzheimer s disease

Environmental enrichment mitigates cognitive deficits in a mouse model for Alzheimer s disease Environmental enrichment mitigates cognitive deficits in a mouse model for Alzheimer s disease Joanna L. Jankowsky California Institute of Technology Tatiana Melnikova, Daniel Fadale, Guilian Xu, Hilda

More information

Molecular Imaging and Prostate Cancer

Molecular Imaging and Prostate Cancer Molecular Imaging and Prostate Cancer Prostate cancer is the second leading cause of cancer death in American men, behind only lung cancer. Based on rates from 2004 2006, the National Cancer Institute

More information

Everyone has mild memory lapses from time to time. You go

Everyone has mild memory lapses from time to time. You go Coping With Memory Loss Everyone has mild memory lapses from time to time. You go from the kitchen to the bedroom to get something, only to find yourself wondering what you needed. You can t find your

More information

Neal Rouzier responds to the JAMA article on Men and Testosterone

Neal Rouzier responds to the JAMA article on Men and Testosterone Neal Rouzier responds to the JAMA article on Men and Testosterone On the first day the JAMA article was released I received 500 emails from physicians and patients requesting my opinion of the article

More information

Lewy body dementia Referral for a Diagnosis

Lewy body dementia Referral for a Diagnosis THE Lewy Body society The more people who know, the fewer people who suffer Lewy body dementia Referral for a Diagnosis Lewy Body Dementias REFERRAL FOR A DIAGNOSIS In the UK people with all forms of dementia

More information

The Family Library. Understanding Strokes. What is a stroke?

The Family Library. Understanding Strokes. What is a stroke? The Family Library Understanding Strokes What is a stroke? A stroke, sometimes called a brain attack, occurs when the blood flow to the brain is interrupted in some way. Brain cells in a specific area

More information

Cholinesterase inhibitors and memantine use for Alzheimer s disease TOPIC REVIEW

Cholinesterase inhibitors and memantine use for Alzheimer s disease TOPIC REVIEW Cholinesterase inhibitors and memantine use for Alzheimer s disease TOPIC REVIEW Diagnosis of Dementia : DSM-IV criteria Loss of memory and one or more other cognitive abilities Aphasia Apraxia Agnosia

More information

The brain s game of telephone

The brain s game of telephone Huntington s disease research news. In plain language. Written by scientists. For the global HD community. A multiple sclerosis drug that works for Huntington's disease: the real deal or too good to be

More information

Coping with Caring: Reducing Stress and Improving Your Quality of Life 1

Coping with Caring: Reducing Stress and Improving Your Quality of Life 1 Leader Version Coping with Caring: Reducing Stress and Improving Your Quality of Life 1 1 Adapted from original (Delores Gallagher-Thompson and colleagues, Stanford University School of Medicine, 2002)

More information

https://secure2.convio.net/adarda/admin/commcenter? =em_previ...

https://secure2.convio.net/adarda/admin/commcenter? =em_previ... Subject: Public Health E-News: Research Roundup from the Alzheimer's Association International Conference (AAIC) 2012 HTML New Research Highlights Possible Avenues for Public Health Efforts Against Alzheimer's

More information

University of California, Irvine. (December 4, 2010, Sapporo, Japan)

University of California, Irvine. (December 4, 2010, Sapporo, Japan) University of California, Irvine 1 2 (December 4, 2010, Sapporo, Japan) This article is an invaluable record of an interview with Prof. Ruth Mulnard, who is a nursing scientist as well as a clinician in

More information

Sometimes people live in homes where a parent or other family member drinks too

Sometimes people live in homes where a parent or other family member drinks too Alcohol and Drugs What If I'm Concerned About Someone Else's Drinking? Sometimes people live in homes where a parent or other family member drinks too much. This may make you angry, scared, and depressed.

More information

Diseases of the Nervous System. Neal G. Simon, Ph.D. Professor, Dept of Biological Sciences Lehigh University

Diseases of the Nervous System. Neal G. Simon, Ph.D. Professor, Dept of Biological Sciences Lehigh University Diseases of the Nervous System Neal G. Simon, Ph.D. Professor, Dept of Biological Sciences Lehigh University Outline A. Stress-related Disorders 1. Emotional Circuitry: Key Components 2. The Hypothalamic

More information

Tom>> In an interview with medical correspondent Kate Milliken, Dr. LaRocca explains what health services research is and what they ve been learning.

Tom>> In an interview with medical correspondent Kate Milliken, Dr. LaRocca explains what health services research is and what they ve been learning. MS Learn Online Feature Presentation Health Services Research Nicholas LaRocca, PhD Tracey>> Hello, I m Tracey Kimball Tom>> And I m Tom Kimball. Welcome to MS Learn Online. When we talk about MS research

More information

WHEN YOU SUSPECT ALZHEIMER S DISEASE

WHEN YOU SUSPECT ALZHEIMER S DISEASE WHEN YOU SUSPECT ALZHEIMER S DISEASE For more information, please contact Alzheimer s & Dementia Services of Northern Indiana: 922 E. Colfax South Bend, IN 46617 (888) 303-0180, toll-free, or (574) 232-4121

More information

10 warning signs of Alzheimer s disease

10 warning signs of Alzheimer s disease 10 warning signs of Alzheimer s disease Memory loss that disrupts daily life Challenges in planning or solving problems Difficulty completing familiar tasks Confusion with time or place Trouble understanding

More information

OLLI Course: Dr Jeffrey N. Keller

OLLI Course: Dr Jeffrey N. Keller OLLI Course: Dr Jeffrey N. Keller Director, Institute for Dementia Research and Prevention Director, Alzheimer Disease Cooperative Study Site Edward G. Schlieder/Hibernia National Bank Chair Professor,

More information

Alzheimer s and dementia: your questions answered

Alzheimer s and dementia: your questions answered Alzheimer s and dementia: your questions answered Contents The basics 04 Questions about risk 08 Questions about diet 09 Questions about keeping active 13 Other medical conditions 14 and dementia Further

More information

Acute Myeloid Leukemia

Acute Myeloid Leukemia Acute Myeloid Leukemia Introduction Leukemia is cancer of the white blood cells. The increased number of these cells leads to overcrowding of healthy blood cells. As a result, the healthy cells are not

More information

What Brain Changes Are Normal for Older Adults?

What Brain Changes Are Normal for Older Adults? Losing keys, misplacing a wallet, or forgetting someone s name are common experiences. But for people nearing or over age 65, such memory lapses can be frightening. They wonder if they have Alzheimer s

More information

Title: Answers to 5 Common Questions About Texas Health Insurance. Word Count: 545

Title: Answers to 5 Common Questions About Texas Health Insurance. Word Count: 545 Title: Answers to 5 Common Questions About Texas Health Insurance Word Count: 545 Summary: Although Texas ranks the highest among U.S. states in the number of uninsured residents, obtaining affordable

More information

Current Industry Neuroimaging Experience in Clinical Trials Jerome Barakos, M.D.

Current Industry Neuroimaging Experience in Clinical Trials Jerome Barakos, M.D. Current Industry Neuroimaging Experience in Clinical Trials Jerome Barakos, M.D. Melbourne Australia March 28, 2012 Synarc Experience and Expertise Largest imaging service provider dedicated to clinical

More information

Mammograms & Breast Health. An Information Guide for Women U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES. Centers for Disease Control and Prevention

Mammograms & Breast Health. An Information Guide for Women U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES. Centers for Disease Control and Prevention U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Mammograms & Breast Health An Information Guide for Women This booklet was developed by the Centers for Disease Control

More information

Delirium. The signs of delirium are managed by treating the underlying cause of the medical condition causing the delirium.

Delirium. The signs of delirium are managed by treating the underlying cause of the medical condition causing the delirium. Delirium Introduction Delirium is a complex symptom where a person becomes confused and shows significant changes in behavior and mental state. Signs of delirium include problems with attention and awareness,

More information

Worried about your memory?

Worried about your memory? Worried about your memory? I remember that birthday as clear as can be... but it s a struggle to recall what I did this morning. Should I worry? What can cause memory problems? What is dementia? This booklet

More information

OCKHAM S RAZOR. September 2005 ALZHEIMER S DISEASE: THE RISE AND FALL OF A CONCEPT

OCKHAM S RAZOR. September 2005 ALZHEIMER S DISEASE: THE RISE AND FALL OF A CONCEPT OCKHAM S RAZOR September 2005 ALZHEIMER S DISEASE: THE RISE AND FALL OF A CONCEPT Jonathan Stone 1 and Karen Cullen 2 1 Research School of Biological Sciences, Institute of Advanced Studies, Australian

More information

Lung cancer (non-small-cell)

Lung cancer (non-small-cell) Patient information from the BMJ Group Lung cancer (non-small-cell) It can be devastating to find out that you or someone close to you has lung cancer. You will have to make some important decisions about

More information