MSD WORLDWIDE BUSINESS DEVELOPMENT & LICENSING

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1 MSD WORLDWIDE BUSINESS DEVELOPMENT & LICENSING Manfred Horst Director, Business Development & Licensing MSD Biovaria Munich, May 11, 2015 *MSD IS KNOWN AS MERCK & CO. IN THE UNITED STATES AND CANADA

2 FORWARD-LOOKING STATEMENT This presentation includes forward-looking statements within the meaning of the safe harbor provisions of the United States Private Securities Litigation Reform Act of These statements are based upon the current beliefs and expectations of MSD s management and are subject to significant risks and uncertainties. There can be no guarantees with respect to pipeline products that the products will receive the necessary regulatory approvals or that they will prove to be commercially successful. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements. Risks and uncertainties include, but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and health care legislation in the United States and internationally; global trends toward health care cost containment; technological advances, new products and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approval; MSD s ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of MSD s patents and other protections for innovative products; and the exposure to litigation, including patent litigation, and/or regulatory actions. MSD undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise. Additional factors that could cause results to differ materially from those described in the forward-looking statements can be found in MSD s 2014 Annual Report on Form 10-K and the company s other filings with the Securities and Exchange Commission (SEC) available at the SEC s Internet site ( 2

3 You ve discovered something significant Now discover MSD! Your MSD contact for: France, Germany, Israel, Italy, Russia and Switzerland Manfred Horst, MD, PhD, MBA Director, Business Development & Licensing, MRL MSD 34, Avenue Léonard de Vinci Courbevoie Cedex, France Phone:

4 Key Company Facts COMPANY NAME We operate as MSD globally except for in the US and Canada, where we operate as Merck. BUSINESSES Pharmaceuticals, Vaccines, Biologics and Animal Health 2014 FINANCIALS GLOBAL OPERATIONS Revenue: $42.2 billion R&D Expense: $7.2 billion MSD operates in more than 140 countries EMPLOYEES Approximately 70,

5 Positioned for Long-Term Growth through Innovation 2015 HOLDS A SUITE OF OPPORTUNITIES FOR MSD Seven Product Launches - KEYTRUDA (advanced melanoma) - BELSOMRA - ZONTIVITY - GARDASIL 9 - GRASTEK / RAGWITEK - VANIHEP (Japan) - ZERBAXA* Filings in HCV, Lung Cancer and Osteoporosis Regulatory Action for Multiple Programs Targeting Business Development & Licensing to Drive Long-Term Value *currently marketed by Cubist 5

6 Partnerships are Key to our Success Approximately 58% of MSD s 2014 human health revenue is attributable to alliance products and patents JANUVIA / JANUMET* REMICADE ZETIA / VYTORIN GARDASIL COZAAR/HYZAAR ZOSTAVAX Licensed Products or Patents: 58% of revenue *Method of use patent Revenue includes 50% of full year JV revenue (Sanofi-Pasteur MSD) 6

7 MSD Scouts brought forth opportunities And Served as Gatekeepers as well MSD Business Development & Licensing Key Acquisitions & Alliances Signed 697 Confidentiality-In agreements 1290 Opportunities reviewed 8672 Opportunities Received But No does not mean Never

8 A New Organization with Increased Global Reach MSD s new BD&L organization resides fully within Merck Research Laboratories (MRL) Growing strategically-located BD&L bases in Boston, San Francisco, London and Asia The MRL Venture Fund (MRLV) is a key component of our commitment to external innovation Iain Dukes, Senior Vice President, BD&L Karen Akinsanya Early-Stage Assessment US & EU (London) Ji Li Late-Stage Assessment Ben Thorner BD&L Boston & San Francisco Joanne Smith-Farrell Transactions Meeta Chatterjee Business Strategy & Operations BD&L, Far East Josh Resnick, MRL Ventures 8

9 2013 Present: MSD BD&L Has a New Approach to Accessing External Innovation OPPORTUNISTIC APPROACH We are interested in any and all opportunities that have a strong scientific rationale No limits surrounding therapeutic area, stage of development or modality FOCUS ON EMERGING SCIENCE A sharper focus on emerging areas of science with an aim to build programs around the most promising approaches UNAMBIGUOUS, PROMOTABLE ADVANTAGES We are seeking programs that will deliver products with unambiguous, promotable advantages over available therapies rather than differentiation through an improved safety profile alone 9

10 Changing our Focus Then Franchise driven Defined areas of interest An emphasis on programs with POC already established Dispersed scout organization Acquisition of cutting edge platform technologies without specific product opportunities Now Idea driven Partnering early and late in areas of emerging science Applying our capabilities to breakthrough opportunities with potential for unambiguous promotable advantages. Regional BD&L hubs Enabling our pipeline and programs via cutting edge technology partnerships 10

11 Seeking Innovation at the Source: MSD Business Development & Licensing Hubs We are building Business Development & Licensing hubs in key geographies that are epicenters of scientific advancement: Boston San Francisco London Far East The strategy focuses on: Being local to build relationships with leading scientists Finding and transacting on great opportunities to supplement the MSD pipeline Raising the profile of MSD in the scientific and business communities Building quality relationships for hands-on collaboration between our scientists and external academic and biotech groups 11

12 European Business Development & Licensing Hub Based in London Karen Akinsanya Head, Early-Stage Assessment and Search & Evaluation for the European Hub Jeanette Evans Head, International Transactions Seeking partnerships with academic and biotech innovators working on therapeutic breakthroughs and enabling technologies to benefit patients around the world. Manfred Horst France, Germany, Israel, Italy, Russian and Switzerland Erik Lund Austria, Baltic States, Benelux, Central EU, Greece, The Balkans, Turkey and Scandinavia Rob Pinnock Ireland, Portugal, South Africa, Spain and United Kingdom Karen McGurk Transactions 12

13 DISCOVERING A BIG IDEA. A novel approach, robust scientific data and a vision for your innovation to bring new hope to patients with serious diseases. DELIVERING BREAKTHROUGH MEDICINES. Integrated global resources for discovery research, clinical development, regulatory, commercial strategy and a sales organization. 13

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